Product References
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.
Stem cell research & therapy
Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon Oct 02 00:00:00 EDT 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H
14-7041-81 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.
Mon Mar 01 00:00:00 EST 2021
Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma.
Biomolecules & therapeutics
Lee JE,Im DS
14-7041 was used in an ELISA assay to investigate the effect of carnosol on a murine allergic asthma model.
Fri Jan 01 00:00:00 EST 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Aug 06 00:00:00 EDT 2021
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.
The Journal of biological chemistry
Tsai SJ,Atai NA,Cacciottolo M,Nice J,Salehi A,Guo C,Sedgwick A,Kanagavelu S,Gould SJ
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration.
iScience
Makino A,Shibata T,Nagayasu M,Hosoya I,Nishimura T,Nakano C,Nagata K,Ito T,Takahashi Y,Nakamura S
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Oct 22 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Tumor suppressor p53 regulates intestinal type 2 immunity.
Nature communications
Chang CY,Wang J,Zhao Y,Liu J,Yang X,Yue X,Wang H,Zhou F,Inclan-Rico JM,Ponessa JJ,Xie P,Zhang L,Siracusa MC,Feng Z,Hu W
14-7041-81 was used in ELISA to demonstrate that p53 plays a pivotal role in intestinal type 2 immunity during parasitic infection.
Mon Jun 07 00:00:00 EDT 2021
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Science advances
Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H
14-7041-81 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.
Fri May 01 00:00:00 EDT 2020
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.
PloS one
O'Connor EB,Muñoz-Wolf N,Leon G,Lavelle EC,Mills KHG,Walsh PT,Porter RK
14-7041-81 was used in ELISA to demonstrate that Ucp3 is expressed in peripheral naive CD4+ T cells at the mRNA level before being markedly downregulated following activation.
Thu Jan 07 00:00:00 EST 2021
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function.
Inflammatory bowel diseases
De Vries LCS,Duarte JM,De Krijger M,Welting O,Van Hamersveld PHP,Van Leeuwen-Hilbers FWM,Moerland PD,Jongejan A,D'Haens GR,De Jonge WJ,Wildenberg ME
14-7041 was used in Flow cytometry/Cell sorting to study the potential of tofacitinib to affect macrophage activation.
Thu Mar 14 00:00:00 EDT 2019
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation.
JCI insight
Nguyen QT,Jang E,Le HT,Kim S,Kim D,Dvorina N,Aronica MA,Baldwin WM,Asosingh K,Comhair S,Min B
14-7041 was used in Flow cytometry/Cell sorting to discover that Tregs during allergic airway inflammation are the primary target cells of IL-27 in order to mediate antinflammatory functions.
Thu Jan 24 00:00:00 EST 2019
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-7041 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-7041 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-7041 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
14-7041 was used in ELISA to study the retrograde traffic of linker for activation of T cells from the plasma membrane to the Golgi-trans-Golgi network.
Mon Apr 02 00:00:00 EDT 2018
Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.
EMBO reports
Lee S,Park K,Kim J,Min H,Seong RH
14-7041 was used in Flow cytometry/Cell sorting to show CCAAT/enhancer-binding protein can enhance TGF-β-induced Foxp3+ regulatory T cell generation.
Sat Dec 01 00:00:00 EST 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
DW2008S and its major constituents from Justicia procumbens exert anti-asthmatic effect via multitargeting activity.
Journal of cellular and molecular medicine
Youm J,Lee H,Choi Y,Yoon J
14-7041-81 was used in Flow Cytometry to suggest that DW2008S can potentially ameliorate Th2-driven airway inflammation and bronchoconstriction through negative regulation and multi-targeting activity.
Tue May 01 00:00:00 EDT 2018
Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma.
Biomolecules & therapeutics
Huang J,Su M,Lee BK,Kim MJ,Jung JH,Im DS
14-7041 was used in an ELISA assay to investigate the effect of 4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione on allergic asthma.
