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Dextran conjugates are hydrophilic polysaccharides with low toxicity that can used for tissue sections, in vivo neurons, and cultured cells. A wide range of fluorescent and biotinylated dextran conjugates are offered in several molecular weights. Most of these dextran conjugates are lysine-fixable and can be treated with formaldehyde or glutaraldehyde.
Dextran, Alexa Fluor | Dextran, Fluorophore, Biotin | |
---|---|---|
Readout | Direct fluorescence imaging of cells | Direct fluorescence imaging of cells; biotins easily accept secondary detection to amplify weak signals |
Tissue sections | Yes | |
In vivo neurons | Yes | |
Fixed tissue sections | No | |
Cultured cells | Yes | |
Cell loading | Microinjection | |
Staining mode | Endogenous | |
Best for | Single cells | |
Transport | Bidirectional | |
Synaptic transfer | No |
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
Dextran, Cascade Blue | DAPI | Cascade Blue | 400/420 | 10 mg | Yes | D7132 |
Dextran, Fluorescein, Lysine Fixable | FITC | Fluorescein | 494/518 | 10 mg | Yes | D3306 |
Dextran, Fluorescein, Anionic | No | D3305 | ||||
Dextran, Fluorescein and Biotin | 5 mg | Yes | D7156 | |||
Dextran, Tetramethylrhodamine, Lysine Fixable | TAMRA | TAMRA | 494/518 | 10 mg | Yes | D3308 |
Dextran, Tetramethylrhodamine, Anionic | No | D3307 | ||||
Dextran, Tetramethylrhodamine and Biotin | 555/580 | 5 mg | Yes | D7162 | ||
Dextran, Texas Red, Lysine Fixable | Texas Red | Texas Red | 595/615 | 10 mg | Yes | D3328 |
Dextran, Texas Red, Neutral | No | D3329 | ||||
Dextran, Biotin | N/A | N/A | N/A | 10 mg | Yes | D7135 |
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
Dextran, Cascade Blue | DAPI | Cascade Blue | 400/420 | 25 mg | Yes | D7132 |
Dextran, Alexa Fluor 488 | FITC | Alexa Fluor 488 | 495/519 | 5 mg | Yes | D22910 |
Dextran, Fluorescein | Fluorescein | 494/518 | 25 mg | Yes | D1820 | |
Dextran, Tetramethylrhodamine | TAMRA | TAMRA | 494/518 | 25 mg | Yes | D1817 |
Dextran, Alexa Fluor 546 | TRITC | Alexa Fluor 546 | 556/573 | 5 mg | Yes | D22911 |
Dextran, Alexa Fluor 555 | Alexa Fluor 555 | 555/565 | 5 mg | Yes | D34679 | |
Dextran, Alexa Fluor 568 | Rhodamine | Alexa Fluor 568 | 578/603 | 5 mg | Yes | D22912 |
Dextran, Alexa Fluor 594 | Texas Red | Alexa Fluor 594 | 590/617 | 5 mg | Yes | D22913 |
Dextran, Texas Red | Texas Red | 595/615 | 25 mg | Yes | D1863 | |
Dextran, Alexa Fluor 647 | Cy5 | Alexa Fluor 647 | 650/668 | 5 mg | Yes | D22914 |
Dextran, Alexa Fluor 680 | Cy5.5 | Alexa Fluor 680 | 679/702 | 5 mg | Yes | D34680 |
Dextran, Biotin | N/A | N/A | N/A | 25 mg | Yes | D1956 |
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
40,000 MW | ||||||
Dextran, Fluorescein, Lysine Fixable | FITC | Alexa Fluor 488 | 495/519 | 25 mg | Yes | D1845 |
Dextran, Fluorescein, Anionic | No | D1844 | ||||
Dextran, Tetramethylrhodamine | TAMRA | TAMRA | 494/518 | 25 mg | No | D1842 |
Dextran, Texas Red | Texas Red | Texas Red | 595/615 | 25 mg | No | D1829 |
40,000 MW | ||||||
Dextran, Fluorescein, Lysine Fixable | FITC | Alexa Fluor 488 | 495/519 | 25 mg | Yes | D1845 |
Dextran, Fluorescein, Anionic | No | D1823 | ||||
Dextran, Tetramethylrhodamine, Lysine Fixable | TAMRA | TAMRA | 494/518 | 25 mg | Yes | D1818 |
Dextran, Tetramethylrhodamine, Neutral | No | D1819 | ||||
Dextran, Texas Red, Lysine Fixable | Texas Red | Texas Red | 595/615 | 25 mg | Yes | D1864 |
Dextran, Texas Red, Neutral | No | D1830 | ||||
500,000 MW | ||||||
Dextran, Fluorescein, 500,000 MW | FITC | Alexa Fluor 488 | 495/519 | 10 mg | Yes | D7136 |
2,000,000 MW | ||||||
Dextran, Fluorescein, 500,000 MW | FITC | Alexa Fluor 488 | 495/519 | 10 mg | Yes | D7137 |
Dextran, Tetramethylrhodamine, 2,000,000 MW | TAMRA | TAMRA | 555/580 | 10 mg | Yes | D7139 |
Don’t see the right Dextran conjugate for your experiment, find more in the Molecular Probes Handbook - Dextran Conjugates table
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
