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Thermo Fisher Scientific offers a range of innovative analytical tools and resources that can help you solve complex challenges in the field of structural biology. We are committed to accelerating your science by providing a comprehensive suite of solutions for the determination of structure and function of macromolecules by developing powerful instrumentation, quality reagents and multifaceted software to deliver the high-performance results and insights to accelerate your research. 

Integrative structural biology

Accelerate the path from structure to function by combining the near-atomic resolution of cryo-electron microscopy with advance biomolecular mass spectrometry.

Mass spectrometry based structural biology

MS-based techniques to analyze single proteins and protein complex in their native biological state, and to reduce the minimum required sample size.

Cryo-electron microscopy based structural biology

Study macromolecules in all their complex conformations, structures, and modified forms at near-atomic resolution. 

What is Structural Biology

Structural biology is the study of the molecular structure and dynamics of biological macromolecules such as proteins and how alterations in their structures can affect their function. 

A protein’s structure and dynamics play a crucial role in its functions. Any changes to the structure of the protein can alter its function. If we needed any additional evidence that structural biology is an important area to emphasize, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has provided a global case study for the need for structural biology. For example, viruses use the glycoproteins on their surface to bind to receptors found on host cells. In order to for this to occur the glycoproteins assume orientations that would be easier for binding and to avoid response from host immune systems. Vaccines are designed to generate proteins that would generate optimum immune response. Furthermore, protein misfolding are known to be the primary cause of number of diseases such as Alzheimer's and cystic fibrosis. Extracting functional information of proteins – rather than structure alone – is key to tackling key research questions within structural biology.

KaiCBA

Krios G4 Cryo-TEM

  • Best image quality for high resolution 3D reconstruction
  • Enables Single Particle Analysis, Cryo Tomography and MicroED
  • Flexible accelerating voltage 80 to 300 kV and highest resolution at 1.22 A
  • Autoloader, 12 grids can be loaded at the same time

 

Orbitrap Ascend Structural Biology MS

  • Scale up characterization of complex structures, including intact proteoforms, post-translational modifications (PTMs) and complex native structures, as well as peptide-level analyses such as hydrogen exchange MS and cross-linked peptides identification
  • Analyze challenging species up to m/z 16,000 with the Native MS option

 

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