Product References
Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.
Journal of biomedical science
Li P,Zhou D,Chen D,Cheng Y,Chen Y,Lin Z,Zhang X,Huang Z,Cai J,Huang W,Lin Y,Ke H,Long J,Zou Y,Ye S,Lan P
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Jun 28 00:00:00 EDT 2023
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma.
International journal of molecular sciences
Sieow JL,Penny HL,Gun SY,Tan LQ,Duan K,Yeong JPS,Pang A,Lim D,Toh HC,Lim TKH,Engleman E,Rotzschke O,Ng LG,Chen J,Tan SM,Wong SC
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Oct 10 00:00:00 EDT 2022
Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung.
Nature communications
Horn KJ,Schopper MA,Drigot ZG,Clark SE
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Jun 09 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.
Nature communications
Tan TCJ,Kelly V,Zou X,Wright D,Ly T,Zamoyska R
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Sat Dec 17 00:00:00 EST 2022
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation.
JCI insight
Linnerbauer M,Lößlein L,Vandrey O,Tsaktanis T,Beer A,Naumann UJ,Panier F,Beyer T,Nirschl L,Kuramatsu JB,Winkler J,Quintana FJ,Rothhammer V
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis.
JCI insight
Ma N,Yuan C,Shi J,Zhu Q,Liu Y,Ma X,Li B,Gong W,Xue J,Lu G,Li W,Li J
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Nov 08 00:00:00 EST 2022
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies.
Theranostics
Li H,Peng K,Yang K,Ma W,Qi S,Yu X,He J,Lin X,Yu G
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Sep 29 00:00:00 EDT 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Oct 31 00:00:00 EDT 2022
Depletion of γδ T Cells Leads to Reduced Angiogenesis and Increased Infiltration of Inflammatory M1-like Macrophages in Ischemic Muscle Tissue.
Cells
Arnholdt C,Kumaraswami K,Götz P,Kübler M,Lasch M,Deindl E
14-7321-81 was used in Immunohistochemistry to show that depletion of γδ T cells leads to increased accumulation of leukocytes and M1-like macrophages, along with impaired angiogenesis.
Fri Apr 29 00:00:00 EDT 2022
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Nature
Zheng J,Wong LR,Li K,Verma AK,Ortiz ME,Wohlford-Lenane C,Leidinger MR,Knudson CM,Meyerholz DK,McCray PB,Perlman S
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Nature immunology
Zhou J,Kryczek I,Li S,Li X,Aguilar A,Wei S,Grove S,Vatan L,Yu J,Yan Y,Liao P,Lin H,Li J,Li G,Du W,Wang W,Lang X,Wang W,Wang S,Zou W
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Molecular therapy : the journal of the American Society of Gene Therapy
Teng Y,Xu F,Zhang X,Mu J,Sayed M,Hu X,Lei C,Sriwastva M,Kumar A,Sundaram K,Zhang L,Park JW,Chen SY,Zhang S,Yan J,Merchant ML,Zhang X,McClain CJ,Wolfe JK,Adcock RS,Chung D,Palmer KE,Zhang HG
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Aug 04 00:00:00 EDT 2021
TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Oxidative medicine and cellular longevity
Luo Y,Guo J,Jia W,Wu M,Yin F,Niu G,Shih DQ,Targan SR,Zhang X
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2023
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Cell death discovery
Pu J,Xu Z,Nian J,Fang Q,Yang M,Huang Y,Li W,Ge B,Wang J,Wei H
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Dec 22 00:00:00 EST 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Aug 11 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Nature communications
Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon May 17 00:00:00 EDT 2021
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.
Cell death & disease
Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Dec 16 00:00:00 EST 2021
Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.
Pathogens (Basel, Switzerland)
Medina-Buelvas DM,Rodríguez-Sosa M,Vega L
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Sat Nov 06 00:00:00 EDT 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Dec 13 00:00:00 EST 2021
Deletion of Ppard in CD11c+ cells attenuates atherosclerosis in ApoE knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tian D,Hong H,Shang W,Ho CC,Dong J,Tian XY
14-7321-81 was used in Flow Cytometry to study the involvement of PPARδ in CD11c+ cells in atherosclerosis.
