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Innate immunity is one of two ways by which vertebrates clear pathogens from the body. Unlike the adaptive immune system, the innate immune system does not provide long-term immunity to specific pathogens. A variety of cell signaling pathways are involved in this area of biology, including the angiopoietin-TIE2 signaling pathway, GSK3 signaling pathway, and CCR5 pathway in macrophages.
The angiopoietins are a new family of growth factor ligands that bind to TIE2/Tek TRK (Receptor Tyrosine Kinase).
CCR5 (Chemokine-CC Motif-Receptor-5) is a member of the chemokine receptor subclass of the GPCR (G-Protein-Coupled Receptor) superfamily.
FAS (also called APO1 or CD95) is a death domain–containing member of the tumor necrosis factor (TNF) receptor superfamily.
Adhesion and diapedesis of granulocytes have mostly been analyzed in context tonon-lymphoid endothelium.
GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.
IL-6 is a pleiotropic cytokine that affects the immune system and many physiological events in various organs.
IL-22 is a member of the IL-10 family of cytokines and exerts multiple effects on the immune system.
Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet.
Transport of plasma proteins and solutes across the endothelium involves two different routes: transcellular and paracellular junctions.
TWEAK is a cell surface-associated protein belonging to the tumor necrosis factor (TNF) superfamily and has multiple biological activities.
Access a targeted collection of scientific application notes, methods, and cell signaling charts.
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