Product References
A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation.
eLife
Xu H,Li Z,Kuo CC,Götz K,Look T,de Toledo MAS,Seré K,Costa IG,Zenke M
14-5921-82 was used in Flow cytometry/Cell sorting to reveal a previously unrecognized negative feedback loop of Irf8 that orchestrates its own expression and thereby controls DC differentiation.
Tue Mar 14 00:00:00 EDT 2023
Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice.
Life (Basel, Switzerland)
Watanabe C,Shibuya H,Ichiyama Y,Okamura E,Tsukiyama-Fujii S,Tsukiyama T,Matsumoto S,Matsushita J,Azami T,Kubota Y,Ohji M,Sugiyama F,Takahashi S,Mizuno S,Tamura M,Mizutani KI,Ema M
14-5921-82 was used in Immunohistochemistry to reveal that Exoc3l2 is essential for cardiovascular and brain development in mice.
Fri Oct 28 00:00:00 EDT 2022
Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
PloS one
Deshycka R,Sudaryo V,Huang NJ,Xie Y,Smeding LY,Choi MK,Ploegh HL,Lodish HF,Pishesha N
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri Dec 24 00:00:00 EST 2021
GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.
JCI insight
Kashgari G,Venkatesh S,Refuerzo S,Pham B,Bayat A,Klein RH,Ramos R,Ta AP,Plikus MV,Wang PH,Andersen B
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.
Life science alliance
Valkov N,Das A,Tucker NR,Li G,Salvador AM,Chaffin MD,Pereira De Oliveira Junior G,Kur I,Gokulnath P,Ziegler O,Yeri A,Lu S,Khamesra A,Xiao C,Rodosthenous R,Srinivasan S,Toxavidis V,Tigges J,Laurent LC,Momma S,Kitchen R,Ellinor P,Ghiran I,Das S
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Dec 01 00:00:00 EST 2021
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.
Life science alliance
Valkov N,Das A,Tucker NR,Li G,Salvador AM,Chaffin MD,Pereira De Oliveira Junior G,Kur I,Gokulnath P,Ziegler O,Yeri A,Lu S,Khamesra A,Xiao C,Rodosthenous R,Srinivasan S,Toxavidis V,Tigges J,Laurent LC,Momma S,Kitchen R,Ellinor P,Ghiran I,Das S
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Dec 01 00:00:00 EST 2021
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Cell reports. Medicine
Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Apr 20 00:00:00 EDT 2021
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.
Nature communications
Jeong SH,Yang MJ,Choi S,Kim J,Koh GY
14-5921-82 was used in Immunohistochemistry to investigate Stimulator of Interferon Genes (STING) therapy in anti-tumour immunity.
Tue Jul 20 00:00:00 EDT 2021
Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas.
Acta neuropathologica communications
Wei X,Meel MH,Breur M,Bugiani M,Hulleman E,Phoenix TN
14-5921-82 was used in Immunohistochemistry (Paraffin) to characterise and directly compare tumor-associated vasculature in cortical pediatric high-grade gliomas and diffuse midline gliomas.
Mon Aug 23 00:00:00 EDT 2021
Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females.
Frontiers in immunology
Mashhouri S,Koleva P,Huynh M,Okoye I,Shahbaz S,Elahi S
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.
Stem cell research & therapy
Wang B,Wang Y,Chen H,Yao S,Lai X,Qiu Y,Cai J,Huang Y,Wei X,Guan Y,Wang T,Wang J,Xiang AP
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Jan 18 00:00:00 EST 2021
Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.
Stem cell research & therapy
Wang B,Wang Y,Chen H,Yao S,Lai X,Qiu Y,Cai J,Huang Y,Wei X,Guan Y,Wang T,Wang J,Xiang AP
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Jan 18 00:00:00 EST 2021
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Science advances
Heino S,Fang S,Lähde M,Högström J,Nassiri S,Campbell A,Flanagan D,Raven A,Hodder M,Nasreddin N,Xue HH,Delorenzi M,Leedham S,Petrova TV,Sansom O,Alitalo K
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri Nov 19 00:00:00 EST 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-5921-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon May 11 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
14-5921 was used in Immunohistochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-5921-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Methylation of a CGATA element inhibits binding and regulation by GATA-1.