Thu Nov 01 00:00:00 EDT 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Genome medicine
Pramanik J,Chen X,Kar G,Henriksson J,Gomes T,Park JE,Natarajan K,Meyer KB,Miao Z,McKenzie ANJ,Mahata B,Teichmann SA
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Wed Oct 24 00:00:00 EDT 2018
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Nature communications
Zhao M,Tan Y,Peng Q,Huang C,Guo Y,Liang G,Zhu B,Huang Y,Liu A,Wang Z,Li M,Gao X,Wu R,Wu H,Long H,Lu Q
14-7041 was used in Functional assays to show reduced expression of the transcription factor RFX1 in CD4+ T cells from patients with systemic lupus erythematosus which leads to IL-17A overexpression through increased histone H3 acetylation and decreased DNA methylation.
Thu Feb 08 00:00:00 EST 2018
Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus.
Frontiers in immunology
De Zuani M,Paolicelli G,Zelante T,Renga G,Romani L,Arzese A,Pucillo CEM,Frossi B
14-7041 was used in an ELISA assay to unravel the mechanisms of reciprocal influence between mucosal mast cells (MCs) and Candida albicans as commensal/opportunistic pathogen species in humans.
Thu Oct 03 00:00:00 EDT 2019
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-7041 was used in an ELISA assay to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-7041 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology
Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
Mycobacterium tuberculosis infection modulates adipose tissue biology.
PLoS pathogens
Beigier-Bompadre M,Montagna GN,Kühl AA,Lozza L,Weiner J,Kupz A,Vogelzang A,Mollenkopf HJ,Löwe D,Bandermann S,Dorhoi A,Brinkmann V,Matuschewski K,Kaufmann SHE
14-7041 was used in Flow cytometry/Cell sorting to conclude that adipose tissue is a potential niche for Mtb and that due to infection CD8+ T cells and NK cells are attracted to this tissue.
Sun Oct 01 00:00:00 EDT 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-7041-81 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.
Journal of immunology (Baltimore, Md. : 1950)
Braune J,Weyer U,Hobusch C,Mauer J,Brüning JC,Bechmann I,Gericke M
14-7041 was used in Neutralization assays to study how IL-6 acts as a Th2 cytokine in obesity by stimulating M2 polarisation and local adipose tissue macrophages proliferation.
Sat Apr 01 00:00:00 EDT 2017
Macrophage regulation of B cell proliferation.
Cellular immunology
Goldman N,Valiuskyte K,Londregan J,Swider A,Somerville J,Riggs JE
14-7041 was used in Neutralization assays to assess the ability of peritoneal cavity B cells to respond to surrogate activating signals in the presence of high numbers of macrophages.
Sat Apr 01 00:00:00 EDT 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
14-7041 was used in an ELISA assay to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
14-7041-81 was used in Flow Cytometry to demonstrate that ORAI1 and ORAI2 form heteromeric CRAC channels in which ORAI2 fine-tunes the magnitude of SOCE to modulate immune responses.
Wed Mar 15 00:00:00 EDT 2017
Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.
Scientific reports
Chien CH,Yu HC,Chen SY,Chiang BL
14704181 was used in flow cytometry to generate and characterize Treg-of-B cells
Wed Apr 12 00:00:00 EDT 2017
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
Nature immunology
Vannella KM,Ramalingam TR,Hart KM,de Queiroz Prado R,Sciurba J,Barron L,Borthwick LA,Smith AD,Mentink-Kane M,White S,Thompson RW,Cheever AW,Bock K,Moore I,Fitz LJ,Urban JF,Wynn TA
14-7041-81 was used in Flow Cytometry to use AMCase-deficient mice as a means to dissect the role of the enzyme in several models of helminth infection and type 2 cytokine–driven airway inflammation.
Sun May 01 00:00:00 EDT 2016
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.
Nature immunology
Muñoz-Ruiz M,Ribot JC,Grosso AR,Gonçalves-Sousa N,Pamplona A,Pennington DJ,Regueiro JR,Fernández-Malavé E,Silva-Santos B
14-7041 was used in Neutralization experiments to determine the role of the T cell antigen receptor in the production of discrete γδ T cell subsets.
Wed Jun 01 00:00:00 EDT 2016
Altered Glycosylation Patterns Increase Immunogenicity of a Subunit Hepatitis C Virus Vaccine, Inducing Neutralizing Antibodies Which Confer Protection in Mice.
Journal of virology
Li D,von Schaewen M,Wang X,Tao W,Zhang Y,Li L,Heller B,Hrebikova G,Deng Q,Ploss A,Zhong J,Huang Z
14-7041 was used in an ELISpot assay to identify a promising broadly protective HCV vaccine candidate that should be considered for further preclinical and clinical development.
