Product References
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.
Stem cell research & therapy
Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Mon Oct 02 00:00:00 EDT 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Autophagy
Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z
17-7041-82 was used in Flow Cytometry to demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1:.
Sat Apr 01 00:00:00 EDT 2023
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Autophagy
Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z
17-7041-82 was used in Flow Cytometry to demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1:.
Sat Apr 01 00:00:00 EDT 2023
TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Zhao J,Jia L,Tao Y,Zhao X,Yang J,Lu Y,Yan Y,Mao L,Hu L,Lu J,Guo M,Chen C,Zhou Y,Wen Z,He Z,Xu L
17-7041-82 was used in Flow cytometry/Cell sorting to suggest that the clone selection in thymus in Endotoxin tolerance may confer protection against microbial sepsis.
Wed Mar 01 00:00:00 EST 2023
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Zhang Y,Li F,Chen C,Li Y,Xie W,Huang D,Zhai X,Yu W,Wan J,Li P
17-7041-82 was used in Flow cytometry/Cell sorting to show that sRAGE can serve as a novel immunometabolic modulator that ameliorates ischemic stroke recovery by inhibiting fatty acid synthesis and thus favoring CD4+ T cells polarization toward Treg after cerebral ischemia injury.
Wed Jun 01 00:00:00 EDT 2022
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Fri Aug 06 00:00:00 EDT 2021
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.
The Journal of biological chemistry
Tsai SJ,Atai NA,Cacciottolo M,Nice J,Salehi A,Guo C,Sedgwick A,Kanagavelu S,Gould SJ
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration.
iScience
Makino A,Shibata T,Nagayasu M,Hosoya I,Nishimura T,Nakano C,Nagata K,Ito T,Takahashi Y,Nakamura S
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Fri Oct 22 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
17-7041-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 EST 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.
Nature communications
Conde E,Bertrand R,Balbino B,Bonnefoy J,Stackowicz J,Caillot N,Colaone F,Hamdi S,Houmadi R,Loste A,Kamphuis JBJ,Huetz F,Guilleminault L,Gaudenzio N,Mougel A,Hardy D,Snouwaert JN,Koller BH,Serra V,Bruhns P,Grouard-Vogel G,Reber LL
17-7041-82 was used in Immunohistochemistry (PFA fixed) to imply that dual IL-4/IL-13 vaccination may represent a cost-effective, long-term therapeutic strategy for the treatment of allergic asthma as demonstrated in mouse models, although additional studies are warranted to assess its safety and feasibility.
Tue May 11 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
17-7041-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.
Fri Mar 19 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
17-7041-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.
Fri Mar 19 00:00:00 EDT 2021
Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo.
Cell reports
Chen ELY,Lee CR,Thompson PK,Wiest DL,Anderson MK,Zúñiga-Pflücker JC
17-7041-82 was used in Flow Cytometry to employ RBPJ-inducible and KN6-transgenic mice to assess the roles of ontogenic timing, T cell receptor (TCR) signal strength, and Notch signaling.
Tue Jun 08 00:00:00 EDT 2021
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
17-7041 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
17-7041 was used in Flow cytometry/Cell sorting to deepen the understanding of the pathogenesis of acute graft-versus-host disease (GVHD) and provide novel approaches for controlling acute GVHD.
Wed Jul 01 00:00:00 EDT 2020
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
17-7041 was used in Flow cytometry/Cell sorting to deepen the understanding of the pathogenesis of acute graft-versus-host disease (GVHD) and provide novel approaches for controlling acute GVHD.
Wed Jul 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
17-7041 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.
Mon May 04 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
17-7041 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.
Mon May 04 00:00:00 EDT 2020
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Nature communications
Mahata B,Pramanik J,van der Weyden L,Polanski K,Kar G,Riedel A,Chen X,Fonseca NA,Kundu K,Campos LS,Ryder E,Duddy G,Walczak I,Okkenhaug K,Adams DJ,Shields JD,Teichmann SA
17-7041 was used in Flow cytometry/Cell sorting to show that tumors induce de novo steroidogenesis in T lymphocytes to evade anti-tumor immunity.
Fri Jul 17 00:00:00 EDT 2020
Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection.
Parasite (Paris, France)
Song Y,Xu J,Wang X,Yang Y,Bai X,Pang J,Wang X,Yu M,Liu M,Liu X,Sun S
17-7041 was used in Flow cytometry/Cell sorting to examine immune cells and cytokine profiles of Trichinella spiralis infected mice by Meso Scale Discovery (MSD) and flow cytometry.
Fri May 08 00:00:00 EDT 2020
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
JCI insight
Lee CG,Kwon HK,Kang H,Kim Y,Nam JH,Won YH,Park S,Kim T,Kang K,Rudra D,Jun CD,Park ZY,Im SH
17-7041 was used in Flow cytometry/Cell sorting to reveal a protective role of Ets1 in restricting pathogenic Th cell responses and suggest a potential therapeutic target for atopic dermatitis (AD) treatment.
