Dynabeads have helped our partners launch tests in a wide range of molecular applications, such as infectious diseases, animal health, reproductive health, and oncology. Some of the products are from our existing bio-discovery portfolio, while others are developed and supplied on an OEM basis. Dedicated kits have been developed for isolation of viral nucleic acids and genomic DNA.

Learn more about how we can support your assay

How have Dynabeads Plus helped Molecular Diagnostic development?

See an example of working with Dynabeads and molecular diagnostic products to measure the impact of radiation exposure.

Customer need How Dynabeads Plus helped Results

  • Government funding for FDA clearance contingent on ability to supply kit
  • Significant product customization required
  • Need a tool for measuring response to ionizing radiation

 

 

 

 

The Dynabeads Plus team initiated multiple meetings at the customer site to develop product transfer and validation process, beginning with a quote and ending with a long-term supply agreement.

 

 

  • Validated process for new product size and concentration
  • Secured contract with government and FDA clearances

Dynabeads molecular diagnostic product benefits include
  • High capacity and wide dynamic range
  • High signal-to-noise ratio
  • Adaptable to any known detection method and assay methodology
  • No magnetic remanence
  • Reproducible automated behavior without mixing
  • Fast and efficient washing
  • Increased sensitivity
  • Easy handling in manufacturing and shortened assay development time

Assay lifecycle support

Business support

  • Evaluation of multiple products at small-scale

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols

Enterprise support

  • Evaluation of multiple products at small-scale
  • Collaboration and innovation with high quality products

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Bead material for robustness testing
  • Borderline bead material
  • Flexible supply volumes
  • Customized products
  • Short-term licensing and commercial supply quote agreements
  • Basic Quality Assurance Agreement (QAA)

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support
  • Instrument supplier partnerships

Enterprise support

  • Evaluation of multiple products at small-scale
  • Further investigations with selected product
  • Assay validation support
  • Joint development sessions to improve processes between our companies

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Borderline material
  • Flexible volumes
  • Customized products
  • Bead material from multiple batches for assay validation
  • Supply security through long-term commercial supply agreement (CSA)
  • Full Quality Assurance Agreement (QAA)

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support
  • Instrument supplier partnerships

Enterprise support

  • Evaluation of multiple products at small-scale
  • Further investigations with selected product
  • Assay validation support
  • Joint development sessions to improve processes between our companies
  • High supply security of the material you need in your regular manufacturing
  • Manufacturing scale up support
  • Joint business reviews and logistics planning

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Borderline material
  • Flexible volumes
  • Customized products
  • Bead material from multiple batches for assay validation
  • Supply security through long-term commercial supply agreement (CSA)
  • Full Quality Assurance Agreement (QAA)
  • High supply security
  • Very low batch to batch variation

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support 
  • Instrument supplier partnerships
Step 1 : Evaluate your assay

Business support

  • Evaluation of multiple products at small-scale

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
Step 2 : Assist in your planning

Enterprise support

  • Evaluation of multiple products at small-scale
  • Collaboration and innovation with high quality products

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Bead material for robustness testing
  • Borderline bead material
  • Flexible supply volumes
  • Customized products
  • Short-term licensing and commercial supply quote agreements
  • Basic Quality Assurance Agreement (QAA)

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support
  • Instrument supplier partnerships
Step 3 : Grow your manufacturing

Enterprise support

  • Evaluation of multiple products at small-scale
  • Further investigations with selected product
  • Assay validation support
  • Joint development sessions to improve processes between our companies

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Borderline material
  • Flexible volumes
  • Customized products
  • Bead material from multiple batches for assay validation
  • Supply security through long-term commercial supply agreement (CSA)
  • Full Quality Assurance Agreement (QAA)

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support
  • Instrument supplier partnerships
Step 4 : Sustain your growth

Enterprise support

  • Evaluation of multiple products at small-scale
  • Further investigations with selected product
  • Assay validation support
  • Joint development sessions to improve processes between our companies
  • High supply security of the material you need in your regular manufacturing
  • Manufacturing scale up support
  • Joint business reviews and logistics planning