Nature communications
Yang L,Chen Z,Stout ES,Delerue F,Ittner LM,Wilkins MR,Quinlan KGR,Crossley M
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri May 22 00:00:00 EDT 2020
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Nature communications
Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels.
International journal of molecular sciences
Garcia-Abrego C,Zaunz S,Toprakhisar B,Subramani R,Deschaume O,Jooken S,Bajaj M,Ramon H,Verfaillie C,Bartic C,Patterson J
14-5921-82 was used in In vitro Assay to evaluate the effect of matrix stiffness values similar to those of the fetal liver on bone marrow-derived hematopoietic stem/progenitor cells expansion.
Wed Sep 02 00:00:00 EDT 2020
Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes.
JCI insight
Weidner H,Baschant U,Lademann F,Ledesma Colunga MG,Balaian E,Hofbauer C,Misof BM,Roschger P,Blouin S,Richards WG,Platzbecker U,Hofbauer LC,Rauner M
14-5921-82 was used in Flow Cytometry to identify FGF-23 as a link between altered bone structure and ineffective erythropoiesis in MDS with the prospects of a targeted therapeutic intervention.
Thu Aug 06 00:00:00 EDT 2020
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
14-5921 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.
Thu Apr 29 00:00:00 EDT 2021
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-5921 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
14-5921 was used in Flow cytometry/Cell sorting to find that the EDA FN is increased in plasma and BM biopsies of PMF patients as compared with healthy controls, correlating with fibrotic phase.
Mon Mar 04 00:00:00 EST 2019
Single cell transcriptome dynamics from pluripotency to FLK1+ mesoderm.
Development (Cambridge, England)
Zhao H,Choi K
14-5921-82 was used in RNA Immunoprecipitation to study the continuous developmental process leading to hemangiogenesis by performing single cell RNA sequencing of in vitro-differentiated mouse embryonic stem cells.
Thu Dec 05 00:00:00 EST 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-5921 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
PloS one
Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F
14-5921-82 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.
Mon Dec 16 00:00:00 EST 2019
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.
Cell
Cohen M,Giladi A,Gorki AD,Solodkin DG,Zada M,Hladik A,Miklosi A,Salame TM,Halpern KB,David E,Itzkovitz S,Harkany T,Knapp S,Amit I
14-5921-82 was used in Flow Cytometry to demonstrate how whole-tissue signaling interaction map on the single-cell level can broaden our understanding of cellular networks in health and disease.
Thu Nov 01 00:00:00 EDT 2018
Genetic Targeting of Organ-Specific Blood Vessels.
Circulation research
Pu W,He L,Han X,Tian X,Li Y,Zhang H,Liu Q,Huang X,Zhang L,Wang QD,Yu Z,Yang X,Smart N,Zhou B
14-5921-82 was used in Immunohistochemistry to illustrate the use of intersectional genetics for more precise gene targeting in vivo, namely manipulation of genes in blood vessels of the heart and brain.
Fri Jun 22 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
14-5921 was used in Immunohistochemistry-immunofluorescence to reveal an unsuspected role for ribonuclease inhibitor 1 in the control of GATA1 mRNA translation and erythropoiesis.
Mon Apr 02 00:00:00 EDT 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
14-5921 was used in Immunohistochemistry-immunofluorescence to reveal an unsuspected role for ribonuclease inhibitor 1 in the control of GATA1 mRNA translation and erythropoiesis.
Mon Apr 02 00:00:00 EDT 2018
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
The Journal of cell biology
Casey AE,Sinha A,Singhania R,Livingstone J,Waterhouse P,Tharmapalan P,Cruickshank J,Shehata M,Drysdale E,Fang H,Kim H,Isserlin R,Bailey S,Medina T,Deblois G,Shiah YJ,Barsyte-Lovejoy D,Hofer S,Bader G,Lupien M,Arrowsmith C,Knapp S,De Carvalho D,Berman H,Boutros PC,Kislinger T,Khokha R
14-5921 was used in Flow cytometry/Cell sorting to investigate the normal cell composition of the mammary epithelium by profiling primary cell epigenomes, transcriptomes and proteomes.
