Custom affinity ligand and resin development
CaptureSelect purification products enable the efficient capture of therapeutic proteins from any feed stream, thereby helping reduce the number of process steps, increase yield, as well as provide a platform approach for purifying any target biotherapeutic.

We offer a unique service for the development of product- and/or process-specific affinity solutions tailored to a target protein and its specific requirements.

The custom ligand can be immobilized on a variety of backbones, including POROS resins, and further developed into an affinity resin, which can be used in large-scale processing of biopharmaceuticals.

Custom CaptureSelect resin development program

Library construction
1 to 10 targets

Lead 
screening
200 → 24 → 6

Prototype 
resin testing
6 → 2

Lead 
selection
2 → 1

cGMP 
suitable resin

Library constructionLead screeningPrototype resin testingLead selectioncGMP suitable resin
 

Ligand screen:

  • Specificity
  • Binding kinetics
  • Mild elution
  • Stability

Prototype screen:

  • Ligand scalability
  • One-step purity with feedstock
  • Elution profiles
  • Ligand stability

Lead testing:

  • Larger scale production of lead prototypes
  • Resin evaluation under process conditions

Final resin:

  • Process validation
  • Leakage ELISA
  • Regulatory support file

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Start from existing candidates in our pipeline

Through our library development process we have identified a number of candidates that may serve as excellent starting points for a custom affinity resin program. Pipeline opportunities include:

Table 1. CaptureSelect affinity products for purification

Product stage

Therapeutic proteins

Antibody types

Viruses

RUO products

Antithrombin III (AT III)
Fibrinogen (POROS FibXL)
C1-inhibitor (POROS C1-InhXL)
Prothrombin
GM-CSF

IgM-XL
IgA-XL

Adenovirus (Adv5)
Baculovirus removal
(BacuClear)
Lentivirus (Lenti VSVG)

Stage WP 4:
Lead resin

Protein C (PC)

 


Exosomes (CD81)

Stage WP 3:
Prototype resin

CHO-Lipase (LAL, PLBL2)
Factor V (FV)
Factor H (FH)
α-Thrombin

Mouse and Rat
IgG-Fc, IgY

Exosomes (CD9)

Stage WP 2:
Ligand screening

Interferon α and β (IFNα/β)
Interleukin 2 (hIL2)
CHO-LPL EPO
Factor XI / XII / XIII

 

Exosomes (CD63)
GP64 protein
dsRNA
Plasmid DNA

Stage WP1:
Libraries

CHO host cell proteins (CHOP)
Human plasma

Human antibodies

Non-immune

Technical resources and literature

Posters:

Scientific publications:

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:

Support

Events & Webinars

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration in to humans or animals.