Product References
Loss of Lkb1 in CD11c+ myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance.
Cellular and molecular life sciences : CMLS
Sun Y,Wang B,Hu Q,Zhang H,Lai X,Wang T,Zhao C,Wang J,Zhang X,Niu Q,He B,Jiang E,Shi M,Feng X,Luo Y
12-5773-82 was used in Flow cytometry/Cell sorting to reveal that Lkb1 is essential for fat CD11c+ dendritic cells responding to HFD exposure and provides new insights into the IL-17A/IFN-γ balance in HFD-induced obesity.
Mon Feb 13 00:00:00 EST 2023
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming.
Nature communications
Aso K,Kono M,Kanda M,Kudo Y,Sakiyama K,Hisada R,Karino K,Ueda Y,Nakazawa D,Fujieda Y,Kato M,Amengual O,Atsumi T
12-5773-82 was used in Flow cytometry/Cell sorting to indicate that itaconate is a crucial metabolic regulator for Th17/Treg cell balance and could be a potential therapeutic agent for autoimmune diseases.
Mon Feb 27 00:00:00 EST 2023
Therapeutic potential of FLT4-targeting peptide in acute myeloid leukemia.
Cancer immunology, immunotherapy : CII
Lee JY,Park S,Han AR,Hwang HS,Kim HJ
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic value of functionally modulating lymphocytes using a peptide targeting FLT4 and proposed the development of advanced therapeutic approaches against AML by using immune cells.
Fri Sep 01 00:00:00 EDT 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that TRAF6 deletion or MALT1 paracaspase inactivation are highly interdependent in causing the distinct immune pathologies.
Mon Feb 13 00:00:00 EST 2023
Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake.
Scientific reports
Kasuya T,Tanaka S,Tamura J,Etori K,Shoda J,Hattori K,Endo Y,Kitajima M,Kageyama T,Iwamoto T,Yokota M,Iwata A,Suto A,Suzuki K,Suzuki H,Ziegler SF,Nakajima H
12-5773-82 was used in Flow cytometry/Cell sorting to show that TSLP modulates the activation status of induced Treg through the enhanced uptake of fatty acids to maintain homeostasis in the large intestine.
Mon Jan 30 00:00:00 EST 2023
Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions.
Clinical immunology (Orlando, Fla.)
Liu P,Hou G,Kuang Y,Li L,Chen C,Yan B,Zhu W,Li J,Chen M,Su J,Lin L,Chen X,Peng C
12-5773-82 was used in Flow cytometry/Cell sorting to reveal implication of C1P pathway in psoriatic skin lesions: enriched in CC1 subtype, augments expression of inflammatory factors and activates primary keratinocytes.
Sun Jan 01 00:00:00 EST 2023
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Neurology(R) neuroimmunology & neuroinflammation
Gupta S,Simic M,Sagan SA,Shepherd C,Duecker J,Sobel RA,Dandekar R,Wu GF,Wu W,Pak JE,Hauser SL,Lim W,Wilson MR,Zamvil SS
12-5773-82 was used in Flow cytometry/Cell sorting to observe that anti-CD19 CAR-T cells ameliorated experimental autoimmune encephalomyelitis and thoroughly deplete B cells in peripheral tissues and in the CNS.
Wed Mar 01 00:00:00 EST 2023
Microbiota-assisted iron uptake promotes immune tolerance in the intestine.
Nature communications
Zhu L,Li G,Liang Z,Qi T,Deng K,Yu J,Peng Y,Zheng J,Song Y,Chang X
12-5773-82 was used in Flow cytometry/Cell sorting to reveal an association between nutrient uptake and immune tolerance in the intestine.
Mon May 15 00:00:00 EDT 2023
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.
Cellular & molecular immunology
Lau P,Zhang G,Zhao S,Liang L,Zhang H,Zhou G,Hung MC,Chen X,Liu H
12-5773-82 was used in Flow cytometry/Cell sorting to reveal a novel role for SPHK1 in tumor evasion mediated by regulating the MTA3-PD-L1 axis, identified SPHK1 and MTA3 as predictors for assessing the efficacy of PD-1 mAb treatment, and provided a therapeutic possibility for the treatment of melanoma patients.
