Product References
Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.
Nature communications
Tundidor I,Seijo-Vila M,Blasco-Benito S,Rubert-Hernández M,Adámez S,Andradas C,Manzano S,Álvarez-López I,Sarasqueta C,Villa-Morales M,González-Lois C,Ramírez-Medina E,Almoguera B,Sánchez-López AJ,Bindila L,Hamann S,Arnold N,Röcken C,Heras-Murillo I,Sancho D,Moreno-Bueno G,Caffarel MM,Guzmán M,Sánchez C,Pérez-Gómez E
13-5921-82 was used in Flow Cytometry to highlight the potential of FAAH as a biomarker with prognostic value in luminal BC and as a therapeutic target in metastatic disease.
Tue May 30 00:00:00 EDT 2023
Immunostimulatory effects of a subcritical water extract of Ganoderma.
Biomedical reports
Hattori K,Takagi H,Ogata Y,Yamada T,Horiba H,Fukata K,Sakaida T,Yashiro Y,Hasegawa S,Tanaka H
13-5921-82 was used in Flow cytometry/Cell sorting to demonstrate that Ganoderma (SWEG) increased hematopoietic precursor cells, immature B cells, and NK cells in the bone marrow, and T cells in the thymus.
Sun Jan 01 00:00:00 EST 2023
Role of FK506-sensitive signals in asthmatic lung inflammation.
Frontiers in immunology
Tomiaki C,Miyauchi K,Ki S,Suzuki Y,Suzuki N,Morimoto H,Mukoyama Y,Kubo M
13-5921-82 was used in Flow cytometry/Cell sorting to study the effects of FK506 on cysteine protease allergen-mediated airway inflammation.
Tue Nov 29 00:00:00 EST 2022
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.
Immunity
Feng J,Pucella JN,Jang G,Alcántara-Hernández M,Upadhaya S,Adams NM,Khodadadi-Jamayran A,Lau CM,Stoeckius M,Hao S,Smibert P,Tsirigos A,Idoyaga J,Reizis B
13-5921-82 was used in Flow cytometry/Cell sorting to reveal the shared origin of pDCs and cDCs and suggest a revised scheme of DC development whereby pDCs share clonal relationship with cDC1s.
Tue Mar 08 00:00:00 EST 2022
Precise control of embolic stroke with magnetized red blood cells in mice.
Communications biology
Jin Y,Shi P,Wang Y,Li J,Zhang J,Zhao X,Ge Y,Huang Y,Guo M,Wang F,Ci B,Xiao X,Gao X,Xu J,Dang B,Ji B,Ge WP,Jia JM
13-5921-82 was used in Magnetic cell separation to provide an animal model mimicking perinatal embolic stroke and imply a potential therapeutic strategy for the treatment of perinatal stroke.
Wed Feb 16 00:00:00 EST 2022
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Cancer cell
Ueda K,Kumari R,Schwenger E,Wheat JC,Bohorquez O,Narayanagari SR,Taylor SJ,Carvajal LA,Pradhan K,Bartholdy B,Todorova TI,Goto H,Sun D,Chen J,Shan J,Song Y,Montagna C,Xiong S,Lozano G,Pellagatti A,Boultwood J,Verma A,Steidl U
13-5921-82 was used in Flow cytometry/Cell sorting to identify MDMX overexpression as a pervasive preleukemic-to-AML transition mechanism in different genetically driven disease subtypes, and reveal Wnt/β-Catenin as a non-canonical MDMX-driven pathway with therapeutic potential for progression prevention and cancer interception.
Mon Apr 12 00:00:00 EDT 2021
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.
The Journal of clinical investigation
Yu W,Zhong L,Yao L,Wei Y,Gui T,Li Z,Kim H,Holdreith N,Jiang X,Tong W,Dyment N,Liu XS,Yang S,Choi Y,Ahn J,Qin L
13-5921 was used in Flow cytometry/Cell sorting to identify MALPs as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
Tue Jan 19 00:00:00 EST 2021
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.
Cardiovascular research
Koay YC,Chen YC,Wali JA,Luk AWS,Li M,Doma H,Reimark R,Zaldivia MTK,Habtom HT,Franks AE,Fusco-Allison G,Yang J,Holmes A,Simpson SJ,Peter K,O'Sullivan JF
13-5921 was used in Immunohistochemistry to reconcile contradictory data on TMAO.
Thu Jan 21 00:00:00 EST 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
13-5921 was used in Flow cytometry/Cell sorting to determine the effect of HDACs, mTOR, GSK‚3β and p38MAPK inhibitor combinations on the efficient expansion of HSCs using flow cytometry.
Fri Jan 01 00:00:00 EST 2021
Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
PloS one
Deshycka R,Sudaryo V,Huang NJ,Xie Y,Smeding LY,Choi MK,Ploegh HL,Lodish HF,Pishesha N
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri Dec 24 00:00:00 EST 2021
GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.
JCI insight
Kashgari G,Venkatesh S,Refuerzo S,Pham B,Bayat A,Klein RH,Ramos R,Ta AP,Plikus MV,Wang PH,Andersen B
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.
Life science alliance
Valkov N,Das A,Tucker NR,Li G,Salvador AM,Chaffin MD,Pereira De Oliveira Junior G,Kur I,Gokulnath P,Ziegler O,Yeri A,Lu S,Khamesra A,Xiao C,Rodosthenous R,Srinivasan S,Toxavidis V,Tigges J,Laurent LC,Momma S,Kitchen R,Ellinor P,Ghiran I,Das S
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Western Blot
Wed Dec 01 00:00:00 EST 2021
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.
