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Life Technologies offers a wide range of high-throughput screening assays for target and lead discovery research. Use the table below to view our available assay types; and find the components necessary to make one of these assays with our Drug Discovery Assay Maker™ tool.
Can’t find the assay you need? Our dedicated Custom Biology Services team can work with you and create a custom assay meeting your defined requirements.
If you have any questions about any of these assay technologies, please contact our Drug Discovery Technical Support team.
| Assay Type | Technology | Definition |
|---|---|---|
| Biochemical ADP accumulation | Adapta® | TR-FRET assay for the detection of ADP produced by kinases or other ATP dependent enzymes |
| Biochemical binding | Predictor™ hERG | A set of validated components to perform hERG channel biochemical binding studies in the absence of radioligand |
| Biochemical binding/kinetic | LanthaScreen® Kinase Binding Assay | A simple mix and read TR-FRET assay where binding or displacement of an ATP competitive Alexa Fluor® conjugate or “tracer" to a kinase |
| Biochemical competitive binding | PolarScreen® | Nuclear receptor ligand domain, binding assay that includes protein, a proprietary fluorescent Fluormone™ ligand, and an optimized buffer system |
| Biochemical coregulator interaction | LanthaScreen® NR Co-regulator Interaction Assay | TR-FRET based assay to evaluate recruitment or displacement of a fluorescein-labeled coregulator peptide. Evaluated conformational changes of nuclear receptors upon ligand binding distinguishing agonists from antagonists. |
| Biochemical europium phospho-specific activity | LanthaScreen® Activity Assay | TR-FRET, Europium based, kinase activity assay |
| Biochemical phospho-specific activity (no antibody) | Z’-LYTE® | FRET based activity assayfor selectivity profiling. It is the primary assay used in our SelectScreen® kinase profiling service. |
| Biochemical terbium phospho-specific activity | LanthaScreen® Activity Assay | TR-FRET, Terbium based ,kinase activity |
| Assay Type | Technology | Definition |
|---|---|---|
| BacMam virus for cellular expression | BacMam | A modified insect cell virus (baculovirus) that acts as a vehicle to efficiently deliver and express genes in mammalian cells |
| Cell-based beta lactamase reporter gene | CellSensor® GeneBLAzer® | Measures compound potency and selectivity and allow for analysis, in a high-throughput manner, of key pathways activated or down-regulated by compounds. |
| Cell-based beta-arrestin recruitment | Tango® | Platform based upon ligand binding to a specific GPCR that triggers desensitization; ensuring a selective readout |
| Cell-based calcium flux | Fluo-4 | Calcium assay formulated to achieve largest assay window by suppressing background fluorescence generated from media with little-to-no impact on the cellular fluorescence |
| Cell-based potassium flux | FluxOR® | An optically based, homogenous assay for high throughput screening (HTS) measurements of potassium ion channel and transporter activities |
| Cell-based terbium modification activity (transient) | LanthaScreen® BacMam-enabled cellular assay | An efficient and robust method for interrogating specific signal transduction events in a cell background of choice |
| Cell-based terbium phospho-specific activity (stable) | LanthaScreen® cellular assay | TR-FRET-based assays to monitor protein modification within the native cell signaling environment |
| Assay Type | Technology | Definition |
|---|---|---|
| Biochemical ADP accumulation | Adapta® | TR-FRET assay for the detection of ADP produced by kinases or other ATP dependent enzymes |
| Biochemical binding | Predictor™ hERG | A set of validated components to perform hERG channel biochemical binding studies in the absence of radioligand |
| Biochemical binding/kinetic | LanthaScreen® Kinase Binding Assay | A simple mix and read TR-FRET assay where binding or displacement of an ATP competitive Alexa Fluor® conjugate or “tracer" to a kinase |
| Biochemical competitive binding | PolarScreen® | Nuclear receptor ligand domain, binding assay that includes protein, a proprietary fluorescent Fluormone™ ligand, and an optimized buffer system |
| Biochemical coregulator interaction | LanthaScreen® NR Co-regulator Interaction Assay | TR-FRET based assay to evaluate recruitment or displacement of a fluorescein-labeled coregulator peptide. Evaluated conformational changes of nuclear receptors upon ligand binding distinguishing agonists from antagonists. |
| Biochemical europium phospho-specific activity | LanthaScreen® Activity Assay | TR-FRET, Europium based, kinase activity assay |
| Biochemical phospho-specific activity (no antibody) | Z’-LYTE® | FRET based activity assayfor selectivity profiling. It is the primary assay used in our SelectScreen® kinase profiling service. |
| Biochemical terbium phospho-specific activity | LanthaScreen® Activity Assay | TR-FRET, Terbium based ,kinase activity |
| Assay Type | Technology | Definition |
|---|---|---|
| BacMam virus for cellular expression | BacMam | A modified insect cell virus (baculovirus) that acts as a vehicle to efficiently deliver and express genes in mammalian cells |
| Cell-based beta lactamase reporter gene | CellSensor® GeneBLAzer® | Measures compound potency and selectivity and allow for analysis, in a high-throughput manner, of key pathways activated or down-regulated by compounds. |
| Cell-based beta-arrestin recruitment | Tango® | Platform based upon ligand binding to a specific GPCR that triggers desensitization; ensuring a selective readout |
| Cell-based calcium flux | Fluo-4 | Calcium assay formulated to achieve largest assay window by suppressing background fluorescence generated from media with little-to-no impact on the cellular fluorescence |
| Cell-based potassium flux | FluxOR® | An optically based, homogenous assay for high throughput screening (HTS) measurements of potassium ion channel and transporter activities |
| Cell-based terbium modification activity (transient) | LanthaScreen® BacMam-enabled cellular assay | An efficient and robust method for interrogating specific signal transduction events in a cell background of choice |
| Cell-based terbium phospho-specific activity (stable) | LanthaScreen® cellular assay | TR-FRET-based assays to monitor protein modification within the native cell signaling environment |
For Research Use Only. Not for use in diagnostic procedures.