Human CD & Other Cellular Antigens | Thermo Fisher Scientific

细胞分型标记蛋白列表

Invitrogen eBioscience human antibodies are available conjugated to a variety of fluorophores to enable multicolor flow cytometry, functional assays, and immunohistochemistry applications. Additional antibodies to other human antigens including novel cell-surface molecules are in our pipeline.

Invitrogen Immune Cell Guide

This guide provides detailed marker information for immune cell types and subtypes for both human and mouse for immune cells, stem cells, and other cell types.

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Human CD cellular antigens

See the antigens and their characteristics

Antigen name	Other names	MW	Structure	Distribution	Function
CD1a	T6	49kD	IgSF, MHC-like	cortical thymocytes, Langerhans cells, DC	antigen presentation, with beta2m
CD1b	T6	45kD	IgSF, MHC-like	cortical thymocytes, Langerhans cells, DC	antigen presentation, with beta2m
CD1c	T6	43kD	IgSF, MHC-like	cortical thymocytes, Langerhans cells, DC, B subset	antigen presentation, with beta2m
CD1d		49kD	IgSF, MHC-like	intestinal epith, B subset, mono^low, DC	antigen presentation, with beta2m
CD1e		28kD	IgSF, MHC-like	DC	antigen presentation, with beta2m
CD2	T11, LFA-2, SRBC-R	45-58kD	IgSF	thymocytes, T, NK	CD58 ligand, adhesion, T cell activation
CD2R	T11-3	50kD	IgSF	T^act	activation-dependent form of CD2
CD3 gamma, CD3 delta	T3	20-30kD	IgSF	T, thymocyte subset	with TCR, TCR surface expression / signal transduction
CD3 epsilon	T3	20kD	IgSF	thymocytes, T cell subsets	with TCR, TCR surface expression / signal transduction
CD4	T4	55kD	IgSF	thymocyte subset, T subset, mono, mac	MHC class II coreceptor, HIV receptor, T cell differentiation / activation
CD5	T1, Tp67	67kD	Scavenger R SF	thymocytes, T, B subset, B-CLL	CD72 receptor, TCR or BCR signaling, T-B interaction
CD6	T12	100-130kD	Scavenger R SF	thymocytes, T cells, B cell subsets	CD166 receptor, T cell differentiation / costimulation
CD7		40kD	IgSF	hematopoietic progenitors, thymocytes, T, NK	T cell costimulation; marker for T cell acute lymphatic leukemia and pluripotential stem cell leukemias
CD8a	T8, Leu-2	32-34kD	IgSF	thymocyte subset, T subset, NK	MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation / activation
CD8b		32-34kD	IgSF	thymocyte subset, T subset	MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation / activation
CD9	p24, MRP-1	22-27kD	TM4SF	pre-B, eosinophils, basophils, platelets, Tact, brain and peripheral nerves, vascular smooth muscle	cellular adhesion and migration; mediates platelet aggregation
CD10	CALLA, NEP, gp100	100kD	type II TM	B and T-cell precursors, bone marrow stromal cells	zinc-binding metalloproteinase, B cell development
CD11a	LFA-1, integrin alphaL	180kD	Integrin family	lymph, gran, mono, mac	CD11a / CD18 receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation
CD11b	Mac-1, integrin alphaM	170kD	Integrin family	myeloid cells, NK	binds CD54, ECM, iC3b
CD11c	p150, 95, CR4, integrin alphaX	150kD	Integrin family	DC, myeloid cells, NK, B, T subset	binds CD54, fibrinogen and iC3b
CD12		90-120kD		mono, gran, platelets	unknown
CD13	Aminopeptidase N, APN	150-170kD	type II TM	myelomonocytic cells	zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains
CD14	LPS-R	53-55kD	GPI-linked	mono, mac, Langerhans cells, gran, myelomonocytic cells	receptor for LPS/LBP, LPS recognition
CD15	Lewis-x, Lex		CHO	neutrophils, eosinophils, mono	terminal trisaccharide expressed on glycolipids and many cell-surface glycoproteins, cell adhesion
CD15s	Sialyl Lewis X		CHO	neutrophils, eosinophils, mono, memory helper T, T^act and B, NK, HEV	CD62L and CD62P ligand, adhesion
CD15u	Sulfated Lewis X		CHO	myeloid subset	sulphated CD15, cell adhesion
CD16a	FcgammaRIIIA	50-65kD	IgSF	neutrophils, mac, NK	component of low affinity Fc receptor, phagocytosis and antibody-dependent cell-mediated cytotoxicity
CD16b	FcgammaRIIIB	48kD	IgSF	neutrophils	component of low affinity Fc receptor, phagocytosis and ADCC
CD17				neutrophils, mono, platelets	lactosyl ceramide, a cell-surface glycosphingolipid
CD18	Integrin beta2	95kD	Integrin family	broad, all leukocytes	with CD11a, b & c, adhesion
CD19	B4	95kD	IgSF	B, FDC	complex with CD21 and CD81, BCR coreceptor, B cell activation / differentiation
CD20	B1, Bp35	33-37kD	TM4SF	B, T subset	B cell activation
CD21	C3DR, CR2, EBV-R	145,110kD	CCRSF	mature B cells, follicular dendritic cells, T subsets	complement C3d and EBV receptor, complex with CD19 and CD81, BCR coreceptor
CD22	BL-CAM, Siglec-2	150kD	IgSF, sialoadhesins	mature B cells	bBinds sialoconjugates, cell adhesion, B mono, B T interactions
CD23	FcepsilonRII	45kD	C-type lectin	B, activated mac, eosinophils, FDC, platelets	CD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction
CD24	BA-1	35-45kD	GPI-linked	thymocytes, erythrocytes, peripheral lymph, myeloid, B cells, granulocytes	binds P-selectin
CD25	Tac, p55	55kD	type I TM	activated B and T cells, macrophages, lymph progenitors, monocytes	IL-2Ralpha, with IL-2Rbeta and gamma to form high affinity complex
CD26	DPP IV	110kD	type II TM	activated B and T cells, macrophages, Thymocyte subset	dipeptidyl peptidase, T costimulation, HIV entry
CD27	T14	50-55kD	TNFRSF	medullary thymocytes, T, B subset, NK subset	CD70 receptor, costimulator for B and T cells
CD28	Tp44, T44	44kD	IgSF	most T, thymocytes, plasma cells	CD80, CD86 receptor, T costimulation
CD29	Integrin beta1	130kD	Integrin family	lymph, mono, gran, platelets, mast cells, fibroblasts, endothelial cells	with CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM
CD30	Ki-1	105-120kD	TNFRSF	B^act, T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma	CD153 receptor, lymph proliferation /apoptosis, adhesion molecule, mediating both leukocyte-endothelial and endothelial-endothelial interactions
CD31	PECAM-1	130-140kD	IgSF	mono, platelets, gran, endoth, lymph subset	CD38 receptor, adhesion
CD32	FcgammaRII	40kD	IgSF	mono, gran, B, platelets	low affinity Fc receptor for aggregated Ig and immune complexes
CD33	p67, Siglec-3	67kD	IgSF, sialoadhesins	myeloid progenitors, mono, gran, DC, mast cells, Tact	cell adhesion, binds sialoconjugates
CD34		105-120kD	Sialomucin, type I TM	hematopoietic precursors, capillary endoth, embryonic fibroblasts	stem cell marker, adhesion, CD62L receptor
CD35	CR1	250kD	CCRSF	erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset	complement receptor 1, binds C3b and C4b, adhesion, phagocytosis
