Invitrogen

CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

64 Published Figures

52 References

View all (83) CD41 antibodies

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CD41a Antibody (12-0411-82) in Flow

Staining of mouse platelets with Anti-Mouse/Rat CD61 (Integrin beta 3) FITC (Product # 11-0611-82) and 0.06 µg of Rat IgG1 K Isotype Contol PE (Product # 12-4301-82) (left) or 0.06 µg of Anti-Mouse CD41 PE (right). Total events were used for analysis.

Product Image Gallery

CD41a Antibody — Figure 2 TGFbeta treatment during BL-CFC culture favours the vascular lineage over the haematopoietic one. ( A ) Experimental workflow of the quantitative secretome analysis by LC-MS/MS. ( B ) Flow cytometry analysis of VE-Cad and CD41 expression after 6 hours of culture following the addition of TGFbeta2 compared to control condition. Upper panel shows one representative example of flow cytometry analysis while the bottom one shows a bar graph representing the average frequency of the EC (VE-Cad + CD41 - ) and HPC (VE-Cad - CD41 + ) populations from 3 independent experiments. The p-values were calculated with Student's t-test (2 tails, type 3). EC population: **Control versus TGFbeta2 p-value = 0.004 (n = 3); HPC population: *Control versus TGFbeta2 p-value = 0.03 (n = 3). ( C ) Heatmap representing Log 2 fold change (Log 2 FC) of protein expression between TGFbeta2 treated and non-treated samples for all the proteins detected in the 3 biological replicates. Each column represents one independent secretome experiment. ( D ) STRING representation of a network involving the proteins detected in C. Nine proteins out of 33 were not part of the network. Different line colours represent the types of evidence for the association between proteins. {TM}

Product Details

12-0411-82

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

0.125 µg/test

View 48 publications 48 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG1, kappa

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

eBioMWReg30 (MWReg30)

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_763485

Product Specific Information

Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

Applications Reported: This eBioMWReg30 (MWReg30) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This eBioMWReg30 (MWReg30) antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps.

BMC immunology

Jiang M,Wu W,Xia Y,Wang X,Liang J

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Aug 09 00:00:00 EDT 2023

Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.

Nature communications

Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu Jul 27 00:00:00 EDT 2023

SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.

The Journal of biological chemistry

Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

12-0411 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.

Mon May 11 00:00:00 EDT 2020

Platelet Dysfunction and Thrombosis in JAK2^V617F-Mutated Primary Myelofibrotic Mice.

Arteriosclerosis, thrombosis, and vascular biology

Matsuura S,Thompson CR,Belghasem ME,Bekendam RH,Piasecki A,Leiva O,Ray A,Italiano J,Yang M,Merill-Skoloff G,Chitalia VC,Flaumenhaft R,Ravid K

12-0411 was used in Flow cytometry/Cell sorting to examine the propensity for thrombosis, as well as platelet activation properties in a mouse model of primary myelofibrosis induced by JAK2V617F mutation.

Thu Oct 01 00:00:00 EDT 2020

All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia.

British journal of haematology

Tang D,Liu S,Sun H,Qin X,Zhou N,Zheng W,Zhang M,Zhou H,Tuersunayi A,Duan C,Chen J

12-0411-82 was used in Immunohistochemistry (Frozen) to show that ATRA was an effective agent to improve AA treatment outcomes.

Tue Dec 01 00:00:00 EST 2020

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Scientific reports

Shvartsman M,Bilican S,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Apr 23 00:00:00 EDT 2019

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.

Epigenetics & chromatin

Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM

Mon May 28 00:00:00 EDT 2018

Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.

Molecular therapy : the journal of the American Society of Gene Therapy

Debnath S,Jaako P,Siva K,Rothe M,Chen J,Dahl M,Gaspar HB,Flygare J,Schambach A,Karlsson S

12-0411 was used in Flow cytometry/Cell sorting to assess the efficacy of the human elongation factor 1α short promoter with or without the locus control region of the Β-globin gene for treatment of ribosomal protein S19-deficient Diamond-Blackfan anaemia.

Wed Aug 02 00:00:00 EDT 2017

A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice.