Thu Dec 01 00:00:00 EST 2016
IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages.
The American journal of pathology
Gabunia K,Ellison S,Kelemen S,Kako F,Cornwell WD,Rogers TJ,Datta PK,Ouimet M,Moore KJ,Autieri MV
14704181 was used in flow cytometry to test if administration of exogenous IL-19 reduces progression of preformed atherosclerotic plaque
Sun May 01 00:00:00 EDT 2016
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction.
Journal of immunology (Baltimore, Md. : 1950)
Bittner-Eddy PD,Fischer LA,Kaplan DH,Thieu K,Costalonga M
14-7041 was used in an ELISpot assay to indicate that both Langerhans cells and Th17 cells are redundant in contributing to alveolar bone destruction in a murine model of periodontitis.
Mon Aug 15 00:00:00 EDT 2016
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Journal of immunology (Baltimore, Md. : 1950)
Harakal J,Rival C,Qiao H,Tung KS
14-7041-81 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.
Fri Jul 01 00:00:00 EDT 2016
Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells.
Mediators of inflammation
Huang P,Zhou Y,Liu Z,Zhang P
14-7041 was used in Functional assays to investigate the interaction effects of ANXA1 and GATA-3 to influence T cell differentiation in CD4(+) T cells.
Fri May 19 00:00:00 EDT 2017
Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments.
Biomolecules & therapeutics
Lee AY,Kang S,Park SJ,Huang J,Im DS
Sun May 01 00:00:00 EDT 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
14704181 was used in flow cytometry to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways
Mon Apr 18 00:00:00 EDT 2016
5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Oncotarget
Wang J,Peng L,Zhang R,Zheng Z,Chen C,Cheung KL,Cui M,Bian G,Xu F,Chiang D,Hu Y,Chen Y,Lu G,Yang J,Zhang H,Yang J,Zhu H,Chen SH,Liu K,Zhou MM,Sikora AG,Li L,Jiang B,Xiong H
14-7041 was used in Flow cytometry/Cell sorting to investigate the function of 5-Fluorouracil in the modulation of immune cells.
Tue Apr 12 00:00:00 EDT 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
14-7041 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.
Wed May 18 00:00:00 EDT 2016
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
Journal of neuroinflammation
Lee JK,Kannarkat GT,Chung J,Joon Lee H,Graham KL,Tansey MG
14-7041 was used in Neutralization experiments to define potential roles for RGS10 in regulating autoimmune responses, showing that deficiency ameliorates the severity of disease in EAE.
Mon Feb 01 00:00:00 EST 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
14704181 was used in flow cytometry to study the contribution of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer cell activation and tumor control
Wed Jun 01 00:00:00 EDT 2016
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
14-7041 was used in Functional assays to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 EST 2015
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
The Journal of clinical investigation
Gerriets VA,Kishton RJ,Nichols AG,Macintyre AN,Inoue M,Ilkayeva O,Winter PS,Liu X,Priyadharshini B,Slawinska ME,Haeberli L,Huck C,Turka LA,Wood KC,Hale LP,Smith PA,Schneider MA,MacIver NJ,Locasale JW,Newgard CB,Shinohara ML,Rathmell JC
14-7041 was used in Functional assays to show that CD4+ subsets require distinct metabolic programs that can be targeted to control specific T cell populations in autoimmune and inflammatory diseases.
Thu Jan 01 00:00:00 EST 2015
Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.
PLoS pathogens
Mitagami Y,Yasunaga J,Kinosada H,Ohshima K,Matsuoka M
14-7041 was used in Flow cytometry/Cell sorting to investigate the effect of interferon-γ on inflammation and T-cell lymphoma development in HTLV-1 bZIP factor transgenic mice.
Sat Aug 01 00:00:00 EDT 2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-7041 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 EDT 2015
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2016
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
The Journal of pharmacology and experimental therapeutics
Mangan PR,Su LJ,Jenny V,Tatum AL,Picarillo C,Skala S,Ditto N,Lin Z,Yang X,Cotter PZ,Shuster DJ,Song Y,Borowski V,Thomas RL,Heimrich EM,Devaux B,Das Gupta R,Carvajal I,McIntyre KW,Xie J,Zhao Q,Struthers M,Salter-Cid LM
14-7041 was used in Neutralization experiments to evaluate the effect of selective IL-23 and IL-17 inhibitors alone and in combination with in vitro and in vivo models of Th17-mediated autoimmunity.
