Advanced Granulation Technology (AGT) | Thermo Fisher Scientific

Gibco Advanced Granulation Technology (AGT) media

The most advanced media format available for cell culture

With today’s high application demands for increased productivity, efficiency and safety, you need an advanced media format that exceeds traditional dry format performance and accelerates time to market with proven success in commercial products. Leave the classical dry media concerns of complicated preparation, filtration difficulties, multistep processes and lot inconsistency behind and start achieving more with Gibco Advanced Granulation Technology (AGT) media format.

What’s new: Efficient-Pro AGT Medium

The Efficient Pro AGT dry media format enables a simple and scalable reconstitution process

The next-generation of AGT media to achieve higher titers, ease-of-use improvements, and streamline scale up.

Sustain cell viability for longer bioreactor runs
Designed to meet metabolic needs of mAb production
Offers significant performance with improved protein quality
Chemically defined without growth factors or insulin for consistency
Works optimally with Efficient-Pro AGT Feed 1 or Feed 2

What is AGT?

Decorative image of Advanced Granulation Technology (AGT) granule

Because not all dry media are equal

AGT is a granular dry media format produced through a technologically advanced process which allows manufacturing of complete formulations in a variety of serum-free, protein-free and chemically-defined media in a dry format. The AGT granules dissolve rapidly for faster media preparation time versus conventional dry powder media. Furthermore, AGT is efficient by nature, in that it is a complete medium that is pH and osmolality pre-adjusted, and offers all the benefits of liquid media without the cost, storage and transportation issues.

Benefits of using AGT

AGT offers high consistency and productivity across all stages of production: from development to commercial manufacturing.

Standard DPM

Disadvantages:

Procurement from different sources
Vast storage space
Monitoring and QC services
Complex hydration process (hydrate, dissolve, adjust pH and osmolality, sterile filter)

AGT Dry Media Format

Advantages:

Single component
Fast dissolution
Minimal storage, monitoring, QC
Simple hydration process (hydrate, dissolve, sterile filter)

Incorporating AGT into your processes:

Enables increased productivity with reduced downtime.
Reduces costs by eliminating the need for multiple raw materials and filters.
Accelerates time to market with ease of scale-up and proven success in commercial products.
Helps mitigate risk with multiple production facilities.

AGT media can therefore help reduce your total cycle costs, decreasing time involved in raw material planning, procurement and testing as well as media preparation. These benefits are all realized while maintaining comparable cell growth to liquid media.

AGT Products

Decorative image of a variety of AGT product container sizes

The AGT process allows production of complete, complex, chemically-defined, serum-free, and protein-free media in a dry format that is easy to use and easy to scale up.

The Gibco catalog cell culture media featured below are available in AGT format off-the-shelf. Your own custom formulation can be manufactured in AGT format on a make-to-order basis. Contact us for more information.