Product References
Therapeutic potential of FLT4-targeting peptide in acute myeloid leukemia.
Cancer immunology, immunotherapy : CII
Lee JY,Park S,Han AR,Hwang HS,Kim HJ
17-7311-82 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic value of functionally modulating lymphocytes using a peptide targeting FLT4 and proposed the development of advanced therapeutic approaches against AML by using immune cells.
Fri Sep 01 00:00:00 EDT 2023
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Neurology(R) neuroimmunology & neuroinflammation
Gupta S,Simic M,Sagan SA,Shepherd C,Duecker J,Sobel RA,Dandekar R,Wu GF,Wu W,Pak JE,Hauser SL,Lim W,Wilson MR,Zamvil SS
17-7311-82 was used in Flow cytometry/Cell sorting to observe that anti-CD19 CAR-T cells ameliorated experimental autoimmune encephalomyelitis and thoroughly deplete B cells in peripheral tissues and in the CNS.
Wed Mar 01 00:00:00 EST 2023
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Autophagy
Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z
17-7311-82 was used in Flow Cytometry to demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1:.
Sat Apr 01 00:00:00 EDT 2023
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Autophagy
Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z
17-7311-82 was used in Flow Cytometry to demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1:.
Sat Apr 01 00:00:00 EDT 2023
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
17-7311-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants.
Vaccines
Zhang Y,Tan W,Lou Z,Zhao Y,Zhang J,Liang H,Li N,Zhu X,Ding L,Huang B,Zhou W,Guo Y,Yang Z,Qiao Y,He Z,Ma B,He Y,Zhu D,Wang Z,Chang Z,Zhao X,Wang W,Xu Y,Zhu H,Zheng X,Wang C,Xu G,Wu G,Wang H,Yang X
17-7311-82 was used in Flow cytometry/Cell sorting to demonstrate that the inactivated Omicron vaccine is safe and effective in recalling immune responses to the HB02, Omicron, and Delta viruses after one or two doses of BBIBP-CorV.
Tue Jul 19 00:00:00 EDT 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
17-7311-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy.
Biomedicines
Liu W,Chen H,Zhu Z,Liu Z,Ma C,Lee YJ,Bartlett DL,Guo ZS
17-7311-82 was used in Flow cytometry/Cell sorting to demonstrate that erastin can exert cytotoxicity on cancer cells via ferroptosis, but has little effect on immune activity by itself.
Wed Jun 15 00:00:00 EDT 2022
Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung.
Cell reports
Kawasaki T,Ikegawa M,Yunoki K,Otani H,Ori D,Ishii KJ,Kuroda E,Takamura S,Kitabatake M,Ito T,Isotani A,Kawai T
17-7311-82 was used in Flow cytometry/Cell sorting to suggest that AMs instruct a rapid expansion of antigen-specific CD8+ T cells in lung, which protect the host from respiratory virus infection.
Tue Dec 13 00:00:00 EST 2022
PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1+CD8+ Terminal Effector T Cells and Promotes Cancer Development.
Journal of immunology (Baltimore, Md. : 1950)
Zheng Y,Chen Z,Zhou B,Chen S,Han L,Chen N,Ma Y,Xie G,Yang J,Nie H,Shen L
17-7311-82 was used in Flow cytometry/Cell sorting to validate the importance of targeting PRMT5 in tumor treatment, because PRMT5 deficiency enforced Klrg1+ terminal CD8+ T cell development and eliminated antitumor activity.
Sat Jan 15 00:00:00 EST 2022
Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis.
PLoS pathogens
Shallberg LA,Phan AT,Christian DA,Perry JA,Haskins BE,Beiting DP,Harris TH,Koshy AA,Hunter CA
17-7311-82 was used in flow cytometry to highlight that recent TCR activation contributes to the phenotypic heterogeneity of the CD8+ T cell response but suggest that this process has a limited impact on memory populations at acute and chronic stages of infection.
Wed Jun 01 00:00:00 EDT 2022
Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Cancer research
Chowdhury S,Kar A,Bhowmik D,Gautam A,Basak D,Sarkar I,Ghosh P,Sarkar D,Deka A,Chakraborty P,Mukhopadhyay A,Mehrotra S,Basak S,Paul S,Chatterjee S
17-7311-82 was used in Flow cytometry/Cell sorting to delineate the metabolic configuration of CD8+ T cells required for stable effector function in tumors and present an affordable approach to promote the efficacy of CD8+ T cells for adoptive T-cell therapy.
Mon Jul 18 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
17-7311-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
17-7311-82 was used in Flow cytometry/Cell sorting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Cell
Ennerfelt H,Frost EL,Shapiro DA,Holliday C,Zengeler KE,Voithofer G,Bolte AC,Lammert CR,Kulas JA,Ulland TK,Lukens JR
17-7311-82 was used in flow cytometry to study the critical intracellular molecules that orchestrate neuroprotective functions of microglia.
Thu Oct 27 00:00:00 EDT 2022
Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants.
Vaccines
Zhang Y,Tan W,Lou Z,Huang B,Zhou W,Zhao Y,Zhang J,Liang H,Li N,Zhu X,Ding L,Guo Y,He Z,He Y,Wang Z,Ma B,Ma M,Zhao S,Chang Z,Zhao X,Zheng X,Wu G,Wang H,Yang X
17-7311-82 was used in Flow cytometry/Cell sorting to suggest that the multivalent COVID-19 inactivated vaccine can provide broad spectrum protection against HB02 and other virus variants in humoral and cellular immunity.
Thu Jun 16 00:00:00 EDT 2022
Human poliovirus receptor contributes to biliary atresia pathogenesis by exacerbating natural-killer-cell-mediated bile duct injury.
Liver international : official journal of the International Association for the Study of the Liver
Li Y,Li TY,Qi Q,Zhang MT,Tong MX,Su PJ,Zhang ZB
17-7311-82 was used in Flow cytometry/Cell sorting to show that poliovirus receptor contributes to BA pathogenesis by regulating NK cell-mediated bile duct injury; PVR has the value as a biomarker of BA.
Thu Dec 01 00:00:00 EST 2022
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer.
Nature immunology
Osman A,Yan B,Li Y,Pavelko KD,Quandt J,Saadalla A,Singh MP,Kazemian M,Gounari F,Khazaie K
17-7311-82 was used in Functional assay to conclude that Treg cell-specific TCF-1 expression differentially regulates TH17-mediated inflammation and T cell cytotoxicity, and can determine colorectal cancer outcome.
Wed Sep 01 00:00:00 EDT 2021
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
17-7311 was used in Flow cytometry/Cell sorting to reveal that the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.
Tue Jun 01 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
17-7311 was used in Flow cytometry/Cell sorting to demonstrate cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice.
Mon Apr 05 00:00:00 EDT 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
17-7311 was used in Flow cytometry/Cell sorting to identify a new role for AIM2 in controlling the onset of EAE.
Mon May 03 00:00:00 EDT 2021
Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.
EMBO molecular medicine
Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR
17-7311-82 was used in Flow Cytometry to test the impact of pre-erythrocytic malaria immunogenicity on the immune system response.
Fri Apr 09 00:00:00 EDT 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
17-7311 was used in Flow cytometry/Cell sorting to show the phenomenon of brown adipose tissue 'whitening' in old mice, induced by IFN-γ secretion by senescent T cells.
Tue Mar 23 00:00:00 EDT 2021
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation.
Frontiers in cell and developmental biology
Li Z,Zhang W,Luo F,Li J,Yang W,Zhu B,Wu Q,Wang X,Sun C,Xie Y,Xu B,Wang Z,Qian F,Chen J,Wan Y,Hu W
17-7311-82 was used in Flow Cytometry to investigate the protective effects of Schistosoma japonicum on allergic airway inflammation.
Sat Jun 26 00:00:00 EDT 2021
Dynamic changes in the systemic immune responses of spinal cord injury model mice.
Neural regeneration research
Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B
17-7311 was used in Flow cytometry/Cell sorting to decipher the dynamics of systemic immune responses, initiated by spinal cord injury.