Life science alliance
Valkov N,Das A,Tucker NR,Li G,Salvador AM,Chaffin MD,Pereira De Oliveira Junior G,Kur I,Gokulnath P,Ziegler O,Yeri A,Lu S,Khamesra A,Xiao C,Rodosthenous R,Srinivasan S,Toxavidis V,Tigges J,Laurent LC,Momma S,Kitchen R,Ellinor P,Ghiran I,Das S
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Western Blot
Wed Dec 01 00:00:00 EST 2021
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Cell reports. Medicine
Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Apr 20 00:00:00 EDT 2021
Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females.
Frontiers in immunology
Mashhouri S,Koleva P,Huynh M,Okoye I,Shahbaz S,Elahi S
13-5921-82 was used in Flow Cytometry to show pronounced sexual dimorphism in CD71+ Erythroid Cells (CECs) with female but not male mice, both BALB/c and C57BL/6, and human females being enriched with CECs.
Mon Dec 20 00:00:00 EST 2021
Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females.
Frontiers in immunology
Mashhouri S,Koleva P,Huynh M,Okoye I,Shahbaz S,Elahi S
13-5921-82 was used in Flow Cytometry to show pronounced sexual dimorphism in CD71+ Erythroid Cells (CECs) with female but not male mice, both BALB/c and C57BL/6, and human females being enriched with CECs.
Mon Dec 20 00:00:00 EST 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
13-5921-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.
Stem cell research & therapy
Wang B,Wang Y,Chen H,Yao S,Lai X,Qiu Y,Cai J,Huang Y,Wei X,Guan Y,Wang T,Wang J,Xiang AP
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Mon Jan 18 00:00:00 EST 2021
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Science advances
Heino S,Fang S,Lähde M,Högström J,Nassiri S,Campbell A,Flanagan D,Raven A,Hodder M,Nasreddin N,Xue HH,Delorenzi M,Leedham S,Petrova TV,Sansom O,Alitalo K
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri Nov 19 00:00:00 EST 2021
Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.
Immunity
Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B
13-5921-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.
Tue Jun 16 00:00:00 EDT 2020
SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy.
Cancer cell
Wang Z,Hausmann S,Lyu R,Li TM,Lofgren SM,Flores NM,Fuentes ME,Caporicci M,Yang Z,Meiners MJ,Cheek MA,Howard SA,Zhang L,Elias JE,Kim MP,Maitra A,Wang H,Bassik MC,Keogh MC,Sage J,Gozani O,Mazur PK
13-5921-82 was used in Magnetic cell separation to investigate if SETD5 can act as a major driver of pancreatic ductal adenocarcinoma resistance to MEK1/2 inhibition (MEKi).
Mon Jun 08 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Mon May 11 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
13-5921-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B,Harbeson DJ,Shannon CP,Cai B,He D,Ben-Othman R,Francis F,Huang J,Varankovich N,Liu A,Bao W,Bjerregaard-Andersen M,Schaltz-Buchholzer F,Sanca L,Golding CN,Larsen KL,Levy O,Kampmann B,Tan R,Charles A,Wynn JL,Shann F,Aaby P,Benn CS,Tebbutt SJ,Kollmann TR,Amenyogbe N
13-5921 was used in Flow cytometry/Cell sorting to show that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration.
Wed May 06 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
13-5921 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
13-5921 was used in Flow cytometry/Cell sorting to define a distinct mechanism of Notch signal response that distinguishes the initial stages of murine T cell development.
Mon Oct 05 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
13-5921 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.
Thu Sep 17 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
13-5921 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.
Thu Sep 17 00:00:00 EDT 2020
Methylation of a CGATA element inhibits binding and regulation by GATA-1.
Nature communications
Yang L,Chen Z,Stout ES,Delerue F,Ittner LM,Wilkins MR,Quinlan KGR,Crossley M
13-5921 was used in Flow cytometry/Cell sorting to show that the erythroid transcription factor GATA-1 - that typically binds T/AGATA sites - can also recognise CGATA elements, but only if the CpG dinucleotide is unmethylated.
Fri May 22 00:00:00 EDT 2020
Methylation of a CGATA element inhibits binding and regulation by GATA-1.
Nature communications
Yang L,Chen Z,Stout ES,Delerue F,Ittner LM,Wilkins MR,Quinlan KGR,Crossley M
13-5921 was used in Flow cytometry/Cell sorting to show that the erythroid transcription factor GATA-1 - that typically binds T/AGATA sites - can also recognise CGATA elements, but only if the CpG dinucleotide is unmethylated.
Fri May 22 00:00:00 EDT 2020
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Nature communications
Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Nature communications
Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
13-5921 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.
Tue Oct 27 00:00:00 EDT 2020
Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
eLife
Cendrowski J,Kaczmarek M,Mazur M,Kuzmicz-Kowalska K,Jastrzebski K,Brewinska-Olchowik M,Kominek A,Piwocka K,Miaczynska M
13-5921 was used in Flow cytometry/Cell sorting to investigate the role of the longer(L) and shorter(S) splicing variant of bone morphogenetic protein 2-inducible kinase(BMP2K) in endocytosis and cell differentiation.
