Oligonucleotide Analysis | Thermo Fisher Scientific

Robust characterization of oligonucleotide therapeutics

The analysis of oligonucleotide therapeutics requires robust and accurate analytical characterization to confirm identity, and to determine purity, quality, and strength. We've developed optimized solutions for characterizing antisense oligonucleotides (ASOs), RNA interference (RNAi) including siRNA and miRNA, aptamers, as well as common oligonucleotide chemical modifications. Thermo Fisher Scientific also utilizes leading instrumentation, consumables, and software to provide optimized mRNA characterization and impurity analysis.

View our full list of solutions as well as helpful tools for oligonucleotide analysis applications below.

Solutions

Leveraging class-leading technologies and products, Thermo Fisher Scientific offers a comprehensive range of optimized analytical solutions to address the diverse needs of oligonucleotide therapeutics development.

Structural characterization

Impurity identification & quantitation

Routine monitoring & quality control

DMPK and bioanalysis

Applications

Applications that enable the accurate and robust confirmation of identity and determination of purity, quality, and strength of oligonucleotide therapeutics.

LC-HRAM MS approaches for characterization and monitoring of therapeutic oligonucleotide impurities

Expanding oligonucleotide UV quality control methods (QC) with MS

LC-UV characterization of oligonucleotides

For Research Use Only. Not for use in diagnostic procedures.