Succinates are used for the derivatization of controlled pore glass, polystyrene, or other supports for solid-phase oligonucleotide synthesis. Our DNA succinates are formulated as triethylammonium (TEA) salts with standard base protection. They provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.

DNA succinates

Thermo Scientific Bz dA, Bz dC, iBu dG, and T succinates are available as TEA salts with standard base protection.

Technical specifications

 Bz dA succinateBz dC succinateiBu dG succinateT succinate
Chemical structure
(Full size images in accordion below)		Bz dA succinate chemical structureBz dC succinate chemical structureiBu dG succinate T succinate chemical structure
Cat. No.27-003027-003227-003427-0036
Chemical name5′-O-(4,4'-dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-thymidine-3′-succinate, triethylammonium salt
FormulaC48H54N6O9C47H54N4O10C45H56N6O10C43H51N3O10
Molecular weight859 g/mol835 g/mol841 g/mol746 g/mol
HPLC purity≥98.0%≥98.0%≥95.0%≥98.0%
Shipping / storage conditionAmbient / –20°C
 Request quote

 

Quality manufacturing and documentation

Processes are monitored from material procurement through final QC and product release for batch-to-batch reproducibility. Purity of each product lot is assessed by HPLC, MS, and NMR. Our expertise in manufacturing processes help minimize levels of impurities that could be incorporated into the oligonucleotide during synthesis and result in the accumulation of by-products.

Quick tour of our manufacturing facility for phosphoramidites

Our phosphoramidites are manufactured in a facility with ISO 9001:2015–certified quality management system and analytical documentation support at the facility in Milwaukee (WI, USA). We have been customizing and scaling up high-quality amidites for oligonucleotide synthesis, for over 40 years.

Resources

Phosphoramidite Learning Resource

Access webinars, videos, articles, and more to optimize your success in oligonucleotide synthesis for diagnostic and therapeutic manufacturing process development.

mRNA Production Learning Library

Browse the educational assets related to raw materials selection, process development using in vitro transcription, scale-up synthesis, and the latest trends in mRNA production.

For Research Use Only. Not for use in diagnostic procedures.

Stylesheet for Classic Wide Template adjustments