Single-cell multi-omics of SARS CoV-2 antigen-specific T-lymphocytes reveals population diversity 

Available on demand

Immunity against SARS-CoV-2 has been studied predominantly regarding antibody responses. However, the T-lymphocyte response against immunodominant viral nucleocapsid protein (NP) derived antigens represents a critical constituent responsible for the elimination of virus infected cells.

This webcast will present work looking at these responses more closely, employing both proteomics and transcriptomics to analyze NP-specific T-cells from acute SARS-CoV-2 patients.

You will learn:

  • How to conduct a single-cell MS (scMS) proteomics study using TMT multiplexing to maximize throughput with high resolution accurate mass (HRAM) Orbitrap mass spectrometry
  • Best practices in designing, executing, and interpreting a multi-omics experiment
  • What is the most critical element to be aware of in single-cell experiments?

About the presenter

Dr. Benedikt Kessler, Professor of Biochemistry and Life Science Mass Spectrometry, Nuffield Department of Medicine University of Oxford

Dr. Benedikt Kessler

Professor of Biochemistry and Life Science Mass Spectrometry 
Nuffield Department of Medicine University of Oxford

 
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