Drug Discovery Scientific Posters | Thermo Fisher Scientific

Our latest research findings in drug discovery and ADME/Tox are illustrated through posters presented at conferences like SBS, AACR and others; and through peer-reviewed articles. Learn more about our workshops and virtual visits for drug discovery and development scientists or view some of our most recent scientific posters by clicking the tabs below.

Poster Title	Authors
High-throughput LanthaScreen cellular assays for interrogating post-translational modifications of p53 and histone H3	Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi
Next-generation cell-based imaging assays for apoptosis and oxidative stress from Molecular Probes	Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman
NA-Fluor and NA-XTD influenza neuraminidase assays for neuraminidase quantitation and inhibition assays	Anthony C. Chiulli, Corinne E. Miller, Albana Mihali, Laura Thibodeau, Rouh-Rong Juo, Brian D’Eon, and Melissa A. Gee
Endogenous GPCR transcript profiling of Life Technologies primary cell offerings: Opening the door to physiologically relevant cell systems for pharmaceutical screens	Rhonda A. Newman & David T. Kuninger
Primary human cells from Life Technologies—offerings, scale, and applications in HCS and HTS formats	David Kuninger, Nick Dolman, Kevin Chambers, Coby Carlson and Daniel Beacham
Next-generation chemiluminescent secreted placental alkaline phosphatase (SEAP) reporter gene assay	Corinne E. Miller, Laura Thibodeau, and Brian J. D’Eon
Expression, capture and display of native GPCRs on soluble mammalian membrane particles	Sanjay Vasu, Wen Chen, Julia Fletcher, Kristin Huwiler, Wieslaw Kudlicki, Kevin Lowitz
The PrestoBlue Cell Viability Reagent: Measure cell viability in a fraction of the time	Bonnie J. Hanson, Michael Hancock, Leisha Kopp, Uma Lakshmipathy
A substrate-independent histone deacetylase inhibitor assay	Steve Riddle, Steve Fakhoury, Bryan Marks, Hildegard Eliason and Jack Frazee
Simply sensitive: Phosphate detection made easy	Kevin R. Kupcho, Caroline M. Wessely, Steve M. Riddle, and Kevin L. Vedvik
Monitoring post-translational modifications and protein-protein interactions using a proximity ligation assay	Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, & Barry Schweitzer
A flexible kinase inhibitor assay platform for active, non-activated, and impure kinase preparations	Caroline Wessely, Connie Lebakken, Laurie Reichling, Jason Ellefson, Kun Bi and Steve Riddle

Poster Title	Authors
Cryopreserved HepaRG Cells: An Alternative In Vitro Screening Tool for Human Hepatic Drug Metabolism	Julie Price, Jonathan P. Jackson, James Lovgren, Stephen S. Ferguson
Developing applications for primary astrocytes to enable drug discovery	Roland Leathers, Spencer Hermanson, Lucas Chase, Connie Lebakken, and Kun Bi
Generation of Zero-footprint iPSCs in Xeno Free or Feeder Free with CytoTune-iPS Reprogramming Kit	Gillian Wallace, Chad MacArthur, Andrew Fontes, Jasmeet Kaur, Mohan Vemuri, and Pauline T. Lieu
High Quality Episomal Human iPSC derived from Cord Blood with a Zero Footprint: Applications in Serum-Free and Xeno-Free Culture	Robby Kelchtermans, Shruthi Pal, Jasmeet Kaur, MacArthur Chad, Ann Peters, Tea Soon Park, Xuan Yuan, Paul Burridge, Udaykumar Kolkundkar, Elias Zambidis, Mohan Vemuri
High-Throughput LanthaScreen Cellular Assays for Interrogating Post-Translational Modifications of p53 and Histone H3	Ann MacDonald, Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi
Next Generation Cell Engineering: The Jump-In™ Cell Engineering Platform	Roland Leathers, Thomas Machleidt, David Thompson, Beth Frey, Leisha Kopp, Bonnie Hanson, David Piper, Justin Wetter
Monitoring Post-Translational Modifications and Protein-Protein Interactions using the Proximity Ligation Assay	Nicol Watson, Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, and Barry Schweitzer
The Next Generation of Cell-Based Imaging Assays for Apoptosis, Autophagy and Oxidative Stress from Molecular Probes	Nicol Watson, Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman
Novel live alkaline phosphatase substrate for identification of pluripotent stem cells	Joanne Hulme, Rene H. Quintanilla, Upinder Singh, Scott Grecian, Kyle Gee, Mahendra Rao, Uma Lakshmipathy

Poster Title	Authors
Functional Genomics Screening with Invitrogen LentiArray CRISPR Libraries and CellSensor Assays	Chetana Revankar, Justin Wetter, Julia Braun, Natasha Roark, Veronica Magnon, LaiYee Wong, Yanfei Zou, Namritha Ravinder, Jian-Ping Yang, Jonathan Chesnut, David Piper
Tools for Profiling Inhibitors for Full-Length LRRK2	Justin Wetter, Kara Machledit, Ryan Fisher, Robert Horton, David Piper
Cellular and Biochemical Assay Applications on the Varioskan LUX Multimode Microplate Reader	Chetana Revankar , Justin Wetter, Jacquelyn Webb, Kyle Kimler, Robert Horton, David Piper
High Content Solutions: Functionality of Primary Hepatocytes and Adaptability to High-Content Screening for In Vitro ADME/Tox Applications	Raquel Vega, Rafal Witek, and David Piper