Sat Feb 01 00:00:00 EST 2020
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Sep 10 00:00:00 EDT 2021
Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways.
JCI insight
Huang T,Fu G,Gao J,Zhang Y,Cai W,Wu S,Jia S,Xia S,Bachmann T,Bekker A,Tao YX
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Immunohistochemistry
Thu Oct 15 00:00:00 EDT 2020
Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways.
JCI insight
Huang T,Fu G,Gao J,Zhang Y,Cai W,Wu S,Jia S,Xia S,Bachmann T,Bekker A,Tao YX
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Immunohistochemistry
Thu Oct 15 00:00:00 EDT 2020
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response.
Journal of neuroinflammation
Lee S,Kim S,Kang HY,Lim HR,Kwon Y,Jo M,Jeon YM,Kim SR,Kim K,Ha CM,Lee S,Kim HJ
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Neutralization
Wed Oct 14 00:00:00 EDT 2020
The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response.
Journal of neuroinflammation
Lee S,Kim S,Kang HY,Lim HR,Kwon Y,Jo M,Jeon YM,Kim SR,Kim K,Ha CM,Lee S,Kim HJ
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Neutralization
Wed Oct 14 00:00:00 EDT 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jul 24 00:00:00 EDT 2020
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed May 13 00:00:00 EDT 2020
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Nature communications
Jaeger-Ruckstuhl CA,Hinterbrandner M,Höpner S,Correnti CE,Lüthi U,Friedli O,Freigang S,Al Sayed MF,Bührer ED,Amrein MA,Schürch CM,Radpour R,Riether C,Ochsenbein AF
14-7321-81 was used in Flow Cytometry to analyse the role of the TRAF2-/NCK-interacting kinase (TNIK), a signaling molecule downstream of the tumor necrosis factor superfamily receptors such as CD27, in the regulation of CD8+ T cell fate during acute infection with lymphocytic choriomeningitis virus.
Thu Apr 02 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis.
Cellular & molecular immunology
Lu Y,Liu H,Bi Y,Yang H,Li Y,Wang J,Zhang Z,Wang Y,Li C,Jia A,Han L,Hu Y,Zhao Y,Wang R,Liu G
14-7321 was used in Flow cytometry/Cell sorting to reveal the dysregulation of glucocorticoid receptor expression in myeloid-derived suppressor cells during innate immunological hepatic injury and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.
Fri Jun 01 00:00:00 EDT 2018
Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.
American journal of physiology. Renal physiology
Privratsky JR,Zhang J,Lu X,Rudemiller N,Wei Q,Yu YR,Gunn MD,Crowley SD
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Molecular pain
Lee S,Shi XQ,Fan A,West B,Zhang J
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Oct 22 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites.
JCI insight
Wasnik S,Rundle CH,Baylink DJ,Yazdi MS,Carreon EE,Xu Y,Qin X,Lau KW,Tang X
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection.
Scientific reports
Li C,Wang Y,Li Y,Yu Q,Jin X,Wang X,Jia A,Hu Y,Han L,Wang J,Yang H,Yan D,Bi Y,Liu G
14-7321 was used in Flow cytometry/Cell sorting to show the HIF1α-dependent glycolytic pathway is essential for pro-inflammatory macrophage functional differentiation in protecting against bacterial and fungal infections.
Mon Feb 26 00:00:00 EST 2018
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.
Oncoimmunology
Hung AL,Maxwell R,Theodros D,Belcaid Z,Mathios D,Luksik AS,Kim E,Wu A,Xia Y,Garzon-Muvdi T,Jackson C,Ye X,Tyler B,Selby M,Korman A,Barnhart B,Park SM,Youn JI,Chowdhury T,Park CK,Brem H,Pardoll DM,Lim M
14-7321 was used in Flow cytometry/Cell sorting to determine the effect of anti-PD-1 and anti-TIGIT combination therapy on survival in a murine glioblastoma model, and to elucidate the underlying immune mechanisms.
