Product References
Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.
Journal of biomedical science
Li P,Zhou D,Chen D,Cheng Y,Chen Y,Lin Z,Zhang X,Huang Z,Cai J,Huang W,Lin Y,Ke H,Long J,Zou Y,Ye S,Lan P
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Jun 28 00:00:00 EDT 2023
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma.
International journal of molecular sciences
Sieow JL,Penny HL,Gun SY,Tan LQ,Duan K,Yeong JPS,Pang A,Lim D,Toh HC,Lim TKH,Engleman E,Rotzschke O,Ng LG,Chen J,Tan SM,Wong SC
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Oct 10 00:00:00 EDT 2022
Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung.
Nature communications
Horn KJ,Schopper MA,Drigot ZG,Clark SE
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Jun 09 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.
Nature communications
Tan TCJ,Kelly V,Zou X,Wright D,Ly T,Zamoyska R
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Sat Dec 17 00:00:00 EST 2022
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation.
JCI insight
Linnerbauer M,Lößlein L,Vandrey O,Tsaktanis T,Beer A,Naumann UJ,Panier F,Beyer T,Nirschl L,Kuramatsu JB,Winkler J,Quintana FJ,Rothhammer V
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis.
JCI insight
Ma N,Yuan C,Shi J,Zhu Q,Liu Y,Ma X,Li B,Gong W,Xue J,Lu G,Li W,Li J
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Nov 08 00:00:00 EST 2022
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies.
Theranostics
Li H,Peng K,Yang K,Ma W,Qi S,Yu X,He J,Lin X,Yu G
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Sep 29 00:00:00 EDT 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Oct 31 00:00:00 EDT 2022
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Nature
Zheng J,Wong LR,Li K,Verma AK,Ortiz ME,Wohlford-Lenane C,Leidinger MR,Knudson CM,Meyerholz DK,McCray PB,Perlman S
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Nature immunology
Zhou J,Kryczek I,Li S,Li X,Aguilar A,Wei S,Grove S,Vatan L,Yu J,Yan Y,Liao P,Lin H,Li J,Li G,Du W,Wang W,Lang X,Wang W,Wang S,Zou W
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Molecular therapy : the journal of the American Society of Gene Therapy
Teng Y,Xu F,Zhang X,Mu J,Sayed M,Hu X,Lei C,Sriwastva M,Kumar A,Sundaram K,Zhang L,Park JW,Chen SY,Zhang S,Yan J,Merchant ML,Zhang X,McClain CJ,Wolfe JK,Adcock RS,Chung D,Palmer KE,Zhang HG
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Aug 04 00:00:00 EDT 2021
TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Oxidative medicine and cellular longevity
Luo Y,Guo J,Jia W,Wu M,Yin F,Niu G,Shih DQ,Targan SR,Zhang X
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2023
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Cell death discovery
Pu J,Xu Z,Nian J,Fang Q,Yang M,Huang Y,Li W,Ge B,Wang J,Wei H
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Dec 22 00:00:00 EST 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Aug 11 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Nature communications
Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon May 17 00:00:00 EDT 2021
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.
Cell death & disease
Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Dec 16 00:00:00 EST 2021
Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.
Pathogens (Basel, Switzerland)
Medina-Buelvas DM,Rodríguez-Sosa M,Vega L
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Sat Nov 06 00:00:00 EDT 2021
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
The Journal of clinical investigation
Tilstam PV,Schulte W,Holowka T,Kim BS,Nouws J,Sauler M,Piecychna M,Pantouris G,Lolis E,Leng L,Bernhagen J,Fingerle-Rowson G,Bucala R
12-7321-41 was used in flow cytometry to study Mif-/- and Mif-2-/- mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency.
Wed Dec 01 00:00:00 EST 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Dec 13 00:00:00 EST 2021
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
12-7321-41 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.
Veterinary research
Sisteré-Oró M,Pedersen GK,Córdoba L,López-Serrano S,Christensen D,Darji A
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Apr 20 00:00:00 EDT 2020
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Sep 10 00:00:00 EDT 2021
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Jul 24 00:00:00 EDT 2020
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed May 13 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.
American journal of physiology. Renal physiology
Privratsky JR,Zhang J,Lu X,Rudemiller N,Wei Q,Yu YR,Gunn MD,Crowley SD
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Molecular pain
Lee S,Shi XQ,Fan A,West B,Zhang J
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Oct 22 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites.