Sat Aug 01 00:00:00 EDT 2015
Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease.
Annals of hematology
Shao L,Lie AK,Zhang Y,Wong CH,Kwong YL
14704181 was used in flow cytometry to explore the roles of T and B cells in chronic graft-versus-host disease
Tue Sep 01 00:00:00 EDT 2015
Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome.
Infection and immunity
Zhang ZQ,Wang J,Hoy Z,Keegan A,Bhagwat S,Gigliotti F,Wright TW
14-7041 was used in Flow cytometry/Cell sorting to demonstrate that restricting the ability of macrophages to polarize in response to Th1 or Th2 cytokines does not impair Pneumocystis clearance.
Tue Dec 01 00:00:00 EST 2015
T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens.
Cell reports
Voisinne G,Nixon BG,Melbinger A,Gasteiger G,Vergassola M,Altan-Bonnet G
14-7041 was used in Neutralization experiments to identify the PI3K pathway as being critical for integrating the antigen and cytokine responses necessary for controlling cell-cycle entry.
Tue May 26 00:00:00 EDT 2015
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
Immunity
Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN
14-7041 was used in Flow cytometry/Cell sorting to demonstrate that ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production.
Thu Aug 21 00:00:00 EDT 2014
Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice.
Gastroenterology
Boué J,Basso L,Cenac N,Blanpied C,Rolli-Derkinderen M,Neunlist M,Vergnolle N,Dietrich G
14-7041-81 was used in In vitro experiments to investigate whether colitogenic CD4(+) T cells that accumulate in the inflamed colon produce opioids and are able to counteract inflammation-induced visceral pain in mice.
Wed Jan 01 00:00:00 EST 2014
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Proceedings of the National Academy of Sciences of the United States of America
Limon JJ,So L,Jellbauer S,Chiu H,Corado J,Sykes SM,Raffatellu M,Fruman DA
14-7041 was used in in vitro experiments to further elucidate the complexity of mTOR signalling in B cells.
Tue Nov 25 00:00:00 EST 2014
Signaling pathways activated by a protease allergen in basophils.
Proceedings of the National Academy of Sciences of the United States of America
Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R
14-7041 was used in Flow cytometry/Cell sorting to study signaling pathways activated by a protease allergen in basophils.
Tue Nov 18 00:00:00 EST 2014
Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.
The Journal of investigative dermatology
Shimizuhira C,Otsuka A,Honda T,Kitoh A,Egawa G,Nakajima S,Nakashima C,Watarai H,Miyachi Y,Kabashima K
14-7041 was used in Flow cytometry/Cell sorting to report the pivotal contribution of dendritic and natural killer T cell interactions to hypersensitivity.
Sat Nov 01 00:00:00 EDT 2014
Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis.
Arthritis research & therapy
Asnagli H,Martire D,Belmonte N,Quentin J,Bastian H,Boucard-Jourdin M,Fall PB,Mausset-Bonnefont AL,Mantello-Moreau A,Rouquier S,Marchetti I,Jorgensen C,Foussat A,Louis-Plence P
14-7041 was used in Functional assays to demonstrate the therapeutic potential of collagen type II-specific type 1 regulatory T cells in two models of rheumatoid arthritis.
Thu May 22 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
14-7041 was used in Flow cytometry/Cell sorting to explore the proneurogenic potential of interleukin 17-producing T helper (Th17) cells.
Fri Mar 06 00:00:00 EST 2020
Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.
Immunity
Bailis W,Yashiro-Ohtani Y,Fang TC,Hatton RD,Weaver CT,Artis D,Pear WS
14-7041 was used in Flow cytometry/Cell sorting to investigate the role of Notch in orchestrating Th cell differentiation.
Thu Jul 25 00:00:00 EDT 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-7041-81 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
The Nlrp3 inflammasome regulates acute graft-versus-host disease.