Wed Nov 03 00:00:00 EDT 2021
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Cell metabolism
Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Sep 05 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-7321 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner.
Cellular & molecular immunology
Xu X,Meng Q,Erben U,Wang P,Glauben R,Kühl AA,Wu H,Ma CW,Hu M,Wang Y,Sun W,Jia J,Wu X,Chen W,Siegmund B,Qin Z
14-7321 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth.
Sat Jul 01 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-7321 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events.
Science translational medicine
Ishihara J,Fukunaga K,Ishihara A,Larsson HM,Potin L,Hosseinchi P,Galliverti G,Swartz MA,Hubbell JA
14-7321 was used in Flow cytometry/Cell sorting to present a viable and safer approach in checkpoint blockade.
Wed Nov 08 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-7321-81 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-7321-81 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
Oncotarget
Cho JH,Lee HJ,Ko HJ,Yoon BI,Choe J,Kim KC,Hahn TW,Han JA,Choi SS,Jung YM,Lee KH,Lee YS,Jung YJ
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Apr 11 00:00:00 EDT 2017
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.
JCI insight
Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
Oncotarget
Muraoka D,Seo N,Hayashi T,Hyuga-Amaike C,Okamori K,Tawara I,Harada N,Shiku H
14-7321 was used in Flow cytometry/Cell sorting to determine the regulatory mechanism of signal transducer and activator of transcription proteins in CD8+T cells.
Tue May 09 00:00:00 EDT 2017
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Oncoimmunology
Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF
14-7321 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.
Tue Jan 12 00:00:00 EST 2021
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
The Journal of experimental medicine
Hu Y,Kim JH,He K,Wan Q,Kim J,Flach M,Kirchhausen T,Vortkamp A,Winau F
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Nov 14 00:00:00 EST 2016
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Arteriosclerosis, thrombosis, and vascular biology
Harmon DB,Srikakulapu P,Kaplan JL,Oldham SN,McSkimming C,Garmey JC,Perry HM,Kirby JL,Prohaska TA,Gonen A,Hallowell P,Schirmer B,Tsimikas S,Taylor AM,Witztum JL,McNamara CA
14-7321 was used in Flow cytometry/Cell sorting to investigate the role of B-cell functions in obesity-induced metabolic dysfunction.
Fri Apr 01 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-7321 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.
Journal of immunology research
Clarke D,Letendre C,Lecours MP,Lemire P,Galbas T,Thibodeau J,Segura M
14-7321 was used in Flow cytometry/Cell sorting to investigate the source of IFN-γ during group B Streptococcus serotype III infection, showing robust IFN-γ response by CD4(+) T cells.
Tue Nov 01 00:00:00 EDT 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Dec 23 00:00:00 EST 2016
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
Cell
Parnas O,Jovanovic M,Eisenhaure TM,Herbst RH,Dixit A,Ye CJ,Przybylski D,Platt RJ,Tirosh I,Sanjana NE,Shalem O,Satija R,Raychowdhury R,Mertins P,Carr SA,Zhang F,Hacohen N,Regev A
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2015
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dai M,Yip YY,Hellstrom I,Hellstrom KE
14732181 was used in flow cytometry to test the efficacy of combining different monoclonal antibodies to treat cancer
Sun Mar 01 00:00:00 EST 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.
Journal of virology
Watanabe S,Chan KW,Wang J,Rivino L,Lok SM,Vasudevan SG
14-7321 was used in Neutralization experiments to examine the relationship between the neutralising level of Dengue virus antibodies at the time of infection and subsequent disease progression in the AG129 mouse model.
Mon Jun 01 00:00:00 EDT 2015
γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice.
Journal of leukocyte biology
Mehta P,Nuotio-Antar AM,Smith CW
14-7321 was used in Flow cytometry/Cell sorting to reveal that isolated γδ T cells directly stimulated RAW264.7 macrophage TNF-α expression but did not stimulate inflammatory mediator expression in 3T3-L1 adipocytes.