Haematologica

Cañete A,Carmona R,Ariza L,Sánchez MJ,Rojas A,Muñoz-Chápuli R

12041182 was used in flow cytometry to utilize a G2-Gata4Cre;R26REYFP mouse line to track the developmental fate of the G2-Gata4 cell lineage

Sat Apr 01 00:00:00 EDT 2017

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.

Development (Cambridge, England)

Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M

12-0411 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.

Wed Mar 15 00:00:00 EDT 2017

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine

Nitulescu II,Meyer SC,Wen QJ,Crispino JD,Lemieux ME,Levine RL,Pelish HE,Shair MD

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.

Cell

Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu Nov 17 00:00:00 EST 2016

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Molecular and cellular biology

Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Jan 15 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.

Scientific reports

Vargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C

12-0411 was used in Flow cytometry/Cell sorting to assess the contribution of transforming growth factor-beta 1 signalling in key haematological developmental processes during embryogenesis.

Fri Feb 19 00:00:00 EST 2016

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

EBioMedicine

Illendula A,Gilmour J,Grembecka J,Tirumala VSS,Boulton A,Kuntimaddi A,Schmidt C,Wang L,Pulikkan JA,Zong H,Parlak M,Kuscu C,Pickin A,Zhou Y,Gao Y,Mishra L,Adli M,Castilla LH,Rajewski RA,Janes KA,Guzman ML,Bonifer C,Bushweller JH

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Novel function of FAXDC2 in megakaryopoiesis.

Blood cancer journal

Jin Q,Ren Y,Wang M,Suraneni PK,Li D,Crispino JD,Fan J,Huang Z

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu Jun 02 00:00:00 EDT 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

12-0411 was used in Immunofluorescence to demonstrate it's possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.

Cell reports

Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K

12-0411 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.

Tue Jul 26 00:00:00 EDT 2016

Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.

British journal of pharmacology

Hwaiz R,Rahman M,Zhang E,Thorlacius H

12-0411 was used in Immunofluorescence to investigate whether platelet-derived CXCL4 might support pulmonary neutrophilia in abdominal sepsis, showing that secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage.

Sun Nov 01 00:00:00 EDT 2015

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1.

eLife

Zhou BO,Ding L,Morrison SJ

12-0411-82 was used in Immunocytochemistry to assess the expression and function of Angiopoietin-1 in bone marrow.

Mon Mar 30 00:00:00 EDT 2015

FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.

Development (Cambridge, England)

Fleury M,Eliades A,Carlsson P,Lacaud G,Kouskoff V

12-0411 was used in Flow cytometry/Cell sorting to investigate the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.

Thu Oct 01 00:00:00 EDT 2015

Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury.

Journal of leukocyte biology

Hwaiz R,Rahman M,Syk I,Zhang E,Thorlacius H

12-0411 was used in Immunofluorescence to assess the role of platelet-derived CCL5 in facilitating sepsis-induced neutrophil accumulation in the lung.

Fri May 01 00:00:00 EDT 2015

Platelets are relevant mediators of renal injury induced by primary endothelial lesions.

American journal of physiology. Renal physiology

Schwarzenberger C,Sradnick J,Lerea KM,Goligorsky MS,Nieswandt B,Hugo CP,Hohenstein B

12-0411 was used in Flow cytometry/Cell sorting to assess the abilities of various modified platelets to undergo relevant activation after the induction of selective endothelial injury.

Mon Jun 01 00:00:00 EDT 2015

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

PloS one

Beaulieu LM,Clancy L,Tanriverdi K,Benjamin EJ,Kramer CD,Weinberg EO,He X,Mekasha S,Mick E,Ingalls RR,Genco CA,Freedman JE

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Stem cell reports

Clarke RL,Robitaille AM,Moon RT,Keller G

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Aug 11 00:00:00 EDT 2015

Endothelial C-type natriuretic peptide maintains vascular homeostasis.