The Journal of experimental medicine
Jankovic D,Ganesan J,Bscheider M,Stickel N,Weber FC,Guarda G,Follo M,Pfeifer D,Tardivel A,Ludigs K,Bouazzaoui A,Kerl K,Fischer JC,Haas T,Schmitt-Gräff A,Manoharan A,Müller L,Finke J,Martin SF,Gorka O,Peschel C,Ruland J,Idzko M,Duyster J,Holler E,French LE,Poeck H,Contassot E,Zeiser R
14-7041 was used in Flow cytometry/Cell sorting to study the establishment and role of the Nlrp3 inflammasome in acute graft-versus-host disease.
Mon Sep 23 00:00:00 EDT 2013
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
The Journal of experimental medicine
Zhang R,Lu G,Shen Y,Peng L,Zhu C,Cui M,Wang W,Arnaboldi P,Tang M,Gupta M,Qi CF,Jayaraman P,Zhu H,Jiang B,Chen SH,He JC,Ting AT,Zhou MM,Kuchroo VK,Morse HC,Ozato K,Sikora AG,Xiong H
14-7041 was used in Flow cytometry/Cell sorting to study the effect of inducible nitric oxide synthase on T(H)17 cell differentiation.
Mon Jul 01 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production.
Acta pharmacologica Sinica
Kong FY,Chen W,He SJ,Lin ZM,Li X,Zhang XH,Yang XQ,Zhu FH,Tong XK,Zhou Y,Tang W,Duan WH,Zuo JP
14-7041 was used in Flow cytometry/Cell sorting to investigate the interaction between the mycophenolic acid derivative, 118, and the immune environment in a murine allogeneic skin graft model.
Mon Jul 01 00:00:00 EDT 2013
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology
Manzke N,Akhmetzyanova I,Hasenkrug KJ,Trilling M,Zelinskyy G,Dittmer U
14-7041 was used in Flow cytometry/Cell sorting to investigate how both Tregs and CD8(+) T cells influence the cytotoxic activity of conventional CD4(+) T cells during an acute retroviral infection.
Sat Jun 01 00:00:00 EDT 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
14-7041 was used in Functional assays to investigate means of promoting stability of Tregs, showing that TNFR2 is critical for stabilisation in the inflammatory environment.
Fri Feb 01 00:00:00 EST 2013
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Frazer LC,Sullivan JE,Zurenski MA,Mintus M,Tomasak TE,Prantner D,Nagarajan UM,Darville T
14-7041 was used in Functional assays to assess the role of MyD88 in immune responses to Chlamydia infection.
Tue Oct 15 00:00:00 EDT 2013
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
The Journal of nutrition
Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS
14-7041 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.
Sun Sep 01 00:00:00 EDT 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using IL-4 monoclonal antibody (Product # 14-7041-81) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
14-7041 was used in Immunofluorescence to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications
Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S
14-7041 was used in Functional assays to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Tue Oct 22 00:00:00 EDT 2013
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Castillo EF,Dekonenko A,Arko-Mensah J,Mandell MA,Dupont N,Jiang S,Delgado-Vargas M,Timmins GS,Bhattacharya D,Yang H,Hutt J,Lyons CR,Dobos KM,Deretic V
14-7041 was used in an ELISA assay to study the role of autophagy during immune responses to tuberculosis.
Tue Nov 13 00:00:00 EST 2012
Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.
Journal of immunology (Baltimore, Md. : 1950)
Kwon MJ,Ma J,Ding Y,Wang R,Sun Z
14-7041 was used in Functional assays to investigate the function of PKC-θ in Th17 differentiation.
Fri Jun 15 00:00:00 EDT 2012
Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury.
Journal of immunology (Baltimore, Md. : 1950)
Bajwa A,Huang L,Ye H,Dondeti K,Song S,Rosin DL,Lynch KR,Lobo PI,Li L,Okusa MD
14-7041-81 was used in Functional assays to study the role of dendritic cell sphingosine 1-phosphate receptor-3 in modulating Natural Killer T cell function and Th1-Th2 polarity in ischaemia-reperfusion injury.
Sat Sep 01 00:00:00 EDT 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-7041 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 EST 2012
Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes.