JCI insight
Wasnik S,Rundle CH,Baylink DJ,Yazdi MS,Carreon EE,Xu Y,Qin X,Lau KW,Tang X
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
12-7321-41 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
12-7321-41 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Cell metabolism
Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Sep 05 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
Oncotarget
Cho JH,Lee HJ,Ko HJ,Yoon BI,Choe J,Kim KC,Hahn TW,Han JA,Choi SS,Jung YM,Lee KH,Lee YS,Jung YJ
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Apr 11 00:00:00 EDT 2017
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.
JCI insight
Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.
Scientific reports
Clemmensen HS,Knudsen NPH,Rasmussen EM,Winkler J,Rosenkrands I,Ahmad A,Lillebaek T,Sherman DR,Andersen PL,Aagaard C
12-7321 was used in Flow cytometry/Cell sorting to investigate the Mycobacterium tuberculosis (M.tb) DK9897 strain, showing that it is attenuated and has a defect in ESX-1 secretion, leading to minimal host immune response and pathology.
Mon Apr 24 00:00:00 EDT 2017
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.
The Journal of clinical investigation
Rackov G,Hernández-Jiménez E,Shokri R,Carmona-Rodríguez L,Mañes S,Álvarez-Mon M,López-Collazo E,Martínez-A C,Balomenos D
12-7321 was used in Flow cytometry/Cell sorting to determine whether p21 regulates macrophage reprogramming by shifting the balance between active p65-p50 and inhibitory p50-p50 NF-κB pathways.
Mon Aug 01 00:00:00 EDT 2016
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
The Journal of experimental medicine
Hu Y,Kim JH,He K,Wan Q,Kim J,Flach M,Kirchhausen T,Vortkamp A,Winau F
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Nov 14 00:00:00 EST 2016
Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus.
Proceedings of the National Academy of Sciences of the United States of America
Finsterbusch M,Hall P,Li A,Devi S,Westhorpe CL,Kitching AR,Hickey MJ
12-7321 was used in Flow cytometry/Cell sorting to examine the contributions of monocytes to antibody- and neutrophil-dependent inflammation in a model of in situ immune complex-mediated glomerulonephritis.
Tue Aug 30 00:00:00 EDT 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Dec 23 00:00:00 EST 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
12-7321 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.
Mon Feb 01 00:00:00 EST 2016
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
Cell
Parnas O,Jovanovic M,Eisenhaure TM,Herbst RH,Dixit A,Ye CJ,Przybylski D,Platt RJ,Tirosh I,Sanjana NE,Shalem O,Satija R,Raychowdhury R,Mertins P,Carr SA,Zhang F,Hacohen N,Regev A
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2015
A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates.
Science translational medicine
Muthumani K,Falzarano D,Reuschel EL,Tingey C,Flingai S,Villarreal DO,Wise M,Patel A,Izmirly A,Aljuaid A,Seliga AM,Soule G,Morrow M,Kraynyak KA,Khan AS,Scott DP,Feldmann F,LaCasse R,Meade-White K,Okumura A,Ugen KE,Sardesai NY,Kim JJ,Kobinger G,Feldmann H,Weiner DB
12-7321 was used in Flow cytometry/Cell sorting to report on the development of a synthetic DNA vaccine against a novel member of the lineage C betacoronaviruses.
Wed Aug 19 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
12-7321 was used in Flow cytometry/Cell sorting to exhibit a novel vaccine platform for inducing robust T cell responses capable of protecting against heterologous influenza A challenges.
Fri Jul 10 00:00:00 EDT 2015
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge.
Human vaccines & immunotherapeutics
Scott VL,Villarreal DO,Hutnick NA,Walters JN,Ragwan E,Bdeir K,Yan J,Sardesai NY,Finnefrock AC,Casimiro DR,Weiner DB
12-7321 was used in Flow cytometry/Cell sorting to demonstrate the protective efficacy of a combinative synthetic DNA vaccine approach targeting three important C. botulinum neurotoxin serotypes.
Wed May 04 00:00:00 EDT 2016
Alarmin IL-33 elicits potent TB-specific cell-mediated responses.
Human vaccines & immunotherapeutics
Villarreal DO,Siefert RJ,Weiner DB
12-7321 was used in Flow cytometry/Cell sorting to highlight IL-33 as a promising adjuvant to significantly improve the immunogenicity of TB DNA vaccines.
Wed May 04 00:00:00 EDT 2016
Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice.
Human vaccines & immunotherapeutics
Scott VL,Patel A,Villarreal DO,Hensley SE,Ragwan E,Yan J,Sardesai NY,Rothwell PJ,Extance JP,Caproni LJ,Weiner DB
12-7321 was used in Flow cytometry/Cell sorting to observe the immune responses to novel synthetic DNA vaccines against a lethal influenza challenge in mice.