Mon Aug 06 00:00:00 EDT 2018
Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Jung B,Arnold TD,Raschperger E,Gaengel K,Betsholtz C
14-5921 was used in Immunohistochemistry-immunofluorescence to study the characteristics of vascular mural cells during vascular development.
Thu Mar 01 00:00:00 EST 2018
Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels.
Development (Cambridge, England)
Zhang Y,Daubel N,Stritt S,Mäkinen T
Thu Feb 08 00:00:00 EST 2018
A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development.
Development (Cambridge, England)
Pichol-Thievend C,Betterman KL,Liu X,Ma W,Skoczylas R,Lesieur E,Bos FL,Schulte D,Schulte-Merker S,Hogan BM,Oliver G,Harvey NL,Francois M
14-5921 was used in Immunohistochemistry-wholemount to describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1-dependent manner to establish discrete lymphatic endothelial cell clusters.
Thu May 17 00:00:00 EDT 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-5921 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 EST 2018
MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.
Human molecular genetics
Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Dec 11 00:00:00 EST 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
14-5921 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Scientific reports
Parigi SM,Czarnewski P,Das S,Steeg C,Brockmann L,Fernandez-Gaitero S,Yman V,Forkel M,Höög C,Mjösberg J,Westerberg L,Färnert A,Huber S,Jacobs T,Villablanca EJ
14-5921 was used in Flow cytometry/Cell sorting to indicate that Flt3L expands CHILPs in the bone marrow, which might be associated with specific inflammatory conditions.
Tue Jan 09 00:00:00 EST 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
14-5921 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 EST 2018
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Developmental cell
Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Mar 21 00:00:00 EDT 2017
Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.
Breast cancer research : BCR
Chamberlin T,D'Amato JV,Arendt LM
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Nov 29 00:00:00 EST 2017
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
JCI insight
Ogura S,Kurata K,Hattori Y,Takase H,Ishiguro-Oonuma T,Hwang Y,Ahn S,Park I,Ikeda W,Kusuhara S,Fukushima Y,Nara H,Sakai H,Fujiwara T,Matsushita J,Ema M,Hirashima M,Minami T,Shibuya M,Takakura N,Kim P,Miyata T,Ogura Y,Uemura A
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Immunohistochemistry
Thu Feb 09 00:00:00 EST 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-5921 was used in Flow Cytometry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 EST 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
14-5921 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 EST 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-5921 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-5921-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
Age-dependent modulation of vascular niches for haematopoietic stem cells.
Nature
Kusumbe AP,Ramasamy SK,Itkin T,Mäe MA,Langen UH,Betsholtz C,Lapidot T,Adams RH
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
14-5921 was used in Flow cytometry/Cell sorting to demonstrate the importance of TfR1 in adaptive immunity.
Fri Jan 01 00:00:00 EST 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-5921 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
The Journal of clinical investigation
Wang S,Chennupati R,Kaur H,Iring A,Wettschureck N,Offermanns S
14-5921 was used in Magnetic cell separation to demonstrate that the cation channel, PIEZO1, is required for the regulation of nitric oxide formation, vascular tone, and blood pressure.
Thu Dec 01 00:00:00 EST 2016
M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.
The Journal of experimental medicine
Kandalla PK,Sarrazin S,Molawi K,Berruyer C,Redelberger D,Favel A,Bordi C,de Bentzmann S,Sieweke MH
14-5921 was used in Flow cytometry/Cell sorting to study the role of M-CSF in the protection against pathogens after hematopoietic stem/progenitor cell transplantation.
Mon Oct 17 00:00:00 EDT 2016
Successful treatment of murine autoimmune cholangitis by parabiosis: Implications for hematopoietic therapy.
