Key methods for structural insights

We offer integrated solutions and support from sample preparation to data analysis for multiple cryo-EM methods, including single particle cryo-EM, microcrystal electron diffraction (MicroED), and cryo-tomography.


Single particle cryo-EM

Single particle cryo-EM can determine structures of challenging proteins and other macromolecules, without the need for crystals, while providing insight into how these proteins function in a way that other methods simply cannot. Single particle analysis is an increasingly popular cryo-EM technique that allows you to investigate biomolecules at near- and atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Tundra Cryo-TEM

Dedicated structural analysis solution designed to bring cryo-EM to your laboratory.

Glacios 2 Cryo-TEM

A complete solution for high-resolution structure determination with unparalleled automation and ease-of-use.

Krios G4 Cryo-TEM

Atomic resolution cryo-EM instrument with enhanced productivity and compact design.


Cryo-electron tomography

Cryo-electron tomography (cryo-ET) provides 3D snapshots of proteins at work within their functional cellular environments, allowing users to see and understand how they, and other molecules, work together to carry out major processes in a cell. This is because cryo-ET delivers both structural information about individual proteins as well as their spatial arrangements within the cell, making it a truly unique technique. Cryo-ET has enormous potential for cell biology as it bridges the gap between light microscopy and near-atomic resolution techniques like single-particle analysis.

Aquilos 2 Cryo-FIB

Dedicated cryo-FIB for cellular cryo-electron tomography sample preparation

Hydra Bio Plasma-FIB

Versatile plasma-FIB for multi-application labs

Arctis Cryo-Plasma-FIB

Automated cryo-plasma-FIB for throughput and connectivity in the cryo-electron tomography workflow


Microcrystal electron diffraction

Microcrystal electron diffraction (MicroED) is a technique that allows fast, high-resolution structural determination of small molecules and proteins. Atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. 

CETA-D Camera and MicroED Package

A complete solution for performing MicroED on Thermo Scientific Cryo-TEMs, including hardware and software needed for fast, high-resolution 3D structure determination.

Talos L120C G2 (S)TEM

Versatile TEM and STEM microscope for 2D and 3D visualization of beam sensitive samples and materials using high contrast

Glacios 2 Cryo-TEM

A complete solution for high-resolution structure determination with unparalleled automation and ease-of-use

Krios G4 Cryo-TEM

Atomic resolution cryo-EM instrument with enhanced productivity and compact design