CD36	GPIV	88kD		platelets, mono, mac, endoth, early erythrocytes	ECM receptor, adhesion, phagocytosis
CD37		40-52kD	TM4SF	mature B cells, mature T cells, myeloid cells	signal transduction
CD38	T10	45kD		variable levels on majority of hematopoietic cells,high expression on plasma cells, early B and T cells, activated T cells, germinal center B cells, plasma cells	ecto-ADP-ribosyl cyclase, cell activation
CD39		78kD	NK, mac, Langerhans cells, DC, B^act	B cell adhesion, protects activated cells from lysis, ecto-apyrase
CD40		48kD	TNFRSF	B cells, macrophages, dendritic cells, basal epithelial cells	CD154 receptor, B differentiation / costimulation, isotype-switching, rescues B cells from apoptosis
CD41	gpIIb	dimer: GPIIba:125, GPIIbb:22	Integrin family	platelets, megakaryocytes	with CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation
CD42a	GPIX	22kD	LRRF	platelets, megakaryocytes	complex with CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices
CD42b	GPIba	145kD	LRRF	platelets, megakaryocytes	complex with CD42a, c and d, binds to vWF and thrombin, platelet adhesion / activation
CD42c	GPIbb	24kD	LRRF	platelets, megakaryocytes	complex with CD42a, b, d
CD42d	GPV	82kD	LRRF	platelets, megakaryocytes	complex with CD42a-c
CD43	Leukosialin, sialophorin	115-135kD	Sialomucin, type I TM	leukocytes, except resting B, platelets^low	inhibition of T cell interaction, CD54R, adhesion
CD44	H-CAM, Pgp-1	80-95kD	hyaladherin family	hematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis	binds hyaluronic acid, adhesion
CD44v			CD44 variants heterogeneous expression, constitutively on epith, mono, upregulated on activated leukocytes	adhesion, metastasis
CD45	LCA, T200, B220	180-240kD		hematopoietic cells, multiple isoforms from alternative splicing	tyrosine phosphatase, enhanced TCR & BCR signals
CD45RA		205-220kD		B, T subset(naive), mono	exon A isoforms of CD45
CD45RB	T200	190-220kD		T subset, B, mono, mac, gran	exon B isoforms of CD45
CD45RO		180kD		Tact, memory T, B subset, mono, mac, gran	isoform of CD45 lacking A, B, C exons
CD46	MCP	56/66kD	CCRSF	hematopoietic and nonhematopoietic nucleated cells	membrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor
CD47	IAP, MER6, OA3	47-52kD	IgSF	hematopoietic cells, epith, endoth, fibroblasts, other tissues	leukocyte adhesion, migration, activation
CD47R				New designation for CDw149, similar distribution as CD47 but dimmer
CD48	Blast-1	45kD	IgSF	broad, all leukocytes	cell adhesion
CD49a	VLA-1	200kD	Integrin family	activated T cells, monocytes, neuronal cells, smooth muscle	integrin alpha1, adhesion, CD49a/CD29 binds collagen and laminin
CD49b	VLA-2	160kD	Integrin family	B cells, monocytes, platelets, megakaryocytes, neuronal, epithelial and endothelial cells, osteoclasts	integrin alpha2, adhesion, CD49b / CD29 binds collagen and laminin
CD49c	VLA-3	125kD	Integrin family	B and T^low, most adhesive cell lines	integrin alpha3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen
CD49d	VLA-4	150kD	Integrin family	T, B, NK, thymocytes, mono, eosinophils, mast, DC	integrin alpha4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1
CD49e	VLA-5	135, 25kD	Integrin family	thymocytes, T, mono, platelets, early and B^act	integrin alpha5, adhesion, CD49e/CD29 binds fibronectin
CD49f	VLA-6	125, 25kD	Integrin family	memory T, thymocytes, mono, platelets, megakaryocytes, epith	integrin alpha6, adhesion, CD49f / CD29 binds laminin
CD50	ICAM-3	130kD	IgSF	thymocytes, T cells, B cells, monocytes, granulocytes	adhesion, costimulation, binds integrin CD11a/CD18
CD51	Vitronectin receptor	125, 24kD	Integrin family	platelets, endothelial cells, osteoblasts, melanomas, megakaryocytes	integrin alphav, adhesion, CD51 / CD61 binds vitronectin, vWF, fibrinogen and thrombospondin
CD52	CAMPATH-1	21-28kD		thymocytes, T, B (not plasma cells), mono, mac	unknown, target for antibodies used therapeutically to deplete T cells from bone marrow
CD53		35-42kD	TM4SF	leukocytes, DC, osteoblasts, osteoclasts	unknown, maybe signal transduction
CD54	ICAM-1	75-115kD	IgSF	hematopoietic and nonhematopoietic cells	receptor for CD11a / CD18 (LFA-1),CD11b/CD18 (Mac-1) and rhinovirus, intracellular adhesion
CD55	DAF	60-70kD	GPI-linked	hematopoietic and nonhematopoietic cells	decay accelerating factor (DAF), binds C3b, complement regulation
CD56	NCAM	135-220kD	IgSF	NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias	adhesion
CD57	HNK-1, Leu-7	110kD		NK cells, subsets of T cells, B cells, and monocytes	oligosaccharide, found on many cell-surface glycoproteins
CD58	LFA-3	55-70kD	IgSF	hematopoietic, non-hematopoietic cells	leukocyte function-associated antigen-3 (LFA-3), binds CD2, adhesion molecule
CD59	hematopoietic and nonhematopoietic cells	19kD	GPI-linked	hematopoietic, non-hematopoietic cells	binds complement C8 and C9, blocks assembly of membrane attack complex
CD60a	GD3		CHO	T subset, platelets, thymic epith, astrocytes	costimulation
CD60b	9-O-sialyl GD3		CHO	T subset, B^act	9-O-acetyl-GD3
CD60c	7-O-sialyl GD3		CHO	T subset	7-O-acetyl-GD3
CD61	GPIIIa	110kD	Integrin family	platelets, megakaryocytes, mac, endoth	integrin beta3, adhesion, CD41/CD61 or CD51 / CD61 mediate adhesion to ECM
CD62E	E-selectin, ELAM-1	140kD	Selectin family	endothelium	endothelium leukocyte adhesion molecule (ELAM), binds sialyl-Lewis x, mediates rolling interaction of neutrophils
CD62L	L-selectin, LECAM-1	150kD	Selectin family	B, naïve and memory T, mono, gran, NK, thymocytes	CD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling
CD62P	P-selectin, PADGEM	140kD	Selectin family	platelets, megakaryocytes, endothelium	CD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions
CD63	LIMP, LAMP-3	53kD	TM4SF	activated platelets, mono, mac	unknown, is lysosomal membrane protein translocated to cell surface after activation
CD64	FcgammaRI	72kD	IgSF	mono, mac, DC, Interferon or G-CSF activated gran	high affinity receptor for IgG, phagocytosis and ADCC
CD65				gran, mono subset, myeloid leukemias	oligosaccharide component of a ceramide dodecasaccharide
CD65s	VIM2			gran, mono, myeloid leukemias	phagocytosis
CD66a	BGP-1, NCA-160	160-180kD	IgSF, CEA family	neutrophils, epith	cell adhesion
CD66b	CD67, CGM6	95-100kD	IgSF, CEA family	gran	cell adhesion, neutrophil activation
CD66c	NCA	90kD	IgSF, CEA family	neutrophils, colon carcinoma	cell adhesion
CD66d	CGM1	35kD	IgSF, CEA family	neutrophils
CD66e	CEA	180-200kD	IgSF, CEA family	colon epith, colon cancer	cell adhesion
CD66f	PSG, Sp-1	54-72kD	IgSF, CEA family	pregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver	immune regulation, protects fetus from maternal immune system
CD68	Macrosialin, gp110	110kD	Sialomucin	intracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver	Unknown
CD69	AIM	28, 32kD	C-type lectin	Tact, B, NK and gran, thymocytes, platelets, Langerhans cells	unknown, early activation antigen, signal transduction
CD70	Ki-24	75, 95, 170kD	TNFSF	activated T and B cells, and macrophages	CD27 ligand, T and B cell costimulation
CD71	T9	95kD		proliferating cells, reticulocytes, erythroid precursors	transferrin receptor, iron uptake
CD72	Lyb-2	42kD	C-type lectin	B, FDC	unknown, maybe CD5, CD100 receptor, B proliferation
CD73		69kD	GPI-linked	B cell subsets, T cell subsets	ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion
CD74	Ii, invariant chain	33, 35, 41, 43kD		B cells, macrophages, monocytes, MHC class II positive cells	MHC class II traffic and function
CD75			CHO Sialoglycan family	B subset, epith	lactosamines
CD75s			CHO Sialoglycan family	B subset, T subset	alpha-2,6-sialylated lactosamines (previously CDw75 and CDw76)
CD77	Gb3, Pk blood group			germinal center B, Burkitt’s lymphomas^high, follicular lymphomas^low	neutral glycosphingolipid (Galα1→4Galβ1 →4Galcβ1 →ceramide), binds Shiga toxin, cross-linking induces apoptosis
CD79a	Iga	40–45kD	IgSF	B cells	component of BCR, BCR surface expression and signal transduction
CD79b	Igb	37kD	IgSF	B cells	component of BCR, BCR surface expression and signal transduction
CD80	B7, B7-1, BB1	60kD	IgSF	B^act and Tact, mac, DC	binds to CD28, CD152, T costimulation
CD81	TAPA-1	26kD	TM4SF	T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas	complex with CD19 & CD21, signaling, T costimulation
CD82	R2	50-53kD	TM4SF	leukocytes	unknown
CD83	HB15	43kD	IgSF	B^act and Tact, DC, Langerhans cells	unknown
CDw84		73kD		mono, platelets, B, T subset, mac subset	unknown
CD85		110kD	IgSF, ILT/LIR family	DC, mono, B, NK, T subset	inhibition of NK, T cell cytolytic function , ILT/LIR family
CD85a	LIR3, ILT5, HL9, LILRB3	110 kDa		monocytes	activation of NK cell–mediated cytotoxicity, association with FcRγ
CD85b	ILT8, LILRA6			NK cells, T cell subsets, monocytes, macrophages, DCs, B cells	activation of NK cell–mediated cytotoxicity, association with FcRγ
CD85c	LIR8, LILRB5			NK cells, T cell subsets, monocytes, macrophages, DCs, B cells	suppression of NK cell–mediated cytotoxicity
CD85d	LIR2, ILT4, MIR10, ILT8	110kDa		NK cells, monocytes, macrophages	activation of NK cell–mediated cytotoxicity, association with FcRγ
CD85e	ILT6, LIR4, LILRA3			B and NK cells	activation of NK cell–mediated cytotoxicity, association with FcRγ
CD85f	ILT11, LIR9, LILRA5			monocytes, neutrophils, macrophages, DCs	signaling for cytokine production
CD85g	LIR4, ILT7	5 kDa		plasmacytoid DCs	activation of NK cell–mediated cytotoxicity
CD85h	LIR7, ILT1, LILRA2	53 kDa		monocytes	activation of NK cell–mediated cytotoxicity, association with FcRγ
CD85i	LIR6, LILRA1			T cell subsets, monocytes, macrophages, DCs, B cells	inhibitory receptor for MHC class I antigens
CD85j	LIR1, ILT2, MIR7	110 kDa		NK cells, DCs, monocytes, T cells	putative inhibitory receptor
CD85k	LIR5, ILT3, HM18, LILRB4	60 kDa		DCs, macrophages, monocytes, plasmacytoid DCs	association with FcRγ
CD85l	ILT9, LILRP1			NK cells, T cell subsets, monocytes, macrophages, DCs, B cells	association with FcRγ
CD85m	ILT10			NK cells, T cell subsets, monocytes, macrophages, DCs, B cells
CD86	B70, B7-2	80kD	IgSF	mono, DC, B^act and Tact	binds to CD28, CD152, T costimulation
CD87	UPA-R	39-66kD	GPI-linked	granulocytes, monocytes, macrophages, T cells, NK cells, wide variety of non-hematopoietic cell types	urokinase plasminogen activator receptor, inflammatory cell invasion, metastasis
CD88	C5aR	43kD	TM7SF	polymorphonuclear leukocytes, macrophages, mast cells	C5a receptor, granulocyte activation
CD89	FcalphaR	55-75kD	IgSF	mono, mac, gran, neutrophils, B subset, T subset	IgA receptor, phagocytosis, degranulation, respiratory burst
CD90	Thy-1	25-35kD	IgSF, GPI-linked	CD34+ hematopoietic subset, neurons	hematopoietic stem cell and neuron differentiation
CD91		515, 85kD	LDLR family	mono, mac, neurons, fibroblasts	receptor for alpha-2-macroglobulin
CD92	GR9	70kD		neutrophils, mono, platelets, endothelium, fibroblasts	unknown
CD93	GR11	120kD		neutrophils, mono, endothelium	unknown
CD94	KP43	43kD	C-type lectin	NK, T subset	complex with NKG2, inhibits NK function
CD95	Apo-1, Fas	45kD	TNFRSF	lymph (high upon activation), mono, neutrophils	FasL (CD178) receptor, apoptosis
CD96	TACTILE	160kD	IgSF	NK, Tact	adhesion of activated T and NK
CD97	GR1	75-85kD	TM7SF	B^act and Tact, mono, gran	binds CD55
CD98	4F2	80, 40kD		T, B, NK, gran, all human cell lines	cellular activation
CD99	MIC2, E2	32kD		peripheral blood lymphocytes, thymocytes	T cell activation, adhesion
CD99R	E2	32kD		T, NK, myeloid cells	isoform of CD99
CD100	GR3	150kD		hematopoietic cells except immature bone marrow cells, RBC and platelets	cell adhesion, cellular activation
CD101	V7, p126	120kD	IgSF	mono, gran, DC, Tact	T cell activation
CD102	ICAM-2	55-65kD	IgSF	lymph, mono, platelets, endoth	binds CD11a / CD18, costimulation
CD103	HML-1, alpha6, integrin alphaE	150, 25kD	Integrin family	intraepithelial lymph, lymph subset, activated lymph	with integrin beta7, binds E-cadherin, lymph homing/retention
CD104	beta4 integrin	220kD	Integrin family	epith, Schwann cells, keratinocytes, some tumor cells	with integrin alpha6 (CD49f), cell adhesion, differentiation, metastasis
CD105	Endoglin	95kD	homodimer	endoth, bone marrow subset, activated mac	cellular response to TGF-beta1
CD106	VCAM-1	110kD	IgSF	activated endoth, FDC	VLA-4 (CD49d / CD29) receptor, leukocyte adhesion, migration, costimulation
CD107a	LAMP-1	110kD		activated platelets, T, endoth, metastatic tumors	a lysosomal membrane protein
CD107b	LAMP-2	120kD		activated platelets, T, endoth, metastatic tumors	a lysosomal membrane protein
CD108	GR2, John Milton-Hagen blood group antigen	80kD		erythrocytes, lymphoblasts, resting lymph^low	unknown
CD109	platelet activation factor, GR56	170kD		Tact and platelets, CD34+ subset, endoth	unknown
CD110	MPL, TPO-R	82-84kD	CRSF	megakaryocytes, platelets, some CD34+ stem cells^low	thrombopoietin receptor, megakaryocyte progenitor cell growth / differentiation
CD111	PRR1, Nectin-1	64-72kD	IgSF	stem cell subset, mac, neutrophils
CD112	PRR2, Nectin-2	64-72kD	IgSF	mono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith	intercellular adhesion
CD113	PVRL3, Nectin3	83kD	IgSF	testis, placenta	adhesion molecule that interacts with afadin
CD114	G-CSFR	150kD	CRSF	myeloid progenitors, granulocytes, monocytes	myeloid differentiation / proliferation
CD115	M-CSFR, c-fms	150kD	IgSF, RTK family	mono, mac, monocytic progenitors	CSF-1R, monocytic differentiation / proliferation
CD116	GM-CSFRalpha	70-85kD	CRSF	monocytes, neutrophils, eosinophils, endothelium	with common beta, myeloid differentiation / proliferation
CD117	c-kit, SCFR	145kD	IgSF, RTK family	hematopoietic progenitors, mast cells	SCF receptor, hematopoietic progenitor development / differentiation
CD118	LIFR, gp190	190kD	Type I CRSF & secreted forms	epithelial cells in adult and embryo	membrane-bound involved in signal transduction, soluble form inhibits activity of LIF
CD119	IFNgammaR	90-100kD		mac, mono, B, T, NK, neutrophils, endoth	IFN-gamma Ralpha, with IFN-gamma AF-1, host defense
CD120a	TNFR-I	50-60kD	TNFRSF	hematopoietic, non-hematopoietic cells	receptor for both TNF-alpha and TNF-beta
CD120b	TNFR-II	75-85kD	TNFRSF	hematopoietic, non-hematopoietic cells	receptor for both TNF-alpha and TNF-beta
CD121a	IL-1R type I	80kD	IgSF	thymocytes, T cells	binds IL-1alpha and IL-1beta, IL-1 signaling
CD121b	IL-1R, type II	60-70kD	IgSF	B, mac, mono, T subset	binds IL-1alpha and IL-1beta, negative signals
CD122	IL-2Rbeta	75kD	CRSF	NK, T, B, mono	IL-2Rbeta and IL-15Rbeta, signal transduction
CD123	IL-3R	70kD	CRSF	lymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes	IL-3Ralpha, with CDw131
CD124	IL-4R	130-150kD	CRSF	lymph^low, mono, hematopoietic precursors, fibroblast, epith	IL-4Ralpha, with CD132 or IL-13Ralpha, T cell growth / differentiation
CD125	IL-5R	60kD	CRSF	eosinophils, basophils	IL-5Ralpha, with CDw131
CD126	IL-6R	80kD	IgSF, CRSF	B^act and plasma cells, most leukocytes^low, fibroblasts	IL-6Ralpha, with CD130
CD127	IL-7R	65-75kD	CRSF	bone marrow lymphoid precursors, pro-B cells, mature T cells, monocytes	IL-7Ralpha, with CD132, B and T cell development
CD128	IL-8R	58-67kD
CD130	IL-6Rbeta, gp130	130kD	CRSF	B^act and plasma cells, most leukocytes^low, endoth	IL-6Rbeta, IL-6, IL-11, LIF, CNF signals
CD131	IL-3R common beta	140kD	CRSF	mono, gran, early B	with alpha subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction
CD132	Common gamma	64kD	CRSF	T, B, NK, mono, gran	subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction
CD133	AC133, prominin-like 1	120kD	TM5SF	hematopoietic stem cell subset, epith, endoth	unknown
CD134	OX-40	48-50kD	TNFRSF	Tact	T cell activation, differentiation, apoptosis
CD135	Flt3/Flk2	130-150kD	RTK family	myelomonocytic, primitive B progenitors	tyrosine kinase, binds FLT3 ligand, early lymph development
CD136	MSP-R, RON	180kD	RTK family	epith, CNS, PNS, hematopoietic subset	migration, morphological change and proliferation of different target cells
CD137	4-1BB	30kD	TNFRSF	Tact	T costimulation
CD138	Syndecan-1	80-150kD	Syndecan family	plasma cells, pre-B, basolateral surface of epith, neurons	receptor for ECM, cell morphology
CD139		229, 228kD		B, mono, gran, erythrocytes^low	unknown
CD140a	PDGFRalpha	180kD	RTK family	stromal cells, some endothelial cells	binds PDGF A and B
CD140b	PDGFRbeta	180kD	RTK family	stromal cells, some endothelial cells	binds PDGF B
CD141	Thrombomodulin	105kD	C-type lectin	mono, neutrophils, endoth, smooth muscle cells	initiation of protein C anticoagulant signal
CD142	Tissue Factor	45-47kD		mono, endoth, keratinocytes, epith	binds clotting factor VIIa, initiator of clotting
CD143	ACE	170-180kD		endoth, epith, neurons, fibroblasts, activated mac	angiotensin converting enzyme, angiotensin II & bradykinin metabolism
CD144	VE-Cadherin, Cadherin-5	130kD	Cadherin family	endoth	adhesion, cell-cell interaction
CD145		25, 90, 110kD		endoth, some stromal cells
CD146	MUC18, S-endo	130kD	IgSF	endoth, melanomas, FDC, Tact	adhesion
CD147	Neurothelin, basoglin	55-65kD	IgSF	leukocytes, erythrocytes, platelets, endoth	adhesion
CD148	HPTP-eta	240-260kD		gran, mono, DC, T (high upon activation)	tyrosine phosphatase R Type III
CD150	SLAM	75-95kD	IgSF	T subset (high upon activation), B, DC, endoth	costimulation, proliferation, Ig production, measles virus receptor
CD151	PETA-3	32kD		endoth, megakaryocytes, platelets, epith	cell adhesion
CD152	CTLA-4	33kD	IgSF	Tact and B	CD80 and CD86 receptor, negative regulation of T cell costimulation
CD153	CD30L	40kD	TNFSF	neutrophils, B, Tact and mac	CD30 ligand, T costimulation
CD154	CD40L, gp39, TRAP	32-39kD	TNFSF	Tact	CD40 ligand, B and DC costimulation
CD155	PVR	80-90kD	IgSF	mono, mac, CD34+ thymocytes	Polio virus receptor (PVR)
CD156a	ADAM8	69kD		neutrophils, mono	leukocyte extravasation
CD156b	TACE / ADAM 17	100kD		broad	cleaves membrane proteins (TNF, TGFalpha) to generate soluble forms
CD156c	ADAM10	98kD	Peptidase M12B family	lymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver	proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP and ephrin-A2
CD157	BST-1	42-45kD		granulocytes, monocytes, bone marrow stromal cells, vascular endothelial cells, follicular dendritic cells	ADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth
CD158a	p58.1	50-58kD	IgSF, KIR family	NK subset, T subset	inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor
CD158b	p58.2	50-58kD	IgSF, KIR family	NK subset, T subset	inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor
CD159a	NKG2A	43kD		T subset, NK	with CD94, NK cell receptor
CD159c	NKG2C	40kD	Type II C-Type Lectin	NK	with MHC class I HLA-E molecules, forms heterodimer with CD94
CD160	BY55	27kD	IgSF	NK subset, T subset	costimulation
CD161	NKR-P1A	40kD	C-type lectin	T subset, NK	NK cell-mediated cytotoxicity
CD162	PSGL-1	120kD	Mucin family	mono, gran, most lymph	CD62P, CD62L ligand, adhesion, rolling
CD162R	PEN-5		CHO	NK subset	unknown
CD163	130kD	130kD	Scavenger receptor SF	mono, mac	unknown
CD164	MGC-24	80kD	epith, mono, lymph^low, bone marrow stromal cells, CD34+ erythroid progenitors	hematopoietic progenitor cell-stromal cell interaction	unknown
CD165	AD2, gp37	37kD	lymph subset, mono, immature thymocytes, platelets	adhesion, thymocyte-thymic epith interaction	adhesion between thymocytes and thymic epithelium
CD166	ALCAM	105kD	IgSF	neurons, mono, epith, fibroblasts, Tact	CD6 ligand, adhesion
CD167a	DDR1	63, 64kD	RTK family	epith, myoblasts	tyrosine kinase, adhesion to collagen
CD168	RHAMM	Five isoforms: 58, 60, 64, 70, 84 kD		mono, T subset, thymocyte subset, intracellularly in breast cancer cells	adhesion, tumor migration, metastasis
CD169	sialoadhesin, Siglec-1	185kD	IgSF, sialoadhesins	tissue mac subset	adhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells
CD170	Siglec-5, CD33-like2	67 kD homodimer	IgSF, sialoadhesins	Mac subset, neutrophils	adhesion
CD171	L1	200-210kD	IgSF	CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells	kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins
CD172a	SIRPgamma	110kD		mono, T subset, stem cells	adhesion, complex with CD47
CD172b	SIRPbeta, SIRB1	50kD	IgSF	mono and DC	negative regulation of RTK-coupled signaling
CD172g	SIRPgamma, SIRPB2	45-50kD	IgSF, ASV	mRNA: liver and at lower levels in many tissues	binds CD47
CD173	Blood group H type 2		CHO	all cells	blood group H type 2; carbohydrate moiety
CD174	Lewis Y		CHO	all cells	Lewis y Blood group; carbohydrate moiety
CD175	Tn		CHO	all cells	Tn blood group; carbohydrate moiety
CD175s	Sialyl-Tn		CHO	all cells	sialyl-Tn blood group; carbohydrate moiety
CD176	Thomson Friedenreich Ag		CHO	all cells	TF blood group; carbohydrate moiety
CD177	NB1	56-62kD		neutrophil subset
CD178	FasL, CD95L	38-42kD	TNFSF	Tact, testis	CD95 ligand, apoptosis, immune privilege, soluble form in serum
CD179a	V pre B	16-18kD	IgSF	Pro- and Pre-B	B cell differentiation / signaling, with IgM
CD179b	Lambda 5	22kD	IgSF	Pro- and Pre-B	B cell differentiation / signaling, with IgM
CD180	RP-105	95-105kD	LRRF, TLR family	B subset, mono, DC	B cell activation, LPS signaling, with MD-1
CD181	CXCR1, IL-8RA	39kD	GPCR1 family	neutrophils, basophils, NK, T subset, mono	binding of IL-8 induces chemotaxis of neutrophils
CD182	CXCR2, IL-8RB	40kD	GPCR1 family	neutrophils, basophils, NK, T subset, mono	binding of IL-8 induces chemotaxis of neutrophils
CD183	CXCR3	46-52kD	TM7SF	eosinophils, Tact and NK, GM-CSF activated CD34+ progenitors	IP-10 , Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response
CD184	CXCR4, fusin	46-52kD	TM7SF	B, DC, T subset, mono, endoth	SDF-1 receptor, X4 HIV-1 coreceptor
CD185	CXCR5, BLR1	45kD	GPCR1 family	mature B and Burkitt Lymphoma cells	with chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B
CD186	CXCR6, BONZO	40kD	GPCR1 family	Tact	receptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1
CD191	CCR1, MIP-1alphaR, RANTES-R	39kD	GPCR1 family	T, mono, stem cell subset	binds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels
CD192	CCR2, MCP-1-R	40kD	GPCR1 family	activated NK and mononuclear phagocytes, T subset, B, endoth	binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection
CD193	CCR3, CKR3	45kD	GPCR1 family	eosinophils, lower expression in neutrophils and mono, T subset	binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1delta, alternative coreceptor with CD4 for HIV-1 infection
CD195	CCR5	40kD		mono, T subset	MIP-1alpha, MIP-1beta and RANTES receptor, R5 HIV-1 coreceptor
CD196	CCR6, LARC receptor, DRY6	45kD	GPCR1 family	T subset, B, DC subset	binds MIP-3alpha/LARC
CD197	CCR7	45kD		T subset, DC Subset	6Ckine and MIP-2beta receptor
CD198	CCR8, GPRCY6, TER1	50kD	GPCR1 family	T, high expression in Th2, NK, mono	allergic inflammation, alternative coreceptor with CD4 for HIV-1 infection
CD199	CCR9, GPR-9-6	43kD	GPCR1 family	subset of memory T, lamina propria mononuclear cells	binds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection
CD200	OX-2	45-50kD		thymocytes, endoth, B, Tact	inhibition of immune response
CD201	EPC-R	50kD		endoth subset	activated protein C receptor
CD202b	Tie2, Tek	150kD	RTK family	stem cells, endoth	angiopoietin-1 receptor
CD203c	NPP3 / PDNP3, ENpp1, PD-1b	101kD	type II TM	basophils, mast cells, glioma cells, megakaryocytes	ectoenzyme, binding to and clearance of extracellular nucleotides
CD204	Macrophage scavenger-R	220kD		mac	endocytosis of macromolecules
CD205	DEC-205	205kD		DC, thymic epith	DC, thymic epith
CD206	macrophage mannose-R	175-190kD		DC subset, mac, mono	phagocytosis and pinocytosis of mannose containing molecules
CD207	Langerin	40kD		Langerhans cells	endocytic receptor
CD208	DC-LAMP	70-90kD		DCact, interdigitating DC
CD209	DC-SIGN	44kD		DC subset	ICAM-3 receptor, HIV-1 binding protein
CD210	IL-10-R	90-110kD		T, B, NK, mono, mac	IL-10 receptor, signal transduction
CD212	IL-12-R beta1	130kD		activated CD4, CD8, and NK cells	binds IL-12 with high affinity, associates with IL-12 receptor beta2
CD213a1	IL-13-R alpha1	60-70kD		B cells, monocytes, fibroblasts, endothelial cells	binds IL-13 with low affinity, with CD124
CD213a2	IL-13-R alpha2	65kD		B cells, monocytes, fibroblasts, endothelial cells	binds IL-13 with high affinity
CD215	IL15R, interleukin 15 receptor α	28 kDa		brain tissue, activated monocytes, macrophages, NK cells	high-affinity receptor for IL-15, signal transduction, development and survival of NK cells
CD217	IL-17-R	120kD		Activated memory T cells	IL-17 receptor
CD218a	IL-18Ralpha, IL-1Rrp	70kD	IL-1R family	T, NK, DCs	binds IL-18, activation of NF-kappaB
CD218b	IL-18Rbeta, IL18RAP	70kD	IL-1R family	T, NK and DCs	heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding
CD220	Insulin-R	140, 70kD		nonlineage molecules	insulin receptor
CD221	IGF-1 R	α: 135 kD, β: 90 KD		nonlineage molecules	binds IGF with high affinity, signaling, cell proliferation/ differentiation
CD222	IGF-II R, mannose-6 phosphate-R	250kD	Type I TM	nonlineage molecules	adhesion, tumor growth, a receptor for TGFbeta-LAP, plasminogen, proliferin, truncated form (220kD) found in serum
CD223	LAG-3	70kD	IgSF	Tact and NK	an MHC class II ligand
CD224	GGT	27, 68kD		leukocytes, stem cells
CD225	Leu-13	17kD		broad
CD226	DNAM-1, PTA-1, TLiSA1	65kD	IgSF	T, NK, mono, platelets, activated HUVEC	activation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum
CD227	MUC1, EMA	300kD	Mucin family, type I TM	epith, stem cell subset, FDC, mono, B subset, some myelomas	adhesion, signaling, binds CD169, CD54, & selectins
CD228	Melanotransferrin	80-95kD		stem cells, melanomas	tumor-associated antigen (melanoma), involved in Iron uptake
CD229	Ly-9	95, 110kD	IgSF	T, B	adhesion
CD230	Prion protein	35kD	broad	expressed both in normal and infected cells
CD231	TALLA-1, A15	150kD	TM4SF	T leukemias, neuroblastomas, brain neurons	marker for T cell acute lymphoblastic leukemia
CD232	VESP-R	200kD		broad
CD233	Band 3, SLC4A1	90kD	Anion exchanger family	erythrocytes	anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton
CD234	Duffy, DARC	35-45kD		erythrocytes	Duffy antigen chemokine receptor
CD235a	Glycophorin A	31kD		erythrocytes	major carbohydrate-rich sialoglycoprotein of human erythrocyte membrane
CD235ab	Glycophorin A/B	20kD		erythrocytes	minor sialoglycoprotein in human erythrocyte membranes
CD235b	Glycophorin B	20kD		erythrocytes
CD236	Glycophorin C/D	32, 23kD		erythrocytes, stem cell subset
CD236R	Glycophorin C	32kD		erythrocytes, stem cell subset	plays an important role in regulating the mechanical stability of red cells and is a putative receptor for the merozoites of Plasmodium falciparum
CD238	Kell	93kD		erythrocytes, stem cell subset	KELL blood group antigen; homology to a family of zinc metalloglyco-proteins
CD239	B-CAM	78-85kD		erythrocytes, stem cell subset	a type I membrane protein, upregulated following malignant transformation in some cell types
CD240CE	Rh30CE	30-32kD		erythrocytes	may be part of an oligomeric complex, which is likely to have a transport or channel function in the erythrocyte membrane
CD240D	Rh30D	30-32kD	TM12SF	erythrocytes	may be part of an oligomeric complex, which is likely to have a transport or channel function in the erythrocyte membrane
CD241	RhAg, Rh50	50kD	TM12SF	erythrocytes	may be part of an oligomeric complex, which is likely to have a transport or channel function in the erythrocyte membrane
CD242	ICAM-4	42kD	IgSF	erythrocytes	adhesion, Landsteiner-Wiener blood group
CD243	MDR-1, p170, P-gp	170kD		stem cells, small intestine, kidney stem cells, small intestine, kidney	ion pump
CD244	2B4	66kD	type II TM	T subset, mono, basophils, NK	NK activation, CD48 ligand
CD245	p220/240	220-240kD		T subset
CD246	ALK, Ki-1	177kD		anaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph	brain development, implicated in ALK lymphomas
CD247	TCRz	16kD	RTK family	T, NK	TCR complex subunit, coupling of antigen recognition to signaling
CD248	TEM1, Endosialin	175kD	C-Type Lectin	endothelial tissue, stromal fibroblasts	tumor progression and angiogenesis
CD249	Aminopeptidase A	160kD	Peptidase M1 family	epith, endoth	renin-angiotensin system
CD252	OX-40Ligand, gp34	34kD	TNFSF	B^act, cardiac myocytes	T costimulation
CD253	TRAIL, Apo-2L, TL2, TNFSF10		TNFSF	Tact, many tissues	apoptosis
CD254	TRANCE, RANKL, OPGL	35kD	TNFSF	lymph node & BM stroma Tact	binds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation
CD256	APRIL, TALL-2	16kD	TNFSF	leukocytes, pancreatic cells, mono, mac	binds TACI & BCMA, B proliferation , aids metastasis
CD257	BLyS, BAFF, TALL-1		TNFSF	B cells, plasma cells, mono, mac, T cells and DCs	costimulator of B cells, T cells and Ig production
CD258	LIGHT, HVEM-L	28kD	TNFSF	Tact, immature DC	binds LTBR, T proliferation, receptor for HVEM
CD261	TRAIL-R1, DR4	57kD	TNFRSF	Tact, peripheral blood leukocytes	contains death domain, apoptosis via FADD & caspase-8
CD262	TRAIL-R2, DR5	60kD	TNFRSF	widely expressed, peripheral blood lymphocytes	contains death domain, apoptosis via FADD and caspase-8
CD263	TRAIL-R3, DcR1, LIT	65kD	TNFRSF	peripheral blood lymphocytes	receptor for TRAIL but lacks death domain
CD265	RANK, TRANCE-R, ODFR	97kD	TNFRSF	broad expression	binds TRANCE, osteoclastogenesis ,T-DC interactions, suppresses apoptosis
CD266	TWEAK-R, FGF-inducible 14	14kD	TNFRSF	heart, placenta and kidney, HUVEC	TWEAK receptor, cell-matrix interactions and endoth growth and migration
CD267	TACI, TNFR SF13B			B, Tact	binds BAFF & APRIL
CD268	BAFFR, TR13C	25kD	TNFRSF	B	binds BLyS, mature B survival
CD269	BCMA, TNFRSF13B	20kD	TNFRSF	mature B (membrane and perinuclear)	receptor for CD256 and CD257, B survival & proliferation
CD271	NGFR, p75 (NTR)	45kD	TNFRSF	neurons (schwann cells, growing neurites), BM mesenchymal cells	NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death
CD272	BTLA	33kD	IgSF	Tact, B , remains on Th1	HVEM receptor, inhibitory response
CD273	B7DC, PD-L2, PDCD1L2	25kD	IgSF	DC subset, mono, mac	PD-1 receptor, costimulation or suppression of T proliferation
CD274	B7-H1, PD-L1	33kD	IgSF	leukocytes, broad	PD-1 receptor, costimulation of lymphocytes
CD275	B7-H2, ICOSL, B7-RP1, GL50	60kD	B7 Family	B, DC, mono	costimulation, cytokine production, ligand for CD278
CD276	B7-H3	40-45kD	B7 Family, ASV	in vitro cultured DC and mono, Tact, mammary tissue	costimulation, T activation
CD277	BT3.1, butyrophilin SF3 A1, BTF5	56kD	B7/BT family, ASV	T, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines	T activation
CD278	ICOS, AILIM	55-60kD	CD28 family	Tact, Th2	binds ICOS-L, T costimulation
CD279	PD1, SLEB2	55kD		Tact and B^act	B7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance
CD280	ENDO180, UPARAP	180kD	C-type lectin SF	chondrocytes, fibroblasts, endothelial, mac	mannose receptor, collagen matrix remodeling and endocytic recycling
CD281	TLR1	90kD	TLR family	low levels in PBMC, mono and possibly DC	innate immunity, with TLR2
CD282	TLR2	90kD	TLR family	mono, neutrophil, upregulated in mac	binds dsRNA, response to bacterialli poproteins, innate immunity, induces IFN secretion
CD283	TLR3	100kD	TLR family, ASV	alveolar macrophages	binds dsRNA, innate immunity
CD284	TLR4	100kD	TLR family, ASV	PBMC (weak in mono, immature DC & neutro), neuronal cells	binds LPS, innate immunity, development of nervous system
CD289	TLR9	120kD	TLR family	pre DC (intracellular), PB leukocytes	binds CpG-DNA, innate immunity
CD290	TLR10	90 kDa		B cells, monocytes, Treg cells, pDCs	pathogen recognition, activation of innate immunity
CD292	BMPR1A, ALK3	57kD	Type I	bone progenitor	BMP 2 & 4 receptor, bone development, apoptosis
CD293	BMPR1B, ALK6	57kD	Type I, ASV	bone progenitor	BMP receptor, bone development
CD294	CRTH2. GPR44	55-70kD	GPCR-7TM	Th2, eosinophils, basophils	binds prostaglandin D2, stimulatory effects on Th2, allergic inflammation
CD295	LeptinR, LEPR	132kD	Type I cytokine-like receptor	broad	adipose metabolism, immune dysfunction in obesity, receptor for Leptin
CD296	ART1, RT6, ART2	37kD	ADP- ribosyl transferase	heart and skeletal muscle, peripheral T, NK subset	modifies integrins during differentiation, ADP ribosylation of target proteins
CD297	ART4, dombrock blood group	38kD	ADP- ribosyl transferase	erythroid, mono^act	ADP ribosylation of target proteins
CD298	Na+/K+-ATPase beta3 subunit	52kD		broad	transport sodium & potassium ions across membrane
CD299	DC-SIGN-related, LSIGN, DC-SIGN2	45kD	Type II, similar to CD209, ASV	endothelial subset	binds ICAM3, HIV-1 gp120, coreceptor with DC-SIGN, HIV infection
CD300a	CMRF35H, IRC1, IRp60	60kD	IgSF, ASV	NK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML	unknown
CD300c	CMRF35A, LIR		IgSF	mono, neutrophils, monocytic cell lines, B & T subsets	unknown
CD300e	CMRF35L		IgSF CMRF family	monocytes, macrophages and DCs	unknown
CD300f	IREM1, MAIR-V	60 kDa		myeloid	inhibitory receptor
CD301	MGL, HML	38kD	C type lectin SF, ASV	mac, mono, immature DCs	binds Tn antigen, uptake of glycosylated antigens innate immunity
CD302	DCL1, BIMLEC	19-28kD	Type I TM C-type lectin receptor	monocytes, macrophages, DCs and granulocytes. Hodgkin's cell lines	a fusion protein in Hodgkin’s lymphoma with DEC-205, cell adhesion, phagocytosis
CD303	BDCA2, HECL	38kD	C-type lectin SF ASV	plasmacytoid dendritic cells	inhibit IFN-alpha production , cytokine production in PDCs
CD304	BDCA4, neuropilin 1	130kD	semaphorin family	neurons, CD4+/CD25+ Treg, DC, endothelial and tumor cells	interacts with VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration
CD305	LAIR1	32-40kD	IgSF, ASV	NK, B, T, mono, mac	inhibitory receptor on NK and T cells
CD306	LAIR2		IgSF, ASV	NK, B, T, mono, mac	soluble, mucosal tolerance
CD307	IRTA2	55-105kD	IgSF (Fc receptor), ASV	B subset, B lymphoma	B cell development, translocation in some lymphomas
CD307a	FCRL1, Fc receptor-like 1, FCRH1, IFGP1, IRTA5, FCRL1	50 kDa		mature B cells	putative role in B cell activation and differentiation –
CD307b	FCRL2, Fc receptor-like 2, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C	55 kDa		memory B cells	putative role in B cell development
CD307c	FCRL3, Fc receptor-like 3, FCRH3, IFGP3, IRTA3, SPAP2	89 kDa		B and NK cells	unknown
CD307d	FCRL4, Fc receptor-like 4, FCRH4, IGFP2, IRTA1	57 kDa		memory B cells	may inhibit B cell receptor
CD307e	FCRL5, Fc receptor-like 5, CD307, FCRH5, IRTA2, BXMAS1, PRO820	106 kDa		B cells	putative role in B cell development and differentiation
CD309	VEGFR2, KDR	230kD	Type III TM tyr kinase	endothelial, angiogenic precursor cells, hemangioblast	binds VEGF, regulates adhesion and cell signaling, proliferation, migration and differentiation
CD312	EMR2	90kD	EGFR-7TM ASV	mono, mac, moDC, grans^low	cell adhesion and migration for phagocytosis
CD314	NKG2D, KLR	42kD	Type II lectin-like receptor	NK, CD8+ activated, NK1.1+ T, some myeloid cells	binds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation
CD315	CD9P1, SMAP6, FPRP, PTGFRN	135kD	IgSF	megakaryocytes, hepatocytes, epithelial cells and endothelium	Angiogenesis
CD316	EWI2, PGRL, CD81P3, KASP	63-75kD	IgSF8	B, T cells, low on NK cells	with CD81 & CD9; involved in cell migration
CD317	BST2, HM1.24	30-36kD	Type II	B, T, NK, mono, DC, fibroblast cell line, myeloma	pre-B cell growth, overexpressed in multiple myeloma
CD318	CDCP1, SIMA135	135kD	Type I, ASV	HSC (subset of CD34+), tumors	cell adhesion with ECM, metastasis
CD319	CRACC, SLAMF7	66kD	Ig TM	T, B and DC subset, NK, upregulated in DC	regulate T and NK cells
CD320	8D6A, 8D6	30kD	LDL receptor	follicular DC, germinal centers	B proliferation, tumor formation
CD321	JAM1, F11 receptor	35kD	IgSF, Type I, ASV	platelet receptor, epithelia and endothelial, platelets	tight junctions, cell proliferation and migration
CD322	JAM2, VE-JAM	43kD	IgSF	HEV, other endoth	cell adhesion, lymphocyte homing to secondary lymphoid organs
CD324	E-Cadherin, Uvomorulin	120kD	cadherin SF	no neutral epithelial cells, keratinocytes, and platelets	cell adhesion, homotypic interaction & binds alphaE/beta7
CD325	N-Cadherin, NCAD	140kD	cadherin SF	brain, skeletal and cardiac muscle	cell adhesion, neuronal recognition
CD326	Ep-CAM, Ly74	35-40kD		most epith cell membranes	proliferation and differentiation of embryonic stem cells
CD327	SIGLEC6		IgSF	placenta, spleen, B . sialic-acid dependent	adhesion, membrane- bound & secreted forms
CD328	SIGLEC7, AIRM-1	75kD	IgSF	resting and activated NK, placenta, liver, spleen, lower in gran & mono	sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis
CD329	SIGLEC9		IgSF	neutrophils and mono	sialic-acid dependent adhesion molecule
CD331	FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM	30kD	TM tyr kinase	fibroblasts, epithelial	binds FGF, high affinity receptor for fibroblast growth factors, muscle and bone development
CD332	FGFR2, BEK, KGFR	115-135kD	TM RTK family	fibroblasts, epithelial	binds FGF, high affinity receptor for fibroblast growth factors
CD333	FGFR3, ACH, CEK2	115kD	TM RTK family	fibroblasts, epithelial	binds FGF, high affinity receptor for fibroblast growth factors
CD334	FGFR4, JTK2, TKF	110kD	TM RTK family	fibroblasts, epithelial	binds FGF, high affinity receptor for fibroblast growth factors
CD335	NKp46, Ly-94 homolog	46kD	IgSF	NK	activates NK cells upon non-MHC ligand binding
CD336	NKp44, Ly-95 homolog	44kD	IgSF	NK	activates NK cells upon non-MHC ligand binding
CD337	NKp30, Ly117	30kD	IgSF	NK	activates NK cells upon non-MHC ligand binding
CD338	ABCG2, BCRP, Bcrp1, MXR	73kD	GPCR 7TM	stem cell subset (side population)	multi-drug resistance transporter
CD339	Jagged-1, JAG1, JAGL1, hJ1	135kD	EGF TM	stromal cells, epithelial, AML	binds Notch, hematopoiesis
CD340	HER2/neu, ERBB2, p185HER2	185 kDa		bone marrow mesenchymal stem cells, endothelial cells, epithelial cells, keratinocytes	lymph node, spleen, thymus, bone marrow
CD344	Frizzled-4, Fz-4, hFz-4, FzE4	59 kDa		adult kidney, lung, brain, liver, fetal neuronal cells, intestinal cells	activation of the Wnt/β-catenin pathway, regulation of tissue and cell polarity
CD349	Frizzled-9, Fz-9, hFz-9	65 kDa		adult and fetal brain; testis, eye, skeletal muscle, and kidney; bone marrow mesenchymal stem cells	activation of the Wnt/β-catenin pathway, regulation of tissue and cell polarity
CD350	Frizzled-10, Fz-10, hFz-10	65 kDa		placenta and kidney; fetal lung and brain	activation of the Wnt/β-catenin pathway, regulation of tissue and cell polarity
CD351	FCAMR, Fc receptor of IgA and IgM, FCA/MR, FKSG87	57 kDa		mesangial cell	downregulates germinal center formation
CD352	SLAMF6, SLAM family member 6, KALI, NTBA, KALIb, Ly108, NTB-A, SF2000	37 kDa		NK, T, and B cells	triggers cytolytic activity of NK cells
CD353	SLAMF8, SLAM family member 8, BLAME, SBBI42	32 kDa		lymph node, spleen, thymus, bone marrow	putative role in B cell signaling and differentiation
CD354	TREM1, triggering receptor expressed on myeloid cells 1, TREM-1	26 kDa		myeloid, hepatocytes, osteoclasts, microglia	stimulation of neutrophils and monocytes
CD355	CRTAM, cytotoxic and regulatory T cell molecule	45 kDa		NKact cells, CD8act cells, γδ T cells, Purkinje neurons	cytotoxicity, tumor rejection
CD357	AITR, GITR, TNFRSF18, tumor necrosis factor receptor superfamily, member 18, GITR-D	26 kDa		activated lymphocytes, T cell subsets	Cross-talk of lymphocytes and endothelial cells, T cell activation
CD358	TNFRSF21, tumor necrosis factor receptor superfamily, member 21, DR6, BM-018	72 kDa		fetal spinal cord, brain	promotion of apoptosis, elevated in Alzheimer’s disease
CD360	IL21R, interleukin 21 receptor, NILR	59 kDa		B, T, and NK cells; DCs	signal transduction
CD361	EVI2B, ecotropic viral integration site 2B, EVDB, D17S376	47 kDa		bone marrow, PBMCs, fibroblasts	cell-surface proteoglycan that bears heparan sulfate
CD362	SDC2, syndecan 2, HSPG, HSPG1, SYND2	22 kDa			T cell migration
CD363	S1PR1, sphingosine-1-phosphate receptor 1, EDG1, S1P1, ECGF1, EDG-1, CHEDG1	42 kDa		lymphocytes, B cells, NK cells, monocytes/macrophages, endothelial cells, neural progenitors, neurons, astrocytes, oligodendrocytes	putative serine protease inhibitor
CD364	PI16, peptidase inhibitor 16, dJ90K10.5, MGC45378, MSMBBP	49 kDa		prostate, testis, ovary, intestine	role in Th cell development, involved in hepatitis A virus entry into cells
CD365	TIM-1, HAVCR1, HAVCR-1, TIMD1	38 kDa		activated CD4+ T cells	inhibitory receptor on Th1 cells
CD366	TIM-3, HAVCR2, TIMD3	33 kDa		Th1 cells, DC subsets	inhibitory receptor on DCs and B cells
CD367	CLEC4A, DCIR, DDB27, CLECSF6	27 kDa		pDCs, myeloid cells, B cells	endocytic receptor
CD368	CLEC4D, MCL, CLECSF8, CLEC-6, MPCL	24 kDa		monocytes, macrophages	TLR2-mediated inflammatory response
CD369	CLEC7A, DECTIN-1, CLECSF12	27 kDa		monocytes, macrophages, DCs, neutrophils, lymphocytes	endocytic receptor
CD370	CLEC9A, HEEE9341, UNQ9341, DNGR1	27 kDa		DC subsets, monocyte subsets	signal transduction
CD371	CLEC12A, CLL-1, myeloid inhibitory C-type lectin-like receptor (MICL), DCAL-2	30 kDa		neutrophils, eosinophils, monocytes, DCs	signaling through FCg

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Human non-CD cellular antigens

See the antigens and their characteristics

Antigen name	Other names	MW	Structure	Distribution	Function
4-1BB Ligand	CD137L		TNFSF	B^act, DC, carcinoma cell lines	T costimulation
AID			RNA-editing deaminase family	B^act, Germinal Center B	Activation-Induced Deaminase, Ig class switch recombination
AITR	TNFRSF18, GITR			Treg, T^act	costimulation
AITRL	TNFSF18, TL6, GITRL			APC
B7 family	see CD273-276
B7-H4	B7-S1, B7x		B7 family		may interact with BTLA (?), inhibition
BAMBI	TGFBR	29kD	TGFBR	carcinoma cell	pseudoreceptor for TGF-beta (short cytoplasmic domain), growth inhibition
BCMA	see CD269
BLyS	see CD257
BR3	see CD268
BTLA	see CD272
CCR7	see CD197
c-Met	HGFR/SFR	190kD	heterodimer, PTK	epith, hematopoietic progenitors, early thymocytes	tumor growth / metastasis, Hepatocyte Growth Factor / Scatter Factor receptor, T development, hematopoiesis
CMKLR1	chemokine-like receptor 1	42kD	GPCR 7TM, chemokine receptor	pDC (CD123+), in vitro derived moDC	binds chemerin, pDC recruitment, bone development
DcR3	TR6, TNFRSF6B		Soluble	tumors	Fas decoy receptor, tumor evasion
DEC-205	see CD205
DR3	TRAMP, Apo-3, WSL-1, LARD, TR3		TNFRSF	T^act, leukocytes	lymphocyte homeostasis
DR6	TR7		TNFRSF		death, Th2 response
Fc epsilonRI alpha	high-affinity IgE receptor		tetramer complex	mast cells, basophils	triggers IgE-mediated allergic reactions
Foxp3	SCURFIN	50kD	Fox family forkhead	T subsets (CD4+/CD25+ subset and CD8+ subset)	transcription factor, upregulated in T regs
Granzyme B	Granzyme-2, CTLA-1	30kD	Peptidase S1 family	Cytotoxic T, NK	target cell apoptotic lysis, cell-mediated immune responses
HLA-ABC		45, 11-12kD		nucleated cells	cell-mediated immune response & tumor surveillance
HLA-DR				APC, T^act	presentation of peptides to CD4+ T lymphocytes
HVEM	TNFRSF14, TR2	60kD	TNFRSF	broad expression	receptor for LIGHT, LT-alpha, BTLA, Herpes Simplex Virus, lymphocyte activation
ICOS	see CD278
ICOSL	see CD275
IL-15R alpha				mono^act	binds to IL-15, w/ IL-2RB and common gamma, IL-15 trans-presentation
Integrin beta5		100kD		carcinoma cell lines, fibroblast lines	w/ alphav subunit, vitronectin receptor
MD-2		30KD		w/ TLR4 distribution and LPS recognition
MICA/MICB		70kD	MHC Class I-related proteins	intestinal epith, some tumors	unregulated on epith after shock, NKG2D receptors
Nanog		34kD		ES cells	transcription factor, self renewal of ES cells
NKG2D	see CD314
NOD2	CARD-15, IBD1			monocytes, intracellular
Notch-1	Lin-12, Tan 1			developing embryo, variety of adult tissues	cell-cell interaction, cell fate determination
OPG	TRAIL-R5, TR1, TNFRSF11B			binds TRAIL?	bone resorption
OX-40	see CD134
OX-40 Ligand	see CD252
p38		38kD	SAP/MAP kinase	NK, CD8+ T subset, upregulated on CD8+T	role in cytolytic activity
PD-1	see CD279
PD-L1	see CD274
PD-L2	see CD273
Perforin		70-75kD		CTL, NK	cytolytic protein
RP105	see CD180
RANK	see CD265
RANKL	see CD254
SAP	SLAM-associated protein	14kD	adaptor protein	T, NK	negatively regulates SLAM- family receptors
SLP-76		76kD		T, Blow	T cell receptor mediated signaling
SSEA-1	stage-specific embryonic antigen-1			ES cells, embryonic carcinomas, germ cells	down regulated by differentiation
SSEA-3	stage-specific embryonic antigen-3
SSEA-4	stage-specific embryonic antigen-4
Stro-1				BM stroma, erythroid progenitors	surface marker for immature mesenchymal cells
TACI	see CD267
T-bet				Th1 cells	transcription factor, T development / differentiation
TCL1				B cell tumors, lymphoid lineages in a developmentally controlled manner, pDC	intracellular, lymphoid proto-oncogene
TCR alpha beta				peripheral T subset	antigen recognition
TCR gamma delta				T subset	antigen recognition
TLR1 - TLR4	see CD281 - CD284
TLR5	TIL3		TLR family	mRNA: leukocytes, prostate, ovary, liver, lung	interacts w/ microbial lipoproteins, NF-kappaB, responds to Salmonella
TLR6			TLR family	mRNA: leukocytes, ovary, lung	interacts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response
TLR7			TLR family	mRNA: spleen, placenta, lung; upregulated on mac
TLR8			TLR family	mRNA: leukocytes, lung
TLR9	see CD289
TLR10			TLR family	mRNA: lymphoid tissues	most closely related to TLR1 and TLR6
TNFRI	see CD120a
TRAIL	see CD253
TSLPR		50kD	heterodimer with IL-7Ralpha/CD127	monocytes, DC, B	binds TSLP (Thymic Stromal Lymphopoietin) to activate DC
TWEAK	TNFSF12, APO3L		TNFSF	activated mono	death
TWEAK Receptor	see CD266
ULBPs			MHC class I-related proteins, GPI-linked	tumors	NKG2D receptors, NK activation
ZAP-70	TCRζ-associated kinase	70kD	Syk family	Intracellular T, NK	TCR signaling & development

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