Search Thermo Fisher Scientific
- Contact Us
- Quick Order
-
Don't have an account ? Create Account
Search Thermo Fisher Scientific
Thermo Scientific TruTools is an add-on chemometrics software package that runs on the TruScan RM Handheld Raman Analyzer. TruTools provides a platform to implement customized chemometric models including PCA, PLS-DA, PCR and PLS algorithms onboard the handheld device. This solution allows method developers to implement advanced preprocessing of spectra, identification of qualitative differences between samples, and facilitate quantitative sample determination.
The TruScan RM analyzer provides robust non-contact and non-destructive scanning, quick material identity testing in the manufacturing plant at any stage of production and is designed to meet stringent good manufacturing practices (GMP) and 21 CFR Part 11 compliance requirements.
TruScan RM’s standard multivariate residual analysis decision engine can qualitatively identify most pharmaceutical materials directly. In some instances, sample complexity—highly similar chemicals, materials with purposeful variation in physical properties, and formulations with nearly similar component concentrations—yields highly overlapping spectra. For these materials TruTools can provide a greater signal-to-noise ratio to enhance qualitative and quantitative spectroscopic measurements.
Using TruScan RM with TruTools, a method developer can customize the acquisition parameters for laser power, detector exposure time, and number of spectral coadditions just like a benchtop instrument. TruScan RM automatically outputs standardized SPC files which can be directly imported into the Eigenvector Research, Inc. SOLO chemometric software package.
Within SOLO a method developer can:
The PCA, PLS-DA, PCR or PLS model is exported as an XML script using the Eigenvector Research, Inc. Model Exporter package. The resultant file is then embedded within a TruScan RM TruTools method as the instructions for data collection and analysis. The custom method is deployed in nearly identical fashion as a standard method on the analyzer.
In operation, TruTools methods are selected through standard TruScan RM menus without requiring chemometric or method development expertise by the end user. The custom TruTools method will then produce qualitative or quantitative results on board the TruScan RM. The ability to rapidly synchronize the data into standard reports is completely consistent with the standard TruScan RM workflow.
TruScan RM with TruTools allows customized acquisition parameters and exports SPC files via SyncServer.
With Eigenvector Solo:
Using Eigenvector's Model_Exporter, models are exported to TruScan RM.
TruScan RM with TruTools embedded math engine runs customized models including PCA, PLS, PLSDA, and PCR. For daily operators, TruTools methods are selected through standard TruScan RM menus without requiring chemometric or method development expertise.
TruTools expands TruScan RM material identification. TruScan RM with TruTools allows control of the verification algorithm and acquisition parameters to target specific materials of interest. Analyses can be tailored for challenging incoming raw materials such as:
If you want to learn more about these enhanced capabilities, watch now this on demand webinar.
For PAT applications TruScan RM with TruTools supplies stable, easy to operate, non-invasive and non-destructive analysis. With TruScan RM with TruTools PAT applications are broadened to include:
At-line inspection of product strength before final lab confirmation assists in ensuring rapid release with:
Biopharmaceutical manufacturing frequently entails complex formulations of starting materials and relatively low concentration protein solutions which benefit strongly from the use of TruTools. Applications which biopharmaceutical customers are employing currently include:
Finished drug product and bulk drug substance product ID at fill-finish sites. For more details see this application note.
TruTools expands TruScan RM material identification. TruScan RM with TruTools allows control of the verification algorithm and acquisition parameters to target specific materials of interest. Analyses can be tailored for challenging incoming raw materials such as:
If you want to learn more about these enhanced capabilities, watch now this on demand webinar.
For PAT applications TruScan RM with TruTools supplies stable, easy to operate, non-invasive and non-destructive analysis. With TruScan RM with TruTools PAT applications are broadened to include:
At-line inspection of product strength before final lab confirmation assists in ensuring rapid release with:
Biopharmaceutical manufacturing frequently entails complex formulations of starting materials and relatively low concentration protein solutions which benefit strongly from the use of TruTools. Applications which biopharmaceutical customers are employing currently include:
Finished drug product and bulk drug substance product ID at fill-finish sites. For more details see this application note.