Endocrinology
Kanzaki M,Wada J,Sugiyama K,Nakatsuka A,Teshigawara S,Murakami K,Inoue K,Terami T,Katayama A,Eguchi J,Akiba H,Yagita H,Makino H
14-7041 was used in Flow cytometry/Cell sorting to investigate the galectin-9 and T cell immunoglobulin mucin-3 pathways as a therapeutic target for type 1 diabetes.
Wed Feb 01 00:00:00 EST 2012
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.
PloS one
Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS
14-7041 was used in Functional assays to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.
Thu Jun 20 00:00:00 EDT 2013
Adenovirus type 5 induces vitamin A-metabolizing enzymes in dendritic cells and enhances priming of gut-homing CD8 T cells.
Mucosal immunology
Ganguly S,Manicassamy S,Blackwell J,Pulendran B,Amara RR
14-7041 was used in Flow cytometry/Cell sorting to investigate how Ad5 modulates peripheral dendritic cell function to induce gut homing potential on CD8+ T cells using Ad5-immunised mice.
Thu Sep 01 00:00:00 EDT 2011
A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis.
The Journal of investigative dermatology
Kautz-Neu K,Kostka SL,Dinges S,Iwakura Y,Udey MC,von Stebut E
14-7041 was used in Flow cytometry/Cell sorting to suggest that in addition to effects on Th education, IL-1α/β signalling also modulates DC homeostasis with increased signalling, leading to down-modulation of IL-12 synthesis and worsened disease outcome after infection with Leishmania major.
Mon Aug 01 00:00:00 EDT 2011
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Xie P,Kraus ZJ,Stunz LL,Liu Y,Bishop GA
14-7041 was used in an ELISA assay to provide insights into the specific function of TNFR-associated factor 3 in T cells.
Sat Jan 01 00:00:00 EST 2011
Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa R,Yoshida H,Asakawa M,Tamiya T,Inoue N,Morita R,Inoue H,Nakao A,Yoshimura A
14-7041 was used in an ELISA assay to suggest that the JAK inhibitor P6 is therapeutic for atopic dermatitis by modulating the balance of Th2 and Th17.
Tue Nov 01 00:00:00 EDT 2011
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A.
Molecular and cellular biology
Joshi S,Pantalena LC,Liu XK,Gaffen SL,Liu H,Rohowsky-Kochan C,Ichiyama K,Yoshimura A,Steinman L,Christakos S,Youssef S
14-7041 was used in Functional assays to investigate the role of 1,25-dihydroxyvitamin D(3) in experimental autoimmune encephalomyelitis.
Thu Sep 01 00:00:00 EDT 2011
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
PloS one
Petersen TR,Sika-Paotonu D,Knight DA,Simkins HM,Hermans IF
14-7041 was used in Functional assays to investigate whether transfer of antigen between APCs is a mechanism to spread antigen to cells with specialised stimulatory functions.
Thu Mar 31 00:00:00 EDT 2011
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
PloS one
Petersen TR,Sika-Paotonu D,Knight DA,Simkins HM,Hermans IF
14-7041 was used in Functional assays to investigate whether transfer of antigen between APCs is a mechanism to spread antigen to cells with specialised stimulatory functions.
Thu Mar 31 00:00:00 EDT 2011
Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery.
Plant biotechnology journal
Davoodi-Semiromi A,Schreiber M,Nalapalli S,Verma D,Singh ND,Banks RK,Chakrabarti D,Daniell H
14-7041 was used in Flow cytometry/Cell sorting to further investigate use of chloroplast-derived vaccines against major diseases.
Mon Feb 01 00:00:00 EST 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
14-7041 was used in in vitro experiments to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
14-7041 was used in in vitro experiments to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
Mast cell function is not altered by Coronin-1A deficiency.
Journal of leukocyte biology
Arandjelovic S,Wickramarachchi D,Hemmers S,Leming SS,Kono DH,Mowen KA
14-7041 was used in in vitro experiments to demonstrate that Coronin-1A activity is not required for mast cell function.
Fri Oct 01 00:00:00 EDT 2010
Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.
Journal of immunology (Baltimore, Md. : 1950)
Kim S,Prout M,Ramshaw H,Lopez AF,LeGros G,Min B
14-7041 was used in Flow cytometry/Cell sorting to investigate the importance of IL-3 in recruiting basophils into the draining lymph nodes and inducing Th2 immune responses following helminth infection.
