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Antibody Purification
CaptureSelect Antibody Toolbox products are designed to enhance the success of your antibody purification processes. The products offer specific advantages over purification using Proteins A, G, and L, including unique target specificity and simplified elution protocols. Each product has defined target specificity for distinct antibody types and regions, minimizing the need for you to test multiple media products to determine the optimal choice.
CaptureSelect Antibody Toolbox products offer:
- Unique selectivity
- High purity in a single step
- Increased yield
- Flexible formats
- Species specificity
Single-step purification of various antibody formats
A large variety of antibody formats can be purified with one of our Antibody Toolbox products. Unlike the common bacterial coat protein matrices, Proteins A, G, and L, CaptureSelect ligands are developed with defined specificity and high avidity to the target protein of interest. This results in affinity chromatography resins well suited for single-step protein purification.
CaptureSelect Antibody Toolbox resins for biomolecule purification
IgG all subclasses | Characteristics | Magnetic beads | Pre-packed column | RoboColumn® | BioProcess |
Suitable for purification of human IgG and all Fab fragments, offering mild elution conditions | |||||
Specific for human IgG, suitable for Fc-fusion proteins, increased binding capacity |
| ||||
Specific for human IgG, suitable for Fc-fusion proteins, increased binding capacity, can be used at high flow rates | |||||
Designed to purify IgG from multiple species by high affinity binding to the Fc region of IgGs |
| ||||
Designed to purify rabbit IgG from recombinant and plasma sources. | |||||
| Light chains | Characteristics | |||
| CaptureSelect KappaXP | To purify all human lambda Ig light chain containing products, offering high recovery and purity in a single step | Pre-packed column | RoboColumn | BioProcess |
| CaptureSelect LambdaXP | To purify all human lambda Ig light chain containing products, offering high recovery and purity in a single step | Pre-packed column | RoboColumn | BioProcess |
| CaptureSelect LC-kappa (mur) | Murine Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments, Poly Ig from mouse, rat and guinea pig | |||
| CaptureSelect LC-lambda (mouse) | Mouse Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain | |||
| Isotype specific | Characteristics |
|---|---|
| POROS CaptureSelect IgM-XL | IgM resin suitable for human, mouse and rat IgM's |
| CaptureSelect IgA | For purification of human IgA, IgA-dimers and secretory IgA (sIgA) |
| CaptureSelect IgA-CH1 (Hu) | For purification of human IgA, IgA-dimers and secretory IgA (sIgA) and Fab fragments thereof |
| CaptureSelect Bovine IgA | For purification of bovine IgA from whey. The resin enables purification of monomeric, dimeric and secretory bovine IgA. |
| CaptureSelect IgE | For the purification of human IgE (immunoglobuline E) from recombinant and plasma sources. |
| IgG subclass specific | Characteristics |
|---|---|
| CaptureSelect IgG4 (Hu) | Specific for human IgG4 without any crossbinding to other subclasses or species |
| CaptureSelect IgG1 (Hu) | Specific for human IgG1 without any crossbinding to other subclasses or species |
| CaptureSelect IgG3 (Hu) | Specific for human IgG3 without any crossbinding to other subclasses or species |
IgG all subclasses | Characteristics | Magnetic beads | Pre-packed column | RoboColumn® | BioProcess |
Suitable for purification of human IgG and all Fab fragments, offering mild elution conditions | |||||
Specific for human IgG, suitable for Fc-fusion proteins, increased binding capacity |
| ||||
Specific for human IgG, suitable for Fc-fusion proteins, increased binding capacity, can be used at high flow rates | |||||
Designed to purify IgG from multiple species by high affinity binding to the Fc region of IgGs |
| ||||
Designed to purify rabbit IgG from recombinant and plasma sources. | |||||
| Light chains | Characteristics | |||
| CaptureSelect KappaXP | To purify all human lambda Ig light chain containing products, offering high recovery and purity in a single step | Pre-packed column | RoboColumn | BioProcess |
| CaptureSelect LambdaXP | To purify all human lambda Ig light chain containing products, offering high recovery and purity in a single step | Pre-packed column | RoboColumn | BioProcess |
| CaptureSelect LC-kappa (mur) | Murine Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments, Poly Ig from mouse, rat and guinea pig | |||
| CaptureSelect LC-lambda (mouse) | Mouse Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain | |||
| Isotype specific | Characteristics |
|---|---|
| POROS CaptureSelect IgM-XL | IgM resin suitable for human, mouse and rat IgM's |
| CaptureSelect IgA | For purification of human IgA, IgA-dimers and secretory IgA (sIgA) |
| CaptureSelect IgA-CH1 (Hu) | For purification of human IgA, IgA-dimers and secretory IgA (sIgA) and Fab fragments thereof |
| CaptureSelect Bovine IgA | For purification of bovine IgA from whey. The resin enables purification of monomeric, dimeric and secretory bovine IgA. |
| CaptureSelect IgE | For the purification of human IgE (immunoglobuline E) from recombinant and plasma sources. |
| IgG subclass specific | Characteristics |
|---|---|
| CaptureSelect IgG4 (Hu) | Specific for human IgG4 without any crossbinding to other subclasses or species |
| CaptureSelect IgG1 (Hu) | Specific for human IgG1 without any crossbinding to other subclasses or species |
| CaptureSelect IgG3 (Hu) | Specific for human IgG3 without any crossbinding to other subclasses or species |
^RoboColumn is a product of Repligen Corp.
Chromatography Learning Lab
Check out the new Chromatography Learning Lab from Thermo Fisher Scientific, providing a robust range of webinars, articles, eBooks, infographics, and other digital resources to help you optimize the use of our purification products in your process.
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Bioprocessing resources
Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: