Product References
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
Cell reports
VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB
47-0038-42 was used in Flow cytometry/Cell sorting to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.
Tue Oct 18 00:00:00 EDT 2022
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation.
Cell host & microbe
Viladomiu M,Metz ML,Lima SF,Jin WB,Chou L,Guo CJ,Diehl GE,Simpson KW,Scherl EJ,Longman RS
47-0038-42 was used in flow cytometry to identify MNPs as metabolic sensors linking AIEC metabolism with intestinal inflammation and identify microbial metabolism as a potential therapeutic target in Crohn's disease treatment.
Wed Apr 14 00:00:00 EDT 2021
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells.
NPJ vaccines
Lee JH,Toy L,Kos JT,Safonova Y,Schief WR,Havenar-Daughton C,Watson CT,Crotty S
47-0038-42 was used in Flow cytometry/Cell sorting to find that IGHV1-2 alleles traditionally thought to be incompatible with VRC01-class responses are relatively common in various human populations and that germline variation within IGHV1-2 associates with gene usage frequencies in the naive BCR repertoire.
Mon Sep 06 00:00:00 EDT 2021
A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics.
Nature medicine
Langenberg MCC,Hoogerwerf MA,Koopman JPR,Janse JJ,Kos-van Oosterhoud J,Feijt C,Jochems SP,de Dood CJ,van Schuijlenburg R,Ozir-Fazalalikhan A,Manurung MD,Sartono E,van der Beek MT,Winkel BMF,Verbeek-Menken PH,Stam KA,van Leeuwen FWB,Meij P,van Diepen A,van Lieshout L,van Dam GJ,Corstjens PLAM,Hokke CH,Yazdanbakhsh M,Visser LG,Roestenberg M
47-0038 was used in Flow cytometry/Cell sorting to performed a dose-escalating clinical safety trial in 17 volunteers with male Schistosoma mansoni cercariae, which do not produce eggs (clinicaltrials.gov NCT02755324), at the Leiden University Medical Center, the Netherlands.
Sun Mar 01 00:00:00 EST 2020
Human umbilical cord-derived mesenchymal stem cells and human cord blood mononuclear cells protect against cisplatin-induced acute kidney injury in rat models.
Experimental and therapeutic medicine
Xu Q,Yan P,Duan XJ,Wu X,Chen XJ,Luo M,Peng JC,Feng LX,Liu J,Zhong HL,Cheng W,Zou QY,Duan SB
47-0038-42 was used in Flow Cytometry to determine the protective effects of hUCMSCs and hCBMNCs transplantation therapies on an established CP-induced rat model and explore their underlying mechanisms of action.
Tue Dec 01 00:00:00 EST 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
47-0038 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.
Oncoimmunology
Dajon M,Iribarren K,Petitprez F,Marmier S,Lupo A,Gillard M,Ouakrim H,Victor N,Vincenzo DB,Joubert PE,Kepp O,Kroemer G,Alifano M,Damotte D,Cremer I
47-0038 was used in Flow cytometry/Cell sorting to identify the role of TLR7 in the recruitment of myeloid derived suppressor cells resulting in accelerated tumor growth and metastasis in lung adenocarcinoma.
Tue Jan 12 00:00:00 EST 2021
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nature medicine
Trotta E,Bessette PH,Silveria SL,Ely LK,Jude KM,Le DT,Holst CR,Coyle A,Potempa M,Lanier LL,Garcia KC,Crellin NK,Rondon IJ,Bluestone JA
47-0038 was used in Flow cytometry/Cell sorting to suggest that IL-2-F5111.2 may provide an immunotherapy to treat autoimmune diseases and graft-versus-host disease.
Sun Jul 01 00:00:00 EDT 2018
Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting.
Cancer cell
Rotolo A,Caputo VS,Holubova M,Baxan N,Dubois O,Chaudhry MS,Xiao X,Goudevenou K,Pitcher DS,Petevi K,Kachramanoglou C,Iles S,Naresh K,Maher J,Karadimitris A
47-0038 was used in Flow cytometry/Cell sorting to investigate whether chimeric antigen receptor anti-CD19-engineering of the CD1d-restricted invariant natural killer T cells would result in enhanced anti-lymphoma activity.
Mon Oct 08 00:00:00 EDT 2018
Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.
The Journal of clinical investigation
Maffucci P,Chavez J,Jurkiw TJ,O'Brien PJ,Abbott JK,Reynolds PR,Worth A,Notarangelo LD,Felgentreff K,Cortes P,Boisson B,Radigan L,Cobat A,Dinakar C,Ehlayel M,Ben-Omran T,Gelfand EW,Casanova JL,Cunningham-Rundles C
47-0038 was used in Flow cytometry/Cell sorting to study the molecular, cellular, and clinical features of 5 patients from 3 kindreds with biallelic mutations in the autosomal LIG1 gene encoding DNA ligase 1.