Dextran, Cascade Blue | DAPI | Cascade Blue | 400/420 | 10 mg | Yes | D7132 |
Dextran, Fluorescein, Lysine Fixable | FITC | Fluorescein | 494/518 | 10 mg | Yes | D3306 |
Dextran, Fluorescein, Anionic | No | D3305 | ||||
Dextran, Fluorescein and Biotin | 5 mg | Yes | D7156 | |||
Dextran, Tetramethylrhodamine, Lysine Fixable | TAMRA | TAMRA | 494/518 | 10 mg | Yes | D3308 |
Dextran, Tetramethylrhodamine, Anionic | No | D3307 | ||||
Dextran, Tetramethylrhodamine and Biotin | 555/580 | 5 mg | Yes | D7162 | ||
Dextran, Texas Red, Lysine Fixable | Texas Red | Texas Red | 595/615 | 10 mg | Yes | D3328 |
Dextran, Texas Red, Neutral | No | D3329 | ||||
Dextran, Biotin | N/A | N/A | N/A | 10 mg | Yes | D7135 |
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
Dextran, Cascade Blue | DAPI | Cascade Blue | 400/420 | 25 mg | Yes | D7132 |
Dextran, Alexa Fluor 488 | FITC | Alexa Fluor 488 | 495/519 | 5 mg | Yes | D22910 |
Dextran, Fluorescein | Fluorescein | 494/518 | 25 mg | Yes | D1820 | |
Dextran, Tetramethylrhodamine | TAMRA | TAMRA | 494/518 | 25 mg | Yes | D1817 |
Dextran, Alexa Fluor 546 | TRITC | Alexa Fluor 546 | 556/573 | 5 mg | Yes | D22911 |
Dextran, Alexa Fluor 555 | Alexa Fluor 555 | 555/565 | 5 mg | Yes | D34679 | |
Dextran, Alexa Fluor 568 | Rhodamine | Alexa Fluor 568 | 578/603 | 5 mg | Yes | D22912 |
Dextran, Alexa Fluor 594 | Texas Red | Alexa Fluor 594 | 590/617 | 5 mg | Yes | D22913 |
Dextran, Texas Red | Texas Red | 595/615 | 25 mg | Yes | D1863 | |
Dextran, Alexa Fluor 647 | Cy5 | Alexa Fluor 647 | 650/668 | 5 mg | Yes | D22914 |
Dextran, Alexa Fluor 680 | Cy5.5 | Alexa Fluor 680 | 679/702 | 5 mg | Yes | D34680 |
Dextran, Biotin | N/A | N/A | N/A | 25 mg | Yes | D1956 |
Standard filter set(s) | Fluorophore/ conjugates | Ex/Em (nm) | Quantity | Fixable | Cat. No. | |
---|---|---|---|---|---|---|
40,000 MW | ||||||
Dextran, Fluorescein, Lysine Fixable | FITC | Alexa Fluor 488 | 495/519 | 25 mg | Yes | D1845 |
Dextran, Fluorescein, Anionic | No | D1844 | ||||
Dextran, Tetramethylrhodamine | TAMRA | TAMRA | 494/518 | 25 mg | No | D1842 |
Dextran, Texas Red | Texas Red | Texas Red | 595/615 | 25 mg | No | D1829 |
40,000 MW | ||||||
Dextran, Fluorescein, Lysine Fixable | FITC | Alexa Fluor 488 | 495/519 | 25 mg | Yes | D1845 |
Dextran, Fluorescein, Anionic | No | D1823 | ||||
Dextran, Tetramethylrhodamine, Lysine Fixable | TAMRA | TAMRA | 494/518 | 25 mg | Yes | D1818 |
Dextran, Tetramethylrhodamine, Neutral | No | D1819 | ||||
Dextran, Texas Red, Lysine Fixable | Texas Red | Texas Red | 595/615 | 25 mg | Yes | D1864 |
Dextran, Texas Red, Neutral | No | D1830 | ||||
500,000 MW | ||||||
Dextran, Fluorescein, 500,000 MW | FITC | Alexa Fluor 488 | 495/519 | 10 mg | Yes | D7136 |
2,000,000 MW | ||||||
Dextran, Fluorescein, 500,000 MW | FITC | Alexa Fluor 488 | 495/519 | 10 mg | Yes | D7137 |
Dextran, Tetramethylrhodamine, 2,000,000 MW | TAMRA | TAMRA | 555/580 | 10 mg | Yes | D7139 |
Don’t see the right Dextran conjugate for your experiment, find more in the Molecular Probes Handbook - Dextran Conjugates table
Several fluorescent and biotinylated dextran conjugates are offered in molecular weights ranging from 3,000 to 2,000,000 daltons. These dextran conjugates can be used for a variety of applications such as cell lineage tracing (Figure 1), neuronal tracing (Figures 2, 3), investigating cell-cell communication in gap junctions, or tracking endocytosis and pinocytosis.
3,000 MW dextrans are rapidly dispersed into fine cellular projections and can be used to investigate gap junctions. 10,000 MW dextrans are retained within the cell and do not cross gap junctions, and they have slower distribution but longer cellular retention. 500,000 and 2,000,000 MW fluorescent dextran conjugates may be particularly useful for lineage tracing at early stages of development, although these biopolymers have lower water solubility and a greater tendency to precipitate or clog microinjection needles than lower molecular weight dextran conjugates.
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