Invitrogen

CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), eFluor™ 450, eBioscience™

FIGURE: 1 / 74

CD41a Antibody (48-0411-82) in Flow

Staining of mouse platelets with Anti-Mouse/Rat CD61 (Integrin beta 3) PE (Product # 12-0611-82) and 0.25 µg of Rat IgG1 K Isotype Control eFluor® 450 (Product # 48-4301-82) (left) or 0.25 µg of Anti-Mouse CD41 eFluor® 450 (right). Total events were used for analysis.

CD41a Antibody in Immunocytochemistry (ICC/IF)

CD41a Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD41a Antibody in Immunohistochemistry (IHC)

CD41a Antibody in Flow Cytometry, Peptide array (Flow, ARRAY)

Product Image Gallery

Product Details

48-0411-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Flow Cytometry (Flow)

0.5 µg/test

View 41 publications 41 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Functional Assay (Functional)

View 2 publications 2 publications

Peptide Array (Array)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Hamster, Human, Mouse

Host/Isotype

Rat / IgG1, kappa

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), eFluor™ 450, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

eBioMWReg30 (MWReg30)

Conjugate

eFluor™ 450 eFluor™ 450 eFluor™ 450

Excitation/Emission Max

405/445 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1582238

Product Specific Information

Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

Applications Reported: This eBioMWReg30 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This eBioMWReg30 antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps.

BMC immunology

Jiang M,Wu W,Xia Y,Wang X,Liang J

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Aug 09 00:00:00 EDT 2023

Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.

Nature communications

Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Thu Jul 27 00:00:00 EDT 2023

PDGFRβ⁺ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny.

Cell reports

Sá da Bandeira D,Kilpatrick AM,Marques M,Gomez-Salazar M,Ventura T,Gonzalez ZN,Stefancova D,Rossi F,Vermeren M,Vink CS,Beltran M,Henderson NC,Jung B,van der Linden R,van de Werken HJG,van Ijcken WFJ,Betsholtz C,Forbes SJ,Cuervo H,Crisan M

48-0411-82 was used in Flow cytometry/Cell sorting to demonstrate that PDGFRβ+ cells play a dual role in murine hematopoiesis.

Tue Jul 19 00:00:00 EDT 2022

SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.

The Journal of biological chemistry

Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

Cell reports

Azzoni E,Frontera V,Anselmi G,Rode C,James C,Deltcheva EM,Demian AS,Brown J,Barone C,Patelli A,Harman JR,Nicholls M,Conway SJ,Morrissey E,Jacobsen SEW,Sparrow DB,Harris AL,Enver T,de Bruijn MFTR

48-0411-82 was used in Immunocytochemistry-immunoflourescence to investigate how and when the onset of circulation affects Hematopoietic stem cells emergence.

Tue Dec 14 00:00:00 EST 2021

All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia.

British journal of haematology

Tang D,Liu S,Sun H,Qin X,Zhou N,Zheng W,Zhang M,Zhou H,Tuersunayi A,Duan C,Chen J

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

Platelets Fuel the Inflammasome Activation of Innate Immune Cells.

Cell reports

Rolfes V,Ribeiro LS,Hawwari I,Böttcher L,Rosero N,Maasewerd S,Santos MLS,Próchnicki T,Silva CMS,Wanderley CWS,Rothe M,Schmidt SV,Stunden HJ,Bertheloot D,Rivas MN,Fontes CJ,Carvalho LH,Cunha FQ,Latz E,Arditi M,Franklin BS

48-0411-82 was used in Flow Cytometry to conclude that platelets provide an additional layer of regulation of inflammasomes and IL-1-driven inflammation.

Tue May 12 00:00:00 EDT 2020

The endothelial protein C receptor plays an essential role in the maintenance of pregnancy.

Science advances

Castillo MM,Yang Q,Sigala AS,McKinney DT,Zhan M,Chen KL,Jarzembowski JA,Sood R

48-0411 was used in Flow cytometry/Cell sorting to investigate the role of thrombotic processes in Placenta-mediated pregnancy complications,.

Sun Nov 01 00:00:00 EDT 2020

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Scientific reports

Shvartsman M,Bilican S,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Apr 23 00:00:00 EDT 2019

The role of platelets in mediating a response to human influenza infection.

Nature communications

Koupenova M,Corkrey HA,Vitseva O,Manni G,Pang CJ,Clancy L,Yao C,Rade J,Levy D,Wang JP,Finberg RW,Kurt-Jones EA,Freedman JE

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunocytochemistry

Tue Apr 16 00:00:00 EDT 2019

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.

Nature medicine

Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunofluorescence

Fri Jun 01 00:00:00 EDT 2018

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Cell stem cell

Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H

48-0411 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.

Thu Apr 05 00:00:00 EDT 2018

Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels.

Development (Cambridge, England)

Zhang Y,Daubel N,Stritt S,Mäkinen T

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunofluorescence

Thu Feb 08 00:00:00 EST 2018

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

Differential cytokine contributions of perivascular haematopoietic stem cell niches.

Nature cell biology

Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunofluorescence

Wed Mar 01 00:00:00 EST 2017

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine

Nitulescu II,Meyer SC,Wen QJ,Crispino JD,Lemieux ME,Levine RL,Pelish HE,Shair MD

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.

