Product References
GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
International journal of molecular sciences
Huntington KE,Louie AD,Srinivasan PR,Schorl C,Lu S,Silverberg D,Newhouse D,Wu Z,Zhou L,Borden BA,Giles FJ,Dooner M,Carneiro BA,El-Deiry WS
25-5893-82 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory properties of the GSK-3 inhibitor elraglusib, revealing its capacity to enhance immune cell-mediated tumor cell killing, sensitize colorectal cancer cells to immune-mediated cytotoxicity, reduce immunosuppressive factors, and improve survival when combined with immune checkpoint blockade therapy in preclinical models and clinical samples.
Thu Jun 29 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Fri Dec 09 00:00:00 EST 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
25-5893-82 was used in Flow Cytometry to demonstrate if killer cell lectin-like receptor G1 is a novel checkpoint inhibitor target that affects NK and T cell anti-tumor immunity.
Tue Jun 15 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
25-5893-82 was used in Flow Cytometry to demonstrate if killer cell lectin-like receptor G1 is a novel checkpoint inhibitor target that affects NK and T cell anti-tumor immunity.
Tue Jun 15 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Generating Mice with Diverse Microbial Experience.
Current protocols
Pierson M,Merley A,Hamilton SE
25-5893-82 was used in Flow cytometry/Cell sorting to outline procedures for exposing laboratory strains of mice to the diverse array of microbes typically found in pet store mice.
Mon Feb 01 00:00:00 EST 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
25-5893-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance.
Cell reports
Goh W,Scheer S,Jackson JT,Hediyeh-Zadeh S,Delconte RB,Schuster IS,Andoniou CE,Rautela J,Degli-Esposti MA,Davis MJ,McCormack MP,Nutt SL,Huntington ND
25-5893 was used in Flow cytometry/Cell sorting to show homeobox transcriptional regulator Hhex regulates NK cell homeostasis and immunity.
Tue Oct 20 00:00:00 EDT 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
25-5893 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.
Cell reports
Dodard G,Tata A,Erick TK,Jaime D,Miah SMS,Quatrini L,Escalière B,Ugolini S,Vivier E,Brossay L
25-5893 was used in Flow cytometry/Cell sorting to characterize the kinetics and immune response of each of the hepatic NK cell populations to viral challenge and other stimuli.
Tue Jul 07 00:00:00 EDT 2020
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
25-5893 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development.
Cell reports
Li A,Herbst RH,Canner D,Schenkel JM,Smith OC,Kim JY,Hillman M,Bhutkar A,Cuoco MS,Rappazzo CG,Rogers P,Dang C,Jerby-Arnon L,Rozenblatt-Rosen O,Cong L,Birnbaum M,Regev A,Jacks T
25-5893-82 was used in Flow Cytometry to profile dynamic shifts in the distribution of Tregs in a genetically engineered mouse model of lung adenocarcinoma.
Tue Dec 03 00:00:00 EST 2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Cell reports
Garg G,Muschaweckh A,Moreno H,Vasanthakumar A,Floess S,Lepennetier G,Oellinger R,Zhan Y,Regen T,Hiltensperger M,Peter C,Aly L,Knier B,Palam LR,Kapur R,Kaplan MH,Waisman A,Rad R,Schotta G,Huehn J,Kallies A,Korn T
25-5893 was used in Flow cytometry/Cell sorting to identify a Blimp1-dependent pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.
Tue Feb 12 00:00:00 EST 2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Yasuda K,Kitagawa Y,Kawakami R,Isaka Y,Watanabe H,Kondoh G,Kohwi-Shigematsu T,Sakaguchi S,Hirota K
25-5893-82 was used in Flow Cytometry to indicate that Satb1 regulates the specific gene expression and function of effector Th17 cells in tissue inflammation.
Fri Feb 01 00:00:00 EST 2019
CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs.
Frontiers in immunology
Ashhurst AS,Flórido M,Lin LCW,Quan D,Armitage E,Stifter SA,Stambas J,Britton WJ
25-5893 was used in Flow cytometry/Cell sorting to show that adoptive transfer of P25-specific CXCR6-deficient T-lymphocytes into WT mice revealed that this functional change in Th1-cytokine production was not due to a T-lymphocyte intrinsic mechanism.
Tue May 26 00:00:00 EDT 2020
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Mon Sep 30 00:00:00 EDT 2019
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
A Mouse Model of West Nile Virus Infection.
Current protocols in mouse biology
Graham JB,Swarts JL,Lund JM
25-5893 was used in Flow cytometry/Cell sorting to develop a mouse model to study the breadth of symptoms and disease severity seen in human West Nile virus infection.
Wed Dec 20 00:00:00 EST 2017
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
T Cell factor 1 represses CD8+ effector T cell formation and function.
Journal of immunology (Baltimore, Md. : 1950)
Tiemessen MM,Baert MR,Kok L,van Eggermond MC,van den Elsen PJ,Arens R,Staal FJ
25-5893 was used in Flow cytometry/Cell sorting to explore the role of the Wnt-responsive transcription factor T cell factor 1 in the initial phases of CD8(+) T effector cell formation.
Mon Dec 01 00:00:00 EST 2014
MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.
Nature communications
Kieckbusch J,Gaynor LM,Moffett A,Colucci F
Published figure using KLRG1 monoclonal antibody (Product # 25-5893-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2014