Mon Feb 01 00:00:00 EST 2021
Peptides Targeting Fms-Related Tyrosine Kinase-4 Activate the Function of Natural Killer Cells in Acute Myeloid Leukemia.
International journal of stem cells
Park S,Kim HJ,Hwang HS,Han AR
17-7311-82 was used in Flow Cytometry to show that there was a trend toward a reduction in leukemic blasts in the BM, spleen, and liver from the AML mice, when we compared the effects of combinational treatments.
Tue Nov 30 00:00:00 EST 2021
Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.
Cell death discovery
Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y
17-7311-82 was used in Flow Cytometry to reveal Wip1 affects MSCs immunomodulation by regulating the expression of IFN-α/BST2.
Fri Oct 29 00:00:00 EDT 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
17-7311-82 was used in Flow Cytometry to show that IL-22, a cytokine produced by RORγt+ lymphocytes inhibits IL-13-induced tuft cell differentiation in vitro, and suppresses the tuft cell-type 2 immune circuit and small intestine lengthening in vivo, highlighting its key role in gut tissue remodeling.
Thu Jul 22 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
17-7311-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Nature immunology
Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY
17-7311-82 was used in flow cytometry to show that Treg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis.
Wed Sep 01 00:00:00 EDT 2021
Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing.
Scientific reports
Nato G,Corti A,Parmigiani E,Jachetti E,Lecis D,Colombo MP,Delia D,Buffo A,Magrassi L
17-7311-82 was used in Flow Cytometry to monitor xeno-transplanted human neural precursor cells derived from induced pluripotent stem cells into the cerebellum and brainstem of mice and rats during prenatal development or the first postnatal week.
Tue Jan 12 00:00:00 EST 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
17-7311 was used in Flow cytometry/Cell sorting to test a hypothesis that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease-like brain β-amyloid (Aβ) pathology.
Sat May 01 00:00:00 EDT 2021
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Nature communications
Wu M,Xia X,Hu J,Fowlkes NW,Li S
17-7311-82 was used in Flow Cytometry to yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.
Wed Jun 09 00:00:00 EDT 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
17-7311-82 was used in Flow Cytometry to provide a window of opportunity for replication of oncolytic VSV and rationale for a paradigm change in oncolytic virotherapy, whereby immune responses could be intentionally induced against a VSV-encoded melanoma-associated antigen to improve safety without abrogating oncolysis.
Tue Jul 27 00:00:00 EDT 2021
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
17-7311-82 was used in T-Cell Activation to propose that PTENα protects tumor from T cell killing and thus PTENα is a potential target in antitumor immunotherapy.
Thu Aug 26 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
17-7311-82 was used in Flow cytometry/Cell sorting to suggest that early secretion of IL-12p40 monomers by sentinel cells at the infection site may help prepare distal host tissues for potential pathogen arrival.
Tue Oct 12 00:00:00 EDT 2021
IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine.
Antioxidants (Basel, Switzerland)
Roux C,Mucciolo G,Kopecka J,Novelli F,Riganti C,Cappello P
17-7311-82 was used in Flow Cytometry to study how IL17A inhibition modulates macrophage differentiation and metabolism in the presence or absence of gemcitabine.
Wed Mar 10 00:00:00 EST 2021
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Cell
Sun J,Zhuang Z,Zheng J,Li K,Wong RL,Liu D,Huang J,He J,Zhu A,Zhao J,Li X,Xi Y,Chen R,Alshukairi AN,Chen Z,Zhang Z,Chen C,Huang X,Li F,Lai X,Chen D,Wen L,Zhuo J,Zhang Y,Wang Y,Huang S,Dai J,Shi Y,Zheng K,Leidinger MR,Chen J,Li Y,Zhong N,Meyerholz DK,McCray PB,Perlman S,Zhao J
17-7311 was used in Flow cytometry/Cell sorting to describe a murine model of immediate utility to investigate COVID-19 pathogenesis and new therapies to treat it.
Thu Aug 06 00:00:00 EDT 2020
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
17-7311-82 was used in Flow Cytometry to reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
Thu Jan 09 00:00:00 EST 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
17-7311 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Immunity
Beltra JC,Manne S,Abdel-Hakeem MS,Kurachi M,Giles JR,Chen Z,Casella V,Ngiow SF,Khan O,Huang YJ,Yan P,Nzingha K,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Wherry EJ
17-7311-82 was used in Flow cytometry/Cell sorting to reveal a four-stage developmental hierarchy for Tex cells and define the molecular, transcriptional, and epigenetic mechanisms that could provide opportunities to improve cancer immunotherapy.
Tue May 19 00:00:00 EDT 2020
A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy.
Nature nanotechnology
Xu J,Lv J,Zhuang Q,Yang Z,Cao Z,Xu L,Pei P,Wang C,Wu H,Dong Z,Chao Y,Wang C,Yang K,Peng R,Cheng Y,Liu Z
17-7311-82 was used in Flow Cytometry to offer a simple and general strategy for the preparation of personalized cancer vaccines to prevent post-operative cancer recurrence and metastasis.
Tue Dec 01 00:00:00 EST 2020
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells.
Cell metabolism
Rosser EC,Piper CJM,Matei DE,Blair PA,Rendeiro AF,Orford M,Alber DG,Krausgruber T,Catalan D,Klein N,Manson JJ,Drozdov I,Bock C,Wedderburn LR,Eaton S,Mauri C
17-7311 was used in Flow cytometry/Cell sorting to investigate butyrate supplementation as a potential therapy for the amelioration of systemic autoimmune disorders.
Tue Apr 07 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
17-7311 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
17-7311 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 EDT 2020
IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.
Molecular medicine reports
Liu M,Li Z,Yao W,Zeng X,Wang L,Cheng J,Ma B,Zhang R,Min W,Wang H
17-7311-82 was used in Flow Cytometry to investigate whether an iindoleamine 2,3‚dioxygenase (IDO) inhibitor synergized with radiotherapy (RT) can further inhibit tumor growth.
Wed Jan 01 00:00:00 EST 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
17-7311 was used in Immunocytochemistry to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.
Frontiers in immunology
Sjaastad FV,Kucaba TA,Dileepan T,Swanson W,Dail C,Cabrera-Perez J,Murphy KA,Badovinac VP,Griffith TS
17-7311-82 was used in Flow Cytometry to show CLP-induced sepsis alters the number and function of Ag-specific memory CD4 T cells, which contributes (in part) to the characteristic long-lasting immunoparalysis seen after sepsis.
Mon Apr 19 00:00:00 EDT 2021
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
17-7311 was used in Flow cytometry/Cell sorting to provide a framework for effective vaccination against cancer-associated herpesviruses through the elimination of latency and key immune evasion mechanisms from the pathogen.
Thu Nov 05 00:00:00 EST 2020
Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.
International journal of biological sciences
Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X
17-7311 was used in Flow cytometry/Cell sorting to indicate that G-MDSC elevation plays a crucial role in asthmatic mice.
Fri Nov 12 00:00:00 EST 2021
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
17-7311-82 was used in Flow Cytometry to investigate the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss.
Wed May 13 00:00:00 EDT 2020
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity.
Cell reports
Khouili SC,Cook ECL,Hernández-García E,Martínez-López M,Conde-Garrosa R,Iborra S
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that SHP-1 inhibition improves CD11c+ cell-based vaccination against the parasite.
Tue Dec 01 00:00:00 EST 2020
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
17-7311 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
BCG vaccination reduces the mortality of Mycobacterium tuberculosis-infected type 2 diabetes mellitus mice.
JCI insight
Radhakrishnan RK,Thandi RS,Tripathi D,Paidipally P,McAllister MK,Mulik S,Samten B,Vankayalapati R
17-7311-82 was used in Flow cytometry/Cell sorting to suggest a potentially novel role for BCG in preventing excess inflammation and mortality in T2DM mice infected with Mtb.
Thu Mar 12 00:00:00 EDT 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
17-7311 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 EDT 2020
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
17-7311-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Science signaling
Jun JE,Kulhanek KR,Chen H,Chakraborty A,Roose JP
17-7311 was used in Flow cytometry/Cell sorting to investigate how both classical and alternative p38 pathways contribute to T cell activation and therefore the immune balance.
Tue Jul 23 00:00:00 EDT 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
17-7311-82 was used in Flow Cytometry to show ROP16III in type III strain Toxoplasma gondii can influence the subacute CNS immune response and mediate parasitic survival and persistence.
Tue Oct 01 00:00:00 EDT 2019
Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.
Molecular therapy oncolytics
Zhu Y,Hu X,Feng L,Yang Z,Zhou L,Duan X,Cheng S,Zhang W,Liu B,Zhang K
17-7311-82 was used in Flow Cytometry to develop a novel oncolytic herpes simplex virus 2 (HSV2) encoding an anti-human programmed cell death 1 (PD-1) monoclonal antibody (oHSV2-aPD1) and demostrate its therapeutic efficacy.
Fri Dec 20 00:00:00 EST 2019
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
17-7311 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
17-7311-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.
Nature communications
Luu M,Pautz S,Kohl V,Singh R,Romero R,Lucas S,Hofmann J,Raifer H,Vachharajani N,Carrascosa LC,Lamp B,Nist A,Stiewe T,Shaul Y,Adhikary T,Zaiss MM,Lauth M,Steinhoff U,Visekruna A
17-7311-82 was used in Flow Cytometry to show that pentanoate, a physiologically abundant SCFA, is a potent regulator of immunometabolism.
Fri Feb 15 00:00:00 EST 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
17-7311 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.
Nature communications
Kang YH,Biswas A,Field M,Snapper SB
17-7311 was used in Flow cytometry/Cell sorting to reveal a critical perspective on JAK-STAT1 signalling that might apply to multiple inflammatory diseases.
Fri Feb 22 00:00:00 EST 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
17-7311-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
17-7311 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
17-7311 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.
Frontiers in immunology
Haug M,Brede G,Håkerud M,Nedberg AG,Gederaas OA,Flo TH,Edwards VT,Selbo PK,Høgset A,Halaas Ø
17-7311 was used in Flow cytometry/Cell sorting to study the ability of photochemical internalisation as a vaccination technology to induce priming of cancer-specific CD8+ cytotoxic T lymphocytes.
Mon Jun 24 00:00:00 EDT 2019
Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice.
PLoS pathogens
Skalski JH,Limon JJ,Sharma P,Gargus MD,Nguyen C,Tang J,Coelho AL,Hogaboam CM,Crother TR,Underhill DM
17-7311 was used in Flow cytometry/Cell sorting to investigate the effects of the population expansion of commensal fungus Wallemia mellicola without overgrowth of the total fungal community.
Sat Sep 01 00:00:00 EDT 2018
Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.
Acta neuropathologica communications
Warford JR,Lamport AC,Clements DR,Malone A,Kennedy BE,Kim Y,Gujar SA,Hoskin DW,Easton AS
17-7311 was used in Flow cytometry/Cell sorting to study surfen, an agent that binds both heparan sulphate proteoglycans and chondroitin sulphate proteoglycans.
Thu Jan 04 00:00:00 EST 2018
Protective immune mechanisms of Yifei Tongluo, a Chinese herb formulation, in the treatment of mycobacterial infection.
PloS one
Fan X,Li N,Wang X,Zhang J,Xu M,Liu X,Wang B
17-7311 was used in Flow cytometry/Cell sorting to establish the mechanisms of the effects of traditional Chinese medicine has on immune regulation with a mouse lung infection model.
Tue Feb 26 00:00:00 EST 2019
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
17-7311 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
Kitagawa Y,Ohkura N,Kidani Y,Vandenbon A,Hirota K,Kawakami R,Yasuda K,Motooka D,Nakamura S,Kondo M,Taniuchi I,Kohwi-Shigematsu T,Sakaguchi S
17-7311 was used in Flow cytometry/Cell sorting to suggest that Satb1-dependent Treg cell-specific super-enhancer activation is crucial for Treg cell lineage specification in the thymus.
Wed Feb 01 00:00:00 EST 2017
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
17-7311 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 EDT 2017
Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Circulation research
Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R
17-7311 was used in Neutralization experiments to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.
Fri Mar 31 00:00:00 EDT 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
17-7311 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy.
Cancer research
Bucsek MJ,Qiao G,MacDonald CR,Giridharan T,Evans L,Niedzwecki B,Liu H,Kokolus KM,Eng JW,Messmer MN,Attwood K,Abrams SI,Hylander BL,Repasky EA
Sun Oct 15 00:00:00 EDT 2017
Dendritic Cells Cross-Present Immunogenic Lentivector-Encoded Antigen from Transduced Cells to Prime Functional T Cell Immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Hotblack A,Seshadri S,Zhang L,Hamrang-Yousefi S,Chakraverty R,Escors D,Bennett CL
17-7311 was used in Flow cytometry/Cell sorting to suggest that DCs cross-present immunogenic antigen from LV-transduced cells, thereby facilitating prolonged activation of T cells in the absence of circulating LV particles.
Wed Feb 01 00:00:00 EST 2017
Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.
Frontiers in immunology
Saroha A,Pewzner-Jung Y,Ferreira NS,Sharma P,Jouan Y,Kelly SL,Feldmesser E,Merrill AH,Trottein F,Paget C,Lang KS,Futerman AH
17-7311 was used in Flow cytometry/Cell sorting to identify a role for very-long acyl chain sphingolipids in invariant natural killer T cell maturation in the thymus and homeostasis in the liver.
Wed Nov 20 00:00:00 EST 2019
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.
Frontiers in immunology
Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL
Wed Nov 20 00:00:00 EST 2019
Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection.
PLoS pathogens
Sia JK,Bizzell E,Madan-Lala R,Rengarajan J
17-7311 was used in Flow cytometry/Cell sorting to determine the mechanism by which dendritic cells generate antigen specific T helper cells in response to Mycobacterium tuberculosis infection.
Tue Aug 01 00:00:00 EDT 2017
Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1.
Immunology and cell biology
Gurung HR,Carr MM,Carr DJ
17-7311 was used in Flow cytometry/Cell sorting to suggest that newly created lymphatic vessels in the cornea driven by HSV-1 infection are critical in the delivery of soluble viral antigen to the draining lymph node.
Sun Jan 01 00:00:00 EST 2017
Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.
Journal of immunology (Baltimore, Md. : 1950)
Kim YH,Kumar A,Chang CH,Pyaram K
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of reactive oxygen species in natural killer T cell function.
Wed Nov 15 00:00:00 EST 2017
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
17-7311 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
Mon May 01 00:00:00 EDT 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
17-7311 was used in Flow cytometry/Cell sorting to investigate how ABX-induced microbial diversity perturbations during post-natal stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine model of AD.
Tue Sep 05 00:00:00 EDT 2017
The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages.
Frontiers in cellular and infection microbiology
Dwivedi VP,Bhattacharya D,Yadav V,Singh DK,Kumar S,Singh M,Ojha D,Ranganathan A,Van Kaer L,Chattopadhyay D,Das G
17-7311 was used in Flow cytometry/Cell sorting to study the role of bergenin in the activation of MAP kinase and ERK pathways in macrophages for host protection against TB.
Wed Dec 27 00:00:00 EST 2017
Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.
PloS one
Pols TWH,Puchner T,Korkmaz HI,Vos M,Soeters MR,de Vries CJM
17-7311 was used in Flow cytometry/Cell sorting to study the mechanism by which lithocholic acid controls adaptive immunity.
Mon Sep 11 00:00:00 EDT 2017
C3d regulates immune checkpoint blockade and enhances antitumor immunity.
JCI insight
Platt JL,Silva I,Balin SJ,Lefferts AR,Farkash E,Ross TM,Carroll MC,Cascalho M
17-7311 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which tumours engage T cell checkpoint regulators and expanding Tregs, showing that C3d regulates immune checkpoint blockade and enhances antitumor immunity.
Thu May 04 00:00:00 EDT 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
17-7311 was used in Flow cytometry/Cell sorting to demonstrate in colon and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-L1 expression on both cancer and immune cells in the tumour.
Mon Mar 27 00:00:00 EDT 2017
The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment.
Journal for immunotherapy of cancer
Poon E,Mullins S,Watkins A,Williams GS,Koopmann JO,Di Genova G,Cumberbatch M,Veldman-Jones M,Grosskurth SE,Sah V,Schuller A,Reimer C,Dovedi SJ,Smith PD,Stewart R,Wilkinson RW
17-7311 was used in Flow cytometry/Cell sorting to characterise the combined effects of MEK inhibition and anti-CTLA-4 monoclonal antibody therapy, examining effects on both T-cells and tumour microenvironment.
Tue Aug 15 00:00:00 EDT 2017
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.
Scientific reports
Yi P,Liang Y,Yuan DMK,Jie Z,Kwota Z,Chen Y,Cong Y,Fan X,Sun J
Tue Jun 20 00:00:00 EDT 2017
NFATc1 controls the cytotoxicity of CD8+ T cells.
Nature communications
Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E
17-7311 was used in Flow cytometry/Cell sorting to indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.
Mon Sep 11 00:00:00 EDT 2017
Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses.
Cell reports
Davari K,Lichti J,Gallus C,Greulich F,Uhlenhaut NH,Heinig M,Friedel CC,Glasmacher E
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that rapid de novo recruitment of RNA polymerase II dictates the course of events during T cell activation.
Tue Apr 18 00:00:00 EDT 2017
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
eLife
Wells AC,Daniels KA,Angelou CC,Fagerberg E,Burnside AS,Markstein M,Alfandari D,Welsh RM,Pobezinskaya EL,Pobezinsky LA
17-7311 was used in Flow cytometry/Cell sorting to identify a let-7-mediated mechanism that acts as a molecular brake controlling the magnitude of CD8 T-cell responses.
Mon Jul 24 00:00:00 EDT 2017
Glucose represses dendritic cell-induced T cell responses.
Nature communications
Lawless SJ,Kedia-Mehta N,Walls JF,McGarrigle R,Convery O,Sinclair LV,Navarro MN,Murray J,Finlay DK
17-7311 was used in Flow cytometry/Cell sorting to reveal a mechanism by which T cells regulate the dendritic cell microenvironment to control DC-induced T-cell responses and indicate that glucose is an important signal for shaping immune responses.
Tue May 30 00:00:00 EDT 2017
CD4(+) T-cell dependence of primary CD8(+) T-cell response against vaccinia virus depends upon route of infection and viral dose.
Cellular & molecular immunology
Hu Z,Molloy MJ,Usherwood EJ
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of of CD4(+) T-cell help in CD8(+) T-cell responses against viral infections.
Fri Jan 01 00:00:00 EST 2016
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.
The Journal of clinical investigation
Rackov G,Hernández-Jiménez E,Shokri R,Carmona-Rodríguez L,Mañes S,Álvarez-Mon M,López-Collazo E,Martínez-A C,Balomenos D
17-7311 was used in Flow cytometry/Cell sorting to determine whether p21 regulates macrophage reprogramming by shifting the balance between active p65-p50 and inhibitory p50-p50 NF-κB pathways.
Mon Aug 01 00:00:00 EDT 2016
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation.
The Journal of clinical investigation
Nguyen HD,Chatterjee S,Haarberg KM,Wu Y,Bastian D,Heinrichs J,Fu J,Daenthanasanmak A,Schutt S,Shrestha S,Liu C,Wang H,Chi H,Mehrotra S,Yu XZ
17-7311 was used in Flow cytometry/Cell sorting to study the metabolic reprogramming of donor T cells following allogeneic haematopoietic cell transplantation.
Fri Apr 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
17-7311 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.
The Journal of clinical investigation
Lewis GM,Wehrens EJ,Labarta-Bajo L,Streeck H,Zuniga EI
17-7311 was used in Flow cytometry/Cell sorting to uncover an eomesodermin-driven CD4 T cell program that is continuously suppressed by TGF-β signalling.
Mon Oct 03 00:00:00 EDT 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
17-7311 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
17-7311 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.
Cancer research
Baird JR,Friedman D,Cottam B,Dubensky TW,Kanne DB,Bambina S,Bahjat K,Crittenden MR,Gough MJ
17-7311 was used in Immunofluorescence to demonstrate that when combined with novel STING agonists, radiation therapy generates T-cell immunity for disease control.
Fri Jan 01 00:00:00 EST 2016
CNS accumulation of regulatory B cells is VLA-4-dependent.
Neurology(R) neuroimmunology & neuroinflammation
Lehmann-Horn K,Sagan SA,Winger RC,Spencer CM,Bernard CC,Sobel RA,Zamvil SS
17-7311 was used in Immunocytochemistry to demonstrate that accumulation of Breg in the CNS is dependent on VLA-4.
Fri Apr 01 00:00:00 EDT 2016
The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.
Journal of virology
Gorman MJ,Poddar S,Farzan M,Diamond MS
17731182 was used in flow cytometry to assess the contribution of interferon-induced transmembrane protein 3 to West Nile virus infection
Thu Sep 15 00:00:00 EDT 2016
IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages.
The American journal of pathology
Gabunia K,Ellison S,Kelemen S,Kako F,Cornwell WD,Rogers TJ,Datta PK,Ouimet M,Moore KJ,Autieri MV
17-7311 was used in Flow cytometry/Cell sorting to investigate how IL-19 can halt progression of atherosclerotic plaques by regulating macrophage inflammation and cholesterol homeostasis.
Sun May 01 00:00:00 EDT 2016
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Gene therapy
Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H
17-7311 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.
Fri Apr 01 00:00:00 EDT 2016
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Gene therapy
Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H
17-7311 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.
Fri Apr 01 00:00:00 EDT 2016
Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation.
Scientific reports
Huang M,Zhang W,Guo J,Wei X,Phiwpan K,Zhang J,Zhou X
17-7311 was used in Flow cytometry/Cell sorting to develop a new transgenic mice model to study the expression and antigen presentation of HLA-I molecules.
Fri Sep 16 00:00:00 EDT 2016
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity.
Oncoimmunology
Li Y,Fang M,Zhang J,Wang J,Song Y,Shi J,Li W,Wu G,Ren J,Wang Z,Zou W,Wang L
17-7311 was used in Flow cytometry/Cell sorting to assess an alginate-hydrogel-mediated, combinatorial therapy of celecoxib and PD-1 mAb as a potential valuable regimen for treating human cancer.
Mon Feb 01 00:00:00 EST 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
17-7311-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
17-7311 was used in Flow cytometry/Cell sorting to indicate a close link between NFATc1 and IL-10 expression in B cells, suggesting that NFATc1 may be a potential target to treat human psoriasis.
Wed May 25 00:00:00 EDT 2016
Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells.
Oncotarget
Si C,Zhang R,Wu T,Lu G,Hu Y,Zhang H,Xu F,Wei P,Chen K,Tang H,Yeretssian G,Xiong H
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that DC-derived nitric oxide restrains effector DC development to treat autoimmune and inflammatory diseases.
Tue Nov 15 00:00:00 EST 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
17-7311 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
CRK proteins selectively regulate T cell migration into inflamed tissues.
The Journal of clinical investigation
Huang Y,Clarke F,Karimi M,Roy NH,Williamson EK,Okumura M,Mochizuki K,Chen EJ,Park TJ,Debes GF,Zhang Y,Curran T,Kambayashi T,Burkhardt JK
17-7311 was used in Flow cytometry/Cell sorting to show that CRK family proteins selectively regulate T-cell adhesion and migration at effector sites.
Mon Mar 02 00:00:00 EST 2015
Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.