Journal of autoimmunity
Yang JB,Wang YH,Yang W,Lu FT,Ma HD,Zhao ZB,Jia YJ,Tang W,Tsuneyama K,Ridgway WM,Gershwin ME,Lian ZX
14-5921 was used in Magnetic cell separation to investigate the pathways that lead to pathology in a model of primary biliary cirrhosis, showing that CD4(-/-) mice had more severe pathology and parabiosis reduced chalangitis.
Fri Jan 01 00:00:00 EST 2016
pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.
Journal of autoimmunity
Duraes FV,Lippens C,Steinbach K,Dubrot J,Brighouse D,Bendriss-Vermare N,Issazadeh-Navikas S,Merkler D,Hugues S
14-5921 was used in Flow cytometry/Cell sorting to investigate novel pDC-based cell therapies in autoimmune diseases, aiming at specifically modulating pathogenic cells that induce and sustain autoimmune inflammation.
Mon Feb 01 00:00:00 EST 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-5921 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
Biochemical and biophysical research communications
Qu X,Li J,Baldwin HS
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Immunofluorescence
Fri Feb 12 00:00:00 EST 2016
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nature communications
Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Dec 21 00:00:00 EST 2016
Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.
PloS one
Sudo T,Yokota T,Okuzaki D,Ueda T,Ichii M,Ishibashi T,Isono T,Habuchi Y,Oritani K,Kanakura Y
14-5921 was used in Flow cytometry/Cell sorting to determine the physiological importance of Endothelial Cell-Selective Adhesion Molecule (ESAM) in erythroid recovery, showing that ESAM is essential for erthryopoiesis recovery following bone marrow injury.
Tue Mar 14 00:00:00 EDT 2017
In vitro Differentiation of Murine Innate Lymphoid Cells from Common Lymphoid Progenitor Cells.
Bio-protocol
Seehus C,Kaye J
14592182 was used in flow cytometry to detail how to obtain innate lymphoid cells from isolated common lymphoid progenitors
Sun Mar 20 00:00:00 EDT 2016
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Cell death & disease
Le Q,Yao W,Chen Y,Yan B,Liu C,Yuan M,Zhou Y,Ma L
14592182 was used in flow cytometry to use knockout mice to determine if GRK6 contributes to hematopoiesis
Thu Nov 24 00:00:00 EST 2016
PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.
Nature
Lee HY,Gao X,Barrasa MI,Li H,Elmes RR,Peters LL,Lodish HF
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2015
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-5921 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 EST 2015
Class-switched memory B cells remodel BCRs within secondary germinal centers.
Nature immunology
McHeyzer-Williams LJ,Milpied PJ,Okitsu SL,McHeyzer-Williams MG
14-5921 was used in Magnetic cell separation to demonstrate that vaccine boosts re-activate a cyclic germinal centre transcriptional program in class-switched memory B cells to remodel existing antibody specificities and enhance durable immunological protection.
Sun Mar 01 00:00:00 EST 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-5921 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.
The Journal of experimental medicine
Inoue T,Morita M,Hijikata A,Fukuda-Yuzawa Y,Adachi S,Isono K,Ikawa T,Kawamoto H,Koseki H,Natsume T,Fukao T,Ohara O,Yamamoto T,Kurosaki T
14-5921 was used in Flow cytometry/Cell sorting to investigate the role of CNOT3 in early B cell development in mice.
Mon Aug 24 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.
American journal of hematology
Ludwig LS,Cho H,Wakabayashi A,Eng JC,Ulirsch JC,Fleming MD,Lodish HF,Sankaran VG
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
14-5921 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 EDT 2015
Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.
Frontiers in endocrinology
Bayindir I,Babaeikelishomi R,Kocanova S,Sousa IS,Lerch S,Hardt O,Wild S,Bosio A,Bystricky K,Herzig S,Vegiopoulos A
14-5921 was used in Magnetic cell separation to develop models for the mechanistic investigation of progenitor-mediated beige/brite adipocyte differentiation.
Tue Sep 08 00:00:00 EDT 2015
The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells.
Journal of cellular and molecular medicine
Ji J,Griffiths KL,Milburn PJ,Hirst TR,O'Neill HC
14-5921 was used in Magnetic cell separation to investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen.
