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Choose the system configuration that meets your throughput, turnaround time, and budget needs.
|
Ion GeneStudio S5 System |
Ion GeneStudio S5 Plus System |
Ion GeneStudio S5 Prime System |
Max. throughput/day (chip type) |
15 Gb |
30 Gb |
50 Gb |
Total sequencing and analysis time at max. throughput |
19 hr (Ion 540 Chip) |
10 hr (Ion 540 Chip) |
6.5 hr (Ion 540 Chip) |
Compatible chips |
Ion 510, 520, 530, 540 chips |
Ion 510, 520, 530, 540, and 550 chips |
Flexibility in throughput and workflow for a broad range of NGS applications
Chip type |
Number of reads |
Read length (output) † |
Ion GeneStudio S5 System |
Ion GeneStudio S5 Plus System |
Ion GeneStudio S5 Prime System |
Turnaround time (sequencing run* and analysis time) |
|||||
Ion 510 Chip |
2–3M |
200 bp (0.3–0.5 Gb) |
4.5 hr |
3 hr |
3 hr |
400 bp (0.6–1 Gb) |
10.5 hr |
5 hr |
5 hr |
||
Ion 520 Chip |
4–6M |
200 bp (0.6–1 Gb) |
7.5 hr |
3.5 hr |
3 hr |
400 bp (1.2–2 Gb) |
12 hr |
5.5 hr |
5.5 hr |
||
3–4M |
600 bp (0.5–1.5 Gb) |
12 hr |
5.5 hr |
5.5 hr |
|
Ion 530 Chip |
15–20M |
200 bp (3–4 Gb) |
10.5 hr |
5 hr |
4 hr |
400 bp |
21.5 hr |
8 hr |
6.5 hr |
||
9–12M |
600 bp (1.5–4.5 Gb) |
21 hr |
8 hr |
7 hr |
|
Ion 540 Chip |
60–80M |
200 bp (10–15 Gb) |
19 hr |
10 hr |
6.5 hr |
200 bp (20–30 Gb) 2 runs in 1 day |
N/A |
20 hr |
10** hr |
||
Ion 550 Chip |
100–130M |
200 bp (20–25 Gb) |
N/A |
11.5 hr |
8.5 hr |
200 bp (40–50 Gb) 2 runs in 1 day |
N/A |
N/A |
12** hr |
† Expected output with >99% aligned/measured accuracy. Output dependent on read length and application.
* Sequencing run times are between 2.5 and 4 hrs.
** Analysis of first run occurs concurrently with the second sequencing run.
Example of our popular panels and applications |
Panel description |
Number of samples per run* |
||||
Ion 510 Chip |
Ion 520 Chip |
Ion 530 Chip |
Ion 540 Chip |
Ion 550 Chip |
||
Cancer research |
||||||
Identify cancer hotspot SNVs from 10 ng of FFPE derived DNA |
4 |
8 |
26 |
84 |
NA |
|
Identify solid tumor-relevant SNVs, indels, CNVs, and gene fusions from 52 genes |
4 |
8 |
26 |
NA |
NA |
|
Enable biomarker discovery of SNVs and indels and full gene sequencing from 161 genes |
NA |
NA |
NA |
8 |
16 |
|
Detect rare somatic mutations in genes relevant to non-small cell lung cancer |
NA |
NA |
8 |
32 |
~60-64 |
|
Detect rare somatic mutations in genes across multiple cancer types |
NA |
NA |
1 |
4 |
7-8 |
|
interrogate genes involved in immune response pathways |
NA |
4 |
8 |
NA |
NA |
|
Gene expression |
||||||
Research global gene expression levels |
NA |
NA |
2 |
8 |
16 |
|
Research global gene expression levels |
NA |
NA |
2 |
8 |
16 |
|
Inherited disease research |
||||||
Discover rare mutations of the whole exome |
NA |
NA |
NA |
2 |
4 |
|
Investigate known variants associated with drug metabolism |
48 |
96 |
384 |
384 |
NA |
|
Identify variants in genes associated with inherited disease |
Up to 384 (varies by number of genes in panel) |
|||||
Reproductive health research |
||||||
Identify aneuploidy in DNA from embryo samples |
16 |
24 |
96 |
NA |
NA |
|
Infectious disease research |
||||||
Identify variants associated with antimicrobial resistance in Mycobacterium tuberculosis (TB) |
48 |
84 |
272 |
384 |
NA |
|
Ion AmpliSeq Ebola Research Panel |
Identify the presence of Ebola virus |
48 |
84 |
272 |
384 |
NA |
Identify bacterial species in mixed samples |
24 |
48 |
192 |
NA |
NA |
|
* The number of samples per run/chip serves as a guide, and the actual number of samples loaded will depend on your needs for number of reads and depth of coverage. It is important to note that as the number of libraries per chip increases, it becomes more difficult to balance the reads between libraries. In addition, libraries from FFPE tissue tend to produce more variable results. We suggest combining fewer libraries initially and determining real limits empirically. |
For Research Use Only. Not for use in diagnostic procedures.