imPULSE Single-Use Mixers

The imPULSE Single-Use Mixer (S.U.M.) can be utilized for many bioprocess mixing applications. The imPULSE design features include innovative disc mixing technology, configurable high-end controls, and monitors to fit specific process requirements. These features all enable uniform, superior mixing—scalable from 30 L to 5,000 L.

The touchscreen console for the imPULSE S.U.M. provides superior integrated sensor monitoring, and pump control for pH and saline titration and for automatic fill and harvest of the S.U.M.

Available in 30, 100, 250, 500, 1,000, 2,000, 3,000 and 5,000 L
Touchscreen Console provides ease of use with multi-functional capabilities to monitor and control mixing parameters
Integrated rolling diaphragm that provides the pumping action to the mixing disc; the diaphragm will not abrade the surfaces or produce particulate
Mixing tank jacket and insulation
Weighing systems that utilize load cells enable accurate batch weight monitoring
Auto inflate and vent control options
Adjustable powder port for 1,000 L and higher that fits 1, 5, and 25 kg Powdertainer BPCs
Open cart frame for easier cleaning

Areas of applications:

Media preparation
Final formulation steps
Buffer preparation
Harvest vessels
Large-volume mixing
Pooling and transfer
Resuspension
Mixing and storing multiple batches
Viral inactivation

The disc is an integrated part of the single-use BPC and is designed with slots and silicone flaps. The moving disc creates a pulsing action that has two effects:

1. On the upstroke, the flaps open as the disc moves up from the bottom of the mixing bag and fluid flows through the slots of the disc.

2. On the downstroke, the flaps close as the disc moves down and energy is directed down and channeled through the space between the mixing disc profile and the vessel side walls.

As a result, the velocity of the displaced liquid provides robust mixing.

Rolling diaphragm: Provides an interface between the BPC and the movable shaft with the mixing disc. There are no contact surfaces between the side walls and the diaphragm; therefore, the system does not generate particulates.

Linear scalability: The imPULSE mixing disc diameter increases proportionally as the size of the vessel increases. The ratio of the displaced liquid volume to the vessel volume is the same from all sizes ranging from 30 L to 5,000 L. This enables consistent and reproducible results, as processes are seamlessly scaled up across all sizes.

Graphical diagram of the mixing disc technology

Key Features

Available in 30, 100, 250, 500, 1,000, 2,000, 3,000 and 5,000 L
Touchscreen Console provides ease of use with multi-functional capabilities to monitor and control mixing parameters
Integrated rolling diaphragm that provides the pumping action to the mixing disc; the diaphragm will not abrade the surfaces or produce particulate
Mixing tank jacket and insulation
Weighing systems that utilize load cells enable accurate batch weight monitoring
Auto inflate and vent control options
Adjustable powder port for 1,000 L and higher that fits 1, 5, and 25 kg Powdertainer BPCs
Open cart frame for easier cleaning

Areas of applications:

Media preparation
Final formulation steps
Buffer preparation
Harvest vessels
Large-volume mixing
Pooling and transfer
Resuspension
Mixing and storing multiple batches
Viral inactivation

Mixing technology

The disc is an integrated part of the single-use BPC and is designed with slots and silicone flaps. The moving disc creates a pulsing action that has two effects:

1. On the upstroke, the flaps open as the disc moves up from the bottom of the mixing bag and fluid flows through the slots of the disc.

2. On the downstroke, the flaps close as the disc moves down and energy is directed down and channeled through the space between the mixing disc profile and the vessel side walls.

As a result, the velocity of the displaced liquid provides robust mixing.

imPULSE S.U.M. featured animation

The imPULSE single-use mixing system is ideal for a wide range of liquid-to-liquid or powder-to-liquid mixing applications, utilizing an innovative mixing disc technology and customizable BPCs.