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Triple Quadrupole LC/MS Comparison Table
TSQ Mass Spectrometer Product Comparison
Different applications require different levels of system sensitivity, resolution, and speed. In this table, we compare different TSQ triple quadrupole systems in order to showcase which ones are most relevant to your laboratory's needs. For more information on these systems, click on our Smartnote: Transitioning to Confident Quantitation – in search of a better tomorrow
Product comparison
| Triple Quad Product Comparison |  Fortis |  Endura |  Quantis |  Altis | |
| Sensitivity | +++ | +++ | ++++ | +++++ | |
| Resolution | ++ | ++ | ++ | +++ | |
| Scan Speed | ++++ | +++ | ++++ | ++++ | |
| Applications across multiple matrices | |||||
| Targeted quantitation in Proteomics | No | Yes | Yes | Yes | |
| Peptide and protein quantitation (Biopharma) | No | Yes | Yes | Yes | |
| Small molecule quantitation (Pharma, Clinical Research) | Yes | Yes | Yes | Yes | |
| Small molecule mixture quantitation (Environmental Safety, Food Safety, Forensic Toxicology, Pharma) | Yes | Yes | Yes | Yes | |
| Analysis and targeted quantitation of trace impurities (Impurity Quantitation) | Yes | Yes | Yes | Yes | |
| Targeted quantitation in Omics (metabolomics, lipidomics) | Yes | Yes | Yes | Yes | |
| Critical Features | |||||
| MRM for reliable identification | Yes | Yes | Yes | Yes | |
| Multiple Source Compatibility | Yes | Yes | Yes | Yes | |
| High Resolution SRM: for increased selectivity and sensitivity for analytes or multiple analytes in complex matrices | ++ | ++ | ++ | +++ | |
| Segmented quadrupoles for increased ion efficiency | Yes | No | Yes | Yes | |
| Neutral blocker for increased robustness | Yes | Yes | Yes | Yes | |
| Increased dynodes in detector for increased lifetime and better linear dynamic range | Yes | No | Yes | Yes | |
| APCI compatible with HESI source | Yes | No | Yes | Yes | |
| Polarity Switching: Fast switching with stabilization enable faster quantitation assays for every molecule type | + | + | + | + | |
| System Remote Monitoring | Yes | Yes | Yes | Yes | |
| Assist with 21 CFR Part 11 Compliance (appropriate software) | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | Yes. With LCQUAN™ Software | |
| Instrument IQ/OQ assist | Yes | Yes | Yes | Yes | |
| Thermo Fisher Cloud: Access, process, review data whenever you like, from wherever you are | No | Yes | Yes | Yes | |
| Wi-Fi Connectivity: Access your data, Check your assay performance remotely | Yes | Yes | Yes | Yes | |
| Size | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | 27x30x33 (in) | |
| IVD Platform | No | Available in certain countries | No | No | |
| Compatible separation technologies | UltiMate, Vanquish, Multiplexing, Capillary LC, Other vendors | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC | |
| Compatible Software? | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | Xcalibur, TraceFinder, Chromeleon | |
| Library availability | Yes | Yes | Yes | Yes | |
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