Mon Dec 03 00:00:00 EST 2018
T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions.
Microbes and infection
Ogendi BMO,Bakshi RK,Gupta K,Kapil R,Brown LT,Jordan SJ,Sabbaj S,Press CG,Lee JY,Geisler WM
47-0038 was used in Flow cytometry/Cell sorting to evaluate differences in T cell phenotypes between Chlamydia trachomatis(CT)-infected women and CT-seronegative controls and investigate changes in T cell phenotype distributions after CT treatment and their association with reinfection.
Thu Mar 01 00:00:00 EST 2018
Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Zeppa JJ,Hancock MA,McCormick JK,Doherty TM,Hendy GN,Madrenas J
47-0038 was used in Flow cytometry/Cell sorting to identify the α2 subunit of the extracellular matrix protein laminin(LAMA2) acts as the coreceptor for staphylococcal superantigens.
Thu Feb 15 00:00:00 EST 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
47-0038-42 was used in Flow Cytometry to describe a protocol for generating functional T cells from Hoxb5-expressing B cells in vivo.
Sat Sep 01 00:00:00 EDT 2018
A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers.
mBio
Claireaux M,Galperin M,Benati D,Nouël A,Mukhopadhyay M,Klingler J,de Truchis P,Zucman D,Hendou S,Boufassa F,Moog C,Lambotte O,Chakrabarti LA
47-0038 was used in Flow cytometry/Cell sorting to suggest that T follicular help may contribute to HIV control and highlight the need for inducing such help in HIV vaccine strategies that aim at eliciting persistent B cell responses.
Tue May 08 00:00:00 EDT 2018
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.
Nature communications
Zhao M,Svensson MND,Venken K,Chawla A,Liang S,Engel I,Mydel P,Day J,Elewaut D,Bottini N,Kronenberg M
47-0038 was used in Flow cytometry/Cell sorting to study the effects of TCR signal strength during thymic differentiation on both IFN-γ production and the protective function of invariant natural killer T cells in arthritis.
Fri Jul 06 00:00:00 EDT 2018
Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation.
Immunity
Domínguez-Andrés J,Feo-Lucas L,Minguito de la Escalera M,González L,López-Bravo M,Ardavín C
47-0038 was used in Flow cytometry/Cell sorting to explore the role of inflammatory Ly6Chigh monocytes in natural killer cell-mediated neutrophil activation during the innate immune response against Candida albicans.
Tue Jun 20 00:00:00 EDT 2017
Staphylococcus aureus Downregulates IP-10 Production and Prevents Th1 Cell Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Levast B,Madrenas J
47-0038 was used in Flow cytometry/Cell sorting to study the mechanisms by which Staphylococcus aureus regulates the profile of superantigen-induced T cell recruitment.
Wed Mar 01 00:00:00 EST 2017
CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Seu L,Tidwell C,Timares L,Duverger A,Wagner FH,Goepfert PA,Westfall AO,Sabbaj S,Kutsch O
47-0038 was used in Flow cytometry/Cell sorting to demonstrate that CD151 in T cells is not a passive marker, but actively changed the cell cycle control and cell death process motifs of T cells.
Wed Nov 01 00:00:00 EDT 2017
DNA Vaccination by Electroporation Amplifies Broadly Cross-Restricted Public TCR Clonotypes Shared with HIV Controllers.
Journal of immunology (Baltimore, Md. : 1950)
Mukhopadhyay M,Galperin M,Patgaonkar M,Vasan S,Ho DD,Nouël A,Claireaux M,Benati D,Lambotte O,Huang Y,Chakrabarti LA
47-0038 was used in Flow cytometry/Cell sorting to provide the first proof-of-concept that clonotypic analysis may be used as a tool to monitor the quality of vaccine-induced responses and modulate these toward "controller-like" responses.
Wed Nov 15 00:00:00 EST 2017
Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women.
American journal of reproductive immunology (New York, N.Y. : 1989)
Ogendi BMO,Bakshi RK,Sabbaj S,Brown L,Lee JY,Kapil R,Geisler WM
47-0038 was used in Flow cytometry/Cell sorting to characterise the distinct peripheral and mucosal T-cell phenotypes in chlamydia-infected women.
Fri Dec 01 00:00:00 EST 2017
Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells.
