Search Thermo Fisher Scientific
- Contáctenos
- Orden Rápida
-
¿No tiene una cuenta? Crear una cuenta
Search Thermo Fisher Scientific
The Thermo Scientific HyPerforma Single-Use Fermentor (S.U.F.) is pioneering the single-use technology market by delivering a unique and rigorous solution for microbial fermentation applications while offering the flexibility, ease of use, and efficiency found in single-use systems.
The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, with performance comparable to conventional stainless-steel systems. S.U.F.s use fundamental engineering principles, helping to make scale-up and process development work readily streamlined. Available in 30 L and 300 L sizes, the S.U.F. consists of a fermentor tank and a standard Thermo Scientific HyPerforma S.U.F. BioProcess Container (BPC).
Enhancements to improve performance of single-use fermentors were made to the 300 L hardware, as well as the 30 L and 300 L BPCs, to match more closely the oxygen delivery and cooling capacity performance of the stainless steel fermentors.
Hardware enhancements
The cooling jacket surface area was increased on the sides and bottom for the 300 L S.U.F. to support adequate cooling of the production process. This 35% increase jacketed surface area will enable faster cooling of the molecule production process.
BioProcessing Container (BPC) enhancements
The BPCs for 30 L and 300 L were redesigned to have three parabolic turbine impellers that increase oxygen delivery from spargers by at least four times (4x). As a result, customer and internal culture comparisons showed that oxygen supplementation was reduced 5–7 fold vs. HyPerforma S.U.F., and is comparable to performance of stainless-steel fermentors, per same strain and procedure.
Developed with standard stainless-steel fermentation design geometry (3:1 height to diameter, 5:1 turndown ratio), the S.U.F. supports scale-up and process development activities.
Powerful agitation facilitates high oxygen transfer (kLa)and a homogeneous reaction
System options
S.U.F.s require a separate external temperature control unit (45 W/L min. cooling capacity recommended for high demanding cultures). You may choose an open-architecture approach or a turnkey, ready-to-use S.U.F. system.
Next-generation centrifuge-ready BioProcess Containers provide a single-use, sterilized, closed system for cell harvesting in bioprocessing.
Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: