Product References
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
Nature communications
Herrejon Chavez F,Luo H,Cifani P,Pine A,Chu KL,Joshi S,Barin E,Schurer A,Chan M,Chang K,Han GYQ,Pierson AJ,Xiao M,Yang X,Kuehm LM,Hong Y,Nguyen DTT,Chiosis G,Kentsis A,Leslie C,Vu LP,Kharas MG
15-5921-82 was used in Flow cytometry/Cell sorting to reveal that the RNA-binding protein SYNCRIP is required for maintenance of blood homeostasis especially after regenerative stress due to defects in HSCs and progenitors.
Fri Apr 21 00:00:00 EDT 2023
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.
Cell
Guilliams M,Bonnardel J,Haest B,Vanderborght B,Wagner C,Remmerie A,Bujko A,Martens L,Thoné T,Browaeys R,De Ponti FF,Vanneste B,Zwicker C,Svedberg FR,Vanhalewyn T,Gonçalves A,Lippens S,Devriendt B,Cox E,Ferrero G,Wittamer V,Willaert A,Kaptein SJF,Neyts J,Dallmeier K,Geldhof P,Casaert S,Deplancke B,Ten Dijke P,Hoorens A,Vanlander A,Berrevoet F,Van Nieuwenhove Y,Saeys Y,Saelens W,Van Vlierberghe H,Devisscher L,Scott CL
15-5921-82 was used in Flow cytometry/Cell sorting to demonstrate that LAMs are induced by local lipid exposure, leading to their induction in steatotic regions of the murine and human liver, while Kupffer cell development crucially depends on their cross-talk with hepatic stellate cells via the evolutionarily conserved ALK1-BMP9/10 axis.
Thu Jan 20 00:00:00 EST 2022
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.
Nature medicine
Cromer MK,Camarena J,Martin RM,Lesch BJ,Vakulskas CA,Bode NM,Kurgan G,Collingwood MA,Rettig GR,Behlke MA,Lemgart VT,Zhang Y,Goyal A,Zhao F,Ponce E,Srifa W,Bak RO,Uchida N,Majeti R,Sheehan VA,Tisdale JF,Dever DP,Porteus MH
15-5921-82 was used in Immunohistochemistry to demonstrate that edited HSPCs were capable of long-term and bilineage hematopoietic reconstitution in mice, establishing proof of concept for replacement of HBA1 with HBB as a novel therapeutic strategy for curing β-thalassemia.
Thu Apr 01 00:00:00 EDT 2021
γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Lee SG,Kalidindi TM,Lou H,Gangangari K,Punzalan B,Bitton A,Lee CJ,Vargas HA,Park S,Bodei L,Kharas MG,Singh VK,Kishore Pillarsetty NV,Larson SM
15-5921-82 was used in Flow Cytometry to report a novel radioprotector drug, a liposomal formulation of gamma-tocotrienol (GT3), or GT3-Nano for short, to mitigate bone marrow radiation damage during targeted radionuclide therapy (TRT).
Thu Apr 01 00:00:00 EDT 2021
Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
PloS one
Deshycka R,Sudaryo V,Huang NJ,Xie Y,Smeding LY,Choi MK,Ploegh HL,Lodish HF,Pishesha N
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri Dec 24 00:00:00 EST 2021
GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.
JCI insight
Kashgari G,Venkatesh S,Refuerzo S,Pham B,Bayat A,Klein RH,Ramos R,Ta AP,Plikus MV,Wang PH,Andersen B
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism.
eLife
Roy A,Tomaz da Silva M,Bhat R,Bohnert KR,Iwawaki T,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.
Life science alliance
Valkov N,Das A,Tucker NR,Li G,Salvador AM,Chaffin MD,Pereira De Oliveira Junior G,Kur I,Gokulnath P,Ziegler O,Yeri A,Lu S,Khamesra A,Xiao C,Rodosthenous R,Srinivasan S,Toxavidis V,Tigges J,Laurent LC,Momma S,Kitchen R,Ellinor P,Ghiran I,Das S
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Dec 01 00:00:00 EST 2021
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Cell reports. Medicine
Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Apr 20 00:00:00 EDT 2021
Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females.
Frontiers in immunology
Mashhouri S,Koleva P,Huynh M,Okoye I,Shahbaz S,Elahi S
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Distinct skeletal stem cell types orchestrate long bone skeletogenesis.
eLife
Ambrosi TH,Sinha R,Steininger HM,Hoover MY,Murphy MP,Koepke LS,Wang Y,Lu WJ,Morri M,Neff NF,Weissman IL,Longaker MT,Chan CK
15-5921-82 was used in Flow Cytometry to address previously unappreciated shortcomings of SSC research.
Mon Jul 19 00:00:00 EDT 2021
Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.
Stem cell research & therapy
Wang B,Wang Y,Chen H,Yao S,Lai X,Qiu Y,Cai J,Huang Y,Wei X,Guan Y,Wang T,Wang J,Xiang AP
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Mon Jan 18 00:00:00 EST 2021
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Science advances
Heino S,Fang S,Lähde M,Högström J,Nassiri S,Campbell A,Flanagan D,Raven A,Hodder M,Nasreddin N,Xue HH,Delorenzi M,Leedham S,Petrova TV,Sansom O,Alitalo K
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri Nov 19 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
15-5921-82 was used in Flow Cytometry to anticipate this methodology could potentially be used for HSPC clonal tracking of Cas9 RNP and AAV6-mediated gene targeting outcomes in translational and basic research settings.
Wed Jan 20 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
15-5921-82 was used in Flow Cytometry to anticipate this methodology could potentially be used for HSPC clonal tracking of Cas9 RNP and AAV6-mediated gene targeting outcomes in translational and basic research settings.
Wed Jan 20 00:00:00 EST 2021
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.
Immunity
Remmerie A,Martens L,Thoné T,Castoldi A,Seurinck R,Pavie B,Roels J,Vanneste B,De Prijck S,Vanhockerhout M,Binte Abdul Latib M,Devisscher L,Hoorens A,Bonnardel J,Vandamme N,Kremer A,Borghgraef P,Van Vlierberghe H,Lippens S,Pearce E,Saeys Y,Scott CL
15-5921 was used in Flow cytometry/Cell sorting to highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in metabolic-associated fatty liver disease (MAFLD).
Tue Sep 15 00:00:00 EDT 2020
A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.
Immunity
Laczkó D,Hogan MJ,Toulmin SA,Hicks P,Lederer K,Gaudette BT,Castaño D,Amanat F,Muramatsu H,Oguin TH,Ojha A,Zhang L,Mu Z,Parks R,Manzoni TB,Roper B,Strohmeier S,Tombácz I,Arwood L,Nachbagauer R,Karikó K,Greenhouse J,Pessaint L,Porto M,Putman-Taylor T,Strasbaugh A,Campbell TA,Lin PJC,Tam YK,Sempowski GD,Farzan M,Choe H,Saunders KO,Haynes BF,Andersen H,Eisenlohr LC,Weissman D,Krammer F,Bates P,Allman D,Locci M,Pardi N
15-5921 was used in Flow cytometry/Cell sorting to study the immunogenicity of lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccines against SARS-CoV-2 in mice.
Tue Oct 13 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Mon May 11 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Methylation of a CGATA element inhibits binding and regulation by GATA-1.
Nature communications
Yang L,Chen Z,Stout ES,Delerue F,Ittner LM,Wilkins MR,Quinlan KGR,Crossley M
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri May 22 00:00:00 EDT 2020
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Nature communications
Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
15-5921 was used in Flow cytometry/Cell sorting to report an efficient CRISPR/Cas9-based approach that targets glucocerebrosidase expression cassettes with a monocyte/macrophage-specific element to the CCR5 safe-harbor locus in human hematopoietic stem and progenitor cells.
Fri Jul 03 00:00:00 EDT 2020
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.
Nature communications
Nguyen DTT,Lu Y,Chu KL,Yang X,Park SM,Choo ZN,Chin CR,Prieto C,Schurer A,Barin E,Savino AM,Gourkanti S,Patel P,Vu LP,Leslie CS,Kharas MG
15-5921 was used in Flow cytometry/Cell sorting to globally map the mRNA targets of the RBP MSI2 in mammalian adult normal and malignant stem cells.
Fri Apr 24 00:00:00 EDT 2020
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.
PLoS genetics
Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.
Cell reports
Cheng Y,Luo H,Izzo F,Pickering BF,Nguyen D,Myers R,Schurer A,Gourkanti S,Brüning JC,Vu LP,Jaffrey SR,Landau DA,Kharas MG
15-5921-82 was used in Flow cytometry/Cell sorting to indicate that RNA methylation controls symmetric commitment and cell identity of hematopoietic stem cells and may provide a general mechanism for how stem cells regulate differentiation fate choice.
Tue Aug 13 00:00:00 EDT 2019
Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche.
Cell reports
Balzano M,De Grandis M,Vu Manh TP,Chasson L,Bardin F,Farina A,Sergé A,Bidaut G,Charbord P,Hérault L,Bailly AL,Cartier-Michaud A,Boned A,Dalod M,Duprez E,Genever P,Coles M,Bajenoff M,Xerri L,Aurrand-Lions M,Schiff C,Mancini SJC
15-5921 was used in Flow cytometry/Cell sorting to study pro-B cells in their support of stroll cells and their interaction network allowing their retention.
Tue Mar 19 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
15-5921 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Isolation and functional assessment of mouse skeletal stem cell lineage.
Nature protocols
Gulati GS,Murphy MP,Marecic O,Lopez M,Brewer RE,Koepke LS,Manjunath A,Ransom RC,Salhotra A,Weissman IL,Longaker MT,Chan CKF
15-5921-82 was used in flow cytometry to describe a flow cytometry-based approach that does not require flow cytometry selection and that uses eight surface markers to distinguish and isolate mouse skeletal stem cells (mSSCs); bone, cartilage, and stromal progenitors (mBCSPs); and five downstream differentiated subtypes, including chondroprogenitors, two types of osteoprogenitors, and two types of hematopoiesis-supportive stroma.
Fri Jun 01 00:00:00 EDT 2018
CRISPR/Cas9 genome editing in human hematopoietic stem cells.
Nature protocols
Bak RO,Dever DP,Porteus MH
15-5921 was used in Flow cytometry/Cell sorting to contribute to a protocol for the production, enrichment, and in vitro and in vivo analyses of HR-targeted hematopoietic stem cells.
Thu Feb 01 00:00:00 EST 2018
MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.
Human molecular genetics
Gallot YS,Straughn AR,Bohnert KR,Xiong G,Hindi SM,Kumar A
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri Jun 22 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Dec 11 00:00:00 EST 2018
The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages.
Autophagy
Mylka V,Deckers J,Ratman D,De Cauwer L,Thommis J,De Rycke R,Impens F,Libert C,Tavernier J,Vanden Berghe W,Gevaert K,De Bosscher K
15-5921-82 was used in Flow cytometry/Cell sorting to demonstrate how off-target mechanisms of selective NR3C1 ligands may contribute to a more efficient anti-inflammatory therapy.
Tue Oct 22 00:00:00 EDT 2019
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
15-5921-82 was used in Flow Cytometry to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.
Tue May 15 00:00:00 EDT 2018
Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.
Molecular cell
Jee D,Yang JS,Park SM,Farmer DT,Wen J,Chou T,Chow A,McManus MT,Kharas MG,Lai EC
15-5921-82 was used in flow cytometry to investigate erythroid miRNA biogenesis in mammalian slicing.
Thu Jan 18 00:00:00 EST 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to show that in leukaemia, GMP clusters are constantly produced due to lack of termination cytokines that restore haematopoietic stem-cell quiescence.
Thu Apr 06 00:00:00 EDT 2017
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Cancer cell
Reyna DE,Garner TP,Lopez A,Kopp F,Choudhary GS,Sridharan A,Narayanagari SR,Mitchell K,Dong B,Bartholdy BA,Walensky LD,Verma A,Steidl U,Gavathiotis E
15-5921 was used in Flow cytometry/Cell sorting to identify BTSA1, a pharmacologically optimised BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
Mon Oct 09 00:00:00 EDT 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
The Journal of clinical investigation
Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice.
Nature protocols
Reinisch A,Hernandez DC,Schallmoser K,Majeti R
Sun Oct 01 00:00:00 EDT 2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Developmental cell
Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Mar 21 00:00:00 EDT 2017
Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity.
Breast cancer research : BCR
Chamberlin T,D'Amato JV,Arendt LM
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Nov 29 00:00:00 EST 2017
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.
Nature communications
Sinha S,Thomas D,Chan S,Gao Y,Brunen D,Torabi D,Reinisch A,Hernandez D,Chan A,Rankin EB,Bernards R,Majeti R,Dill DL
15-5921 was used in Flow cytometry/Cell sorting to demonstrate that MiSL can accelerate precision oncology by identifying mutation-specific targets and biomarkers.
Wed May 31 00:00:00 EDT 2017
Age-dependent modulation of vascular niches for haematopoietic stem cells.
Nature
Kusumbe AP,Ramasamy SK,Itkin T,Mäe MA,Langen UH,Betsholtz C,Lapidot T,Adams RH
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nature communications
Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Dec 21 00:00:00 EST 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
15-5921 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.
Nature medicine
Chan SM,Thomas D,Corces-Zimmerman MR,Xavy S,Rastogi S,Hong WJ,Zhao F,Medeiros BC,Tyvoll DA,Majeti R
15-5921 was used in Flow cytometry/Cell sorting to provide evidence that IDH1/2 mutation status may identify AML patients that are likely to respond to pharmacologic BCL-2 inhibition.
Sun Feb 01 00:00:00 EST 2015
PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal.
Nature
Lee HY,Gao X,Barrasa MI,Li H,Elmes RR,Peters LL,Lodish HF
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
15-5921 was used in Flow cytometry/Cell sorting to investigate the critical niche components and resident signals required for hematopoietic stem cell induction and self-renewal ex vivo.
Fri May 01 00:00:00 EDT 2015
Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.