Fri Aug 14 00:00:00 EDT 2020
Use of Busulfan to Condition Mice for Bone Marrow Transplantation.
STAR protocols
Montecino-Rodriguez E,Dorshkind K
13-5921 was used in Flow cytometry/Cell sorting to describe a protocol for the use of busulfan to condition mice for bone marrow transplantation and several of the variables to consider for effective implementation.
Fri Dec 18 00:00:00 EST 2020
Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production.
Journal of visualized experiments : JoVE
Upadhye A,Marshall M,Garmey JC,Bender TP,McNamara C
13-5921 was used in Magnetic cell separation to describe a method to target B-1a cell migration to the bone marrow by retroviral-mediated overexpression of the C-X-C motif chemokine receptor 4 (CXCR4).
Sun May 31 00:00:00 EDT 2020
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
eLife
Zhong L,Yao L,Tower RJ,Wei Y,Miao Z,Park J,Shrestha R,Wang L,Yu W,Holdreith N,Huang X,Zhang Y,Tong W,Gong Y,Ahn J,Susztak K,Dyment N,Li M,Long F,Chen C,Seale P,Qin L
13-5921 was used in Flow cytometry/Cell sorting to computationally define mesenchymal progenitors at different stages and delineate their bi-lineage differentiation paths in young, adult and aging mice.
Tue Apr 14 00:00:00 EDT 2020
Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics.
eLife
Ricci B,Tycksen E,Celik H,Belle JI,Fontana F,Civitelli R,Faccio R
13-5921 was used in Flow cytometry/Cell sorting to find Osx transcript and Osx protein expression early during hematopoiesis, in subsets of hematopoietic stem cells and multipotent progenitor populations.
Wed Aug 05 00:00:00 EDT 2020
CD71+ Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal Mice.
Frontiers in immunology
Elahi S,Vega-López MA,Herman-Miguel V,Ramírez-Estudillo C,Mancilla-Ramírez J,Motyka B,West L,Oyegbami O
13-5921-82 was used in Flow Cytometry to study the frequency and functionality of CD71+ erythroid cells in the peripheral blood of human newborns/children from 1-day to 5-year and compared them with their counterparts in the neonatal mice.
Mon Dec 28 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
13-5921 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Cell
Wang H,Xiang D,Liu B,He A,Randle HJ,Zhang KX,Dongre A,Sachs N,Clark AP,Tao L,Chen Q,Botchkarev VV,Xie Y,Dai N,Clevers H,Li Z,Livingston DM
13-5921 was used in Flow cytometry/Cell sorting to investigate if in vivo single-cell analysis reveals a time-dependent evolution from normal luminal mammary epithelial cells to luminal progenitor-like tumor cells with basal/mesenchymal transdifferentiation during murine BRCA1 basal-like breast cancer development.
Thu Jun 27 00:00:00 EDT 2019
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
13-5921 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
13-5921-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
13-5921 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.
Developmental cell
Li H,Natarajan A,Ezike J,Barrasa MI,Le Y,Feder ZA,Yang H,Ma C,Markoulaki S,Lodish HF
13-5921-82 was used in Flow Cytometry to show that glucocorticoids enhance erythrocyte production by slowing the rate of progression through this developmental continuum of transit-amplifying progenitors, permitting more cell divisions prior to terminal erythroid differentiation.
Mon Apr 08 00:00:00 EDT 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.
Molecular metabolism
Meln I,Wolff G,Gajek T,Koddebusch J,Lerch S,Harbrecht L,Hong W,Bayindir-Buchhalter I,Krunic D,Augustin HG,Vegiopoulos A
13-5921 was used in Flow cytometry/Cell sorting to show that dietary lipids and calories differentially and synergistically drive adipose tissue proliferative growth and the programming of the metabolic syndrome in childhood.
Sat Jun 01 00:00:00 EDT 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
13-5921 was used in Flow cytometry/Cell sorting to provide methods for target validation using in vitro and in vivo mouse models.
Mon Jan 07 00:00:00 EST 2019
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Nature medicine
Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G
13-5921 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.
Tue May 01 00:00:00 EDT 2018
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.
Immunity
Hu G,Cui K,Fang D,Hirose S,Wang X,Wangsa D,Jin W,Ried T,Liu P,Zhu J,Rothenberg EV,Zhao K
13-5921 was used in Flow cytometry/Cell sorting to find that abrupt genome-wide changes at all three levels of chromatin organization occur during the transition from double-negative stage 2 (DN2) to DN3, accompanying the T lineage commitment.
Tue Feb 20 00:00:00 EST 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
13-5921 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunocytochemistry
Mon Apr 02 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunocytochemistry
Mon Apr 02 00:00:00 EDT 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
13-5921 was used in Immunopurification to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.
Tue Jan 02 00:00:00 EST 2018
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
The Journal of clinical investigation
Li L,Guturi KKN,Gautreau B,Patel PS,Saad A,Morii M,Mateo F,Palomero L,Barbour H,Gomez A,Ng D,Kotlyar M,Pastrello C,Jackson HW,Khokha R,Jurisica I,Affar EB,Raught B,Sanchez O,Alaoui-Jamali M,Pujana MA,Hakem A,Hakem R
13-5921 was used in Flow cytometry/Cell sorting to study the correlation between low expression of full-length RNF8 and poor prognosis for breast cancer patients.
