Resources for Viral Vector Purification

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Optimize your downstream process for your cell and gene therapeutics

Our goal is to support you in optimizing the downstream process for cell and gene therapeutics. Gain  insights into the utilization of our chromatography resins, purposefully engineered to streamline purification steps and improve the scalability of your product.

Simplify downstream development with Bioprocessing calculators

Articles

Advancing the purification of VSV-G pseduotyped lentiviral vectors by using affinity chromatography

Review the highlights of our discussion on an affinity resin that addresses the major challenges in manufacturing processes for cell and gene therapy vectors derived from lentivirus.

 

Downstream purification of adeno-associated virus for large-scale manufacturing of gene therapies

Learn how affinity chromatography can contribute to the overall viral clearance in the AAV downstream process.

 

Development of purification steps for several AAV serotypes using POROS CaptureSelect AAVX affinity chromatography

Learn how a gene therapy company is testing POROS CaptureSelect AAVX affinity resin as a platform solution for the purification of various AAV vectors.

 

Evolution in AAV Process Development: 2022 and beyond

Discover what is on the mind of key opinion leaders on how viral vector manufacture is evolving and what we can expect in the future.

 

Getting a gene therapy product to market: Pitfalls and how to prevent them

Gain insights into key considerations for getting a gene therapy to market from leading specialists in the field.

 

Optimizing AAV Manufacture

Learn more on AAV affinity chromatography and get key considerations when designing a process using affinity capture of AAVs.

 

Scalable AAV manufacturing: Addressing challenges across the workflow

Expand your knowledge on how to minimize challenges across the AAV manufacturing workflow and how innovative tools can help improve AAV production.

 

Current technological trends and advancements in vector purification

Read specialists' opinions on AAV vector purification as they share their thoughts on future developments in the downstream process of this gene therapy vector.

 

Platform optimization for efficient AAV purification—Insights from a CDMO

Learn how POROS CaptureSelect AAVX resin can be used as a pan-affinity tool for the universal capture of AAV vectors and how a leading CDMO optmized the process of this resin to establish a robust purification platform.

 

AAV Downstream Process and Product Characterization

Discover how to integrate advanced purification and analytical tools into the AAV manufacturing workflow.

 

Viral Clearance in a Downstream AAV Process—A Case Study Using a Model Virus Panel and a Noninfectious Surrogate

Discover how four companies worked together on a study addressing viral clearance in an AAV8 two-step chromatography process.

 

Optimizing vector production and purification to enhance scalable AAV manufacturing

Gain more insights into how to intensify your AAV purification process through this wash and elution optimization study.

 

Simplifying lentiviral downstream processing with a novel affinity resin and robust analytical tools

Learn more about an affinity chromatography resin to purify lentiviral particles and rapid analytical tools for titer determination and impurity quantification.

 

eBooks

Quality Innovations in Monoclonal Antibody Manufacturing

Explores solutions for common purification, analysis, and quality evaluation challenges when manufacturing modern antibody-derived therapies.

 

AAV Purification and Scale-Up

Explore innovative solutions that surmount technical hurdles and enhance downstream processes, producing high product yield at lower costs.

 

Viral Vector Purification

Explore recent advancements that can help solve purification challenges for mRNA and viral vectors such as AAV.

 

Infographic

Manufacturing and Analytics for Lentivirus and AAV Vectors: A Visual Guide

Review the manufacturing processes and analytical testing for adeno-associated virus (AAV) and lentivirus (LV) side-by-side.

 

Posters

Productivity Optimization and Process Calculations for AAV Affinity Chromatography

Find out how to leverage the dynamic binding capacity of a purification resin to address multiple AAV serotypes for bioprocess conditions for clinical and commercial scale manufacturing.

 

Accelerating Advancement in Gene Therapy Purification

Review this technical poster demonstrating the benefits of implementing affinity chromatography in the downstream purification of viral vectors.

 

Webinars

AAV Downstream Challenges: Expert Insights

Watch this roundtable discussion to learn from experts about the latest trends, challenges, and best practices in AAV manufacturing, focusing on purification and regulatory compliance.

 

Advancing Gene therapy Development with a Multi-Serotype AAV Affinity Resin

Discover how the use of POROS CaptureSelect AAVX affinity resin in AAV purification can enhance the downstream process, achieving high purity and yield for different serotypes.

Evaluation and Performance of an AAV Affinity Resin: A CDMO Case Study

Discover how a CDMO's efficient platform process, utilizing universal capture resin, achieves high recovery and purity for purifying various serotypes of AAV.

AAV Purification Solving Downstream Challenges

Hear from technical specialists in AAV purification and process development who discuss industry trends, platform ability, and the importance of innovation in solving downstream AAV purification challenges.

Enhancing AAV Purification in Gene Therapy Manufacturing

Review the chromatography solutions for the efficient purification of multiple AAV serotypes including expert insights into bioprocessing and downstream processing optimization. 

Considerations for Affinity Capture in AAV Platform Downstream Process

Explore considerations when evaluating a platform affinity capture step for the purification of AAV vectors.

Platform Optimization for Efficient AAV Purification—Insights from a CDMO

Watch and learn how POROS CaptureSelect AAVX resin can be used as a pan-affinity tool for the universal capture of AAV vectors and how a leading CDMO optmized the process of this resin to establish a robust purification platform.

Simplifying AAV Downstream Process and Product Characterization: A Look at Purification Analytical Tools

Discover how to integrate advanced purification and analytical tools into the AAV manufacturing workflow.

Viral Safety in AAV Production How Affinity Chromatography Effectively Contributes

Discover how POROS CaptureSelect AAVX resin can be used as a pan-affinity tool for the universal capture of AAV vectors and how a leading CDMO optmized the process of this resin to establish a robust purification platform.

Optimizing Vector Production and Purification to Enhance Scalable AAV Manufacturing

Explore how to intensify your AAV purification process through this wash and elution optimization study.

For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.