Presented at SBS

Poster Title	Authors
High-throughput LanthaScreen cellular assays for interrogating post-translational modifications of p53 and histone H3	Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi
Next-generation cell-based imaging assays for apoptosis and oxidative stress from Molecular Probes	Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman
NA-Fluor and NA-XTD influenza neuraminidase assays for neuraminidase quantitation and inhibition assays	Anthony C. Chiulli, Corinne E. Miller, Albana Mihali, Laura Thibodeau, Rouh-Rong Juo, Brian D’Eon, and Melissa A. Gee
Endogenous GPCR transcript profiling of Life Technologies primary cell offerings: Opening the door to physiologically relevant cell systems for pharmaceutical screens	Rhonda A. Newman & David T. Kuninger
Primary human cells from Life Technologies—offerings, scale, and applications in HCS and HTS formats	David Kuninger, Nick Dolman, Kevin Chambers, Coby Carlson and Daniel Beacham
Next-generation chemiluminescent secreted placental alkaline phosphatase (SEAP) reporter gene assay	Corinne E. Miller, Laura Thibodeau, and Brian J. D’Eon
Expression, capture and display of native GPCRs on soluble mammalian membrane particles	Sanjay Vasu, Wen Chen, Julia Fletcher, Kristin Huwiler, Wieslaw Kudlicki, Kevin Lowitz
The PrestoBlue Cell Viability Reagent: Measure cell viability in a fraction of the time	Bonnie J. Hanson, Michael Hancock, Leisha Kopp, Uma Lakshmipathy
A substrate-independent histone deacetylase inhibitor assay	Steve Riddle, Steve Fakhoury, Bryan Marks, Hildegard Eliason and Jack Frazee
Simply sensitive: Phosphate detection made easy	Kevin R. Kupcho, Caroline M. Wessely, Steve M. Riddle, and Kevin L. Vedvik
Monitoring post-translational modifications and protein-protein interactions using a proximity ligation assay	Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, & Barry Schweitzer
A flexible kinase inhibitor assay platform for active, non-activated, and impure kinase preparations	Caroline Wessely, Connie Lebakken, Laurie Reichling, Jason Ellefson, Kun Bi and Steve Riddle

Presented at ELRIG

Poster Title	Authors
Cryopreserved HepaRG Cells: An Alternative In Vitro Screening Tool for Human Hepatic Drug Metabolism	Julie Price, Jonathan P. Jackson, James Lovgren, Stephen S. Ferguson
Developing applications for primary astrocytes to enable drug discovery	Roland Leathers, Spencer Hermanson, Lucas Chase, Connie Lebakken, and Kun Bi
Generation of Zero-footprint iPSCs in Xeno Free or Feeder Free with CytoTune-iPS Reprogramming Kit	Gillian Wallace, Chad MacArthur, Andrew Fontes, Jasmeet Kaur, Mohan Vemuri, and Pauline T. Lieu
High Quality Episomal Human iPSC derived from Cord Blood with a Zero Footprint: Applications in Serum-Free and Xeno-Free Culture	Robby Kelchtermans, Shruthi Pal, Jasmeet Kaur, MacArthur Chad, Ann Peters, Tea Soon Park, Xuan Yuan, Paul Burridge, Udaykumar Kolkundkar, Elias Zambidis, Mohan Vemuri
High-Throughput LanthaScreen Cellular Assays for Interrogating Post-Translational Modifications of p53 and Histone H3	Ann MacDonald, Mark Federici, Thomas Machleidt, Spencer Hermanson, Coby Carlson and Kun Bi
Next Generation Cell Engineering: The Jump-In™ Cell Engineering Platform	Roland Leathers, Thomas Machleidt, David Thompson, Beth Frey, Leisha Kopp, Bonnie Hanson, David Piper, Justin Wetter
Monitoring Post-Translational Modifications and Protein-Protein Interactions using the Proximity Ligation Assay	Nicol Watson, Kristin G. Huwiler, Tina Settineri, Rica Bruinsma, Bryan Marks, Mark Shannon, Dave Ruff, and Barry Schweitzer
The Next Generation of Cell-Based Imaging Assays for Apoptosis, Autophagy and Oxidative Stress from Molecular Probes	Nicol Watson, Daniel Beacham, Michelle Yan, Scott Clarke, Bhaskar Mandavilli, Bonnie Hanson, Shih-Jung Huang, Upinder Singh, Michael Janes and Nicholas Dolman
Novel live alkaline phosphatase substrate for identification of pluripotent stem cells	Joanne Hulme, Rene H. Quintanilla, Upinder Singh, Scott Grecian, Kyle Gee, Mahendra Rao, Uma Lakshmipathy

Presented at SLAS

Poster Title	Authors
Functional Genomics Screening with Invitrogen LentiArray CRISPR Libraries and CellSensor Assays	Chetana Revankar, Justin Wetter, Julia Braun, Natasha Roark, Veronica Magnon, LaiYee Wong, Yanfei Zou, Namritha Ravinder, Jian-Ping Yang, Jonathan Chesnut, David Piper
Tools for Profiling Inhibitors for Full-Length LRRK2	Justin Wetter, Kara Machledit, Ryan Fisher, Robert Horton, David Piper
Cellular and Biochemical Assay Applications on the Varioskan LUX Multimode Microplate Reader	Chetana Revankar , Justin Wetter, Jacquelyn Webb, Kyle Kimler, Robert Horton, David Piper
High Content Solutions: Functionality of Primary Hepatocytes and Adaptability to High-Content Screening for In Vitro ADME/Tox Applications	Raquel Vega, Rafal Witek, and David Piper

For Research Use Only. Not for use in diagnostic procedures.