Mon Oct 01 00:00:00 EDT 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
13-5921 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
Aging alters the epigenetic asymmetry of HSC division.
PLoS biology
Florian MC,Klose M,Sacma M,Jablanovic J,Knudson L,Nattamai KJ,Marka G,Vollmer A,Soller K,Sakk V,Cabezas-Wallscheid N,Zheng Y,Mulaw MA,Glauche I,Geiger H
13-5921 was used in Flow cytometry/Cell sorting to show aging can change hematopoietic stem cell division to preferentially asymmetric.
Sat Sep 01 00:00:00 EDT 2018
Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection.
PLoS pathogens
Opata MM,Ibitokou SA,Carpio VH,Marshall KM,Dillon BE,Carl JC,Wilson KD,Arcari CM,Stephens R
13-5921 was used in Flow cytometry/Cell sorting to elucidate four mechanisms of Tem maintenance, and identify two long-lived T cell subsets (TemLate, TeffEarly) that may represent correlates of protection or a target for longerlived vaccine-induced protection against malaria blood-stages.
Sun Apr 01 00:00:00 EDT 2018
Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels.
Development (Cambridge, England)
Zhang Y,Daubel N,Stritt S,Mäkinen T
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunofluorescence
Thu Feb 08 00:00:00 EST 2018
Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.
Disease models & mechanisms
Parada-Kusz M,Penaranda C,Hagedorn EJ,Clatworthy A,Nair AV,Henninger JE,Ernst C,Li B,Riquelme R,Jijon H,Villablanca EJ,Zon LI,Hung D,Allende ML
13-5921 was used in Functional assays to develop a xenotransplantation technique that transiently generates hundreds of haematopoietic tissue chimeric embryos by transplanting murine bone marrow cells into zebrafish blastulae.
Mon Nov 05 00:00:00 EST 2018
CCDC134 serves a crucial role in embryonic development.
International journal of molecular medicine
Yu B,Zhang T,Xia P,Gong X,Qiu X,Huang J
13-5921 was used in Immunohistochemistry to suggest that Coiled-coil domain containing 134 may have specific biological functions in regulating mouse embryonic development.
Mon Jan 01 00:00:00 EST 2018
MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.
Human molecular genetics
Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2018
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Experimental hematology
Serrano-Lopez J,Nattamai K,Pease NA,Shephard MS,Wellendorf AM,Sertorio M,Smith EA,Geiger H,Wells SI,Cancelas JA,Privette Vinnedge LM
13-5921 was used in Flow cytometry/Cell sorting to investigate the role of DEK in normal hematopoiesis and response to DNA damaging agents in vivo.
Thu Mar 01 00:00:00 EST 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
13-5921 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell stem cell
Tadokoro Y,Hoshii T,Yamazaki S,Eto K,Ema H,Kobayashi M,Ueno M,Ohta K,Arai Y,Hara E,Harada K,Oshima M,Oshima H,Arai F,Yoshimura A,Nakauchi H,Hirao A
13-5921-82 was used in Flow Cytometry to demonstrate the involvement of diet-induced stress on hematopoietic stem cell self-renewal.
Thu May 03 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
13-5921-82 was used in Flow Cytometry to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
13-5921 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
Small non-coding RNA expression in mouse nephrogenic mesenchymal progenitors.
Scientific data
Phua YL,Clugston A,Chen KH,Kostka D,Ho J
13-5921-82 was used in Magnetic cell separation to characterise the microRNA profile of mouse nephrogenic mesenchymal progenitors.
Tue Nov 13 00:00:00 EST 2018
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Nature communications
Chandra S,Gray J,Kiosses WB,Khurana A,Hitomi K,Crosby CM,Chawla A,Fu Z,Zhao M,Veerapen N,Richardson SK,Porcelli SA,Besra G,Howell AR,Sharma S,Peters B,Kronenberg M
Mon Oct 15 00:00:00 EDT 2018
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
13-5921 was used in Flow cytometry/Cell sorting to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo.
Biomarker research
Ichim CV,Dervovic DD,Chan LSA,Robertson CJ,Chesney A,Reis MD,Wells RA
13-5921 was used in Flow cytometry/Cell sorting to show that EAR-2 inhibits maturation of normal bone marrow in vitro and in vivo and that EAR-2 transplant chimeras demonstrate key features of myelodysplastic syndrome.
Wed Mar 30 00:00:00 EDT 2022
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Scientific reports
Parigi SM,Czarnewski P,Das S,Steeg C,Brockmann L,Fernandez-Gaitero S,Yman V,Forkel M,Höög C,Mjösberg J,Westerberg L,Färnert A,Huber S,Jacobs T,Villablanca EJ
13-5921 was used in Flow cytometry/Cell sorting to indicate that Flt3L expands CHILPs in the bone marrow, which might be associated with specific inflammatory conditions.
Tue Jan 09 00:00:00 EST 2018
Proliferative heterogeneity of murine epithelial cells in the adult mammary gland.
Communications biology
Shehata M,Waterhouse PD,Casey AE,Fang H,Hazelwood L,Khokha R
13-5921 was used in Flow cytometry/Cell sorting to characterise the proliferative changes within the reproductive cycle in the mammalian mammary gland.
