Family of Thermo Scientific DynaDrive Single-Use Bioreactors with capacities of 5,000 L, 3,000 L, 500 L, and 50 L.

Dynamic cell culture performance with right sizing flexibility

With a continued focus on large-scale monoclonal antibody production, and tremendous growth of gene therapy and viral vector vaccines, companies are facing the decision on how to scale manufacturing processes efficiently. The Thermo Scientific DynaDrive Single-Use Bioreactor (S.U.B.) is the latest advancement based on our history of proven single-use innovation, offering superior performance to accommodate volumes from pilot to production.

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Explore the DynaDrive S.U.B. 3D Product Tour

Virtually interact with our 5,000 L DynaDrive S.U.B. to learn more about the overall design elements and operations, experience an inside view of the mixing technology, turndown performance, and view a seed train sequence all within this 3D product tour.

Substitute high costs for high performance with the DynaDrive S.U.B.

Performance:

  • Improved turndown ratio:
    • Uniquely designed to allow mixing at very low volumes
    • 10:1 for the 50 L S.U.B. and 20:1 for the 500 L S.U.B.
    • Seed directly from flasks into S.U.B.
  • Optimized for modern cell culture processes, accommodating high power input per volume (PIV) and volumetric mass transfer performance (measured by kLa)
    • Easily capable of supporting viable cell densities of >100 million cells/mL
    • Scaled PIV and kLa for various terminal volumes
    • Characterized linear kLa performance
  • Considerable savings in OPEX due to reduced seed-train and scale-up processes
    • Reduced steps, labor and documentation required for the seed train processes
    • Minimized contamination risks
    • Improved facility footprint space utilization

Bold hardware design:

  • Ergonomic unit design for easy, consistent, and reliable BPC loading and deployment
  • Cutouts in hardware allow for unique customization and ease of use/access to ports
  • New cubical geometry and design improves mixing by providing baffles in corners and better BPC fit
  • Lower probe cutouts on vessel for accurate sensing of pH, DO, and temperature
  • Bottom-jacketed vessel for better heat transfer and temperature control at lower volumes
  • BPCs and probe ports readily installed and accessed within ergonomically designed stainless steel unit of the DynaDrive S.U.B.
  • Simple BPC loading with vertical access door on all sizes
  • Drive-train integrated within the BPC
  • Innovative drive-train design
    • Multiple impellers increase and distribute power within reactor
    • Allows for mixing at very low volumes, truly mixing through harvest
  • Enhanced laser-cut drilled-hole sparger for effective stripping of CO2 and sufficient O2 delivery to cells
  • Standard bioprocess container (BPC) designs are optimized for batch, fed-batch, perfusion, and adherent cell cultures
  • Patented cross-flow sparger technology for efficient cell culture at lower volumes or terminal cell cultures
  • Latest sensor technology in single-use or autoclavable probes (pH, pO2, foam, capacitance, raman, and more)
  • Most robust film available in industry—the Thermo Scientific Aegis 5-14 film
  • BPC film and components tested for leachable and extractable (L&E) evaluation per BioPhorum Operations Group (BPOG) guidelines
  • Ability to fully integrate with the Thermo Scientific HyPerforma G3Lite and G3Pro Bioprocess Controllers with Thermo Scientific TruBio software, powered by the DeltaV Distributed Control Platform from Emerson
  • Capable of integrating with any controller of choice
  • Designed to function as a ready-to-use solution for mammalian cell culture
  • Reduced capital investment by utilizing existing control systems already in use in facility, with any software platforms
Key features

Performance:

  • Improved turndown ratio:
    • Uniquely designed to allow mixing at very low volumes
    • 10:1 for the 50 L S.U.B. and 20:1 for the 500 L S.U.B.
    • Seed directly from flasks into S.U.B.
  • Optimized for modern cell culture processes, accommodating high power input per volume (PIV) and volumetric mass transfer performance (measured by kLa)
    • Easily capable of supporting viable cell densities of >100 million cells/mL
    • Scaled PIV and kLa for various terminal volumes
    • Characterized linear kLa performance
  • Considerable savings in OPEX due to reduced seed-train and scale-up processes
    • Reduced steps, labor and documentation required for the seed train processes
    • Minimized contamination risks
    • Improved facility footprint space utilization

Bold hardware design:

  • Ergonomic unit design for easy, consistent, and reliable BPC loading and deployment
  • Cutouts in hardware allow for unique customization and ease of use/access to ports
  • New cubical geometry and design improves mixing by providing baffles in corners and better BPC fit
  • Lower probe cutouts on vessel for accurate sensing of pH, DO, and temperature
  • Bottom-jacketed vessel for better heat transfer and temperature control at lower volumes
BioProcess Containers (BPCs)
  • BPCs and probe ports readily installed and accessed within ergonomically designed stainless steel unit of the DynaDrive S.U.B.
  • Simple BPC loading with vertical access door on all sizes
  • Drive-train integrated within the BPC
  • Innovative drive-train design
    • Multiple impellers increase and distribute power within reactor
    • Allows for mixing at very low volumes, truly mixing through harvest
  • Enhanced laser-cut drilled-hole sparger for effective stripping of CO2 and sufficient O2 delivery to cells
  • Standard bioprocess container (BPC) designs are optimized for batch, fed-batch, perfusion, and adherent cell cultures
  • Patented cross-flow sparger technology for efficient cell culture at lower volumes or terminal cell cultures
  • Latest sensor technology in single-use or autoclavable probes (pH, pO2, foam, capacitance, raman, and more)
  • Most robust film available in industry—the Thermo Scientific Aegis 5-14 film
  • BPC film and components tested for leachable and extractable (L&E) evaluation per BioPhorum Operations Group (BPOG) guidelines
Controllers
  • Ability to fully integrate with the Thermo Scientific HyPerforma G3Lite and G3Pro Bioprocess Controllers with Thermo Scientific TruBio software, powered by the DeltaV Distributed Control Platform from Emerson
  • Capable of integrating with any controller of choice
  • Designed to function as a ready-to-use solution for mammalian cell culture
  • Reduced capital investment by utilizing existing control systems already in use in facility, with any software platforms
Ordering information
50 L DynaDrive S.U.B. and BPC
500 L DynaDrive S.U.B. and BPC
3,000 L DynaDrive S.U.B. and BPC
5,000 L DynaDrive S.U.B. and BPC

Related resources

 Application note: DynaDrive S.U.B.s
 Application note: DynaDrive S.U.B. for perfusion cell culture applications
 Application note: Scale-up evaluation of the DynaDrive S.U.B.s
 Application note: Streamlining seed train scale-up through utilization of the turndown ratio of the DynaDrive S.U.B.
 Application note: Process performance comparison between the 50 L DynaDrive S.U.B. and legacy S.U.B. platforms
 Application note: Production of AAV vector in S.U.B.s using the ExpiSf Expression System
 Brochure: Modular perfusion workflow
 Brochure: DynaDrive S.U.B.
 Data Sheet: 50 L DynaDrive S.U.B.
 Data Sheet: 500 L DynaDrive S.U.B.
 Data Sheet: 3,000 L and 5,000 L DynaDrive S.U.B.
 White Paper: Enabling high-performing perfusion cell culture
 White Paper: 5,000 L S.U.B.s: The next generation in biologics manufacturing

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