Sat Aug 01 00:00:00 EDT 2015
Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
Platelets
Ramsey H,Zhang Q,Wu MX
14-5921 was used in Flow cytometry/Cell sorting to investigate whether increased ROS production in myelodysplastic syndromes is an instigator or a byproduct of the disease.
Tue Mar 08 00:00:00 EST 2016
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Immunohistochemistry
Mon Oct 12 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-5921 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-5921 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.
Nature communications
Liebl J,Zhang S,Moser M,Agalarov Y,Demir CS,Hager B,Bibb JA,Adams RH,Kiefer F,Miura N,Petrova TV,Vollmar AM,Zahler S
14-5921 was used in Immunohistochemistry-wholemount to study the mechanism of action of Cdk5 in the vascular system using two endothelial-specific Cdk5 knockout mouse models.
Mon Jun 01 00:00:00 EDT 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-5921 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-5921 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-5921 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-5921 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
The Journal of clinical investigation
Park DY,Lee J,Park I,Choi D,Lee S,Song S,Hwang Y,Hong KY,Nakaoka Y,Makinen T,Kim P,Alitalo K,Hong YK,Koh GY
14-5921 was used in Immunohistochemistry to indicate that PROX1 is an accurate and reliable biosensor of schlemm''s canal (SC) integrity and identity.
Mon Sep 01 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-5921 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 EDT 2014
Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors.
Journal of immunology (Baltimore, Md. : 1950)
Chernova I,Jones DD,Wilmore JR,Bortnick A,Yucel M,Hershberg U,Allman D
14-5921 was used in Flow cytometry/Cell sorting to investigate the role of subpopulations of bone marrow plasma cells in long-term humoral responses to T cell-dependent Ag.
Sat Nov 15 00:00:00 EST 2014
Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes.
mBio
de Oliveira RB,Wang JP,Ram S,Gazzinelli RT,Finberg RW,Golenbock DT
14-5921 was used in Flow cytometry/Cell sorting to investigate the role of complement receptor 1 (CR1) in an experimental model of cerebral malaria.
Tue Mar 18 00:00:00 EDT 2014
Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.
Nature communications
Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A
14-5921 was used in Flow cytometry/Cell sorting to study whether epigenetic modifications affecting T-cells persist following adoptive transfer of the cells.
Fri Mar 28 00:00:00 EDT 2014
Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by modulating adipogenesis and osteogenesis.
PloS one
Sato F,Miyaoka Y,Miyajima A,Tanaka M
14-5921-82 was used in Magnetic cell separation to investigate the mechanisms underlying mesenchymal stromal cell differentiation, showing that oncostatin M maintains the hematopoietic microenvironment in the bone marrow.
Wed May 04 00:00:00 EDT 2016
T cell factor 1 is required for group 2 innate lymphoid cell generation.
Immunity
Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A
14-5921 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.
Thu Apr 18 00:00:00 EDT 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-5921 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 EDT 2013
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Nature immunology
Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB
14-5921 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.
Tue Jan 01 00:00:00 EST 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-5921 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.
Blood
Yoshida A,Kato JY,Nakamae I,Yoneda-Kato N
14-5921 was used in Flow cytometry/Cell sorting to investigate the role of COP1 in tumourigenesis.
Thu Sep 05 00:00:00 EDT 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
14-5921 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-5921 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 EST 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-5921 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy.
eLife
Heinrichs S,Conover LF,Bueso-Ramos CE,Kilpivaara O,Stevenson K,Neuberg D,Loh ML,Wu WS,Rodig SJ,Garcia-Manero G,Kantarjian HM,Look AT
14-5921 was used in Flow cytometry/Cell sorting to demonstrate that low MYBL2 activity is the underlying cause of the expansion of haematopoietic progenitors in a large fraction of myeloid malignancies.
Tue Jul 16 00:00:00 EDT 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Immunofluorescence
Fri Feb 01 00:00:00 EST 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-5921 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 EST 2013
Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development.
Cellular microbiology
Pei Y,Miller JL,Lindner SE,Vaughan AM,Torii M,Kappe SHI
14-5921 was used in Immunofluorescence to show that an inhibitor of cysteine proteases may be important in regulating proteolytic processes during blood-stage development.
