Invitrogen

CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE-Cyanine7, eBioscience™

FIGURE: 1 / 67

CD41a Antibody (25-0411-82) in Flow

Staining of mouse platelets with Anti-Mouse CD61 PE (Product # 12-0611-82) and 0.25 µg of Anti-Mouse CD41 PE-Cyanine7.

Product Image Gallery

Product Details

25-0411-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.5 µg/test

View 48 publications 48 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG1, kappa

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), PE-Cyanine7, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

eBioMWReg30 (MWReg30)

Conjugate

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

Excitation/Emission Max

569/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1234970

Product Specific Information

Description: The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

Applications Reported: This eBioMWReg30 (MWReg30) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This eBioMWReg30 (MWReg30) antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps.

BMC immunology

Jiang M,Wu W,Xia Y,Wang X,Liang J

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Wed Aug 09 00:00:00 EDT 2023

Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.

Nature communications

Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu Jul 27 00:00:00 EDT 2023

A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification.

Nature communications

Edginton-White B,Maytum A,Kellaway SG,Goode DK,Keane P,Pagnuco I,Assi SA,Ames L,Clarke M,Cockerill PN,Göttgens B,Cazier JB,Bonifer C

25-0411-82 was used in Flow cytometry/Cell sorting to provide an important resource for studies of hematopoietic specification and highlights the mechanisms of how and where extrinsic signals program a cell type-specific chromatin landscape driving hematopoietic differentiation.

Tue Jan 17 00:00:00 EST 2023

Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis.

Nature cardiovascular research

Su M,Chen C,Li S,Li M,Zeng Z,Zhang Y,Xia L,Li X,Zheng D,Lin Q,Fan X,Wen Y,Liu Y,Chen F,Luo W,Bu Y,Qin J,Guo M,Qiu M,Sun L,Liu R,Wang P,Hwa J,Tang WH

25-0411-82 was used in Flow cytometry/Cell sorting to demonstrate a requirement for GSDMD in triggering platelet pyroptosis in cecal ligation and puncture (CLP)-induced sepsis.

Tue Aug 16 00:00:00 EDT 2022

SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.

The Journal of biological chemistry

Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.

iScience

Gabriely G,Ma D,Siddiqui S,Sun L,Skillin NP,Abou-El-Hassan H,Moreira TG,Donnelly D,da Cunha AP,Fujiwara M,Walton LR,Patel A,Krishnan R,Levine SS,Healy BC,Rezende RM,Murugaiyan G,Weiner HL

25-0411-82 was used in Flow cytometry/Cell sorting to identify a previously unknown function by which LAPHi MCs promote tumor growth and offer therapeutic intervention to target these cells in cancer.

Fri Nov 19 00:00:00 EST 2021

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research

Woods B,Chen W,Chiu S,Marinaccio C,Fu C,Gu L,Bulic M,Yang Q,Zouak A,Jia S,Suraneni PK,Xu K,Levine RL,Crispino JD,Wen QJ

25-0411 was used in Flow cytometry/Cell sorting to study the role of JAK/STAT signalling in megakaryocyte myeloproliferation.

Tue Oct 01 00:00:00 EDT 2019

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Scientific reports

Shvartsman M,Bilican S,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Apr 23 00:00:00 EDT 2019

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Epigenetics & chromatin

Gilmour J,O'Connor L,Middleton CP,Keane P,Gillemans N,Cazier JB,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Epigenetics & chromatin

Gilmour J,O'Connor L,Middleton CP,Keane P,Gillemans N,Cazier JB,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.

eLife

Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Mar 20 00:00:00 EDT 2018

The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification.

Scientific reports

Gilmour J,Assi SA,Noailles L,Lichtinger M,Obier N,Bonifer C

25-0411 was used in Flow cytometry/Cell sorting to investigate how the expression of a single transcription factor can drive the rapid and replication-independent transitions in cellular shape.

Tue Jul 10 00:00:00 EDT 2018

LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.