Molecular psychiatry
Choi EY,Lim JH,Neuwirth A,Economopoulou M,Chatzigeorgiou A,Chung KJ,Bittner S,Lee SH,Langer H,Samus M,Kim H,Cho GS,Ziemssen T,Bdeir K,Chavakis E,Koh JY,Boon L,Hosur K,Bornstein SR,Meuth SG,Hajishengallis G,Chavakis T
17-7311 was used in Flow cytometry/Cell sorting to provide mechanistic underpinnings for the previous implication of Del-1 as a candidate MS susceptibility gene.
Wed Jul 01 00:00:00 EDT 2015
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.
Cancer immunology research
Rahbar R,Lin A,Ghazarian M,Yau HL,Paramathas S,Lang PA,Schildknecht A,Elford AR,Garcia-Batres C,Martin B,Berman HK,Leong WL,McCready DR,Reedijk M,Done SJ,Miller N,Youngson B,Suh WK,Mak TW,Ohashi PS
17-7311 was used in Flow cytometry/Cell sorting to demonstrate a positive role for B7-H4 in promoting antitumor immunity.
Sun Feb 01 00:00:00 EST 2015
B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
Annals of neurology
Lehmann-Horn K,Sagan SA,Bernard CC,Sobel RA,Zamvil SS
17-7311 was used in Flow cytometry/Cell sorting to report that the selective inhibition of VLA-4 expression on B cells impedes CNS accumulation of B cells, and recruitment of Th17 cells and macrophages.
Fri May 01 00:00:00 EDT 2015
Control of murine cytomegalovirus infection by γδ T cells.
PLoS pathogens
Sell S,Dietz M,Schneider A,Holtappels R,Mach M,Winkler TH
17-7311 was used in Neutralization experiments to show that γδ T cells can provide an effective control mechanism of acute cytomegalovirus infections.
Sun Feb 01 00:00:00 EST 2015
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 EDT 2015
Induction of Th17 cells by segmented filamentous bacteria in the murine intestine.
Journal of immunological methods
Farkas AM,Panea C,Goto Y,Nakato G,Galan-Diez M,Narushima S,Honda K,Ivanov II
17-7311 was used in Flow cytometry/Cell sorting to study the ability of segmented filamentous bacteria (SFB) to modulate the host immune system through induction of IgA and Th17 cells, and examine the kinetics of SFB colonisation and Th17 cell induction.
Mon Jun 01 00:00:00 EDT 2015
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
Nature communications
Polte T,Petzold S,Bertrand J,Schütze N,Hinz D,Simon JC,Lehmann I,Echtermeyer F,Pap T,Averbeck M
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as a possible target for therapeutic intervention in this disease.
Mon Jul 13 00:00:00 EDT 2015
Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice.
PloS one
Longley RJ,Halbroth BR,Ewer KJ,Hill AV,Spencer AJ
17-7311 was used in Flow cytometry/Cell sorting to investigate the cellular immune response in mice to three viral vectored vaccines expressing Plasmodium falciparum antigens PfUIS3, PfLSA1 and PfLSAP2.
Sun Jun 26 00:00:00 EDT 2016
Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae.
Frontiers in microbiology
Pettini E,Fiorino F,Cuppone AM,Iannelli F,Medaglini D,Pozzi G
17-7311 was used in Flow cytometry/Cell sorting to elucidate the role of IFN-γ in the neuroinflammatory response following type 4 Streptococcus pneumoniae-induced meningitis in mice.
Wed Dec 09 00:00:00 EST 2015
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.
Nature communications
Kamimura D,Katsunuma K,Arima Y,Atsumi T,Jiang JJ,Bando H,Meng J,Sabharwal L,Stofkova A,Nishikawa N,Suzuki H,Ogura H,Ueda N,Tsuruoka M,Harada M,Kobayashi J,Hasegawa T,Yoshida H,Koseki H,Miura I,Wakana S,Nishida K,Kitamura H,Fukada T,Hirano T,Murakami M
17-7311 was used in Flow cytometry/Cell sorting to investigate the mechanism by which KDEL receptor 1 regulates the integration of stress responses in T cells.
Wed Jun 17 00:00:00 EDT 2015
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Nature communications
Mikucki ME,Fisher DT,Matsuzaki J,Skitzki JJ,Gaulin NB,Muhitch JB,Ku AW,Frelinger JG,Odunsi K,Gajewski TF,Luster AD,Evans SS
17-7311 was used in Flow cytometry/Cell sorting to investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma.
Thu Jun 25 00:00:00 EDT 2015
CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice.
PloS one
O'Flaherty BM,Matar CG,Wakeman BS,Garcia A,Wilke CA,Courtney CL,Moore BB,Speck SH
17-7311 was used in Flow cytometry/Cell sorting to investigate the role that the MHV68 gene plays in the development of pulmonary fibrosis.
Thu Jun 09 00:00:00 EDT 2016
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.
Cell death & disease
Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D
17-7311 was used in Flow cytometry/Cell sorting to define the clearance of infected neutrophils by dendritic cells as central to the early immune evasion strategies of L. major.
Thu Dec 10 00:00:00 EST 2015
Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.
The Journal of clinical investigation
Shan M,You R,Yuan X,Frazier MV,Porter P,Seryshev A,Hong JS,Song LZ,Zhang Y,Hilsenbeck S,Whitehead L,Zarinkamar N,Perusich S,Corry DB,Kheradmand F
17-7311 was used in Flow cytometry/Cell sorting to reveal a proinflammatory pathway, in which reduced PPARγ activity promotes emphysema.
Sat Mar 01 00:00:00 EST 2014
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
17-7311 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 EST 2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
eLife
Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.
Wed Nov 19 00:00:00 EST 2014
Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease.
Immune network
Ju JM,Lee H,Oh K,Lee DS,Choi EY
17-7311 was used in Flow cytometry/Cell sorting to study production of IFN-γ and IL-17 by CD4 and CD8 T cells during graft-versus-host disease progression.
Tue Apr 01 00:00:00 EDT 2014
IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus.
Journal of immunology (Baltimore, Md. : 1950)
Shibata K,Yamada H,Nakamura M,Hatano S,Katsuragi Y,Kominami R,Yoshikai Y
17-7311 was used in Flow cytometry/Cell sorting to compare the functions of γδ T cells derived from double-negative 2 and double-negative 3 cells in the murine fetal thymus.
Sat Mar 01 00:00:00 EST 2014
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.
Journal of immunology (Baltimore, Md. : 1950)
Donnelly RP,Loftus RM,Keating SE,Liou KT,Biron CA,Gardiner CM,Finlay DK
17-7311 was used in Flow cytometry/Cell sorting to investigate whether mTORC1-controlled metabolism underpins normal natural killer cell proinflammatory functions.
Sat Nov 01 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
17-7311 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Schedel M,Takeda K,Jia Y,Ashino S,Dakhama A,Lluis A,Okamoto M,Gelfand EW
17-7311 was used in Flow cytometry/Cell sorting to study the mechanism by which GITR stimulation of naturally occurring regulatory T cells triggers the loss of regulatory function while concomitantly gaining pathogenic CD4(+) effector function.
Mon Sep 01 00:00:00 EDT 2014
Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitis.
Infection and immunity
Spees AM,Kingsbury DD,Wangdi T,Xavier MN,Tsolis RM,Bäumler AJ
17-7311 was used in Flow cytometry/Cell sorting to identify the cells responsible for IFN-γ production in the cecal mucosa during the acute phase of an S. Typhimurium infection.
Tue Apr 01 00:00:00 EDT 2014
Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.
PloS one
Nouri M,Bredberg A,Weström B,Lavasani S
17-7311 was used in Flow cytometry/Cell sorting to show that disruption of intestinal homeostasis is an early and immune-mediated event in experimental autoimmune encephalomyelitis.
Thu May 14 00:00:00 EDT 2015
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.
Journal for immunotherapy of cancer
Spranger S,Koblish HK,Horton B,Scherle PA,Newton R,Gajewski TF
17-7311 was used in Flow cytometry/Cell sorting to assess the effectiveness of different immunotherapy combination treatments against the murine B16.SIY melanoma model.
Thu May 15 00:00:00 EDT 2014
Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.
