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PeproTech Proteins |
PeproTech recombinant cytokines and proteins for life science research through clinical development
The need for high-quality biological materials to support cutting-edge disease research and development is constantly growing. Thermo Fisher Scientific acquired PeproTech in 2021 and is now offering their wide portfolio of recombinant proteins under the Gibco brand. Backed by thousands of peer-reviewed publications and decades of expertise, PeproTech recombinant cytokines and proteins help life science, biotech, and pharma companies achieve success in their endeavors to discover new biological insights and develop cutting-edge cell and gene therapies.
Because every step of the production process is expertly managed within, PeproTech recombinant cytokines and growth factors are trusted for quality, consistency, and reliability as well as their ability to support the RUO-to-GMP transition.
Clinical development and bioproduction
The development and production of cellular and gene therapies requires the use of well-characterized ancillary materials produced using GMP (Good Manufacturing Practices). For biotherapeutics developers looking for a qualified source of recombinant cytokines and growth factors, Gibco PeproGMP recombinant proteins provide high quality and consistency as well as the documentation you need. All PeproTech recombinant cytokines are made in-house to maintain rigorous quality control, which helps you seamlessly convert your cell production process to meet clinical requirements.
PeproGMP cytokines
Based on human sequences and produced in E. coli, PeproGMP cytokines and growth factors are designed and manufactured to meet rigorous standards for producing advanced therapy medicinal products (ATMP) for clinical use.
“We use PeproGMP EGF for ATMP production in clinical trials. Major advantages are good lot-to-lot consistency, a comprehensive CoA for GMP purposes and good product performance.” - Daniela
Cell biology and disease research
When conducting cell culture, signaling pathway research, protein/antibody assays, or animal studies, quality and purity are crucial to achieving reliable results. Scientists rely on PeproTech recombinant cytokines to help them develop and perform cell-based functional assays as well as sophisticated tumor and other disease models in mice.
Recombinant cytokines, chemokines, and other RUO proteins
PeproTech research-grade proteins comprise not only cytokines but recombinant growth factors, chemokines, neurotrophins, proteases, other enzymes, ligands, and receptors. Well-characterized growth factors are key components in development of organoids as in vitro disease models.
Most PeproTech recombinant proteins are based on native sequences from human, mouse, and rat, and are produced in bacterial, mammalian, or insect cells. Many PeproTech E. coli–produced proteins are animal origin–free as they are made without using animal-derived cell culture components or purification resins.
The PeproTech product line includes RUO recombinant cytokines important for research in:
- Stem cells
- 3D cell culture models
- Cancer cell biology
- Neurobiology
- Immunology
- Cardiovascular
With the addition of PeproTech proteins to the portfolio, Thermo Fisher Scientific offers an even wider variety of recombinant proteins that serve many applications and research areas.
Quality assurance for RUO recombinant cytokines
PeproTech RUO recombinant cytokines and other proteins are subject to a rigorous set of quality control standards. Our Quality Assurance department verifies that every product passes a prescribed set of quality control tests.
Authenticity | Verified by N-terminal sequence analysis, SDS-PAGE and, where possible, by RP-HPLC, mass spectrometry, and western blot analyses versus standards. |
Biological activity | Determined in a relevant in vitro and/or in vivo bioassay. |
Endotoxin contamination | Tested by kinetic LAL (Limulus Amebocyte Lysate) method to ensure the lowest possible endotoxin levels (<1.0 EU/μg). |
Protein content | Verified by UV spectroscopy, SDS-PAGE and, where possible, by RP-HPLC. |
Purity | Verified by SDS-PAGE and, where possible, by RP-HPLC. Minimum purity 95% by SDS-PAGE. |
Sterility | All products are sterile filtered through a 0.2-micron filter. |
PeproTech animal-free cytokines and growth factors
When developing in vitro organoid or in vivo disease models, it is important to reduce the likelihood that a hidden xenobiotic agent of mammalian origin will contaminate the model and influence the results. Animal origin–free cytokines and growth factors are popular for this reason.
We go a step further to minimize potential risks that can arise from trace amounts of animal-derived components. PeproTech animal-free cytokines and growth factors are produced within an animal-free bioprocessing lab using chemically defined, animal-free components under animal-free conditions.
Produced in E. coli, HEK293, or CHO cells, PeproTech animal-free cytokines and growth factors maintain favorably high activity and purity compared to corresponding proteins produced using standard bioproduction techniques. Therefore, life science researchers choose PeproTech animal-free recombinant cytokines to develop and maintain cellular and animal disease models.
Quality assurance for animal-free cytokines
PeproTech animal-free recombinant cytokines and growth factors are subject to the same rigorous standards for identity, purity, protein content, and sterility as those for research-grade proteins. In addition, they are verified to:
- Exhibit comparable biological activity compared to their RUO counterparts
- Have endotoxin levels <0.1 EU/ug
Cell Therapy Systems products for each step in your workflow
Thermo Fisher Scientific offers products for cell therapy development and manufacturing including GMP-grade reagents, media, and consumables as well as specialized equipment, expertise and support.
Tools and techniques for 3D cell culture models
From media and growth factors to equipment and instruments, Thermo Fisher Scientific produces a wide assortment of products as well as protocols and guides to support your 3D cell culture and analysis efforts.
Resources
Recombinant proteins learning center
Learn what recombinant proteins are, what they are used for, and what types are available
About PeproTech proteins
Learn about the PeproTech brand of recombinant proteins
Gibco cell culture basics
Learn about all aspects of cell culture
3D cell culture protocols
See which recombinant proteins are used to generate organoids
Western transfer protocols and recipes
Procedures and buffers for performing western blots
Cytokine and growth factor signaling pathways
Explore the role of proteins and cytokines in various signaling pathways
Support
Recombinant Proteins Support Center
Find Getting Started guides, protocols, troubleshooting, and other resources
Recombinant proteins FAQs
Search the database to find answers to your questions
Contact general support
Get technical or customer support for any recombinant protein; find SDS, CoA, and phone numbers based on a specific product
Contact GMP support
Get in touch with GMP technical and regulatory experts
Related Products
Intended use of the products mentioned on this page vary. For specific intended use statements please refer to the product label.
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