Thu Jan 01 00:00:00 EST 2015
Ly6C(high) monocytes control cerebral toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950)
Biswas A,Bruder D,Wolf SA,Jeron A,Mack M,Heimesaat MM,Dunay IR
14-7321 was used in Flow cytometry/Cell sorting to indicate the critical importance of recruited Ly6C monocytes upon cerebral toxoplasmosis.
Wed Apr 01 00:00:00 EDT 2015
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells.
PloS one
Zhang W,Cho SY,Xiang G,Min KJ,Yu Q,Jin JO
14-7321 was used in Flow cytometry/Cell sorting to demonstrate the potential for ginseng extract as a novel therapeutic tumour vaccine adjuvant.
Wed Apr 13 00:00:00 EDT 2016
Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells.
PloS one
Zhang W,Cho SY,Xiang G,Min KJ,Yu Q,Jin JO
14-7321 was used in Flow cytometry/Cell sorting to demonstrate the potential for ginseng extract as a novel therapeutic tumour vaccine adjuvant.
Wed Apr 13 00:00:00 EDT 2016
Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.
PloS one
Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S
14-7321 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.
Tue Feb 23 00:00:00 EST 2016
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-7321 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
The Journal of experimental medicine
Wang X,Sumida H,Cyster JG
14-7321 was used in Flow cytometry/Cell sorting to study the role of the G protein-coupled receptor 18 (GPR18) in CD8αα intraepithelial lymphocyte homeostasis and positioning.
Mon Nov 17 00:00:00 EST 2014
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Cancer research
Guéry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S
14-7321 was used in Flow cytometry/Cell sorting to investigate the role of Ag-presenting CpG-activated pDCs in Th17 differentiation and antitumor immunity.
Sat Nov 15 00:00:00 EST 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
14-7321 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice.
Diabetologia
Vaitaitis GM,Olmstead MH,Waid DM,Carter JR,Wagner DH
14-7321 was used in Flow cytometry/Cell sorting to develop small peptides based on the CD154 domain that interacts with CD40, but does not cause thrombotic events.
Sat Nov 01 00:00:00 EDT 2014
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
14-7321-81 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-7321-81 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection.
Infection and immunity
Jeong YH,Jeon BY,Gu SH,Cho SN,Shin SJ,Chang J,Ha SJ
14-7321 was used in Flow cytometry/Cell sorting to investigate the phenotype and function of different antigen-specific T cells during Mycobacterium tuberculosis infection.
Wed Jan 01 00:00:00 EST 2014
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
14-7321 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nature immunology
Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ
14-7321 was used in Flow cytometry/Cell sorting to provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.
Wed May 01 00:00:00 EDT 2013
Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.
PLoS pathogens
Hafalla JC,Bauza K,Friesen J,Gonzalez-Aseguinolaza G,Hill AV,Matuschewski K
14-7321 was used in Flow cytometry/Cell sorting to investigate antigenic epitopes in a murine malaria immunisation model.
Wed May 01 00:00:00 EDT 2013
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
PLoS pathogens
Villegas-Mendez A,de Souza JB,Lavelle SW,Gwyer Findlay E,Shaw TN,van Rooijen N,Saris CJ,Hunter CA,Riley EM,Couper KN
14-7321 was used in Flow cytometry/Cell sorting to investigate the molecular basis of IL-27 receptor/ WSX-1-mediated regulation of Th1 responses in vivo during malaria infection.
Fri Jan 10 00:00:00 EST 2014
Persistently active microbial molecules prolong innate immune tolerance in vivo.
PLoS pathogens
Lu M,Varley AW,Munford RS
14-7321 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism for tolerance reprogramming following exposure to Gram-negative bacteria.
Wed May 01 00:00:00 EDT 2013
Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection.
Journal of virology
Trujillo JA,Fleming EL,Perlman S
14-7321 was used in Flow cytometry/Cell sorting to examine the role of CCL2 during virus infection, showing that CCL2 expression in the CNS results in a dysregulated immune response after coronavirus infection.
