Search Thermo Fisher Scientific
Technology Derived From Nature
At Life Technologies we’re committed to helping improve the human condition and the world around us, by way of breakthrough research and scientific advancements. In 2012, we launched our GeneArt® TALs custom genome editing service; a novel technology derived from Xanthomonas. The precision TAL technology has been shown to be effective in a broad range of organisms including plants, algae, and fungi. GeneArt® TALs is the first technology of its kind that’s ideal for plant research scientists, offering research use access with a clear licensing path for commercial use through the Two Blades Foundation.
Precise plant genome editing has arrived; every locus is now within your reach.
About This Plant-Based Technology
Precision TALs derived from Xanthomonas, a genus of plant pathogens. The pathogen specifically recognizes DNA of the host with a protein containing 17–18 repeats of approximately 34 amino acids each. The nucleotide specificity is conferred by amino acids 12 and 13 within each repeat. Each nucleotide in the target DNA is recognized by one repeat.
This 1-to-1 relationship can be used to specifically target any locus in the genome.
- Learn more about GeneArt® Precision TALs
Ordering GeneArt® Precision TALs for Plants
The fastest and easiest way to design, edit, optimize, and order GeneArt® Precision TALs is through the GeneArt® portal.
The ordering process is simple; just follow the three steps below:
- Select the functionality (effector domain) of your TAL from Table 1. For details, refer to the ‘TALEN functionality overview’
- Select the product name from Table 1.
- Then place your order through our online design tool within the GeneArt® portal, or you can downloadand complete the TALs order form and email it to geneartsupport@lifetech.com.
If you have a question or need free design consultation, contact us here and we’ll be happy to assist.
We will ship you a clone with a verified, optimized sequence approximately 2 weeks after confirming your order.
Table 1: Available effector domains
| Product | DNA-binding domain | Effector domain | Functionalities | Applications |
|---|---|---|---|---|
| Native TAL Fok1 | Native | Fok1 endonuclease | Gene targeting |
|
| Truncated TAL Fok1 | Truncated | Fok1 endonuclease | Gene targeting |
|
| Native TAL VP16 activator | Native | VP16 activator | Activation of transcription |
|
| Native TAL VP64 activator | Native | VP64 activator | Activation of transcription |
|
| TAL repressor | Modified | KRAB repressor | Epigenetic repression of transcription |
|
| Native TAL MCS | Native | (MCS) | Steric repression & custom design |
|
| Truncated TAL MCS | Truncated | (MCS) | Steric repression & custom design |
|
KRAB: Krüppel associated box; MCS: multiple cloning site; TAL: transcription activator–like (DNA-binding domain).
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.
For Research Use Only. Not for use in diagnostic procedures.
Stylesheet for Classic Wide Template adjustments