Nucleic acids research

Stanulovic VS,Cauchy P,Assi SA,Hoogenkamp M

25-0411 was used in Flow cytometry/Cell sorting to show that Lmo2-/- mouse embryonic stem cells differentiated to Flk-1+ haemangioblasts, but less efficiently to haemogenic endothelium.

Fri Sep 29 00:00:00 EDT 2017

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine

Nitulescu II,Meyer SC,Wen QJ,Crispino JD,Lemieux ME,Levine RL,Pelish HE,Shair MD

Fri Dec 01 00:00:00 EST 2017

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.

EBioMedicine

Nitulescu II,Meyer SC,Wen QJ,Crispino JD,Lemieux ME,Levine RL,Pelish HE,Shair MD

Fri Dec 01 00:00:00 EST 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.

Cell

Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu Nov 17 00:00:00 EST 2016

Probing chromatin landscape reveals roles of endocardial TBX20 in septation.

The Journal of clinical investigation

Boogerd CJ,Aneas I,Sakabe N,Dirschinger RJ,Cheng QJ,Zhou B,Chen J,Nobrega MA,Evans SM

25-0411 was used in Flow cytometry/Cell sorting to investigate how TBX30 interacts with endocardial gene networks to drive the mesenchymal and myocardial movements essential for outflow tract and atrioventricular septation.

Mon Aug 01 00:00:00 EDT 2016

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1.

Cell death and differentiation

Watson EC,Whitehead L,Adams RH,Dewson G,Coultas L

25-0411 was used in Flow cytometry/Cell sorting to investigate the in vivo role of myeloid cell leukaemia 1 (MCL1) in endothelial cell survival during angiogenesis.

Mon Aug 01 00:00:00 EDT 2016

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Molecular and cellular biology

Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Jan 15 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.

Scientific reports

Vargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Feb 19 00:00:00 EST 2016

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

EBioMedicine

Illendula A,Gilmour J,Grembecka J,Tirumala VSS,Boulton A,Kuntimaddi A,Schmidt C,Wang L,Pulikkan JA,Zong H,Parlak M,Kuscu C,Pickin A,Zhou Y,Gao Y,Mishra L,Adli M,Castilla LH,Rajewski RA,Janes KA,Guzman ML,Bonifer C,Bushweller JH

25-0411 was used in Flow cytometry/Cell sorting to investigate whether targeting RUNX proteins could have broad utility in cancer therapeutics.

Wed Jun 01 00:00:00 EDT 2016

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

EBioMedicine

25-0411 was used in Flow cytometry/Cell sorting to investigate whether targeting RUNX proteins could have broad utility in cancer therapeutics.

Wed Jun 01 00:00:00 EDT 2016

Novel function of FAXDC2 in megakaryopoiesis.

Blood cancer journal

Jin Q,Ren Y,Wang M,Suraneni PK,Li D,Crispino JD,Fan J,Huang Z

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu Jun 02 00:00:00 EDT 2016

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.

Journal of hematology & oncology

Liu HD,Zhang AJ,Xu JJ,Chen Y,Zhu YC

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Wed Feb 24 00:00:00 EST 2016

FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.

Development (Cambridge, England)

Fleury M,Eliades A,Carlsson P,Lacaud G,Kouskoff V

25-0411 was used in Flow cytometry/Cell sorting to investigate the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.

Thu Oct 01 00:00:00 EDT 2015

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.

Biology open

Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE

25041182 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.

Fri May 15 00:00:00 EDT 2015

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Nature communications

Regha K,Assi SA,Tsoulaki O,Gilmour J,Lacaud G,Bonifer C

25-0411 was used in Flow cytometry/Cell sorting to study the differentiation of mouse embryonic stem cells, expressing an inducible RUNX1-ETO gene, into blood cells.

