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Learning Resources for mRNA Production |
Browse through our curated selection of learning resources to enable your success in development of mRNA therapeutics and vaccines. View available technical assets related to raw materials for mRNA production, process development using in vitro transcription, scale-up synthesis of mRNA, and more. Find the information and resources you need by looking through our scientific content below.
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eBooks
Achieving consistency in process development of mRNA therapeutics
Read about how raw materials can influence process development and quality of mRNA produced.
Making the promise of mRNA a reality: overcoming scale-up challenges
Read about the prospects of the mRNA technology, tips on scaling up mRNA production, and analytical solutions for mRNA vaccines and therapeutics.
Riding the mRNA highway
Read about expert views on mRNA development and manufacturing, advantages of mRNA processes, and best practices for scale up of in vitro transcription for mRNA production.
mRNA technology market and trend
Find information about the mRNA market, future, potentials, and challenges.
Case studies
Scaling up raw material manufacturing for mRNA production
In ~10 months, Thermo Fisher Scientific drastically scaled up raw material manufacturing for mRNA production, from concept to clinical development and on to industrial-scale production.
Breaking new ground on animal origin-free reagents
Thermo Fisher Scientific quickly developed and executed manufacturing processes to deliver animal origin-free (AOF) enzymes at scale to a biopharmaceutical client.
Infographics
Accelerating development and manufacturing of mRNA vaccines and therapeutics—why raw materials matter
Review the mRNA production process and some critical considerations for choosing raw materials to support clinical manufacturing efforts.
Beyond GMP grade—how to ensure more robust development and manufacturing processes
Understand how your processes and material usage strategy during the development phase could impact your manufacturing processes and regulatory approval downstream.
Scaling mRNA vaccine production
Enable agility in your process from vaccine development to manufacture with one technology designed for flexible mRNA synthesis and purification.
Explaining IVT and enabling mRNA quality
How do scientists make mRNA for mRNA vaccines and therapeutics?
Articles
mRNA technology future
Collaboration, innovation, and partnership are key to more efficient, accessible, and scalable mRNA technology.
mRNA process development
Pay attention to process robustness, raw materials, and how partners can help at the very beginning of the journey of mRNA drug development.
mRNA raw material considerations
Learn why raw materials matter in the development and manufacturing of mRNA vaccines and therapeutics.
mRNA raw material quality
Is GMP grade good enough? What mRNA manufacturers need to know when buying raw materials.
mRNA production scale-up tips
Find five tips on scaling up in vitro transcription for mRNA production in the development and manufacturing of mRNA vaccines and therapeutics.
Selecting mRNA enzyme suppliers
Find out how an enzyme supplier can help or hinder your development of mRNA vaccines and therapeutics.
Posters
Determination of the optimal buffer conditions and nucleotide concentrations to maximize mRNA yield using in vitro transcription
By using design of experiments (DoE) principles and analytics, a variety of IVT reaction conditions were assessed for their impact on the IVT reactions.
Single-use–based bioproduction process for manufacturing of high-quality recombinant enzymes for mRNA and DNA workflows
A closed system based on single-use technology was used to drastically minimize the risk of contamination inherent to the conventional manufacturing process of IVT enzymes.
A trinucleotide cap analog bearing a locked nucleic acid moiety: synthesis, mRNA modification, and translation for therapeutic applications
A new cap analog was synthesized and evaluated for its translational performance against the standard trinucleotide cap and anti-reverse cap analog.
White papers
Quality and consistency of N1-methylpseudouridine triphosphate
Read about an analysis of some of the key product quality attributes of a modified nucleotide product, and their impact on the development and manufacturing of a therapeutic.
Impurity profiling and analysis of TheraPure GMP nucleotides
Read about the importance of quality of nucleoside triphosphates (NTPs) that are used for the production of mRNA therapeutics.
Videos
Webinars
The “what” and the “why” of mRNA production
Examine why raw materials are crucial for mRNA production and learn solutions to overcome mRNA production challenges.
Simple and flexible workflows designed for modular and automatable manufacturing strategies
Discover the benefits of a magnetic bead–based modular approach for mRNA production.
mRNA synthesis considerations for vaccine and therapeutic development
Learn about key considerations in mRNA synthesis and scale-up to help you accelerate research and development of mRNA vaccines and therapeutics.
The long and short of mRNA production
Learn the importance of raw materials in mRNA production, their quality attributes, and mRNA scale-up considerations.
For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.