artistic 3D model of a monoclonal antibody

We have developed an innovative portfolio of affinity chromatography resins to help you solve challenges in the downstream process of next-generation antibody therapeutics. These resins are specifically designed for the purification of engineered monoclonal antibody (mAbs) modalities.

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Selectivity of the antibody affinity resins

Due to the unique selectivity of each resin, a broad range of antibody modalities can be captured. The antibody-subdomain-specific resins help to improve downstream processing of monoclonal antibodies and antibody fragments, and serve as an alternative solution when Protein A does not yield optimal results.

CaptureSelect affinity resins antibody subdomain diagram

CaptureSelect affinity resins are scalable platform purification solutions, non-animal derived, and suitable for cGMP manufacturing.

Benefit from:

  • High capacity, addressing process demand and high-titer feedstocks
  • Mild elution conditions for successful purification of pH-sensitive modalities
  • Efficient antibody fragment purification, without co-purification of light chains
  • Alternative purification solutions when Protein A doesn't yield desired results

IgE purification

In addition to our subdomain-specific IgG resins, we offer a highly specific resin for when you are working on IgE drug development. The CaptureSelect IgE affinity matrix  helps provide efficient purification of IgE from plasma and recombinant sources.

Rapid implementation of novel affinity purification

This article describes the performance of CaptureSelect antibody affinity resins, including rapid implementation into a commercial manufacturing process of a next-generation antibody therapeutic.

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Find your desired antibody affinity matrix 

All CaptureSelect antibody purification resins are available as loose resin in different unit sizes. For your process development needs, the resins are available in pre-packed columns in high-throughput screening format and for bench-scale screening purposes. Additionally, when your unique purification needs cannot be met with off-the-shelf resins, our custom chromatography resin service can help with solving your specific challenge. Click on the product table below to see all available resins.

Resin

Purifies

Characteristics

Unit size

Catalog number

CaptureSelect CH1-XL

  • Fab fragments
  • Human IgG
  • Fab fragment purification platform (all Fab κ/λ)
  • No binding of free light chains
  • Efficient elution at milder pH

5 mL

1943462005

10 mL

1943462010

50 mL

1943462050

250 mL

1943462250

1 L

194346201L

5 L

194346205L

CaptureSelect KappaXP

  • Human Ig (all isotypes)
  • Fab fragments containing a kappa light chain
  • High dynamic binding capacity
  • Efficient elution at milder pH
  • Suitable for bi-specific antibodies

5 mL

2943212005

10 mL

2943212010

50 mL

2943212050

250 mL

1943212250

1 L

194321201L

5 L

194321205L

CaptureSelect LambdaXP

  • Human Ig (all isotypes)
  • Fab fragments containing a lambda light chain
  • High dynamic binding capacity
  • Efficient elution at milder pH
  • Suitable for bi-specific antibodies

5 mL

2943752005

10 mL

2943752010

50 mL

2943752050

250 mL

1943752250

1 L

194375201L

5 L

194375205L

CaptureSelect FcXP Affinity Matrix

  • Fc-fusion proteins
  • Poor Protein A-binding IgG molecules
  • High dynamic binding capacity
  • Efficient elution at milder pH

5 mL

1943712005

10 mL

1943712010

50 mL

1943712005

250 mL

1943712250

1 L

194371201L

5 L

194371205L

POROS CaptureSelect FcXP Affinity Resin

  • Human IgG
  • Fc-fusion proteins
  • High dynamic binding capacity
  • Efficient elution at milder pH
  • Efficient purification of larger biomolecules

50 mL

A56249

250 mL

A56251

1000 mL

A56252

5000 mL

A56253

10000 mL

A56254
CaptureSelect Leakage ELISAs

Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologics. To complement each affinity resin, we offer product specific ELISAs to measure ligand potentially leaching from the column. Click on the product table below to see all available ELISAs.

Product

Catalog number

Unit size

Complementing resin

CaptureSelect CH1-XL Ligand Leakage ELISA

810346201

1 assay

CaptureSelect CH1-XL

810346210

10 assays

CaptureSelect KappaXP Ligand Leakage ELISA

810321201

1 assay

CaptureSelect KappaXP

810321210

10 assays

CaptureSelect LambdaXP Ligand Leakage ELISA

810375201

1 assay

CaptureSelect LambdaXP

810375210

10 assays

CaptureSelect FcXP Ligand Leakage ELISA

810371201

1 assay

CaptureSelect FcXP

810371210

10 assays

CaptureSelect IgG-CH1 Ligand Leakage ELISA

810320001

1 assay

CaptureSelect IgG-CH1

810320010

10 assays

810320050

50 assays

CaptureSelect KappaXL Ligand Leakage ELISA

810321001

1 assay

CaptureSelect KappaXL

810321010

10 assays

810321050

50 assays

CaptureSelect FcXL Ligand Leakage ELISA

810328001

1 assay

CaptureSelect FcXL

810328010

10 assays

CaptureSelect KappaSelect Leakage ELISA

810083301

1 assay

KappaSelect affinity resin*

810083310

10 assays

CaptureSelect LambdaFabSelect Leakage ELISA

810308001

1 assay

LambdaFabSelect affinity resin*

810308010

10 assays

CaptureSelect IgSelect Leakage ELISA

810083501

1 assay

IgSelect affinity resin*

*Products sold through Cytiva Life Sciences


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Bioprocessing resources

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