PloS one
Zeng Y,Liu B,Rubio MT,Wang X,Ojcius DM,Tang R,Durrbach A,Ru Z,Zhou Y,Lone YC
47-0038 was used in Flow cytometry/Cell sorting to generate a novel immuno-deficient mouse strain expressing human HLA molecules instead of mouse MHC molecules.
Tue Sep 05 00:00:00 EDT 2017
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4⁺ T Cells.
Viruses
Tremblay-McLean A,Bruneau J,Lebouché B,Lisovsky I,Song R,Bernard NF
47-0038 was used in Flow cytometry/Cell sorting to characterise the expression profiles of ligands for activating natural killer cell receptors on HIV infected and uninfected CD4+ T cells.
Thu Oct 12 00:00:00 EDT 2017
Evidence for Resident Memory T Cells in Rasmussen Encephalitis.
Frontiers in immunology
Owens GC,Chang JW,Huynh MN,Chirwa T,Vinters HV,Mathern GW
47-0038 was used in Flow cytometry/Cell sorting to demonstrate that a cellular immune response to an as yet unidentified antigen(s) occurs at an early stage of Rasmussen encephalitis.
Fri Mar 04 00:00:00 EST 2016
Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.
Journal of virology
Eller MA,Goonetilleke N,Tassaneetrithep B,Eller LA,Costanzo MC,Johnson S,Betts MR,Krebs SJ,Slike BM,Nitayaphan S,Rono K,Tovanabutra S,Maganga L,Kibuuka H,Jagodzinski L,Peel S,Rolland M,Marovich MA,Kim JH,Michael NL,Robb ML,Streeck H
47-0038 was used in Flow cytometry/Cell sorting to offer the first immunologic evidence of CD8(+)T cell dysfunction during acute infection.
Fri Apr 01 00:00:00 EDT 2016
B cells from African American lupus patients exhibit an activated phenotype.
JCI insight
Menard LC,Habte S,Gonsiorek W,Lee D,Banas D,Holloway DA,Manjarrez-Orduno N,Cunningham M,Stetsko D,Casano F,Kansal S,Davis PM,Carman J,Zhang CK,Abidi F,Furie R,Nadler SG,Suchard SJ
47-0038 was used in Flow cytometry/Cell sorting to investigate immunological differences between African American and European American patients with systemic lupus erythematosus, showing that B cells from African American patients exhibit an activated phenotype.
Thu Jun 16 00:00:00 EDT 2016
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment.
PloS one
Hotta R,Ohira M,Matsuura T,Muraoka I,Tryphonopoulos P,Fan J,Tekin A,Selvaggi G,Levi D,Ruiz P,Ricordi C,Vianna R,Ohdan H,Waldmann H,Tzakis AG,Nishida S
47-0038 was used in Flow cytometry/Cell sorting to study the effects of the anti-CD52 monoclonal antibody, Alemtuzumab, on NK cell function.
Mon Aug 07 00:00:00 EDT 2017
Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsets.
PloS one
Wendt ER,Ferry H,Greaves DR,Keshav S
47-0038 was used in Flow cytometry/Cell sorting to describe a technique for monitoring calcium flux in both discrete and heterogeneous populations of primary cells, using a single calcium dye.
Tue Mar 15 00:00:00 EDT 2016
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
47-0038 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 EDT 2014
A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Robinet P,Baychelier F,Fontaine T,Picard C,Debré P,Vieillard V,Latgé JP,Elbim C
47-0038 was used in Flow cytometry/Cell sorting to demonstrate that crosstalk between polymorphonuclear neutrophils (PMN) and natural killer cells is essential to galactosaminogalactan-induced PMN apoptosis.
Sun Jun 01 00:00:00 EDT 2014
Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system.
Molecular therapy. Nucleic acids
Vogel R,Al-Daccak R,Drews O,Alonzeau J,Mester G,Charron D,Stevanovic S,Mallet J
47-0038 was used in Flow cytometry/Cell sorting to assess whether the rapamycin-inducible gene regulation system minimises the immune response.
Tue Feb 12 00:00:00 EST 2013
Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab.
Mucosal immunology
Bedoret D,Singh AK,Shaw V,Hoyte EG,Hamilton R,DeKruyff RH,Schneider LC,Nadeau KC,Umetsu DT
47-0038 was used in Flow cytometry/Cell sorting to investigate the immunological changes that occur in a group of children undergoing an allergen desensitisation protocol.
Tue May 01 00:00:00 EDT 2012
Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis.
Journal of immunological methods
Vicetti Miguel RD,Maryak SA,Cherpes TL
47-0038 was used in Flow cytometry/Cell sorting to compare the ability of brefeldin A and monensin to concurrently trap 4 cytokines within peripheral blood mononuclear cells.
Wed Oct 31 00:00:00 EDT 2012