Extractables and Leachables

Extractable and leachable (E&L) testing methods, such as draft pharmacopeial chapters USP 1663 and USP 1664, demand carefully controlled extraction. Traditionally, routine extractables testing has been performed using soxhlet and reflux extraction, which have lengthy extraction times (over 24 hours), variability in manual handling, and require disposal of potentially flammable and hazardous organic solvents.

Automate extraction, in-cell cleanup and evaporation of compounds from solid and semi-solid samples using the Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor. The EXTREVA ASE system can perform four parallel sample extractions, substantially increasing throughput and efficiency. Because the entire sample preparation workflow is automated in one seamless operation, no manual transfer of samples between steps is required. Get reproducible and efficient parallel extractions that cut manual sample preparation steps from hours to minutes, increase productivity, minimize errors, and dramatically reduce solvent use to meet laboratory sustainability and cost goals.

• Application Note: Identifying plastic additives in pharmaceutical packaging

The Thermo Scientific Orbitrap IQ-X Tribrid Mass Spectrometer combines industry-leading mass analyzer technology dedicated for small molecule analysis with the Thermo Scientific AcquireX intelligent MSⁿ data acquisition strategy, to collect more meaningful data.