The Journal of experimental medicine
Kim PG,Nakano H,Das PP,Chen MJ,Rowe RG,Chou SS,Ross SJ,Sakamoto KM,Zon LI,Schlaeger TM,Orkin SH,Nakano A,Daley GQ
15-5921 was used in Flow cytometry/Cell sorting to identify a novel signalling pathway that regulates haematopoietic stem cell emergence in the aorta-gonad-mesonephros.
Mon May 04 00:00:00 EDT 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.
American journal of hematology
Ludwig LS,Cho H,Wakabayashi A,Eng JC,Ulirsch JC,Fleming MD,Lodish HF,Sankaran VG
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Sleep disruption impairs haematopoietic stem cell transplantation in mice.
Nature communications
Rolls A,Pang WW,Ibarra I,Colas D,Bonnavion P,Korin B,Heller HC,Weissman IL,de Lecea L
15-5921 was used in Flow cytometry/Cell sorting to provide insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs.
Wed Oct 14 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
15-5921 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
15-5921 was used in Flow cytometry/Cell sorting to assess the potential of antisense splice-correcting oligonucleotides targeting mutated Bruton's tyrosine kinase transcripts for treating X-linked agammaglobulinemia.
Mon Sep 01 00:00:00 EDT 2014
Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.
PloS one
Vanoaica L,Richman L,Jaworski M,Darshan D,Luther SA,Kühn LC
15-5921 was used in Flow cytometry/Cell sorting to investigate the effect of ferritin H deletion on lymphocytes, showing that it reduces B and T lymphocyte populations.
Tue Jan 13 00:00:00 EST 2015
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
15-5921 was used in Flow cytometry/Cell sorting to demonstrate that autophagy is essential for maintenance of the HSC compartment and for supporting an old, failing blood system.
Thu Feb 21 00:00:00 EST 2013
Flow cytometry analysis of murine hematopoietic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Mayle A,Luo M,Jeong M,Goodell MA
15-5921 was used in Flow cytometry/Cell sorting to discuss methods for rapid flow cytometric analysis of peripheral blood cell types and novel strategies for working with rare cell populations such as hematopoietic stem cells in the analysis of cell cycle status by BrdU, Ki-67, and Pyronin Y staining.
Tue Jan 01 00:00:00 EST 2013
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Thu May 10 00:00:00 EDT 2012
An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells.
PloS one
Glotzbach JP,Januszyk M,Vial IN,Wong VW,Gelbard A,Kalisky T,Thangarajah H,Longaker MT,Quake SR,Chu G,Gurtner GC
15-5921 was used in Flow cytometry/Cell sorting to develop a novel method to characterize and predict transcriptional programs across individual homogeneous stem cells.
Wed Nov 02 00:00:00 EDT 2011
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Blood
Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL
15-5921 was used in Flow cytometry/Cell sorting to indicate that Gfi1 loss of function deregulates 2 separable transcriptional programs, one of which controls the accumulation and lineage specification of myeloid progenitors, but not terminal granulopoiesis.
Thu May 28 00:00:00 EDT 2009
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Blood
Minamishima YA,Moslehi J,Bardeesy N,Cullen D,Bronson RT,Kaelin WG
15-5921 was used in Magnetic cell separation to find that conditional inactivation of PHD2 is sufficient to activate erythropoietin, causing increases in red blood cell production.
Sat Mar 15 00:00:00 EDT 2008
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
15-5921 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.
The Journal of biological chemistry
Mori M,Yoneda-Kato N,Yoshida A,Kato JY
15-5921 was used in Flow cytometry/Cell sorting to investigate how the expression and function of JAB1 are critical for the proliferation and maintenance of hematopoietic progenitors.
Fri Oct 24 00:00:00 EDT 2008
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.
Blood
Dumble M,Moore L,Chambers SM,Geiger H,Van Zant G,Goodell MA,Donehower LA
15-5921 was used in Flow cytometry/Cell sorting to study how altering p53 dosage during ageing impacts hematopoietic stem cell dynamics.
Thu Feb 15 00:00:00 EST 2007
CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Hosen N,Park CY,Tatsumi N,Oji Y,Sugiyama H,Gramatzki M,Krensky AM,Weissman IL
15-5921 was used in Flow cytometry/Cell sorting to isolate cell surface molecules expressed on human acute myeloid leukemia-leukemic stem cells.
Tue Jun 26 00:00:00 EDT 2007
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
The EMBO journal
Vassen L,Fiolka K,Möröy T
Published figure using TER-119 monoclonal antibody (Product # 15-5921-82) in Flow Cytometry
Wed Jun 07 00:00:00 EDT 2006
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
15-5921 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.
The Journal of experimental medicine
Cobas M,Wilson A,Ernst B,Mancini SJ,MacDonald HR,Kemler R,Radtke F
15-5921 was used in Flow cytometry/Cell sorting to investigate an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
Mon Jan 19 00:00:00 EST 2004