The Journal of biological chemistry
Mueller AM,Yoon BH,Sadiq SA
17-7311 was used in Flow cytometry/Cell sorting to assess the potential proinflammatory role of hyaluronan in experimental autoimmune encephalomyelitis.
Fri Aug 15 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
17-7311 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.
Mon Jul 06 00:00:00 EDT 2015
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.
PloS one
Markwart R,Condotta SA,Requardt RP,Borken F,Schubert K,Weigel C,Bauer M,Griffith TS,Förster M,Brunkhorst FM,Badovinac VP,Rubio I
17-7311 was used in Flow cytometry/Cell sorting to investigate the nature of defects of T-cell immunity in post-acute phases of systemic inflammatory response, showing an induced loss of naive T-cells but no enduring cell-autonomous defects in T-cell function.
Thu Aug 27 00:00:00 EDT 2015
Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.
Journal of translational medicine
Fisher SA,Cleaver A,Lakhiani DD,Khong A,Connor T,Wylie B,Lesterhuis WJ,Robinson BW,Lake RA
17-7311 was used in Flow cytometry/Cell sorting to characterise changes in the proportion and activation status of immune cells associated with anti-tumour immunity.
Thu Sep 04 00:00:00 EDT 2014
A new recombinant BCG vaccine induces specific Th17 and Th1 effector cells with higher protective efficacy against tuberculosis.
PloS one
da Costa AC,Costa-Júnior Ade O,de Oliveira FM,Nogueira SV,Rosa JD,Resende DP,Kipnis A,Junqueira-Kipnis AP
17-7311 was used in Flow cytometry/Cell sorting to evaluate the immunogenicity and protection of a new BCG vaccine against TB, showing that it induces specific Th17 and Th1 effector cells with higher protective efficacy.
Fri Dec 18 00:00:00 EST 2015
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
17-7311 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.
PloS one
Yea SS,So L,Mallya S,Lee J,Rajasekaran K,Malarkannan S,Fruman DA
17-7311 was used in Flow cytometry/Cell sorting to support the targeting of PIK3CA mutant tumours with selective p110α inhibitors to preserve natural killer cell function.
Thu Jan 29 00:00:00 EST 2015
Measurement of CD8 and CD4 T Cell Responses in Mouse Lungs.
Bio-protocol
Fett C,Zhao J,Perlman S
17-7311 was used in Flow cytometry/Cell sorting to study the methods used to characterise the CD8 & CD4 T cell responses after a viral challenge in the lung.
Thu Feb 10 00:00:00 EST 2022
Induction of broad cytotoxic T cells by protective DNA vaccination against Marburg and Ebola.
Molecular therapy : the journal of the American Society of Gene Therapy
Shedlock DJ,Aviles J,Talbott KT,Wong G,Wu SJ,Villarreal DO,Myles DJ,Croyle MA,Yan J,Kobinger GP,Weiner DB
17-7311 was used in Flow cytometry/Cell sorting to investigate the efficacy of cytotoxic T cell induction by a novel polyvalent-filovirus DNA vaccine against Marburg and Ebola.
Mon Jul 01 00:00:00 EDT 2013
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.
Molecular therapy : the journal of the American Society of Gene Therapy
Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW
17-7311 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.
Fri Feb 01 00:00:00 EST 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
17-7311 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
17-7311 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.
Wed Mar 06 00:00:00 EST 2013
CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model.
Immune network
Oh K,Seo MW,Kim IG,Hwang YI,Lee HY,Lee DS
17-7311 was used in Flow cytometry/Cell sorting to evaluate the therapeutic effect of CP-690550 on established arthritis using an SKG arthritis model.
Sun Dec 01 00:00:00 EST 2013
Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Zhang F,Wei W,Chai H,Xie X
17-7311 was used in Flow cytometry/Cell sorting to investigate the effect of aurintricarboxylic acid (ATA) on experimental autoimmune encephalomyelitis (EAE), showing that ATA ameliorates EAE by blocking chemokine-mediated pathogenic cell migration and infiltration.
Fri Feb 01 00:00:00 EST 2013
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.
PloS one
Tkaczyk C,Hamilton MM,Datta V,Yang XP,Hilliard JJ,Stephens GL,Sadowska A,Hua L,O'Day T,Suzich J,Stover CK,Sellman BR
17-7311 was used in Flow cytometry/Cell sorting to investigate the effect of alpha toxin on the immune response against soft tissue infections, showing that alpha toxin suppresses effective innate and adaptive immune responses.
Mon Jun 23 00:00:00 EDT 2014
Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.
Gastroenterology
Huang LR,Gäbel YA,Graf S,Arzberger S,Kurts C,Heikenwalder M,Knolle PA,Protzer U
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that infection of immunocompetent mice with low doses of adenovirus vectors results in persistent HBV infection.
Fri Jun 01 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
The Journal of experimental medicine
Rivollier A,He J,Kole A,Valatas V,Kelsall BL
17-7311 was used in Immunocytochemistry to demonstrate the dual capacity of Ly6C(hi) blood MOs, which is dictated by microenvironmental conditions.
Mon Jan 16 00:00:00 EST 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
17-7311 was used in Flow cytometry/Cell sorting to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.
Mon Apr 09 00:00:00 EDT 2012
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
17-7311 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Reyes-Sandoval A,Rollier CS,Milicic A,Bauza K,Cottingham MG,Tang CK,Dicks MD,Wang D,Longley RJ,Wyllie DH,Hill AV
17-7311 was used in Immunocytochemistry to investigate whether the two vaccine components adenovirus and modified vaccinia virus Ankara can be co-injected to enhance protection against malaria.
Wed Aug 01 00:00:00 EDT 2012
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
17-7311 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Altin JA,Goodnow CC,Cook MC
17-7311 was used in Flow cytometry/Cell sorting to investigate the mechanism and molecules involved in the formation of IL10+CTLA-4+Th2 inhibitory cells during chronic inflammation.
Fri Jun 01 00:00:00 EDT 2012
Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
Break TJ,Jun S,Indramohan M,Carr KD,Sieve AN,Dory L,Berg RE
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that ecSOD activity reduces innate immune responses during bacterial infection and provides a potential target for therapeutic intervention.
Sun Apr 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
17-7311 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Journal of immunology (Baltimore, Md. : 1950)
Gowda NM,Wu X,Gowda DC
17-7311 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.
Tue May 15 00:00:00 EDT 2012
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Gowdy KM,Cardona DM,Nugent JL,Giamberardino C,Thomas JM,Mukherjee S,Martinu T,Foster WM,Plevy SE,Pastva AM,Wright JR,Palmer SM
17-7311 was used in Flow cytometry/Cell sorting to hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the development of Graft-versus-host disease after allogeneic BMT.
Tue May 15 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
17-7311 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice.
Human vaccines & immunotherapeutics
Shedlock DJ,Talbott KT,Wu SJ,Wilson CM,Muthumani K,Boyer JD,Sardesai NY,Awasthi S,Weiner DB
17-7311 was used in Flow cytometry/Cell sorting to design a novel panel of highly-optimized synthetic vaccines encoding major CMV proteins and evaluate their immune potential.
Thu Nov 01 00:00:00 EDT 2012
Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis.
BMC neuroscience
Müller AM,Jun E,Conlon H,Sadiq SA
17-7311 was used in Flow cytometry/Cell sorting to study how SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity and its neutralization may be beneficial for EAE.
Wed Mar 21 00:00:00 EDT 2012
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
PloS one
Buchwald ZS,Kiesel JR,DiPaolo R,Pagadala MS,Aurora R
17-7311 was used in Flow cytometry/Cell sorting to demonstrate the effects of activated CD8 T cell-produced cytokines on osteoclast activity.
Thu Nov 08 00:00:00 EST 2012
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
17-7311 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications
Matsumura T,Ato M,Ikebe T,Ohnishi M,Watanabe H,Kobayashi K
17-7311 was used in Flow cytometry/Cell sorting to indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections.
Tue Feb 14 00:00:00 EST 2012
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
17-7311 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model.