Thu May 28 00:00:00 EDT 2015

Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

PloS one

Beaulieu LM,Clancy L,Tanriverdi K,Benjamin EJ,Kramer CD,Weinberg EO,He X,Mekasha S,Mick E,Ingalls RR,Genco CA,Freedman JE

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Stem cell reports

Clarke RL,Robitaille AM,Moon RT,Keller G

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Aug 11 00:00:00 EDT 2015

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.

Nature medicine

Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA

25-0411 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.

Wed Oct 01 00:00:00 EDT 2014

Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis.

The EMBO journal

Li H,Yue R,Wei B,Gao G,Du J,Pei G

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Tue Jun 17 00:00:00 EDT 2014

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

Arteriosclerosis, thrombosis, and vascular biology

Corken A,Russell S,Dent J,Post SR,Ware J

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this.

Development (Cambridge, England)

Liakhovitskaia A,Rybtsov S,Smith T,Batsivari A,Rybtsova N,Rode C,de Bruijn M,Buchholz F,Gordon-Keylock S,Zhao S,Medvinsky A

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.

Development (Cambridge, England)

Wilkinson AC,Kawata VK,Schütte J,Gao X,Antoniou S,Baumann C,Woodhouse S,Hannah R,Tanaka Y,Swiers G,Moignard V,Fisher J,Hidetoshi S,Tijssen MR,de Bruijn MF,Liu P,Göttgens B

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.

Stem cells (Dayton, Ohio)

Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN.

Cell death & disease

Liu L,Wen Q,Gong R,Gilles L,Stankiewicz MJ,Li W,Guo M,Li L,Sun X,Li W,Crispino JD,Huang Z

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu Jan 09 00:00:00 EST 2014

A directional switch of integrin signalling and a new anti-thrombotic strategy.

Nature

Shen B,Zhao X,O'Brien KA,Stojanovic-Terpo A,Delaney MK,Kim K,Cho J,Lam SC,Du X

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Thu Nov 07 00:00:00 EST 2013

Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.

PloS one

Faraday N,Schunke K,Saleem S,Fu J,Wang B,Zhang J,Morrell C,Dore S

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Mon Apr 14 00:00:00 EDT 2014

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.

Blood

Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W

25-0411 was used in Flow cytometry/Cell sorting to investigate the potential for SIRT1 as a therapeutic target for CML treatment to overcome resistance.

Thu Feb 23 00:00:00 EST 2012

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.

Stem cells (Dayton, Ohio)

Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ

25-0411 was used in Flow cytometry/Cell sorting to define the role of Ets variant gene 2 in yolk sac haematopoeisis in mice.

Wed Aug 01 00:00:00 EDT 2012

Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.

Stem cells (Dayton, Ohio)

Du J,Wang J,Kong G,Jiang J,Zhang J,Liu Y,Tong W,Zhang J

Published figure using CD41a monoclonal antibody (Product # 25-0411-82) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2012

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

The Journal of experimental medicine

Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK

25-0411 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.

Mon Mar 14 00:00:00 EDT 2011

ER71 directs mesodermal fate decisions during embryogenesis.

Development (Cambridge, England)

Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ

25-0411 was used in Flow cytometry/Cell sorting to further define the functional role for ER71 in cell lineage decisions using genetically modified mouse models.

Tue Nov 01 00:00:00 EDT 2011

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Blood

Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE

25-0411 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.

Thu Jun 17 00:00:00 EDT 2010

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells.

Stem cells (Dayton, Ohio)

Zhang H,Fraser ST,Papazoglu C,Hoatlin ME,Baron MH

25-0411 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of Mixl1-mediated transcriptional regulation.

Tue Dec 01 00:00:00 EST 2009

Bioinformatics

Protein Aliases: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb

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Gene Aliases: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b

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UniProt ID: (Mouse) Q9QUM0

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Entrez Gene ID: (Mouse) 16399

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Function(s)

identical protein binding metal ion binding extracellular matrix binding fibrinogen binding integrin

Process(es)

positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway platelet aggregation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE-Cyanine7, eBioscience™

CD41a Antibody (25-0411-82) in Flow

Product Details

25-0411-82

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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