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In the phage display method1, an experimentally modified coat protein gene within a bacteriophage genome encodes a product that "displays" a specific ligand-binding domain on the bacteriophage surface. The resulting bacteriophage, in which genotype and phenotype are linked, can provide an effective tool for in vitro phenotype selection ("biopanning"). Dynabeads® magnetic beads may be used as the solid support for biopanning for phage display, as well as for Systematic Evolution of Ligands by Exponential Enrichment (SELEX)2. They have been used to help identify research targets for therapy3, diagnostic markers4 and to generate lead molecules in drug discovery5.
For Research Use Only. Not for use in diagnostic procedures.