Fri Mar 01 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-7321 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
14-7321 was used in Immunofluorescence to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 EST 2013
Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.
Vaccine
Beverley P,Ronan E,Lee L,Arnold I,Bolinger B,Powrie F,Tchilian E
14-7321 was used in Flow cytometry/Cell sorting to show that exposure to environmental microorganisms can alter the protective immune response to a parenterally administered subunit vaccine.
Mon Feb 04 00:00:00 EST 2013
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
14-7321 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
14-7321 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.
PloS one
Gahring LC,Enioutina EY,Myers EJ,Spangrude GJ,Efimova OV,Kelley TW,Tvrdik P,Capecchi MR,Rogers SW
14-7321 was used in Flow cytometry/Cell sorting to investigate how inflammatory responses are mechanistically modulated by nicotinic acetylcholine receptors.
Tue Aug 27 00:00:00 EDT 2013
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-7321 was used in Functional assays to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.
PLoS pathogens
Szretter KJ,Daniels BP,Cho H,Gainey MD,Yokoyama WM,Gale M,Virgin HW,Klein RS,Sen GC,Diamond MS
14-7321 was used in Flow cytometry/Cell sorting to examine the role of Ifit1 in restricting pathogenesis in vivo of WT and a mutant lacking 2''-O methylation of the 5'' viral RNA cap.
Thu Nov 08 00:00:00 EST 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
Tissue specific deletion of inhibitor of kappa B kinase 2 with OX40-Cre reveals the unanticipated expression from the OX40 locus in skin epidermis.
PloS one
Cornish GH,Tung SL,Marshall D,Ley S,Seddon BP
Published figure using TNF alpha monoclonal antibody (Product # 14-7321-81) in Immunofluorescence
Fri Jun 29 00:00:00 EDT 2012
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.
The Journal of clinical investigation
Cheung R,Shen F,Phillips JH,McGeachy MJ,Cua DJ,Heyworth PG,Pierce RH
14-7321 was used in Flow cytometry/Cell sorting to identify the MDL-1/Syk/PI3K/Akt/eNOS pathway as a potential new target for the prevention of the progression of SIRS to shock.
Tue Nov 01 00:00:00 EDT 2011
CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.
PLoS pathogens
Fischer MA,Davies ML,Reider IE,Heipertz EL,Epler MR,Sei JJ,Ingersoll MA,Rooijen NV,Randolph GJ,Norbury CC
14-7321 was used in Flow cytometry/Cell sorting to demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus.
Tue Nov 01 00:00:00 EDT 2011
Programmed death (PD)-1-deficient mice are extremely sensitive to murine hepatitis virus strain-3 (MHV-3) infection.
PLoS pathogens
Chen Y,Wu S,Guo G,Fei L,Guo S,Yang C,Fu X,Wu Y
14-7321 was used in Neutralization experiments to investigate the functional mechanisms of PD-1 as related to fulminant viral hepatitis pathogenesis.
Fri Jul 01 00:00:00 EDT 2011
Deletion of Syk in neutrophils prevents immune complex arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Elliott ER,Van Ziffle JA,Scapini P,Sullivan BM,Locksley RM,Lowell CA
14-7321 was used in Flow cytometry/Cell sorting to investigate the specific cell types in which FcγR signalling through spleen tyrosine kinase is required for arthritis development in the serum transfer model.
Sat Oct 15 00:00:00 EDT 2011
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Weiss KA,Christiaansen AF,Fulton RB,Meyerholz DK,Varga SM
14-7321 was used in Flow cytometry/Cell sorting to evaluate the role of IL-10 in the modulation of the respiratory syncytial virus-specific immune response.
Thu Sep 15 00:00:00 EDT 2011
TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.
Molecular and cellular biochemistry
Massilamany C,Gangaplara A,Gardner DJ,Musser JM,Steffen D,Somerville GA,Reddy J
14-7321 was used in Flow Cytometry to study the mechanisms by which Staphylococci can evade innate immune responses and enhance their ability to survive in infected hosts.