PloS one

Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M

48-0411 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.

Tue Sep 26 00:00:00 EDT 2017

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.

Cell

Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Thu Nov 17 00:00:00 EST 2016

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Molecular and cellular biology

Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Jan 15 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.

Scientific reports

Vargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Feb 19 00:00:00 EST 2016

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

EBioMedicine

Illendula A,Gilmour J,Grembecka J,Tirumala VSS,Boulton A,Kuntimaddi A,Schmidt C,Wang L,Pulikkan JA,Zong H,Parlak M,Kuscu C,Pickin A,Zhou Y,Gao Y,Mishra L,Adli M,Castilla LH,Rajewski RA,Janes KA,Guzman ML,Bonifer C,Bushweller JH

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Novel function of FAXDC2 in megakaryopoiesis.

Blood cancer journal

Jin Q,Ren Y,Wang M,Suraneni PK,Li D,Crispino JD,Fan J,Huang Z

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunocytochemistry

Thu Jun 02 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunocytochemistry

Thu Jun 02 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunocytochemistry

Thu Jun 02 00:00:00 EDT 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

48-0411 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Blood

Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J

48-0411 was used in Flow cytometry/Cell sorting to identify a novel role for Pak2 as an important regulator of megakaryopoiesis, polyploidization and cytoskeletal mechanics in developing megakaryocytes.

Thu May 07 00:00:00 EDT 2015

FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.

Development (Cambridge, England)

Fleury M,Eliades A,Carlsson P,Lacaud G,Kouskoff V

48-0411 was used in Flow cytometry/Cell sorting to investigate the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.

Thu Oct 01 00:00:00 EDT 2015

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

PloS one

Beaulieu LM,Clancy L,Tanriverdi K,Benjamin EJ,Kramer CD,Weinberg EO,He X,Mekasha S,Mick E,Ingalls RR,Genco CA,Freedman JE

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Stem cell reports

Clarke RL,Robitaille AM,Moon RT,Keller G

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Aug 11 00:00:00 EDT 2015

Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.

The EMBO journal

Li H,Yue R,Wei B,Gao G,Du J,Pei G

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Jun 17 00:00:00 EDT 2014

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

Arteriosclerosis, thrombosis, and vascular biology

Corken A,Russell S,Dent J,Post SR,Ware J

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.

PLoS pathogens

Nacer A,Movila A,Sohet F,Girgis NM,Gundra UM,Loke P,Daneman R,Frevert U

48-0411 was used in Immunofluorescence to show that significantly more CD8(+) T cells, neutrophils, and macrophages are recruited to postcapillary venules during ECM compared to hyperparasitemia.

Mon Dec 01 00:00:00 EST 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.

Development (Cambridge, England)

Wilkinson AC,Kawata VK,Schütte J,Gao X,Antoniou S,Baumann C,Woodhouse S,Hannah R,Tanaka Y,Swiers G,Moignard V,Fisher J,Hidetoshi S,Tijssen MR,de Bruijn MF,Liu P,Göttgens B

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.

European journal of immunology

Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG

48-0411 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.

Sun Jun 01 00:00:00 EDT 2014

Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.

Stem cells (Dayton, Ohio)

Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.

Cell death & disease

Liu L,Wen Q,Gong R,Gilles L,Stankiewicz MJ,Li W,Guo M,Li L,Sun X,Li W,Crispino JD,Huang Z

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Thu Jan 09 00:00:00 EST 2014

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunofluorescence

Thu Nov 07 00:00:00 EST 2013

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Immunofluorescence

Thu Nov 07 00:00:00 EST 2013

Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.

PloS one

Faraday N,Schunke K,Saleem S,Fu J,Wang B,Zhang J,Morrell C,Dore S

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Apr 14 00:00:00 EDT 2014

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Neuroimmunological blood brain barrier opening in experimental cerebral malaria.

PLoS pathogens

Nacer A,Movila A,Baer K,Mikolajczak SA,Kappe SH,Frevert U

48-0411 was used in in vivo experiments to better understand disease progression in experimental cerebral malaria.

Thu Apr 04 00:00:00 EDT 2013

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

Stem cells (Dayton, Ohio)

Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2012

Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Du J,Wang J,Kong G,Jiang J,Zhang J,Liu Y,Tong W,Zhang J

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2012

ER71 directs mesodermal fate decisions during embryogenesis.

Development (Cambridge, England)

Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 48-0411-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2011

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.

Blood

Nieswandt B,Echtenacher B,Wachs FP,Schröder J,Gessner JE,Schmidt RE,Grau GE,Männel DN

Thu Jul 15 00:00:00 EDT 1999

Bioinformatics

Protein Aliases: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb

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Gene Aliases: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b

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UniProt ID: (Mouse) Q9QUM0

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Entrez Gene ID: (Mouse) 16399

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Function(s)

identical protein binding metal ion binding extracellular matrix binding fibrinogen binding integrin

Process(es)

positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway platelet aggregation

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CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), eFluor™ 450, eBioscience™

CD41a Antibody (48-0411-82) in Flow

Product Details

48-0411-82

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Functional Assay (Functional)

Peptide Array (Array)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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