Thu Mar 07 00:00:00 EST 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Immunity
Mamedov MR,Scholzen A,Nair RV,Cumnock K,Kenkel JA,Oliveira JHM,Trujillo DL,Saligrama N,Zhang Y,Rubelt F,Schneider DS,Chien YH,Sauerwein RW,Davis MM
17-7041-82 was used in Flow Cytometry to point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.
Tue Feb 20 00:00:00 EST 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Genome medicine
Pramanik J,Chen X,Kar G,Henriksson J,Gomes T,Park JE,Natarajan K,Meyer KB,Miao Z,McKenzie ANJ,Mahata B,Teichmann SA
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Wed Oct 24 00:00:00 EDT 2018
Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference.
Scientific reports
Brombacher TM,De Gouveia KS,Cruywagen L,Makena N,Booley F,Tamgue O,Brombacher F
17-7041 was used in Flow cytometry/Cell sorting to identify cognitive changes during Nippostrongylus brasiliensis infection.
Tue Feb 13 00:00:00 EST 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
17-7041 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Sumoylation of RORγt regulates TH17 differentiation and thymocyte development.
Nature communications
He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z
17-7041 was used in Flow cytometry/Cell sorting to study the mechanism underlying the regulation of RORyt function.
Mon Nov 19 00:00:00 EST 2018
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.
Frontiers in immunology
Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL
Wed Nov 20 00:00:00 EST 2019
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology
Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD
17-7041 was used in Flow cytometry/Cell sorting to identify a crucial role for caspase-8 in the development of allergic airway inflammation.
Sun Jan 01 00:00:00 EST 2017
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
PLoS pathogens
Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM
17-7041 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.
Sun Oct 01 00:00:00 EDT 2017
Rediscovering peritoneal macrophages in a murine endometriosis model.
Human reproduction (Oxford, England)
Yuan M,Li D,An M,Li Q,Zhang L,Wang G
17-7041 was used in Flow Cytometry to study the role of large and small peritoneal macrophages in endometriosis.
Sun Jan 01 00:00:00 EST 2017
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Movassagh H,Shan L,Mohammed A,Halayko AJ,Gounni AS
17-7041 was used in Flow cytometry/Cell sorting to identify Semaphorin 3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events.
Wed Mar 01 00:00:00 EST 2017
Oriental Medicine Samhwangsasim-tang Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 Cell Responses and Upregulating Treg Cell Responses.
Frontiers in pharmacology
Lee MJ,Choi JH,Lee SJ,Cho IH
17-7041 was used in Flow cytometry/Cell sorting to investigate whether Samhwangsasim-tang has a beneficial effect in treating myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Thu Oct 01 00:00:00 EDT 2020
Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.
EBioMedicine
Lirussi D,Ebensen T,Schulze K,Trittel S,Duran V,Liebich I,Kalinke U,Guzmán CA
17-7041 was used in Immunocytochemistry-immunoflourescence to demonstrate that stimulation of interferon-γ-secreting CD8+ cytotoxic T lymphocytes is significantly decreased after vaccination in the absence of type I interferon signalling.
Tue Aug 01 00:00:00 EDT 2017
p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
European journal of immunology
Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P
17-7041-82 was used in Flow Cytometry to suggest that both in vitro and in vivo differentiation of Th17 cells were positively regulated by p70(S6K1).
Fri Jan 01 00:00:00 EST 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
17-7041 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation.
Blood
Chen S,Smith BA,Iype J,Prestipino A,Pfeifer D,Grundmann S,Schmitt-Graeff A,Idzko M,Beck Y,Prinz G,Finke J,Duyster J,Zeiser R
17-7041 was used in Flow cytometry/Cell sorting to indicate that during graft-versus-host disease, miR-155 promotes DC migration toward sites of ATP release accompanied by inflammasome activation.
Thu Jul 02 00:00:00 EDT 2015
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America
Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y
17-7041 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.
Tue May 19 00:00:00 EDT 2015
Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
Mucosal immunology
Platzer B,Baker K,Vera MP,Singer K,Panduro M,Lexmond WS,Turner D,Vargas SO,Kinet JP,Maurer D,Baron RM,Blumberg RS,Fiebiger E
17-7041 was used in Flow cytometry/Cell sorting to confirm a novel immune regulatory function of Immunoglobulin E.
Fri May 01 00:00:00 EDT 2015
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2016
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Nature immunology
Simpson LJ,Patel S,Bhakta NR,Choy DF,Brightbill HD,Ren X,Wang Y,Pua HH,Baumjohann D,Montoya MM,Panduro M,Remedios KA,Huang X,Fahy JV,Arron JR,Woodruff PG,Ansel KM
17-7041 was used in Flow cytometry/Cell sorting to study how upregulation of miR-19a in asthma may be an indicator and a cause of increased TH2 cytokine production in the airways.
Mon Dec 01 00:00:00 EST 2014
Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.
The Journal of allergy and clinical immunology
Farhadi N,Lambert L,Triulzi C,Openshaw PJ,Guerra N,Culley FJ
17-7041 was used in Flow cytometry/Cell sorting to investigate the importance of natural killer cells in house dust mite-triggered allergic response.