Sat Oct 01 00:00:00 EDT 2022
Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice.
Current microbiology
Tang T,Wang F,Liu J,Ye W,Zhao T,Li Z
12-5773-82 was used in Flow Cytometry to show that rhubarb promoted Alistipes, Clostridium, and Lactobacillus proliferation, increased the HDAC6 concentration, restored the Th17/Treg cell balance, and protected against acute lung injury.
Sat Feb 26 00:00:00 EST 2022
SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models.
Clinical & translational immunology
Synn CB,Kim SE,Lee HK,Kim MH,Kim JH,Lee JM,Jo HN,Lee W,Kim DK,Byeon Y,Kim YS,Yun MR,Park CW,Yun J,Lim S,Heo SG,Yang SD,Lee EJ,Lee S,Choi H,Lee YW,Cho JS,Kim DH,Park S,Kim JH,Choi Y,Lee SS,Ahn BC,Kim CG,Lim SM,Hong MH,Kim HR,Pyo KH,Cho BC
12-5773-82 was used in Flow Cytometry to evaluate the anti-tumor and anti-metastatic activities of SKI-G-801, a small-molecule inhibitor of AXL, alone and in combination with anti-PD-1 therapy.
Fri Apr 29 00:00:00 EDT 2022
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.
Oncoimmunology
Sommer A,Berndt S,Lerchen HG,Forveille S,Sauvat A,Mumberg D,Kroemer G,Kepp O
12-5773-82 was used in Flow Cytometry to conclude that the antineoplastic effects of TWEAKR-KSPi-ADCs can partly be attributed to its ICD-stimulatory properties.
Fri Apr 08 00:00:00 EDT 2022
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype.
Journal of hematology & oncology
Su Y,Sun X,Liu X,Qu Q,Yang L,Chen Q,Liu F,Li Y,Wang Q,Huang B,Huang XJ,Zhang XH
12-5773-82 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect and potential mechanisms of hUC-EVs-ATO in a mouse model of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (HSCT).
Thu Jul 21 00:00:00 EDT 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Cancer immunology research
Fedoriw A,Shi L,O'Brien S,Smitheman KN,Wang Y,Hou J,Sherk C,Rajapurkar S,Laraio J,Williams LJ,Xu C,Han G,Feng Q,Bedford MT,Wang L,Barbash O,Kruger RG,Hwu P,Mohammad HP,Peng W
12-5773-82 was used in Flow cytometry/Cell sorting to indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade to induce durable antitumor responses in a T cell-dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
Fri Apr 01 00:00:00 EDT 2022
Non-lethal rodent malarial infection prevents collagen-induced arthritis in mice via anti-arthritic immunomodulation.
Parasite immunology
Gaballah EM,Morita K,Shimizu S,Elhenawy AA,Nabih N,Elsawey AM,Abdel-Mageed SA,Osada Y
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that experimental malarial infection alleviated autoimmune arthritis via immunomodulation, suggesting the importance of malaria in the hygiene hypothesis and the significance of searching for therapeutic immunomodulatory molecules from malarial parasites.
Sat Jan 01 00:00:00 EST 2022
Quantitative increase in T regulatory cells enhances bone remodeling in osteogenesis imperfecta.
iScience
Kang IH,Baliga UK,Chatterjee S,Chakraborty P,Choi S,Buchweitz N,Li H,Wu Y,Yao H,Mehrotra S,Mehrotra M
12-5773-82 was used in Flow cytometry/Cell sorting to investigate regulatory T cells in osteogenesis imperfecta.
Fri Sep 16 00:00:00 EDT 2022
Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy.
Biomedicines
Liu W,Chen H,Zhu Z,Liu Z,Ma C,Lee YJ,Bartlett DL,Guo ZS
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that erastin can exert cytotoxicity on cancer cells via ferroptosis, but has little effect on immune activity by itself.
Wed Jun 15 00:00:00 EDT 2022
PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1+CD8+ Terminal Effector T Cells and Promotes Cancer Development.