Product support

  • Samples of different bead types
  • Samples coupled with antibody/antigen for rapid screening
  • Customized protocols
  • Borderline material
  • Flexible volumes
  • Customized products
  • Bead material from multiple batches for assay validation
  • Supply security through long-term commercial supply agreement (CSA)
  • Full Quality Assurance Agreement (QAA)
  • High supply security
  • Very low batch to batch variation

Technical support

  • Technical support
  • Custom projects
  • Seminars
  • Assay automation support 
  • Instrument supplier partnerships
Dynabeads products that support molecular diagnostic assay development
ProductCharacteristicsSelected applications
Dynabeads MyOne 
SILANE
  • Monosized beads with an optimized silica-like surface chemistry
  • Highly reproducible binding of both DNA and RNA
  • High specific surface area
    (approx. 20 m2/g)
  • Size: 1 micrometer, monodisperse
  • Isoelectric point: pH 3.5
  • Increased iron content compared to the traditional Dynabeads MyOne product range, and hence a better mobility to magnet
  • Low sedimentation rate and favorable reaction kinetics
  • Flexible starting volumes
  • Isolation of total nucleic acids (DNA/RNA)
  • From biological samples (serum/plasma, human whole blood etc.)
  • Well suited for automated applications
  • Validation and customization (bead, buffer, protocol or format) available upon request.
  • Adjusted to customer requirements on a custom OEM basis
Dynabeads 
SILANE
viral NA
  • Contains Dynabeads MyOne SILANE (see above for characteristics), buffers and a protocol optimized for isolation of viral DNA/RNA
  • High sensitivity for viral DNA and RNA, e.g. can detect HBV DNA in a 200 µl serum sample containing only 40 infectious units
  • Isolation of viral DNA/RNA from human serum/plasma samples
  • Effective isolation of nucleic acids even from challenging viruses (e.g. HBV)
Dynabeads 
SILANE
genomic DNA
  • Contains Dynabeads MyOne SILANE (see above for characteristics), buffers and a protocol optimized for isolation of genomic DNA
  • High integrity and purity of isolated DNA
  • Typically isolates 10 µg DNA from a 350 µl blood sample using 50 µl (2 mg) Dynabeads
  • Linear range of DNA yield relative to white blood cell (WBC) counts
  • Isolation of genomic DNA from human whole blood
  • From fresh/frozen blood samples, and with a wide range of anticoagulants
Dynabeads Oligo(dT)25
  • Hydrophilic bead surface
  • Size: 2.8 micrometer
  • Iron content (ferrites): 14% (20%)
  • Amount of coupled oligo-dT25 probe: 70 pmol/mg beads
  • Capture of polyA mRNA: >2 µg/mg beads

 

  • Capture of polyA+ mRNA directly from crude starting samples
  • Build a solid-phase cDNA library
  • Specific capture of nucleic acid targets (using capture probes with oligo-dA tail)

 

Dynabeads 
M-270
Streptavidin
  • Hydrophilic bead surface
  • Based on carboxylic acid beads
  • Size: 2.8 micrometer, monodisperse
  • Isoelectric point: pH 4.5
  • Highly charged (-50 mV, at pH 7)
  • Iron content (ferrites): 14% (20%)
  • Low aggregation of beads in high salt solutions
  • Free biotin binding: 650–1,350 pmoles/mg beads
  • Binding biotinylated Ig: 5–10 µg/mg beads

 

  • Isolation of biotinylated molecules
  • Sequence specific DNA/RNA capture in nucleic acid based diagnostics
  • Preparation of single-stranded DNA.
  • For use in protocols that require GTC lysis or high salt concentrations, or protocols not compatible with BSA.
  • Immunodiagnostics with hydrophobic targets

 