Cancer gene therapy
Chaves KC,Peron JP,Chammas R,Turaça LT,Pesquero JB,Braga MS,Foguer K,Schor N,Bellini MH
17-7311-82 was used in Flow cytometry/Cell sorting to demonstrate an antitumor inflammatory effect of Endostatin (ES) in an mRCC model, and this effect is mediated by an increase in ICAM-1 and VCAM-1 expression in tumor-associated endothelial cells.
Wed Aug 01 00:00:00 EDT 2012
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
17-7311 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Nature immunology
Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW
17-7311 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.
Sun Nov 06 00:00:00 EDT 2011
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood
Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A
17-7311 was used in Immunocytochemistry to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.
Thu Aug 18 00:00:00 EDT 2011
EpiChIP: gene-by-gene quantification of epigenetic modification levels.
Nucleic acids research
Hebenstreit D,Gu M,Haider S,Turner DJ,Liò P,Teichmann SA
17-7311 was used in Flow cytometry/Cell sorting to develop a software package that analyses ChIP-seq data in order to quantify epigenetic modification levels for individual genes.
Tue Mar 01 00:00:00 EST 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
17-7311 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
The Journal of experimental medicine
Hashimoto D,Chow A,Greter M,Saenger Y,Kwan WH,Leboeuf M,Ginhoux F,Ochando JC,Kunisaki Y,van Rooijen N,Liu C,Teshima T,Heeger PS,Stanley ER,Frenette PS,Merad M
17-7311 was used in Flow cytometry/Cell sorting to investigate the contribution of host macrophages in graft-versus-host disease.
Mon May 09 00:00:00 EDT 2011
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.
Tue Jul 12 00:00:00 EDT 2011
Immunotherapy of murine retrovirus-induced acquired immunodeficiency by CD4 T regulatory cell depletion and PD-1 blockade.
Journal of virology
Li W,Green WR
17-7311 was used in Flow cytometry/Cell sorting to discover that following in vivo CD4 Treg depletion and interruption of PD-1 negative signaling in CD8 T-cells, retroviral pathogenesis decreases.
Thu Dec 01 00:00:00 EST 2011
Effects of Pre-conditioning Dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation.
Immune network
Choi JH,Yoon H,Min CK,Choi EY
17-7311 was used in Flow cytometry/Cell sorting to analyse chimerism formation and immune kinetics of leukocytes during graft-versus-host disease.
Tue Feb 01 00:00:00 EST 2011
Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus.
Clinical and experimental immunology
Chen S,Akbar SM,Abe M,Hiasa Y,Onji M
17-7311 was used in Flow cytometry/Cell sorting to localise and assess functions of hepatic myeloid-derived suppressor cells in a normal liver and in a murine model of chronic hepatitis B virus infection.
Sat Oct 01 00:00:00 EDT 2011
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Harty JT
17-7311 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.
Fri Apr 01 00:00:00 EDT 2011
Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Butler NS,Harty JT
17-7311 was used in Flow cytometry/Cell sorting to investigate how the threshold of memory CD8 T cells required for protective immunity is influenced by Plasmodium-host interactions.
Sun May 15 00:00:00 EDT 2011
Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference.
Journal of immunology (Baltimore, Md. : 1950)
Forbes EK,Biswas S,Collins KA,Gilbert SC,Hill AV,Draper SJ
17-7311 was used in Flow cytometry/Cell sorting to investigate the various mechanisms of CD8(+) T cell interference and the implications for the development of a multistage or multicomponent viral vectored malaria vaccine for use in humans.
Sat Oct 01 00:00:00 EDT 2011
The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.
Journal of immunology (Baltimore, Md. : 1950)
Brincks EL,Gurung P,Langlois RA,Hemann EA,Legge KL,Griffith TS
17-7311 was used in Flow cytometry/Cell sorting to study how TRAIL affects the T cell response and ultimately influences the outcome of viral infection.
Tue Nov 01 00:00:00 EDT 2011
Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity.
Infection and immunity
Prajeeth CK,Haeberlein S,Sebald H,Schleicher U,Bogdan C
17-7311 was used in Immunocytochemistry to study whether whether natural killer cells contribute to the control of Leishmania infections by lysing or by activating infected host cells.
Fri Jul 01 00:00:00 EDT 2011
Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity.
Infection and immunity
Prajeeth CK,Haeberlein S,Sebald H,Schleicher U,Bogdan C
17-7311 was used in Immunocytochemistry to study whether whether natural killer cells contribute to the control of Leishmania infections by lysing or by activating infected host cells.
Fri Jul 01 00:00:00 EDT 2011
Early MyD88-dependent induction of interleukin-17A expression during Salmonella colitis.
Infection and immunity
Keestra AM,Godinez I,Xavier MN,Winter MG,Winter SE,Tsolis RM,Bäumler AJ
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that myeloid differentiation primary response protein 88-dependent mechanisms are important in initiating early inflammatory responses during Salmonella colitis.
Mon Aug 01 00:00:00 EDT 2011
Preferential replication of vaccinia virus in the ovaries is independent of immune regulation through IL-10 and TGF-β.
Viral immunology
Zhao Y,Adams YF,Croft M
17-7311 was used in Flow cytometry/Cell sorting to study how the preferential replication of VACV in the ovaries may not be dependent on immune suppressive mechanisms in this tissue.
Sat Oct 01 00:00:00 EDT 2011
Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses.
PloS one
Kapadia D,Sadikovic A,Vanloubbeeck Y,Brockstedt D,Fong L
17-7311 was used in Flow cytometry/Cell sorting to examine the contribution of different primary APCs during Listeria monocytogenes infection, showing interplay between dendritic cells and monocytes during infection.
Fri Apr 29 00:00:00 EDT 2011
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
The Journal of experimental medicine
Thompson ED,Enriquez HL,Fu YX,Engelhard VH
17-7311 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.
Mon Aug 02 00:00:00 EDT 2010
Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
The Journal of experimental medicine
Scapini P,Hu Y,Chu CL,Migone TS,Defranco AL,Cassatella MA,Lowell CA
17-7311 was used in Flow cytometry/Cell sorting to suggest that the reciprocal production of BAFF and IFN- establishes an inflammatory loop between myeloid and T-cells that exacerbates autoimmunity.
Mon Aug 02 00:00:00 EDT 2010
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells.
European journal of immunology
Weaver DJ,Reis ES,Pandey MK,Köhl G,Harris N,Gerard C,Köhl J
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that C5aR signalling in DCs affects the development of immune cells.
Mon Mar 01 00:00:00 EST 2010
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.
European journal of immunology
Reimer T,Shaw MH,Franchi L,Coban C,Ishii KJ,Akira S,Horii T,Rodriguez A,Núñez G
17-7311 was used in Flow cytometry/Cell sorting to study the role of Nlrp3 in experimental cerebral malaria.
Mon Mar 01 00:00:00 EST 2010
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010
Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.
Journal of immunology (Baltimore, Md. : 1950)
Motz GT,Eppert BL,Wortham BW,Amos-Kroohs RM,Flury JL,Wesselkamper SC,Borchers MT
17-7311 was used in Flow cytometry/Cell sorting to demonstrate an entirely novel mechanism of NK cell activation resulting from chronic cigarette smoke exposure.
Thu Apr 15 00:00:00 EDT 2010
Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response.
Cellular immunology
Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells.
Wed Dec 29 00:00:00 EST 2010
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.
The Journal of experimental medicine
Maynard CL,Hatton RD,Helms WS,Oliver JR,Stephensen CB,Weaver CT
17-7311 was used in Flow cytometry/Cell sorting to investigate alternative roles for all-trans retinoic acid in developing regulatory T cells.
Mon Feb 16 00:00:00 EST 2009
Inflammasome recognition of influenza virus is essential for adaptive immune responses.
The Journal of experimental medicine
Ichinohe T,Lee HK,Ogura Y,Flavell R,Iwasaki A
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that ASC inflammasomes play a central role in adaptive immunity to influenza virus.
