Product References
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
17-5893-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 EST 2023
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
17-5893-82 was used in Flow cytometry/Cell sorting to show that ILC2s undergo translocation via the lung-gut axis upon IL-33 treatment.
Fri Dec 09 00:00:00 EST 2022
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
17-5893-82 was used in Flow cytometry/Cell sorting to show that ILC2s undergo translocation via the lung-gut axis upon IL-33 treatment.
Fri Dec 09 00:00:00 EST 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
17-5893-82 was used in Flow Cytometry to demonstrate that ID2 sets a threshold for TCF1 during NK cell development, thus controlling the balance of immature and terminally differentiated cells that support future NK cell responses.
Mon Jun 07 00:00:00 EDT 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
17-5893-82 was used in Flow Cytometry to demonstrate that ID2 sets a threshold for TCF1 during NK cell development, thus controlling the balance of immature and terminally differentiated cells that support future NK cell responses.
Mon Jun 07 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Tue Jun 15 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.
Immunity
Zenke S,Palm MM,Braun J,Gavrilov A,Meiser P,Böttcher JP,Beyersdorf N,Ehl S,Gerard A,Lämmermann T,Schumacher TN,Beltman JB,Rohr JC
17-5893 was used in Flow cytometry/Cell sorting to conclude that CD8+ T cell-population-intrinsic mechanisms regulate cellular behavior, thereby promoting robustness of population dynamics.
Tue Feb 18 00:00:00 EST 2020
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
17-5893 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
17-5893-82 was used in Flow Cytometry to develop enhanced adoptive T cell therapy using immunomodulatory fusion proteins for use in solid tumours.
Mon Dec 07 00:00:00 EST 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
17-5893 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
17-5893 was used in Flow cytometry/Cell sorting to suggest a revised model for ILC differentiation that redefines the cell-fate potential of helper-ILC-restricted Zbtb16+ ILCPs.
Tue Apr 16 00:00:00 EDT 2019
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
Immunity
Schneider C,Lee J,Koga S,Ricardo-Gonzalez RR,Nussbaum JC,Smith LK,Villeda SA,Liang HE,Locksley RM
17-5893 was used in Flow cytometry/Cell sorting to show that ILC2 appeared in multiple organs during lat gestation like tissue macrophages, but, unlike the latter, a majority of peripheral ILC2 pools were generated de novo during the postnatal window.
Tue Jun 18 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
17-5893 was used in Flow cytometry/Cell sorting to provide genetic evidence supporting that NKG2A and the inhibitory members of Ly49 family receptors synergize to regulate NK cell education.
Fri Nov 01 00:00:00 EDT 2019
Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity.
Nature microbiology
David SC,Norton T,Tyllis T,Wilson JJ,Singleton EV,Laan Z,Davies J,Hirst TR,Comerford I,McColl SR,Paton JC,Alsharifi M
17-5893 was used in Flow cytometry/Cell sorting to provide an additional explanation for the synergistic pathogenicity of IAV and S. pneumoniae, as well as heralding the prospect of exploiting the phenomenon to develop better vaccine strategies for both pathogens.
Thu Aug 01 00:00:00 EDT 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
17-5893 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.
Frontiers in immunology
Demeyer A,Skordos I,Driege Y,Kreike M,Hochepied T,Baens M,Staal J,Beyaert R
17-5893 was used in Flow cytometry/Cell sorting to establish that suppression of autoimmune responses is due to the T-cell intrinsic role of MALT1 proteolytic activity.
Mon Oct 05 00:00:00 EDT 2020
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Mon Sep 30 00:00:00 EDT 2019
Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes.
Frontiers in immunology
Albareda MC,Natale MA,De Rissio AM,Fernandez M,Serjan A,Alvarez MG,Cooley G,Shen H,Viotti R,Bua J,Castro Eiro MD,Nuñez M,Fichera LE,Lococo B,Scollo K,Tarleton RL,Laucella SA
17-5893 was used in Flow cytometry/Cell sorting to evaluate Trypanosoma cruzi-specific T-cell and antibody immune responses, T-cell phenotypes and paraseitemia in children undergoing anti-trypanosoma cruzi treatment.
Wed Sep 18 00:00:00 EDT 2019
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
17-5893 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
Cell
Van Dyken SJ,Liang HE,Naikawadi RP,Woodruff PG,Wolters PJ,Erle DJ,Locksley RM
17-5893 was used in Flow cytometry/Cell sorting to show that altered chitin clearance could exacerbate fibrogenic pathways in the setting of lung diseases characterised by epithelial cell dysfunction.
Thu Apr 20 00:00:00 EDT 2017
Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Mucosal immunology
Woodworth JS,Cohen SB,Moguche AO,Plumlee CR,Agger EM,Urdahl KB,Andersen P
17-5893 was used in Flow cytometry/Cell sorting to elucidate how H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Wed Mar 01 00:00:00 EST 2017
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Wellcome open research
Dutton EE,Camelo A,Sleeman M,Herbst R,Carlesso G,Belz GT,Withers DR
17-5893 was used in Flow cytometry/Cell sorting to compare the innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Sat Jan 09 00:00:00 EST 2021
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
17-5893 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Woodworth JS,Aagaard CS,Hansen PR,Cassidy JP,Agger EM,Andersen P
17-5893 was used in Flow cytometry/Cell sorting to compare the functionality of CD4 T cell responses mounted against dominant and cryptic epitopes of the Mycobacterium tuberculosis 6-kDa early secreted antigen before and postinfection.
Tue Apr 01 00:00:00 EDT 2014
MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.
Nature communications
Kieckbusch J,Gaynor LM,Moffett A,Colucci F
Published figure using KLRG1 monoclonal antibody (Product # 17-5893-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2014
Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.
Infection and immunity
Cyktor JC,Carruthers B,Stromberg P,Flaño E,Pircher H,Turner J
17-5893 was used in Flow cytometry/Cell sorting to investigate the requirement of the T cell differentiation marker KLRG1 during M. tuberculosis infection, showing that deficiency significantly enhances survival.
Mon Apr 01 00:00:00 EDT 2013
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
17-5893 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 EDT 2012
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Nature immunology
Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW
17-5893 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.
Sun Nov 06 00:00:00 EDT 2011
Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Butler NS,Harty JT
17-5893 was used in Flow cytometry/Cell sorting to investigate how the threshold of memory CD8 T cells required for protective immunity is influenced by Plasmodium-host interactions.
Sun May 15 00:00:00 EDT 2011
Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection.
PLoS pathogens
Martinez J,Huang X,Yang Y
17-5893 was used in Flow cytometry/Cell sorting to study the mechanisms underlying natural killer cell function in response to poxviruses.
Fri Mar 12 00:00:00 EST 2010
Antigen display, T-cell activation, and immune evasion during acute and chronic ehrlichiosis.
Infection and immunity
Nandi B,Chatterjee M,Hogle K,McLaughlin M,MacNamara K,Racine R,Winslow GM
17-5893 was used in Flow cytometry/Cell sorting to indicate that the ehrlichiae maintain chronic infection in part by avoiding signals mediated by activated T cells.
Thu Oct 01 00:00:00 EDT 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
17-5893 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