Sat Jan 11 00:00:00 EST 2020
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Genome biology
Koohy H,Bolland DJ,Matheson LS,Schoenfelder S,Stellato C,Dimond A,Várnai C,Chovanec P,Chessa T,Denizot J,Manzano Garcia R,Wingett SW,Freire-Pritchett P,Nagano T,Hawkins P,Stephens L,Elderkin S,Spivakov M,Fraser P,Corcoran AE,Varga-Weisz PD
13-5921 was used in Flow cytometry/Cell sorting to profile gene expression and chromatin features genome-wide, in bone marrow pro-B and pre-B cells from young and aged mice.
Wed Sep 05 00:00:00 EDT 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
13-5921 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.
Cell
Isoda T,Moore AJ,He Z,Chandra V,Aida M,Denholtz M,Piet van Hamburg J,Fisch KM,Chang AN,Fahl SP,Wiest DL,Murre C
13-5921-82 was used in Flow Cytometry to study the repositioning of the Bcl11b enhancer to dictate the fate of developing T cells.
Thu Sep 21 00:00:00 EDT 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
Thu May 18 00:00:00 EDT 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.
Circulation research
Abdel Malik R,Zippel N,Frömel T,Heidler J,Zukunft S,Walzog B,Ansari N,Pampaloni F,Wingert S,Rieger MA,Wittig I,Fisslthaler B,Fleming I
13-5921 was used in Flow cytometry/Cell sorting to elucidate the role of the AMPKa2 catalytic subunit in vascular repair following ischemia.
Fri Jan 06 00:00:00 EST 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Developmental cell
Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Mar 21 00:00:00 EDT 2017
Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Audzevich T,Bashford-Rogers R,Mabbott NA,Frampton D,Freeman TC,Potocnik A,Kellam P,Gilroy DW
13-5921 was used in Flow cytometry/Cell sorting to study the developmental plasticity of immature B cells and their role as the source of tissue resident macrophages.
Tue May 16 00:00:00 EDT 2017
Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.
Breast cancer research : BCR
Chamberlin T,D'Amato JV,Arendt LM
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Nov 29 00:00:00 EST 2017
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
JCI insight
Ogura S,Kurata K,Hattori Y,Takase H,Ishiguro-Oonuma T,Hwang Y,Ahn S,Park I,Ikeda W,Kusuhara S,Fukushima Y,Nara H,Sakai H,Fujiwara T,Matsushita J,Ema M,Hirashima M,Minami T,Shibuya M,Takakura N,Kim P,Miyata T,Ogura Y,Uemura A
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunohistochemistry
Thu Feb 09 00:00:00 EST 2017
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Nature communications
Tao L,Xiang D,Xie Y,Bronson RT,Li Z
13-5921 was used in Flow cytometry/Cell sorting to investigate how p53 deficiency contributes to breast tumourigenesis from luminal cells.
Mon Feb 13 00:00:00 EST 2017
Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture.
Stem cell reports
Batsivari A,Rybtsov S,Souilhol C,Binagui-Casas A,Hills D,Zhao S,Travers P,Medvinsky A
13-5921 was used in Flow cytometry/Cell sorting to observe time-specific changes in intra-aortic hematopoietic clusters corresponding to HSC maturation stages.
Tue Jun 06 00:00:00 EDT 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
13-5921 was used in Flow cytometry/Cell sorting to suggest a potential for treating haematological cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.
Mon Jan 09 00:00:00 EST 2017
Age-dependent modulation of vascular niches for haematopoietic stem cells.
Nature
Kusumbe AP,Ramasamy SK,Itkin T,Mäe MA,Langen UH,Betsholtz C,Lapidot T,Adams RH
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Cell
Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K
13-5921 was used in Flow cytometry/Cell sorting to suggest that HSCs accumulate discrete memory stages over their divisional history and identify cellular memory in HSC aging.
Thu Nov 17 00:00:00 EST 2016
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
Nature cell biology
Blaas L,Pucci F,Messal HA,Andersson AB,Josue Ruiz E,Gerling M,Douagi I,Spencer-Dene B,Musch A,Mitter R,Bhaw L,Stone R,Bornhorst D,Sesay AK,Jonkers J,Stamp G,Malanchi I,Toftgård R,Behrens A
13-5921 was used in Flow cytometry/Cell sorting to demonstrate that Lgr6 can be used to identify rare populations of cells in both basal and luminal mammary gland compartments that can develop luminal mammary tumours in mice.
Thu Dec 01 00:00:00 EST 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
13-5921 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
Biochemical and biophysical research communications
Qu X,Li J,Baldwin HS
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunofluorescence
Fri Feb 12 00:00:00 EST 2016
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nature communications
Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Dec 21 00:00:00 EST 2016
SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
PloS one
Ripich T,Chacón-Martínez CA,Fischer L,Pernis A,Kiessling N,Garbe AI,Jessberger R
13-5921 was used in Flow cytometry/Cell sorting to investigate the role of SWAP-70 and DEF6 in hematopoietic stem and precursor cells.
Mon Jul 31 00:00:00 EDT 2017
Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.
Bio-protocol
Sinha M,Lowell CA
13-5921 was used in Flow cytometry/Cell sorting to describe an improved method for isolating highly pure and viable primary ATII cells from the lungs of naive mice.
Sun Nov 20 00:00:00 EST 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
13-5921 was used in Magnetic cell separation to investigate relationship between the strength of antigenic stimulation and the response of mouse CD4+ T cells.