Sat Mar 01 00:00:00 EST 2014
Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.
Cancer research
Schadler KL,Crosby EJ,Zhou AY,Bhang DH,Braunstein L,Baek KH,Crawford D,Crawford A,Angelosanto J,Wherry EJ,Ryeom S
17-7041 was used in Flow cytometry/Cell sorting to establish that tumorigenesis can be stanched by antiangiogenic surveillance triggered by an acute viral infection.
Tue Apr 15 00:00:00 EDT 2014
CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.
European journal of immunology
Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG
17-7041 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.
Sun Jun 01 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes.
Vaccines
Becker PD,Nörder M,Weissmann S,Ljapoci R,Erfle V,Drexler I,Guzmán CA
17-7041 was used in Flow cytometry/Cell sorting to evaluate the effect of overexpressing recombinant Ag using modified vaccinia virus early/late promoter H5 (mPH5), showing that overexpression enhances antibody responses and increases vaccination efficiency.
Tue Jul 22 00:00:00 EDT 2014
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of experimental medicine
Bronevetsky Y,Villarino AV,Eisley CJ,Barbeau R,Barczak AJ,Heinz GA,Kremmer E,Heissmeyer V,McManus MT,Erle DJ,Rao A,Ansel KM
17-7041 was used in Flow cytometry/Cell sorting to reveal T cell activation induces global post-transcriptional miRNA down-regulation, promoting acquisition of helper T cell effector functions.
Mon Feb 11 00:00:00 EST 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
17-7041 was used in Flow cytometry/Cell sorting to study exacerbation of atherogenesis with genetic deletion of chemokine receptor Ccr7 in ApoE-deficient mice.
Fri Mar 01 00:00:00 EST 2013
Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production.
Journal of immunology (Baltimore, Md. : 1950)
Khan TN,Wong EB,Soni C,Rahman ZS
17-7041 was used in Flow cytometry/Cell sorting to study the effect of Mer receptor tyrosine kinase deficiency on the clearance of apoptotic cells.
Fri Feb 15 00:00:00 EST 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using IL-4 monoclonal antibody (Product # 17-7041-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
17-7041 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 EST 2013
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.
PloS one
Nakanishi W,Yamaguchi S,Matsuda A,Suzukawa M,Shibui A,Nambu A,Kondo K,Suto H,Saito H,Matsumoto K,Yamasoba T,Nakae S
17-7041 was used in Flow cytometry/Cell sorting to determine that IL-33, but not IL-25, is crucial for the development of house dust mice antigen-induced allergic rhinitis.
Thu Sep 18 00:00:00 EDT 2014
PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis.
Journal of the American Society of Nephrology : JASN
Ito H,Yan X,Nagata N,Aritake K,Katsumata Y,Matsuhashi T,Nakamura M,Hirai H,Urade Y,Asano K,Kubo M,Utsunomiya Y,Hosoya T,Fukuda K,Sano M
17-7041 was used in Flow cytometry/Cell sorting to explore the contribution of L-PGDS to the development of chronic kidney disease.
Thu Nov 01 00:00:00 EDT 2012
Host basophils are dispensable for induction of donor T helper 2 cell differentiation and severity of experimental graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Tawara I,Nieves E,Liu C,Evers R,Toubai T,Sun Y,Alrubaie M,Reddy P
17-7041 was used in Flow cytometry/Cell sorting to demonstrate that, in contrast to their role in inducing Th2 responses in certain contexts, basophils are dispensable for the induction of donor Th2 responses and for the severity of GVHD.
Thu Dec 01 00:00:00 EST 2011
Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Li Z,Mao K,Zou J,Wang Y,Tao Z,Lin G,Tian L,Ji Y,Wu X,Zhu X,Sun S,Chen W,Xiang C,Sun B
17-7041 was used in Flow cytometry/Cell sorting to investigate the role of Dec2 in Th cell differentiation, showing that it is progressively induced at the late stage of Th2 differentiation, and that upregulation of Dec2 can promote Th2 differentiation under Th2-inducing conditions, which is due to CD25 expression elicited by Dec2.
Sun Nov 15 00:00:00 EST 2009
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells.
Blood
De Fanis U,Mori F,Kurnat RJ,Lee WK,Bova M,Adkinson NF,Casolaro V
17-7041 was used in Flow cytometry/Cell sorting to study whether GATA-3 and T-box genes are regulated in human Th cells, showing that GATA3 up-regulation is associated with surface expression of CD294/CRTH2.
Tue May 15 00:00:00 EDT 2007
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The Journal of experimental medicine
Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF
17-7041 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.
Mon Aug 15 00:00:00 EDT 2005
Cross-presentation of disialoganglioside GD3 to natural killer T cells.
The Journal of experimental medicine
Wu DY,Segal NH,Sidobre S,Kronenberg M,Chapman PB
17-7041 was used in an ELISpot assay to demonstrate that immunising mice with the SK-MEL-28 cell line or with syngeneic APCs loaded with GD3 can induce a GD3-reactive natural killer T cell response.
Mon Jul 07 00:00:00 EDT 2003