Sun Sep 01 00:00:00 EDT 2013
Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis.
Cell reports
Poulos MG,Guo P,Kofler NM,Pinho S,Gutkin MC,Tikhonova A,Aifantis I,Frenette PS,Kitajewski J,Rafii S,Butler JM
14-5921 was used in Flow cytometry/Cell sorting to demonstrate that Jagged-1 expressed in the bone marrow vascular niche regulates homeostatic and regenerative haematopoiesis through a Notch-dependent mechanism.
Thu Sep 12 00:00:00 EDT 2013
PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels.
PloS one
Zotes TM,Spada R,Mulens V,Pérez-Yagüe S,Sorzano CO,Okkenhaug K,Carrera AC,Barber DF
14-5921 was used in Flow cytometry/Cell sorting to study the expression and function of p110δ in the murine spleen and lymph node.
Wed Apr 16 00:00:00 EDT 2014
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-5921 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-5921 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-5921 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.
Developmental cell
Chhabra A,Lechner AJ,Ueno M,Acharya A,Van Handel B,Wang Y,Iruela-Arispe ML,Tallquist MD,Mikkola HK
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Immunohistochemistry
Tue Mar 13 00:00:00 EDT 2012
Myelopoiesis in spleen-producing distinct dendritic-like cells.
Journal of cellular and molecular medicine
Tan JK,O'Neill HC
14-5921 was used in Magnetic cell separation to investigate whether the spleen represents a niche for development of myeloid dendritic-like cells.
Wed Aug 01 00:00:00 EDT 2012
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-5921 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 EDT 2012
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-5921 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.
Blood
Uhrin P,Zaujec J,Breuss JM,Olcaydu D,Chrenek P,Stockinger H,Fuertbauer E,Moser M,Haiko P,Fässler R,Alitalo K,Binder BR,Kerjaschki D
14-5921 was used in Immunofluorescence in immunohistochemistry on frozen tissues to study the involvement of platelet activation by podoplanin in the developmental separation of blood and lymphatic circulation.
Thu May 13 00:00:00 EDT 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-5921 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
PLoS biology
Sabnis AJ,Cheung LS,Dail M,Kang HC,Santaguida M,Hermiston ML,Passegué E,Shannon K,Braun BS
14-5921 was used in Flow cytometry/Cell sorting to conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice.
Tue Mar 17 00:00:00 EDT 2009
Biochemical characterization of membrane fractions in murine sperm: identification of three distinct sub-types of membrane rafts.
Journal of cellular physiology
Asano A,Selvaraj V,Buttke DE,Nelson JL,Green KM,Evans JE,Travis AJ
14-5921 was used in Western Blotting to show that the common practice of characterizing membrane domains as either "raft" or "non-raft" oversimplifies the actual biochemical complexity of cellular membranes.
Sun Mar 01 00:00:00 EST 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-5921 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-5921 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 EST 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5921-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-5921-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
Unique receptor repertoire in mouse uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F
14-5921-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.
Sat Nov 01 00:00:00 EDT 2008
Distinct roles of Mdm2 and Mdm4 in red cell production.
Blood
Maetens M,Doumont G,Clercq SD,Francoz S,Froment P,Bellefroid E,Klingmuller U,Lozano G,Marine JC
14-5921 was used in Immunohistofluorescence to explore the tissue-specific functions of Mdm2 and Mdm4 in the erythroid lineage.
Thu Mar 15 00:00:00 EDT 2007
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation.
Blood
Desponts C,Hazen AL,Paraiso KH,Kerr WG
14-5921-82 was used in Immunocytochemistry to examine the role of SH2 domain-containing inositol 5'-phosphatase-1 in modulating normal haematopoietic stem cell function, homeostasis and homing.
Thu Jun 01 00:00:00 EDT 2006
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
The EMBO journal
Vassen L,Fiolka K,Möröy T
Published figure using TER-119 monoclonal antibody (Product # 14-5921-82) in Flow Cytometry
Wed Jun 07 00:00:00 EDT 2006