Mon Jul 04 00:00:00 EDT 2016
p38 MAPK Inhibitor Insufficiently Attenuates HSC Senescence Administered Long-Term after 6 Gy Total Body Irradiation in Mice.
International journal of molecular sciences
Lu L,Wang YY,Zhang JL,Li DG,Meng AM
13-5921 was used in Flow cytometry/Cell sorting to investigate the effects of SB203580 on long-term TBI-induced myelosuppression.
Wed Jun 08 00:00:00 EDT 2016
H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function.
Scientific reports
Zhao B,Tan TL,Mei Y,Yang J,Yu Y,Verma A,Liang Y,Gao J,Ji P
13-5921 was used in Flow cytometry/Cell sorting to reveal important roles of H2AX in late-stage terminal erythropoiesis and hematopoietic stem cell function.
Thu Jan 21 00:00:00 EST 2016
PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.
Nature
Lee HY,Gao X,Barrasa MI,Li H,Elmes RR,Peters LL,Lodish HF
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2015
Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.
Circulation research
Ye YX,Calcagno C,Binderup T,Courties G,Keliher EJ,Wojtkiewicz GR,Iwamoto Y,Tang J,Pérez-Medina C,Mani V,Ishino S,Johnbeck CB,Knigge U,Fayad ZA,Libby P,Weissleder R,Tawakol A,Dubey S,Belanger AP,Di Carli MF,Swirski FK,Kjaer A,Mulder WJ,Nahrendorf M
13-5921 was used in Flow cytometry/Cell sorting to perform (18)F-FLT positron emission tomography-computed tomography was performed in mice, rabbits, and humans with atherosclerosis.
Fri Oct 23 00:00:00 EDT 2015
Distinct germinal center selection at local sites shapes memory B cell response to viral escape.
The Journal of experimental medicine
Adachi Y,Onodera T,Yamada Y,Daio R,Tsuiji M,Inoue T,Kobayashi K,Kurosaki T,Ato M,Takahashi Y
13-5921 was used in Flow cytometry/Cell sorting to investigate the cellular events dictating the cross-reactive memory B cell responses, showing that distinct germinal center selection at local sites shapes response to viral escape.
Mon Sep 21 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.
American journal of hematology
Ludwig LS,Cho H,Wakabayashi A,Eng JC,Ulirsch JC,Fleming MD,Lodish HF,Sankaran VG
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
13-5921 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Journal of immunology (Baltimore, Md. : 1950)
Abidin BM,Owusu Kwarteng E,Heinonen KM
13-5921 was used in Flow cytometry/Cell sorting to reveal that Fzd6 has an essential role in HSPC maintenance and survival.
Tue Sep 01 00:00:00 EDT 2015
Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.
Hepatology research : the official journal of the Japan Society of Hepatology
Saiman Y,Jiao J,Fiel MI,Friedman SL,Aloman C,Bansal MB
13-5921 was used in Flow cytometry/Cell sorting to suggest that inhibition of the CXCR4/CXCL12 chemokine axis is injurious through modulation of the hepatic inflammatory response.
Wed Jul 01 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunohistochemistry
Mon Oct 12 00:00:00 EDT 2015
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.
Nature communications
Khaled WT,Choon Lee S,Stingl J,Chen X,Raza Ali H,Rueda OM,Hadi F,Wang J,Yu Y,Chin SF,Stratton M,Futreal A,Jenkins NA,Aparicio S,Copeland NG,Watson CJ,Caldas C,Liu P
13-5921 was used in Flow cytometry/Cell sorting to identify the transcription factor BCL11A as a novel triple-negative breast cancer oncogene.
Fri Jan 09 00:00:00 EST 2015
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.
Nature communications
Giraddi RR,Shehata M,Gallardo M,Blasco MA,Simons BD,Stingl J
13-5921 was used in Flow cytometry/Cell sorting to investigate the division properties of mammary stem and progenitor cells, showing that most cell division in the adult gland is restricted to the oestrogen receptor-expressing luminal cell lineage.
Thu Oct 29 00:00:00 EDT 2015
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
13-5921 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
13-5921 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
The influence of tamoxifen on normal mouse mammary gland homeostasis.
Breast cancer research : BCR
Shehata M,van Amerongen R,Zeeman AL,Giraddi RR,Stingl J
13-5921 was used in Flow cytometry/Cell sorting to determine if varying doses of tamoxifen skews the distribution and the apoptosis and proliferation status of different types of mammary epithelial cells in vivo.
Thu Jul 24 00:00:00 EDT 2014
Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes.
Journal of immunology (Baltimore, Md. : 1950)
Geem D,Medina-Contreras O,McBride M,Newberry RD,Koni PA,Denning TL
13-5921 was used in Magnetic cell separation to investigate whether GALT and/or mesenteric lymph nodes are required for intestinal Th17 differentiation, showing that specific microbiota-induced intestinal Th17 differentiation requires MHC class II.
Tue Jul 01 00:00:00 EDT 2014
Arteriolar niches maintain haematopoietic stem cell quiescence.
Nature
Kunisaki Y,Bruns I,Scheiermann C,Ahmed J,Pinho S,Zhang D,Mizoguchi T,Wei Q,Lucas D,Ito K,Mar JC,Bergman A,Frenette PS
13-5921 was used in Flow cytometry/Cell sorting to investigate the spatial localisation of quiescent haematopoietic stem cells in bone marrow, showing that arteriolar niches maintain quiescence.