Mon Feb 01 00:00:00 EST 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
14-7041 was used in Flow cytometry/Cell sorting to elucidate a role for CD30 in T cell differentiation.
Sun Aug 15 00:00:00 EDT 2010
Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Journal of immunology (Baltimore, Md. : 1950)
Kemp KL,Levin SD,Bryce PJ,Stein PL
14-7041 was used in Magnetic cell separation to imply that Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Thu Apr 15 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-7041 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
Langerhans cells serve as immunoregulatory cells by activating NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Fukunaga A,Khaskhely NM,Ma Y,Sreevidya CS,Taguchi K,Nishigori C,Ullrich SE
14-7041 was used in Neutralization experiments to investigate the function of Langerhans cells isolated from UV-irradiated mice.
Fri Oct 15 00:00:00 EDT 2010
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology
Perrigoue JG,Saenz SA,Siracusa MC,Allenspach EJ,Taylor BC,Giacomin PR,Nair MG,Du Y,Zaph C,van Rooijen N,Comeau MR,Pearce EJ,Laufer TM,Artis D
14-7041 was used in an ELISA assay to suggest that major histocompatibility complex class II-dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
Wed Jul 01 00:00:00 EDT 2009
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
Blood
Jin W,Zhou XF,Yu J,Cheng X,Sun SC
14-7041 was used in Blocking experiments to investigate the molecular mechanism underlying Th17 differentiation.
Thu Jun 25 00:00:00 EDT 2009
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
The Journal of experimental medicine
Doisne JM,Bartholin L,Yan KP,Garcia CN,Duarte N,Le Luduec JB,Vincent D,Cyprian F,Horvat B,Martel S,Rimokh R,Losson R,Benlagha K,Marie JC
14-7041 was used in Flow cytometry/Cell sorting to show that TGF-beta controls the differentiation program of iNKT cells.
Mon Jun 08 00:00:00 EDT 2009
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.
Glia
Bai L,Lennon DP,Eaton V,Maier K,Caplan AI,Miller SD,Miller RH
14-7041 was used in an ELISpot assay to suggest that bone marrow-derived mesenchymal stem cells represent a viable option for therapeutic approaches to multiple sclerosis.
Sat Aug 15 00:00:00 EDT 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-7041 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
14-7041 was used in Functional assays to investigate the role of Runx3 in Th1 and Th2 cells.
Tue Dec 15 00:00:00 EST 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
14-7041 was used in Blocking experiments to investigate the physiological functions of NF-kappaB inhibitors, showing that p105 regulates T cell homeostasis and prevents chronic inflammation.
Sun Mar 01 00:00:00 EST 2009
CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuwabara T,Ishikawa F,Yasuda T,Aritomi K,Nakano H,Tanaka Y,Okada Y,Lipp M,Kakiuchi T
14-7041 was used in an ELISA assay to deduce the role of CCL19 and CCL21 in inducing experimental autoimmune encephalomyelitis.
Sat Aug 15 00:00:00 EDT 2009
Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.
Vaccine
Seavey MM,Mosmann TR
14-7041 was used in an ELISpot assay to investigate the effect of estradiol during intravaginal immunisation, showing that estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming.
Tue Apr 14 00:00:00 EDT 2009
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
Nature immunology
Xiao C,Srinivasan L,Calado DP,Patterson HC,Zhang B,Wang J,Henderson JM,Kutok JL,Rajewsky K
14-7041 was used in Flow cytometry/Cell sorting to investigate the mechanism behind the promotion of miR-17-92-induced lymphomagenesis.
Tue Apr 01 00:00:00 EDT 2008
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
14-7041 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Immunity
Marie JC,Liggitt D,Rudensky AY
14-7041 was used in Immunocytochemistry to demonstrate that TGF-beta signalling in T cells is crucial to restrain fatal autoimmune processes.
Fri Sep 01 00:00:00 EDT 2006
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell
Wegener E,Oeckinghaus A,Papadopoulou N,Lavitas L,Schmidt-Supprian M,Ferch U,Mak TW,Ruland J,Heissmeyer V,Krappmann D
14-7041 was used in Flow cytometry/Cell sorting to investigate the physiological function of antigen-induced phosphorylation of Bcl10.
Fri Jul 07 00:00:00 EDT 2006