The Journal of clinical investigation

Moyes AJ,Khambata RS,Villar I,Bubb KJ,Baliga RS,Lumsden NG,Xiao F,Gane PJ,Rebstock AS,Worthington RJ,Simone MI,Mota F,Rivilla F,Vallejo S,Peiró C,Sánchez Ferrer CF,Djordjevic S,Caulfield MJ,MacAllister RJ,Selwood DL,Ahluwalia A,Hobbs AJ

12-0411 was used in Flow cytometry/Cell sorting to evaluate mice with endothelial-specific deletion of C-type natriuretic peptide (CNP), showing that it is essential for multiple aspects of vascular regulation.

Mon Sep 01 00:00:00 EDT 2014

Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.

The EMBO journal

Li H,Yue R,Wei B,Gao G,Du J,Pei G

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Jun 17 00:00:00 EDT 2014

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

Arteriosclerosis, thrombosis, and vascular biology

Corken A,Russell S,Dent J,Post SR,Ware J

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.

Development (Cambridge, England)

Wilkinson AC,Kawata VK,Schütte J,Gao X,Antoniou S,Baumann C,Woodhouse S,Hannah R,Tanaka Y,Swiers G,Moignard V,Fisher J,Hidetoshi S,Tijssen MR,de Bruijn MF,Liu P,Göttgens B

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.

Stem cells (Dayton, Ohio)

Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.

Cell death & disease

Liu L,Wen Q,Gong R,Gilles L,Stankiewicz MJ,Li W,Guo M,Li L,Sun X,Li W,Crispino JD,Huang Z

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu Jan 09 00:00:00 EST 2014

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.

Nature medicine

Shi L,Cui S,Engel JD,Tanabe O

12-0411 was used in Flow cytometry/Cell sorting to examine the effect of lysine-specific demethylase 1 inhibition on the expression of foetal γ-globin.

Fri Mar 01 00:00:00 EST 2013

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Thu Nov 07 00:00:00 EST 2013

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.

Blood

Brancaleone V,Gobbetti T,Cenac N,le Faouder P,Colom B,Flower RJ,Vergnolle N,Nourshargh S,Perretti M

12-0411 was used in Flow cytometry/Cell sorting to study the involvement of formyl peptide receptor 2 in postischemia reperfusion injury.

Thu Jul 25 00:00:00 EDT 2013

Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.

PloS one

Faraday N,Schunke K,Saleem S,Fu J,Wang B,Zhang J,Morrell C,Dore S

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Mon Apr 14 00:00:00 EDT 2014

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

The Journal of experimental medicine

Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM

12-0411 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.

Mon Jun 04 00:00:00 EDT 2012

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

Stem cells (Dayton, Ohio)

Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2012

Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Du J,Wang J,Kong G,Jiang J,Zhang J,Liu Y,Tong W,Zhang J

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2012

The transcriptional programme controlled by Runx1 during early embryonic blood development.

Developmental biology

Tanaka Y,Joshi A,Wilson NK,Kinston S,Nishikawa S,Göttgens B

12-0411 was used in Flow cytometry/Cell sorting to analyse the transcriptional programme controlled by a key haematopoietic regulator during the process of early blood cell specification.

Fri Jun 15 00:00:00 EDT 2012

Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.

Blood

Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S

12-0411 was used in Flow cytometry/Cell sorting to demonstrate the feasibility of transgenic RNA interference to generate models for diseases caused by haploinsufficient expression of a gene.

Thu Dec 01 00:00:00 EST 2011

ER71 directs mesodermal fate decisions during embryogenesis.

Development (Cambridge, England)

Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ

Published figure using CD41a monoclonal antibody (Product # 12-0411-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2011

Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels.

BMC cell biology

Schniedermann J,Rennecke M,Buttler K,Richter G,Städtler AM,Norgall S,Badar M,Barleon B,May T,Wilting J,Weich HA

12-0411 was used in Flow cytometry/Cell sorting to evaluate the differentiation capacity of resident lung endothelial progenitor cells from mice.

Thu Jul 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb

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Gene Aliases: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b

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UniProt ID: (Mouse) Q9QUM0

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Entrez Gene ID: (Mouse) 16399

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Function(s)

identical protein binding metal ion binding extracellular matrix binding fibrinogen binding integrin

Process(es)

positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway platelet aggregation

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE, eBioscience™

CD41a Antibody (12-0411-82) in Flow

Product Details

12-0411-82

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

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Excitation/Emission Max

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