Thu Oct 31 00:00:00 EDT 2013
HDAC3 is essential for DNA replication in hematopoietic progenitor cells.
The Journal of clinical investigation
Summers AR,Fischer MA,Stengel KR,Zhao Y,Kaiser JF,Wells CE,Hunt A,Bhaskara S,Luzwick JW,Sampathi S,Chen X,Thompson MA,Cortez D,Hiebert SW
13-5921 was used in Flow cytometry/Cell sorting to demonstrate that Hdac3 is required for several aspects of hematopoietic stem cell DNA replication.
Mon Jul 01 00:00:00 EDT 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2013
Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.
Journal of immunology (Baltimore, Md. : 1950)
Zook EC,Zhang S,Gerstein RM,Witte PL,Le PT
13-5921 was used in Flow cytometry/Cell sorting to report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg.
Sun Dec 01 00:00:00 EST 2013
Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.
Molecular and cellular biology
Yasunaga S,Ohtsubo M,Ohno Y,Saeki K,Kurogi T,Tanaka-Okamoto M,Ishizaki H,Shirai M,Mihara K,Brock HW,Miyoshi J,Takihara Y
13-5921 was used in Flow cytometry/Cell sorting to investigate the effects of Scmh1 on Geminin and Histone H2A, and the mechanisms therein.
Fri Feb 01 00:00:00 EST 2013
Flow cytometry analysis of murine hematopoietic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Mayle A,Luo M,Jeong M,Goodell MA
13-5921 was used in Flow cytometry/Cell sorting to discuss methods for rapid flow cytometric analysis of peripheral blood cell types and novel strategies for working with rare cell populations such as hematopoietic stem cells in the analysis of cell cycle status by BrdU, Ki-67, and Pyronin Y staining.
Tue Jan 01 00:00:00 EST 2013
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.
Cell
Rankin EB,Wu C,Khatri R,Wilson TL,Andersen R,Araldi E,Rankin AL,Yuan J,Kuo CJ,Schipani E,Giaccia AJ
13-5921 was used in Flow cytometry/Cell sorting to study the role of osteoblasts in the production of EPO and modulation of erythropoiesis through the HIF signalling pathway.
Fri Mar 30 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.
Blood
Carbonneau CL,Despars G,Rojas-Sutterlin S,Fortin A,Le O,Hoang T,Beauséjour CM
13-5921 was used in Flow cytometry/Cell sorting to investigate the effect of ionizing radiation on murine bone marrow-derived stromal cell populations, and overall bone marrow homeostasis.
Thu Jan 19 00:00:00 EST 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
13-5921 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
13-5921 was used in Magnetic cell separation to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.
Mon Apr 09 00:00:00 EDT 2012
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.
Developmental cell
Chhabra A,Lechner AJ,Ueno M,Acharya A,Van Handel B,Wang Y,Iruela-Arispe ML,Tallquist MD,Mikkola HK
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunohistochemistry
Tue Mar 13 00:00:00 EDT 2012
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.
Developmental cell
Chhabra A,Lechner AJ,Ueno M,Acharya A,Van Handel B,Wang Y,Iruela-Arispe ML,Tallquist MD,Mikkola HK
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Immunohistochemistry
Tue Mar 13 00:00:00 EDT 2012
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.
Genes & development
Sankaran VG,Ludwig LS,Sicinska E,Xu J,Bauer DE,Eng JC,Patterson HC,Metcalf RA,Natkunam Y,Orkin SH,Sicinski P,Lander ES,Lodish HF
13-5921 was used in Magnetic cell separation to illustrate how cell type-specific specialisation can occur for general cell cycle components.
Sat Sep 15 00:00:00 EDT 2012
The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
Genes & development
Oliver CH,Khaled WT,Frend H,Nichols J,Watson CJ
13-5921 was used in Flow cytometry/Cell sorting to investigate the mechanisms that control cell fate, showing that Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
Tue May 15 00:00:00 EDT 2012
Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Shokeen M,Zheleznyak A,Wilson JM,Jiang M,Liu R,Ferdani R,Lam KS,Schwarz JK,Anderson CJ
13-5921 was used in Flow cytometry/Cell sorting to study bone marrow-derived cellular expression of VEGFR1 and VLA-4 in the development of a premetastatic niche.
Tue May 01 00:00:00 EDT 2012
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
13-5921 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 EDT 2012
Inflammatory spleen monocytes can upregulate CD11c expression without converting into dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Kendall JC,Trombetta ES
13-5921 was used in Magnetic cell separation to establish the contribution of inflammatory DCs (iDCs) and conventional DCs (cDCs) in response to anti-CD40 administration in mice.
Sun Apr 15 00:00:00 EDT 2012
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Kaneko T,Saito Y,Kotani T,Okazawa H,Iwamura H,Sato-Hashimoto M,Kanazawa Y,Takahashi S,Hiromura K,Kusakari S,Kaneko Y,Murata Y,Ohnishi H,Nojima Y,Takagishi K,Matozaki T
13-5921 was used in Flow cytometry/Cell sorting to investigate the molecules that regulate dendritic cells to protect against autoimmunity, showing that loss of Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Fri Jun 01 00:00:00 EDT 2012
Global transcriptional analysis of primitive thymocytes reveals accelerated dynamics of T cell specification in fetal stages.