Wed May 04 00:00:00 EDT 2016
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
The Journal of investigative dermatology
Yoshiki R,Kabashima K,Honda T,Nakamizo S,Sawada Y,Sugita K,Yoshioka H,Ohmori S,Malissen B,Tokura Y,Nakamura M
12-7321 was used in Flow cytometry/Cell sorting to clarify the role of Langerhans cells in psoriasis.
Tue Jul 01 00:00:00 EDT 2014
CD40 ligand preferentially modulates immune response and enhances protection against influenza virus.
Journal of immunology (Baltimore, Md. : 1950)
Hashem AM,Gravel C,Chen Z,Yi Y,Tocchi M,Jaentschke B,Fan X,Li C,Rosu-Myles M,Pereboev A,He R,Wang J,Li X
12-7321 was used in Flow cytometry/Cell sorting to characterise an increased in vivo load of CD40-targeted Ag upon the secretion of the NP-CD40L fusion protein from adenovirus-infected cells.
Tue Jul 15 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.
Vaccine
Yan J,Villarreal DO,Racine T,Chu JS,Walters JN,Morrow MP,Khan AS,Sardesai NY,Kim JJ,Kobinger GP,Weiner DB
12-7321 was used in Flow cytometry/Cell sorting to investigate how synthetic DNA vaccine is a new tool for targeting emerging infection and providing protective immunity to H7N9 influenza viruses.
Mon May 19 00:00:00 EDT 2014
Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain.
Journal of pain & relief
Draleau K,Maddula S,Slaiby A,Nutile-McMenemy N,De Leo J,Cao L
12-7321 was used in Flow cytometry/Cell sorting to investigate the phenotype of spinal cord-infiltrating CD4+ T lymphocytes involved in the maintenance of neuropathic pain in a murine model.
Sun Jun 01 00:00:00 EDT 2014
Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.
PloS one
Markwart R,Condotta SA,Requardt RP,Borken F,Schubert K,Weigel C,Bauer M,Griffith TS,Förster M,Brunkhorst FM,Badovinac VP,Rubio I
12-7321 was used in Flow cytometry/Cell sorting to investigate the nature of defects of T-cell immunity in post-acute phases of systemic inflammatory response, showing an induced loss of naive T-cells but no enduring cell-autonomous defects in T-cell function.
Thu Aug 27 00:00:00 EDT 2015
Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection.
PloS one
Hartwig SM,Holman KM,Varga SM
12-7321 was used in Flow cytometry/Cell sorting to demonstrate that alveolar macrophages play a critical role in modulating MHV-1-induced morbidity and mortality.
Tue Dec 30 00:00:00 EST 2014
UNC93B1 mediates differential trafficking of endosomal TLRs.
eLife
Lee BL,Moon JE,Shu JH,Yuan L,Newman ZR,Schekman R,Barton GM
12-7321 was used in Flow cytometry/Cell sorting to describe the mechanisms by which UNC93B1 regulates multiple aspects of Toll-like receptor trafficking, showing that post-Golgi trafficking of TLR7 and TLR9 are distinct.
Tue Feb 19 00:00:00 EST 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
12-7321 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
CD22 is required for protection against West Nile virus Infection.
Journal of virology
Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA
12-7321 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.
Fri Mar 01 00:00:00 EST 2013
Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.
Journal of virology
Walker JM,Raué HP,Slifka MK
12-7321 was used in Flow cytometry/Cell sorting to investigate the specific immune cell response to H(2)O(2)-LCMV vaccination.
Sat Dec 01 00:00:00 EST 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using TNF alpha monoclonal antibody (Product # 12-7321-41) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.
Infection and immunity
Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S
12-7321 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.
Sun Jan 01 00:00:00 EST 2012
High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.
Scientific reports
Ohtaki H,Ito H,Hoshi M,Osawa Y,Takamatsu M,Hara A,Ishikawa T,Moriwaki H,Saito K,Seishima M
12-7321 was used in Flow cytometry/Cell sorting to examine and explore the effect of lipopolysaccharide on encephalomyocarditis virus-infected mice.
Fri Apr 12 00:00:00 EDT 2013
Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.
Immunity
Mouchess ML,Arpaia N,Souza G,Barbalat R,Ewald SE,Lau L,Barton GM
12-7321 was used in Flow cytometry/Cell sorting to elucidate residues within the TLR9 transmembrane region that confer the requirement for ectodomain proteolysis.
Wed Nov 23 00:00:00 EST 2011
Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.
Alcoholism, clinical and experimental research
Fan J,Edsen-Moore MR,Turner LE,Cook RT,Legge KL,Waldschmidt TJ,Schlueter AJ
12-7321 was used in Flow cytometry/Cell sorting to assess the functional capability of ethanol-exposed dendritic cells, using a murine model of chronic alcohol abuse.
Sat Jan 01 00:00:00 EST 2011
Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses.
PloS one
Kapadia D,Sadikovic A,Vanloubbeeck Y,Brockstedt D,Fong L
12-7321 was used in Functional assays to examine the contribution of different primary APCs during Listeria monocytogenes infection, showing interplay between dendritic cells and monocytes during infection.
Fri Apr 29 00:00:00 EDT 2011
Interplay between CD8α+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses.
PloS one
Kapadia D,Sadikovic A,Vanloubbeeck Y,Brockstedt D,Fong L
12-7321 was used in Functional assays to examine the contribution of different primary APCs during Listeria monocytogenes infection, showing interplay between dendritic cells and monocytes during infection.
Fri Apr 29 00:00:00 EDT 2011
Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor.
The Journal of infectious diseases
Khounlotham M,Subbian S,Smith R,Cirillo SL,Cirillo JD
12-7321 was used in Flow cytometry/Cell sorting to suggest that induction of the erythropoietin-producing hepatoma (Eph) receptor, ephA2, is important for the survival of M. tuberculosis during latency.
Mon Jun 15 00:00:00 EDT 2009
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SW,Salek-Ardakani S,Mittler RS,Croft M
12-7321 was used in Flow cytometry/Cell sorting to investigate the potential side effects of immunotherapeutic strategies using Abs against costimulatory molecules.
Mon Jun 01 00:00:00 EDT 2009
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-7321 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Journal of the American Society of Nephrology : JASN
Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR
12-7321 was used in Immunohistochemistry to identify additional therapeutic chemokine targets for immune-mediated nephritis.
Sun Jun 01 00:00:00 EDT 2008
Regulation of cytokine production by virus-specific CD8 T cells in the lungs.
Journal of virology
Fulton RB,Olson MR,Varga SM
12-7321 was used in Flow cytometry/Cell sorting to show that both virus-induced inflammation and the host tissue environment influence the capacity of virus-specific T cells to produce cytokines.
Fri Aug 01 00:00:00 EDT 2008
Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance.
International immunology
Ito H,Ando K,Ishikawa T,Nakayama T,Taniguchi M,Saito K,Imawari M,Moriwaki H,Yokochi T,Kakumu S,Seishima M
12-7321 was used in Flow cytometry/Cell sorting to open up a new method for clearing the virus from patients with persistent HBV infection.
Tue Jul 01 00:00:00 EDT 2008
Deletion of both ICAM-1 and C3 enhances severity of experimental autoimmune encephalomyelitis compared to C3-deficient mice.
Neuroscience letters
Smith SS,Ludwig M,Wohler JE,Bullard DC,Szalai AJ,Barnum SR
12-7321 was used in Flow cytometry/Cell sorting to examine experimental autoimmune encephalitis in ICAM-1 x C3 double knockout mice.
Fri Sep 12 00:00:00 EDT 2008
Disruption of the beta2-integrin CD11d (alphaDbeta2) gene fails to protect against experimental autoimmune encephalomyelitis.
Journal of neuroimmunology
Adams JE,Webb MS,Hu X,Staunton D,Barnum SR
12-7321 was used in Flow cytometry/Cell sorting to show that deletion of the β2-integrin CD11d has no effect on the development and progression of EAE.
Thu Mar 01 00:00:00 EST 2007
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Infection and immunity
Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG
12-7321 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.
Wed Nov 01 00:00:00 EST 2006
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The Journal of experimental medicine
Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF
12-7321 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.
Mon Aug 15 00:00:00 EDT 2005
Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.
The Journal of experimental medicine
Auerbuch V,Brockstedt DG,Meyer-Morse N,O'Riordan M,Portnoy DA
12-7321 was used in Flow cytometry/Cell sorting to investigate the role of type I interferon receptors in viral defense using Listeria monocytogenes infection of mice as a model.
Mon Aug 16 00:00:00 EDT 2004
Listeria-based cancer vaccines that segregate immunogenicity from toxicity.
Proceedings of the National Academy of Sciences of the United States of America
Brockstedt DG,Giedlin MA,Leong ML,Bahjat KS,Gao Y,Luckett W,Liu W,Cook DN,Portnoy DA,Dubensky TW
12-7321 was used in Flow cytometry/Cell sorting to propose that recombinant Listeria DeltaactA/DeltainlB expressing human tumor-associated antigens represents a therapeutic strategy for human clinical trials.
Tue Sep 21 00:00:00 EDT 2004