Fri Jan 16 00:00:00 EST 2009
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology
Barnes MJ,Krebs P,Harris N,Eidenschenk C,Gonzalez-Quintial R,Arnold CN,Crozat K,Sovath S,Moresco EM,Theofilopoulos AN,Beutler B,Hoebe K
17-7311 was used in Flow cytometry/Cell sorting to investigate methods to distinguish between Tregs of thymic or peripheral origin, showing that commitment requires CARMA1 in the thymus but not in the periphery.
Tue Mar 03 00:00:00 EST 2009
Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.
Journal of virology
Kassim SH,Rajasagi NK,Ritz BW,Pruett SB,Gardner EM,Chervenak R,Jennings SR
17-7311 was used in Flow cytometry/Cell sorting to provide evidence that functional DCs are required for optimal IFN-gamma expression and cytolytic function by NK cells following HSV-1 infection.
Wed Apr 01 00:00:00 EDT 2009
Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Journal of immunology (Baltimore, Md. : 1950)
Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH
17-7311 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.
Sat Aug 01 00:00:00 EDT 2009
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Astrakhan A,Ochs HD,Rawlings DJ
17-7311 was used in Flow cytometry/Cell sorting to investigate the role for WASp within the iNKT lineage.
Mon Jun 15 00:00:00 EDT 2009
Impact of preexisting vector-specific immunity on vaccine potency: characterization of listeria monocytogenes-specific humoral and cellular immunity in humans and modeling studies using recombinant vaccines in mice.
Infection and immunity
Leong ML,Hampl J,Liu W,Mathur S,Bahjat KS,Luckett W,Dubensky TW,Brockstedt DG
17-7311 was used in Flow cytometry/Cell sorting to establish the level of L. monocytogenes-specific cellular immunity in healthy adults and support the protocol of repeated L. monocytogenes vaccination regimens to elicit a desired therapeutic effect.
Tue Sep 01 00:00:00 EDT 2009
Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.
Experimental hematology
Banerjee ER,Jiang Y,Henderson WR,Latchman Y,Papayannopoulou T
17-7311 was used in Flow cytometry/Cell sorting to explore, to what extent, two molecular pathways control the development of structural airway remodelling in chronic asthma.
Mon Jun 01 00:00:00 EDT 2009
Natural killer T cells are critical for dendritic cells to induce immunity in Chlamydial pneumonia.
American journal of respiratory and critical care medicine
Joyee AG,Qiu H,Fan Y,Wang S,Yang X
17-7311 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism by which natural killer T cells modulate T cell responses in chlamydial pneumonia.
Wed Oct 01 00:00:00 EDT 2008
IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8+ T cells.
The Journal of experimental medicine
Tajima M,Wakita D,Noguchi D,Chamoto K,Yue Z,Fugo K,Ishigame H,Iwakura Y,Kitamura H,Nishimura T
17-7311 was used in Flow cytometry/Cell sorting to reveal a critical role for interleukin 6 in the development of CD8+ T cell-dependent autoimmune colitis.
Mon May 12 00:00:00 EDT 2008
Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
The Journal of infectious diseases
Beaumier CM,Mathew A,Bashyam HS,Rothman AL
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection.
Fri Feb 15 00:00:00 EST 2008
Regulation of cytokine production by virus-specific CD8 T cells in the lungs.
Journal of virology
Fulton RB,Olson MR,Varga SM
17-7311 was used in Flow cytometry/Cell sorting to show that both virus-induced inflammation and the host tissue environment influence the capacity of virus-specific T cells to produce cytokines.
Fri Aug 01 00:00:00 EDT 2008
Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.
Journal of immunology (Baltimore, Md. : 1950)
Brinkman CC,Sheasley-O'Neill SL,Ferguson AR,Engelhard VH
17-7311 was used in Flow cytometry/Cell sorting to characterise the activation and differentiation of CD8 T cells in individual lymphoid compartments over time, and their migration between compartments.
Fri Aug 01 00:00:00 EDT 2008
CD8 T cells utilize TRAIL to control influenza virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Brincks EL,Katewa A,Kucaba TA,Griffith TS,Legge KL
17-7311 was used in Flow cytometry/Cell sorting to determine that TRAIL deficiency decreases CD8(+) T cell-mediated cytotoxicity.
Wed Oct 01 00:00:00 EDT 2008
TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help.
Journal of immunology (Baltimore, Md. : 1950)
Sacks JA,Bevan MJ
17-7311 was used in Flow cytometry/Cell sorting to investigate the role of the proapoptotic molecule TRAIL in unhelped CD8(+) T cells.
Tue Apr 01 00:00:00 EDT 2008
Mechanisms underlying blockade of allograft acceptance by TLR ligands.
Journal of immunology (Baltimore, Md. : 1950)
Porrett PM,Yuan X,LaRosa DF,Walsh PT,Yang J,Gao W,Li P,Zhang J,Ansari JM,Hancock WW,Sayegh MH,Koulmanda M,Strom TB,Turka LA
17-7311 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying blockade of allograft acceptance by TLR ligands as a barrier to tolerance induction.
Fri Aug 01 00:00:00 EDT 2008
Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein.
Clinical and vaccine immunology : CVI
Liao JB,Publicover J,Rose JK,DiMaio D
17-7311 was used in Flow cytometry/Cell sorting to demonstrate the antitumor responses to HPV16 E7, suggesting that recombinant-VSV-based vaccination could be explored as a therapeutic strategy for HPV-associated cancers.
Thu May 01 00:00:00 EDT 2008
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.
PloS one
Sen D,Deerinck TJ,Ellisman MH,Parker I,Cahalan MD
17-7311 was used in Flow cytometry/Cell sorting to investigate the potential of QDs for imaging of DCs and as a particle-based antigen-delivery system.
Mon Sep 29 00:00:00 EDT 2008
Dendritic cells prime natural killer cells by trans-presenting interleukin 15.
Immunity
Lucas M,Schachterle W,Oberle K,Aichele P,Diefenbach A
17-7311 was used in Flow cytometry/Cell sorting to study the in vivo role of dendritic cells for the priming of natural killer cells by trans-presenting interleukin 15.
Sun Apr 01 00:00:00 EDT 2007
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
Proceedings of the National Academy of Sciences of the United States of America
Kimura A,Naka T,Kishimoto T
Tue Jul 17 00:00:00 EDT 2007
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Proceedings of the National Academy of Sciences of the United States of America
Joetham A,Takeda K,Miyahara N,Matsubara S,Ohnishi H,Koya T,Dakhama A,Gelfand EW
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that functional activation of nTregs requires the interaction between MHC I on CD4(+)CD25(+) T cells and CD8.
Tue Sep 18 00:00:00 EDT 2007
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity
Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG
17-7311 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.
Wed Nov 01 00:00:00 EST 2006
The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display.
Infection and immunity
Porter BB,Harty JT
17-7311 was used in Flow cytometry/Cell sorting to study the direct relationship between the course of Listeria monocytogenes infection and antigen display, and examine the role this plays in shaping the T-cell response.
Wed Mar 01 00:00:00 EST 2006
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The Journal of experimental medicine
Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.
Mon Aug 15 00:00:00 EDT 2005
Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Proceedings of the National Academy of Sciences of the United States of America
Brockstedt DG,Giedlin MA,Leong ML,Bahjat KS,Gao Y,Luckett W,Liu W,Cook DN,Portnoy DA,Dubensky TW
17-7311 was used in Flow cytometry/Cell sorting to propose that recombinant Listeria DeltaactA/DeltainlB expressing human tumor-associated antigens represents a therapeutic strategy for human clinical trials.
Tue Sep 21 00:00:00 EDT 2004
Cross-presentation of disialoganglioside GD3 to natural killer T cells.
The Journal of experimental medicine
Wu DY,Segal NH,Sidobre S,Kronenberg M,Chapman PB
17-7311 was used in Flow cytometry/Cell sorting to demonstrate that immunising mice with the SK-MEL-28 cell line or with syngeneic APCs loaded with GD3 can induce a GD3-reactive natural killer T cell response.
Mon Jul 07 00:00:00 EDT 2003
