TH22 cells are a CD4+ cell subset dedicated to the production of IL-22, an IL-10 family member. Maturation of TH22 cells requires TNFα and IL-6. High numbers of TH22 cells have been found in the epidermis of inflammatory skin disorders and they are believed to be important at other barrier interfaces.
Relevant recombinant proteins
- IL-6
- Necessary for the maintenance of Th22 cells in vitro
- TNF-alpha
- Necessary for induction and maintenance of Th22 cells in vitro
- Associated with both pro and anti-inflammatory activities of T cells including Th22 cells