Thu Sep 01 00:00:00 EDT 2011
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.
PloS one
Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K
14-7321 was used in Neutralization experiments to investigate the role of mast cells in contact hypersensitivity, showing that interaction between mast cells and skin dendritic cells is required.
Thu Jan 26 00:00:00 EST 2012
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease.
Cell host & microbe
Zellweger RM,Prestwood TR,Shresta S
14-7321 was used in Neutralization experiments to demonstrate that DENV-specific antibodies can increase severity of disease from mostly nonlethal to a fatal disease resembling human DHF/DSS.
Thu Feb 18 00:00:00 EST 2010
Regulation of human NK-cell cytokine and chemokine production by target cell recognition.
Blood
Fauriat C,Long EO,Ljunggren HG,Bryceson YT
14-7321 was used in Flow cytometry/Cell sorting to demonstrate how specific target cell ligands dictate qualitative and temporal aspects of NK-cell cytokine and chemokine responses.
Thu Mar 18 00:00:00 EDT 2010
T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice.
Journal of virology
Zhao J,Zhao J,Perlman S
14-7321 was used in Flow cytometry/Cell sorting to investigate the role of T cells in clearance of severe acute respiratory syndrome coronavirus.
Wed Sep 01 00:00:00 EDT 2010
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
Journal of immunology (Baltimore, Md. : 1950)
Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U
14-7321 was used in Flow cytometry/Cell sorting to investigate the mode of action of poly(I:C) in antiretroviral immunotherapy.
Mon Nov 15 00:00:00 EST 2010
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950)
Findlay EG,Greig R,Stumhofer JS,Hafalla JC,de Souza JB,Saris CJ,Hunter CA,Riley EM,Couper KN
14-7321 was used in Flow cytometry/Cell sorting to demonstrate the essential role of IL-27R signalling in regulating effector T cell function during malaria infection.
Sun Aug 15 00:00:00 EDT 2010
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Matsushita T,Horikawa M,Iwata Y,Tedder TF
14-7321 was used in Flow cytometry/Cell sorting to investigate how the regulatory functions of B10 cells and FoxP3(+) Tregs overlap or influence EAE immunopathogenesis independently.
Sun Aug 15 00:00:00 EDT 2010
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-7321 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.
The Journal of biological chemistry
Li D,Molldrem JJ,Ma Q
14-7321 was used in Flow cytometry/Cell sorting to demonstrate that LFA-1 enhances TCR signaling through the immunological synapse and delivers distinct signals in CD8+ T-cell activation.
Fri Jul 31 00:00:00 EDT 2009
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.
Diabetes
Tritt M,Sgouroudis E,d'Hennezel E,Albanese A,Piccirillo CA
14-7321 was used in Flow cytometry/Cell sorting to study how Foxp3-expressing nT(reg) cells in NOD mice regulate diabetogenesis, but temporal alterations in nT(reg) cell function promote immune dysregulation and the onset of spontaneous autoimmunity.
Tue Jan 01 00:00:00 EST 2008
Tentative T cells: memory cells are quick to respond, but slow to divide.
PLoS pathogens
Whitmire JK,Eam B,Whitton JL
14-7321 was used in Flow cytometry/Cell sorting to evaluate whether memory T cells initiate cell division much more rapidly than their naïve counterparts upon encountering the relevant pathogen.
Fri Apr 11 00:00:00 EDT 2008
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Immunity
Marie JC,Liggitt D,Rudensky AY
14-7321 was used in Immunocytochemistry to demonstrate that TGF-beta signalling in T cells is crucial to restrain fatal autoimmune processes.
Fri Sep 01 00:00:00 EDT 2006
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity
Nagai Y,Garrett KP,Ohta S,Bahrun U,Kouro T,Akira S,Takatsu K,Kincade PW
14-7321 was used in Flow cytometry/Cell sorting to investigate the expression of toll-like receptors on different hematopoietic stem cells and the mechanism by which they stimulate innate immune system replenishment.
Thu Jun 01 00:00:00 EDT 2006