Immunogenetics
Belyaev NN,Biró J,Athanasakis D,Fernandez-Reyes D,Potocnik AJ
13-5921 was used in Magnetic cell separation to compare the development of T cells in foetal and adult stages, showing that adult and foetal T cell progenitors.
Wed Aug 01 00:00:00 EDT 2012
TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer.
Nature communications
Bruna A,Greenwood W,Le Quesne J,Teschendorff A,Miranda-Saavedra D,Rueda OM,Sandoval JL,Vidakovic AT,Saadi A,Pharoah P,Stingl J,Caldas C
13-5921 was used in Flow cytometry/Cell sorting to show that TGFβ increases breast tumour-initiating cell numbers in claudin(low) breast cancer cell lines.
Fri Feb 01 00:00:00 EST 2013
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
13-5921 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.
Thu Sep 01 00:00:00 EDT 2011
Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues.
Biology of reproduction
Lew BJ,Manickam R,Lawrence BP
13-5921 was used in Flow cytometry/Cell sorting to determine whether activation of the aryl hydrocarbon receptor (AHR) during pregnancy modulates mammary development.
Wed Jun 01 00:00:00 EDT 2011
Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland.
Developmental dynamics : an official publication of the American Association of Anatomists
Anderson LH,Boulanger CA,Smith GH,Carmeliet P,Watson CJ
13-5921 was used in Flow cytometry/Cell sorting to reveal a novel, functional role for the stem cell marker Prom1 that is not related to stem cell activity.
Tue Mar 01 00:00:00 EST 2011
Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells.
Blood
Tan JK,Periasamy P,O'Neill HC
13-5921 was used in Magnetic cell separation to confirm that long-term cultures are a physiologically relevant culture system for the in vitro development of a novel dendritic cell type from spleen progenitors.
Thu May 06 00:00:00 EDT 2010
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
13-5921 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Genes & development
Tremblay M,Tremblay CS,Herblot S,Aplan PD,Hébert J,Perreault C,Hoang T
13-5921 was used in Flow cytometry/Cell sorting to study the collaboration of the SCL and LMO1 oncogenes to expand primitive thymocyte progenitors and inhibit later stages on differentiation.
Tue Jun 01 00:00:00 EDT 2010
Dendritic cells continue to capture and present antigens after maturation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Trombetta ES
13-5921 was used in Magnetic cell separation to study the dynamics of Ag capture and presentation in situ, showing that dendritic cells continue to capture and present antigens after maturation.
Sun Aug 15 00:00:00 EDT 2010
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Nature immunology
Derudder E,Cadera EJ,Vahl JC,Wang J,Fox CJ,Zha S,van Loo G,Pasparakis M,Schlissel MS,Schmidt-Supprian M,Rajewsky K
13-5921 was used in Magnetic cell separation to define two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappaB signaling.
Mon Jun 01 00:00:00 EDT 2009
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Blood
Kimura A,Rieger MA,Simone JM,Chen W,Wickre MC,Zhu BM,Hoppe PS,O'Shea JJ,Schroeder T,Hennighausen L
13-5921 was used in Flow cytometry/Cell sorting to assess the contribution of the downstream mediating transcription factors STAT5A/B to the development of granulocytes.
Thu Nov 19 00:00:00 EST 2009
Characterisation of microRNA expression in post-natal mouse mammary gland development.
BMC genomics
Avril-Sassen S,Goldstein LD,Stingl J,Blenkiron C,Le Quesne J,Spiteri I,Karagavriilidou K,Watson CJ,Tavaré S,Miska EA,Caldas C
13-5921 was used in Flow cytometry/Cell sorting to further understand the role of differential expression pattern of microRNAs in regulating the homeostasis of the mammary epithelium.
Fri Nov 20 00:00:00 EST 2009
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder.
The Journal of experimental medicine
O'Connell RM,Rao DS,Chaudhuri AA,Boldin MP,Taganov KD,Nicoll J,Paquette RL,Baltimore D
13-5921 was used in Flow cytometry/Cell sorting to demonstrate the role of miR-155 in driving granulocyte/monocyte expansion during inflammation, and in myeloproliferative disorders.
Mon Mar 17 00:00:00 EDT 2008
Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.
Stem cells (Dayton, Ohio)
Singh P,Yao Y,Weliver A,Broxmeyer HE,Hong SC,Chang CH
13-5921 was used in Flow cytometry/Cell sorting to show that in vivo VV infection results in the expansion of c-Kit(hi)Sca-1+Lin- (KSL) haematopoietic stem cells.
Tue Apr 01 00:00:00 EDT 2008
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
13-5921-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
13-5921-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
The EMBO journal
Vassen L,Fiolka K,Möröy T
Published figure using TER-119 monoclonal antibody (Product # 13-5921-82) in Flow Cytometry
Wed Jun 07 00:00:00 EDT 2006
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.
Genes & development
Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV
13-5921 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.
Fri Apr 15 00:00:00 EDT 2005
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.
The Journal of experimental medicine
Rifa'i M,Kawamoto Y,Nakashima I,Suzuki H
13-5921 was used in Flow cytometry/Cell sorting to investigate the effect of transfer of CD8+CD122+ cells into CD122-deficient neonates, showing that CD8+CD122+ regulatory T cells are essential for T cell homeostasis.
Mon Nov 01 00:00:00 EST 2004
