NMR Tech Talk: March 2015

Chemistry students Kelsey Holbert and Marie Nider from the University of Wisconsin Milwaukee will be giving presentations at this year's Pittcon, demonstrating online reaction monitoring with our Thermo Scientific™ picoSpin™ spectrometers.

Thursday, March 12
Poster Session - A Kinetic Study of the Maillard Reaction by On-Line Monitoring with Sequential Injection-Nuclear Magnetic Resonance Spectroscopy
Session #: 2530
Exposition Floor, Hall F, Aisles 3900-4500

Thursday, March 12, 8:50 a.m.
Oral Session - Development of a Sequential Injection Method for Online Reaction Monitoring by Low-Field Nuclear Magnetic Resonance Spectroscopy
Session #: 2490
Location: 271

Congratulations to John Frost, Jessica Bonjour and Joy Pitzer for their recent publication in the Journal of Chemical Education. The article reviews the implementation of NMR spectroscopy into the (U.S.) high school or first year college undergraduate curriculum. This article presents a simple laboratory experiment using benchtop NMR to determine the percent composition in a series of household solutions explored with high school honors chemistry students.

Read the article

Aspirin (C₉H₈O₄), acetylsalicylic acid, is a salicylate drug used to treat a variety of conditions, including headaches, fever and inflammation. It is also used in low doses in preventive treatment against heart attacks, strokes and blood clots.  

The ¹H NMR spectrum of a 4% (w/w; 330 mM) solution of aspirin in chloroform-D was measured at 82 MHz using the Thermo Scientific picoSpin 80 NMR spectrometer.  

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Flow chemistry is a widely accepted technique in the synthesis field and makes optimization fast and convenient. Using a benchtop NMR instrument allows chemists to measure ¹H NMR spectra directly in the fume hood and monitor pseudo real-time behavior of reaction chemistries.

Read this application note from ThalesNano to get details on both the flow synthesis at extremely high temperature as well as the following analysis.

Read the application note

Butanol, C₄H₉OH, is a high value C₄ alcohol collectively represented by fopur isometric structures: 1-butanol, 2-butanol, isobutanol and tert-butanol. Isomers are compounds that have the same molecular formular but which the connectivity of the atoms differ.

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(±)-Propranolol hydrochloride (C₁₆H₂₁NO₂ · HCl), a nonselective beta-blocker, is representative of a class of drugs that target the beta receptor. It is prescribed medication for treatment of hypertension, severe headaches, and cardiac related dysrhythmia and ischemia.

The ¹H NMR spectrum of a 11.2% (w/w; 420 mM) solution of propranolol in protonated DMSO was measured at 82 MHz using the Thermo Scientific picoSpin 80 spectrometer.

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