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GeneArt® Precision TALs: 정밀 유전체공학 (Precise Genome Engineering)
정밀한 유전체공학이 바로 여기 있습니다
GeneArt® Precision TALs는 정확한 DNA 표적화 및 정밀한 게놈 편집을 위한 맞춤 DNA 결합 단백질을 제공합니다. 표적 선택을 제한하거나 모호한 결과를 제공하는 다른 기술과 달리, GeneArt® Precision TALs 는 모든 게놈 locus의 표적화를 가능하게 합니다.
- 정밀성 - 특정 DNA 염기서열을 인식합니다
- 활용성 - 필요에 부합하는effector 및 Gateway® 기술에 적합한 벡터를 선택할 수 있습니다
- 신뢰성 - 최종 클론에 발현 개선을 위해 검증되고, 최적화된 서열이 포함됩니다
- 신속성주문 확인 후 보통 2주만에 (주문한)클론을 받습니다
GeneArt® Precision TALs 은 nuclease, activator, repressors, chromatin modifier, genomic label, 교차결합 분자의 부위 특이적 전달을 제공합니다. 이러한 유전체 편집기술은 세균, 효모, 식물, 곤충, 제브라피시(zebrafish), 포유동물을 포함한 다양한 숙주시스템의 함수로 알려져 있습니다. TALs 전문가와 이야기를 나눠보세요
NEW! GeneArt® Precision TAL-edited 세포주서비스를 지금 바로 이용하실 수 있습니다.
Design with precision
GeneArt® Precision TALEN™ providea custom DNA-binding proteins for accurate DNA targeting and precise genome editing. Unlike other technologies that limit the choice of targets, or provide ambiguous results, GeneArt® Precision TALEN™ enables the targeting of any locus in the genome. GeneArt® Precision TALEN™ offers site-specific delivery of nucleases, activators, repressors, chromatin modifiers, genomic labels, and cross-linking molecules. This genome editing technology is known to function in a variety of host systems, including bacteria, yeast, plants, insects, zebrafish, and mammals.
Precise genome editing for every gene locus is now within your reach
Free TALEN Design Consultation
TALEN Design Support Request
Custom TALEN Cell Line Service
Request information about GeneArt® Precision TALs
Ordering GeneArt® Precision TALEN™
The fastest and easiest way to design, edit, optimize, and order GeneArt® Precision TALEN™ is through the GeneArt® portal.
The ordering process is simple; just follow the three steps below:
- Select the functionality (effector domain) of your TALEN from Table 1. For details, refer to the ‘TALEN functionality overview’
- Select the product name from Table 1.
- Then place your order through our online design tool within the GeneArt® portal, or you can downloadand complete the TALEN order form and email it to geneartsupport@lifetech.com.
If you have a question or need free design consultation, contact us here and we’ll be happy to assist.
We will ship you a clone with a verified, optimized sequence approximately 2 weeks after confirming your order.
Table 1: Available effector domains
| Product | DNA-binding domain | Effector domain | Functionalities | Applications |
|---|---|---|---|---|
| Native TAL Fok1 | Native | Fok1 endonuclease | Gene targeting |
|
| Truncated TAL Fok1 | Truncated | Fok1 endonuclease | Gene targeting |
|
| Native TAL VP16 activator | Native | VP16 activator | Activation of transcription |
|
| Native TAL VP64 activator | Native | VP64 activator | Activation of transcription |
|
| TAL repressor | Modified | KRAB repressor | Epigenetic repression of transcription |
|
| Native TAL MCS | Native | (MCS) | Steric repression & custom design |
|
| Truncated TAL MCS | Truncated | (MCS) | Steric repression & custom design |
|
KRAB: Krüppel associated box; MCS: multiple cloning site; TAL: transcription activator–like (DNA-binding domain).
An essential tool for monitoring the efficiency of your genome editing experiments
When using genome editing tools such as CRISPRs, TALs, or zinc finger nucleases to obtain targeted mutations, it is necessary to determine the efficiency with which these nucleases cleave the target sequence prior to continuing with labor-intensive and expensive experiments. The GeneArt® Genomic Cleavage Detection Kit provides a simple, reliable, and rapid method to determine the nuclease cleavage efficiency at a given locus.
기능 선택가이드
추가 자료 GeneArt® Precision TALs 사용자 매뉴얼 | Video on TALs technology
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연구용으로만 사용해야 합니다. 사람이나 동물의 치료 또는 진단 목적으로 사용할 수 없습니다.
For Research Use Only. Not for use in diagnostic procedures.
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