Dynabeads 
M-280
Streptavidin

  • Hydrophobic bead surface
  • Based on tosylactivated beads
  • Size: 2.8 micrometer, monodisperse
  • BSA as blocking protein
  • Isoelectric point: pH 5.0
  • Low charge (-10 mV, at pH 7)
  • Iron content (ferrites): 12% (17%)
  • Free biotin binding: 650–900 pmoles/mg beads
  • Binding biotinylated Ig: 5–10 µg/mg beads
  • Isolation of biotinylated molecules
  • Sequence specific DNA/RNA capture in nucleic acid based diagnostics
  • Purification of DNA/RNA binding proteins
  • Protein purification, phage display and biopanning
  • Immunodiagnostics
Dynabeads MyOne 
Streptavidin C1
  • Hydrophilic bead surface
  • Based on carboxylic acid beads (C1)
  • Size: 1 micrometer, monodisperse
  • No blocking proteins used
  • Tween 20 in the buffer
  • Isoelectric point: pH 5.2
  • Medium charged (-35 mV, at pH 7)
  • Iron content (ferrites): 26% (37%)
  • Low sedimentation rate and improved reaction kinetics compared to M-280/M-270 beads
  • Very low aggregation
  • Free biotin binding: >2,500 pmoles/mg beads
  • Binding biotinylated Ig: 20–25 µg/mg beads

 

  • Isolation of biotinylated molecules
  • Sequence specific DNA/RNA capture in nucleic acid based diagnostics
  • Preparation of single-stranded DNA
  • High throughput nucleic acid clean-up protocols
  • Well suited for automated applications

 

Dynabeads MyOne 
Carboxylic Acid
  • Hydrophilic bead surface with carboxylic acid groups
  • Size: 1 micrometer, monodisperse
  • Iron content (ferrites): 26% (37%)
  • Low sedimentation rate and improved reaction kinetics compared to M-280/M-270 beads
  • Very low aggregation
  • Active chemical functionality: 0.6 mmol/g beads
  • Coupling capacity: 20–25 µg proteins or 700 pmol oligonucleotides per mg beads

 

  • Immobilization of amino-modified oligonucleotides, antibodies or other ligands, for capture of specific DNA/RNA sequences, proteins or any other analyte
  • Well suited for automated applications

 

Dynabeads 
M-270
Carboxylic Acid
  • Hydrophilic bead surface with carboxylic acid groups
  • Size: 2.8 micrometer, monodisperse
  • Iron content (ferrites): 26% (37%)
  • Very low aggregation
  • Active chemical functionality: 150 µmol/g beads
  • Immobilization of amino-modified oligonucleotides, antibodies or other ligands, for capture of specific DNA/RNA sequences, proteins or any other analyte
  • Well suited for automated applications
Dynabeads MyOne 
Tosylactivated

 


  • Hydrophobic bead surface
  • Size: 1 micrometer, monodisperse
  • Iron content (ferrites): 26% (37%)
  • Low sedimentation rate and improved reaction kinetics compared to M-280/M-270 beads
  • Active chemical functionality: 0.04–0.06 mmol/g beads
  • Immobilization via primary amino- or sulfhydryl groups.
  • Protein purification, phage display and biopanning
  • Immunodiagnostics
Dynabeads 
M-280
Tosylactivated
  • Hydrophobic bead surface with
    p-toluene-sulfonyl (tosyl) groups
  • Size: 2.8 micrometer, monodisperse
  • Iron content (ferrites): 12% (17%)
  • Active chemical functionality: 0.1–0.2 mmol/g beads
  • Immobilization via primary amino- or sulfhydryl groups
  • Protein purification, phage display and biopanning
  • Immunodiagnostics

Benefits of partnership

There’s a reason Thermo Fisher Scientific already works with some of the world’s leading diagnostic companies.

Premium products: All Dynabeads products are validated with a unique level of reproducibility within and between batches. Patented manufacturing processes ensure careful control of bead parameters and product properties, securing their performance.

Unrivaled bead manufacturing: World-class manufacturing facilities can manufacture batches ranging in size from 1 g up to 2 kg with close to zero off-grade batches and flexible production scales. This meets relevant regulatory and quality systems compliance.

Comprehensive technical support: Extensive proprietary knowledge enables customized product development, decreases quality control costs, and increases manufacturing efficiency with hands-on support from R&D scientists.

Resources

Epigenomics (press release)
Crucial Components for Second-Generation Colorectal Cancer Blood Test

Contact us

For Research Use Only. Not for use in diagnostic procedures.