Invitrogen

CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

74 Published Figures

70 References

View all (83) CD41 antibodies

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CD41a Antibody (11-0411-82) in Flow

Staining of C57BL/6 platelets with Anti-Mouse/Rat CD61 (Integrin beta 3) PE (Product # 12-0611-82) and 0.06 µg of Rat IgG1 K Isotype Control FITC (Product # 11-4301-82) (left) or 0.06 µg of Anti-Mouse CD41 FITC (right).

CD41a Antibody in Flow Cytometry, Peptide array (Flow, ARRAY)

CD41a Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD41a Antibody in Immunocytochemistry (ICC/IF)

CD41a Antibody in Immunohistochemistry (IHC)

Product Image Gallery

CD41a Antibody — Fig. 2 H 2 S treatment promotes generation of megakaryocytes/platelets in cultured fetal liver cells. a NaHS treatment caused a concentration-dependent increase in megakaryocytes which were identified as CD61-positive cells using flow cytometry in fetal liver cells isolated from WT mice. b Platelets were identified as CD41-positive and 7-AAD-negative signals using flow cytometry. Platelet counts were significantly increased with NaHS treatment at 50 and 100 mumol L -1 in the culture medium of fetal liver cells. TPO treatment (10 ng mL -1 ) also increased platelet counts. c Morphology of megakaryocytes in cultured fetal liver cells were shown with a confocal fluorescence microscopy with staining of DAPI, CD41-FITC, and CD61-PE. Scale bar = 50 mum. d Scanning electron microscopy revealed pseudopod formation ( blue arrow ) and membrane blebbing ( yellow arrow ) in the megakaryocytes identified in cultured fetal liver cells treated with NaHS (100 mumol L -1 ). Data in the graphs are means +- SEM. P values less than 0.05 represent statistical significance {TM}

Product Details

11-0411-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Flow Cytometry (Flow)

0.125 µg/test

View 52 publications 52 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Functional Assay (Functional)

View 1 publication 1 publication

Peptide Array (Array)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Hamster, Human, Mouse

Host/Isotype

Rat / IgG1, kappa

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

eBioMWReg30 (MWReg30)

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_763481

Product Specific Information

Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha Iib). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

Applications Reported: This eBioMWReg30 (MWReg30) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This eBioMWReg30 (MWReg30) antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps.

BMC immunology

Jiang M,Wu W,Xia Y,Wang X,Liang J

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Aug 09 00:00:00 EDT 2023

Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.

Nature communications

Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Thu Jul 27 00:00:00 EDT 2023

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.

Nature cell biology

Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E

11-0411-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.

Sun Jan 01 00:00:00 EST 2023

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.

Nature cell biology

Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E

11-0411-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.

Sun Jan 01 00:00:00 EST 2023

Myristica fragrans Extract Inhibits Platelet Desialylation and Activation to Ameliorate Sepsis-Associated Thrombocytopenia in a Murine CLP-Induced Sepsis Model.

International journal of molecular sciences

Jeong SH,Park JY,Ryu YB,Kim WS,Lee IC,Kim JH,Kim D,Ha JH,Lee BW,Nam J,Cho KO,Kwon HJ

11-0411-82 was used in Flow Cytometry to investigate the effects of Myristica fragrans ethanol extract (MF) on sepsis and SAT.

Tue May 16 00:00:00 EDT 2023

Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces.

Shock (Augusta, Ga.)

Arnold S,Shah SA,Cleary SJ,O'Shaughnessy BG,Amison RT,Arkless K,Page CP,Pitchford SC

11-0411-82 was used in Flow Cytometry to determine if whole RBCs or lysed RBCs administered to airways can induce an inflammatory response and to assess the importance of platelets in this response.

Sun Aug 01 00:00:00 EDT 2021

SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.

The Journal of biological chemistry

Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.

Developmental cell

Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS

11-0411-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.

Mon Jun 08 00:00:00 EDT 2020

All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia.

British journal of haematology

Tang D,Liu S,Sun H,Qin X,Zhou N,Zheng W,Zhang M,Zhou H,Tuersunayi A,Duan C,Chen J

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.

Frontiers in immunology

Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S

11-0411-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.

Mon Apr 19 00:00:00 EDT 2021

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Scientific reports

Shvartsman M,Bilican S,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Apr 23 00:00:00 EDT 2019

The role of platelets in mediating a response to human influenza infection.

Nature communications

Koupenova M,Corkrey HA,Vitseva O,Manni G,Pang CJ,Clancy L,Yao C,Rade J,Levy D,Wang JP,Finberg RW,Kurt-Jones EA,Freedman JE

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunocytochemistry

Tue Apr 16 00:00:00 EDT 2019

Pollen-derived RNAs Are Found in the Human Circulation.

iScience

Koupenova M,Mick E,Corkrey HA,Singh A,Tanriverdi SE,Vitseva O,Levy D,Keeler AM,Ezzaty Mirhashemi M,ElMallah MK,Gerstein M,Rozowsky J,Tanriverdi K,Freedman JE

11-0411 was used in Immunofluorescence to demonstrate that pollen-derived plant miRNAs can be horizontally transferred into the circulation via the pulmonary system in humans.

Fri Sep 27 00:00:00 EDT 2019

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.

Nature medicine

Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS

11-0411 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.

Fri Jun 01 00:00:00 EDT 2018

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Cell stem cell

Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H

11-0411 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.

Thu Apr 05 00:00:00 EDT 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

11-0411 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.

Tue Jan 02 00:00:00 EST 2018

Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels.

Development (Cambridge, England)

Zhang Y,Daubel N,Stritt S,Mäkinen T

Thu Feb 08 00:00:00 EST 2018

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nature communications

Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B

11-0411 was used in Flow cytometry/Cell sorting to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.

Tue May 15 00:00:00 EDT 2018

Differential cytokine contributions of perivascular haematopoietic stem cell niches.

Nature cell biology

Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunofluorescence

Wed Mar 01 00:00:00 EST 2017

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.

Developmental cell

Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH

11-0411 was used in Flow cytometry/Cell sorting to propose that Samd14-Enh and an ensemble of anemia-responsive enhancers are essential for erythrocyte regeneration in stress erythropoiesis.

Mon Aug 07 00:00:00 EDT 2017

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine

Nitulescu II,Meyer SC,Wen QJ,Crispino JD,Lemieux ME,Levine RL,Pelish HE,Shair MD

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

Cell reports

Mehta C,Johnson KD,Gao X,Ong IM,Katsumura KR,McIver SC,Ranheim EA,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Sep 19 00:00:00 EDT 2017

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.

Cell

Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Thu Nov 17 00:00:00 EST 2016

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Nature cell biology

Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E

11-0411 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.

Wed Jun 01 00:00:00 EDT 2016

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Molecular and cellular biology

Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Jan 15 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.

Scientific reports

Vargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Feb 19 00:00:00 EST 2016

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

EBioMedicine

Illendula A,Gilmour J,Grembecka J,Tirumala VSS,Boulton A,Kuntimaddi A,Schmidt C,Wang L,Pulikkan JA,Zong H,Parlak M,Kuscu C,Pickin A,Zhou Y,Gao Y,Mishra L,Adli M,Castilla LH,Rajewski RA,Janes KA,Guzman ML,Bonifer C,Bushweller JH

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Novel function of FAXDC2 in megakaryopoiesis.

Blood cancer journal

Jin Q,Ren Y,Wang M,Suraneni PK,Li D,Crispino JD,Fan J,Huang Z

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunocytochemistry

Thu Jun 02 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunocytochemistry

Thu Jun 02 00:00:00 EDT 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

The Journal of clinical investigation

Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID

11-0411 was used in Flow cytometry/Cell sorting to investigate the critical niche components and resident signals required for hematopoietic stem cell induction and self-renewal ex vivo.

Fri May 01 00:00:00 EDT 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

11-0411 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.

Tue Sep 01 00:00:00 EDT 2015

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

PloS one

Beaulieu LM,Clancy L,Tanriverdi K,Benjamin EJ,Kramer CD,Weinberg EO,He X,Mekasha S,Mick E,Ingalls RR,Genco CA,Freedman JE

11-0411 was used in Flow cytometry/Cell sorting to compare the effects of specific stimuli on platelet responses in ApoE-/- mice, showing that specific inflammatory stimuli cause distinct responses in both mice and humans.

Fri Mar 25 00:00:00 EDT 2016

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

PloS one

Beaulieu LM,Clancy L,Tanriverdi K,Benjamin EJ,Kramer CD,Weinberg EO,He X,Mekasha S,Mick E,Ingalls RR,Genco CA,Freedman JE

Fri Mar 25 00:00:00 EDT 2016

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Stem cell reports

Clarke RL,Robitaille AM,Moon RT,Keller G

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Aug 11 00:00:00 EDT 2015

CLEC-2 is required for development and maintenance of lymph nodes.

Blood

Bénézech C,Nayar S,Finney BA,Withers DR,Lowe K,Desanti GE,Marriott CL,Watson SP,Caamaño JH,Buckley CD,Barone F

11-0411 was used in Immunofluorescence to investigate the role that CLEC-2 plays in the development and maintenance of lymph nodes.

Thu May 15 00:00:00 EDT 2014

Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.

The EMBO journal

Li H,Yue R,Wei B,Gao G,Du J,Pei G

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Jun 17 00:00:00 EDT 2014

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

Arteriosclerosis, thrombosis, and vascular biology

Corken A,Russell S,Dent J,Post SR,Ware J

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Maresin 1 mitigates LPS-induced acute lung injury in mice.

British journal of pharmacology

Gong J,Wu ZY,Qi H,Chen L,Li HB,Li B,Yao CY,Wang YX,Wu J,Yuan SY,Yao SL,Shang Y

11-0411 was used in Flow cytometry/Cell sorting to demonstrate that high-dose MaR1 mitigates LPS-induced lung injury in mice by inhibiting neutrophil adhesions and decreasing pro-inflammatory cytokines levels.

Tue Jul 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.

Development (Cambridge, England)

Wilkinson AC,Kawata VK,Schütte J,Gao X,Antoniou S,Baumann C,Woodhouse S,Hannah R,Tanaka Y,Swiers G,Moignard V,Fisher J,Hidetoshi S,Tijssen MR,de Bruijn MF,Liu P,Göttgens B

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.

Stem cells (Dayton, Ohio)

Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.

Cell death & disease

Liu L,Wen Q,Gong R,Gilles L,Stankiewicz MJ,Li W,Guo M,Li L,Sun X,Li W,Crispino JD,Huang Z

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Thu Jan 09 00:00:00 EST 2014

Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells.

PloS one

Zhu J,Bi Z,Yang T,Wang W,Li Z,Huang W,Wang L,Zhang S,Zhou Y,Fan N,Bai Y,Song W,Wang C,Wang H,Bi Y

11-0411 was used in Flow cytometry/Cell sorting to investigate regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells.

Tue Sep 15 00:00:00 EDT 2015

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunofluorescence

Thu Nov 07 00:00:00 EST 2013

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunofluorescence

Thu Nov 07 00:00:00 EST 2013

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Immunofluorescence

Thu Nov 07 00:00:00 EST 2013

Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Cell

Yamamoto R,Morita Y,Ooehara J,Hamanaka S,Onodera M,Rudolph KL,Ema H,Nakauchi H

11-0411 was used in Flow cytometry/Cell sorting to identify multipotent progenitors of myeloid cells and study differentiation pathways giving rise to common myeloid cells.

Thu Aug 29 00:00:00 EDT 2013

Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.

PloS one

Faraday N,Schunke K,Saleem S,Fu J,Wang B,Zhang J,Morrell C,Dore S

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Mon Apr 14 00:00:00 EDT 2014

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

11-0411 was used in Flow cytometry/Cell sorting to identify a novel mutation in a GATA2 cis-element which causes deficits in haematopoietic stem/progenitor activity.

Mon Oct 01 00:00:00 EDT 2012

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

Stem cells (Dayton, Ohio)

Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2012

Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Du J,Wang J,Kong G,Jiang J,Zhang J,Liu Y,Tong W,Zhang J

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2012

Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.

Blood

Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY

11-0411 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.

Thu Aug 25 00:00:00 EDT 2011

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression.

Blood

Tzeng YS,Li H,Kang YL,Chen WC,Cheng WC,Lai DM

11-0411 was used in Immunofluorescence to elucidate the function of the chemokine, Cxcl12, in adult hematopoietic stem/progenitor cell (HSPC) regulation.

Thu Jan 13 00:00:00 EST 2011

ER71 directs mesodermal fate decisions during embryogenesis.

Development (Cambridge, England)

Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 11-0411-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2011

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Chou S,Lodish HF

11-0411 was used in Flow cytometry/Cell sorting to show that SCF(+)DLK(+) cells are highly homogenous, expressing a complete set of factors for hematopoietic stem cell (HSC) expansion and support HSC expansion in the fetal liver.

Tue Apr 27 00:00:00 EDT 2010

Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development.

Stem cell research & therapy

Ciriza J,García-Ojeda ME

11-0411 was used in Flow cytometry/Cell sorting to demonstrate that several genes are upregulated in the Lineage-Sca-1+c-Kit+ population in their transition to the bone marrow microenvironment.

Thu May 20 00:00:00 EDT 2010

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Bioinformatics

Protein Aliases: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb

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Gene Aliases: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b

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UniProt ID: (Mouse) Q9QUM0

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Entrez Gene ID: (Mouse) 16399

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Function(s)

identical protein binding metal ion binding extracellular matrix binding fibrinogen binding integrin

Process(es)

positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway platelet aggregation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), FITC, eBioscience™

CD41a Antibody (11-0411-82) in Flow

Product Details

11-0411-82

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