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Stem Cell Genome Editing
Leverage our Stem Cell Genome Editing service to generate stable cell lines today
Our CellModel genome editing and stem cell scientists can custom-design stable stem cell lines using the most robust and reliable technologies on the market. We offer both CRISPR-Cas9 and TALEN as genome editing tools depending on your application, cell type, gene edit, delivery method, and more. You can choose to provide your own pluripotent stem cells (PSCs), or have us reprogram your somatic cells into iPCSs for you. The choice is yours!
Stem Cell Genome Editing workflow and timeline
Stem cell line generation projects are typically completed within 4-8 weeks of initiation. Actual timelines will vary depending on the unique aspects of each project. Modification options include knock-out and knock-in (SNPs, Large Donor).
Following the receipt of PSCs, target gene name or mutation information is confirmed before proceeding.
Cells are recovered and then subjected to initial testing. Additional characterization steps are recommended before genome editing step.
We offer both CRISPR-Cas9 and TALEN as genome editing tools. Our R&D specialists will design and construct the genome editing tool of choice to meet your requirements.
Following stable pool generation, on-target editing efficiency is evaluated and potential off-target effect assessed using next generation sequencing.
Single cell sorting, identification, consolidation, isolation, and expansion of clones. The clones are then screened.
A report containing the final genome editing results is provided to the customer along with the shipment of the edited cryopreserved cells.
Following the receipt of PSCs, target gene name or mutation information is confirmed before proceeding.
Cells are recovered and then subjected to initial testing. Additional characterization steps are recommended before genome editing step.
We offer both CRISPR-Cas9 and TALEN as genome editing tools. Our R&D specialists will design and construct the genome editing tool of choice to meet your requirements.
Following stable pool generation, on-target editing efficiency is evaluated and potential off-target effect assessed using next generation sequencing.
Single cell sorting, identification, consolidation, isolation, and expansion of clones. The clones are then screened.
A report containing the final genome editing results is provided to the customer along with the shipment of the edited cryopreserved cells.
Optional services
Choose from a number of additional services available to enable full customization of your stem cell project or continue your project with downstream applications such as differentiation analyses.
- Additional stable cell line clones
- Post-editing characterization including karyotyping, cell identification, evaluating for any genomic mutation, and pluripotency assessment
- TEG-Seq Off-Target Analysis service
Start your stem cell genome editing project today
Contact us today to discuss your stem cell genome editing project with a technical specialist.