Journal of immunology (Baltimore, Md. : 1950)
Zheng Y,Chen Z,Zhou B,Chen S,Han L,Chen N,Ma Y,Xie G,Yang J,Nie H,Shen L
12-5773-82 was used in Flow cytometry/Cell sorting to validate the importance of targeting PRMT5 in tumor treatment, because PRMT5 deficiency enforced Klrg1+ terminal CD8+ T cell development and eliminated antitumor activity.
Sat Jan 15 00:00:00 EST 2022
Enhancing the therapeutic efficacy of programmed death ligand 1 antibody for metastasized liver cancer by overcoming hepatic immunotolerance in mice.
Hepatology (Baltimore, Md.)
Xin B,Yang M,Wu P,Du L,Deng X,Hui E,Feng GS
12-5773-82 was used in Flow cytometry/Cell sorting to show that the success of a combinatorial immunotherapy relies on coordinated inhibition or activation of various innate and adaptive immune cell activities.
Thu Sep 01 00:00:00 EDT 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
12-5773-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma.
Nature communications
Zhang S,Li Y,Sun S,Liu L,Mu X,Liu S,Jiao M,Chen X,Chen K,Ma H,Li T,Liu X,Wang H,Zhang J,Yang J,Zhang XD
12-5773-82 was used in Flow cytometry/Cell sorting to develop single-atom nanozymes of RhN4, VN4, and Fe-Cu-N6 with catalytic activities surpassing natural enzymes.
Fri Aug 12 00:00:00 EDT 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
12-5773-82 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
12-5773-82 was used in Flow Cytometry to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.
Mon Aug 01 00:00:00 EDT 2022
Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors.
Journal for immunotherapy of cancer
Potluri HK,Ferreira CA,Grudzinski J,Massey C,Aluicio-Sarduy E,Engle JW,Kwon O,Marsh IR,Bednarz BP,Hernandez R,Weichert JP,McNeel DG
12-5773-82 was used in Flow cytometry/Cell sorting to suggest that the combination of 90Y-NM600 TRT and PD-1 blockade therapy is ineffective in these prostate cancer models due to the activating effect of anti-PD-1 on Tregs.
Mon Aug 01 00:00:00 EDT 2022
Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing.
Clinical and translational medicine
Hoover AR,Liu K,DeVette CI,Krawic JR,Medcalf AD,West CL,Hode T,Lam SSK,Welm AL,Sun XH,Hildebrand WH,Chen WR
12-5773-82 was used in Flow cytometry/Cell sorting to reveal that localized ablative immunotherapy (LAIT) prompts immunological remodelling of T cells by inducing broad proinflammatory responses and inhibiting suppressive signalling to drive antitumour immunity.
Fri Jul 01 00:00:00 EDT 2022
A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte.
Cell regeneration (London, England)
Chen D,Xu Z,Cui J,Chen T
12-5773-82 was used in Flow cytometry/Cell sorting to describe a vitiligo mouse model which recapitulates key clinical features of vitiligo, including epidermis depigmentation, CD8 + T cell infiltration in skin, and melanocyte loss.
Sun Oct 02 00:00:00 EDT 2022
Accumulation of pTreg cells is detrimental in late-onset (aged) mouse model of multiple sclerosis.
Aging cell
Wang W,Thomas R,Oh J,Su DM
12-5773-82 was used in Flow cytometry/Cell sorting to provide evidence and mechanism that accumulated aged pTreg cells play a detrimental role in neuronal inflammation of aged multiple sclerosis.
Wed Jun 01 00:00:00 EDT 2022
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Zhang Y,Li F,Chen C,Li Y,Xie W,Huang D,Zhai X,Yu W,Wan J,Li P
12-5773-82 was used in Flow cytometry/Cell sorting to show that sRAGE can serve as a novel immunometabolic modulator that ameliorates ischemic stroke recovery by inhibiting fatty acid synthesis and thus favoring CD4+ T cells polarization toward Treg after cerebral ischemia injury.
Wed Jun 01 00:00:00 EDT 2022
Populations of NK Cells and Regulatory T Cells in the Endometrium of Cycling Mares-A Preliminary Study.
Animals : an open access journal from MDPI
Jaworska J,de Mestre AM,Wiśniewska J,Wagner B,Nowicki A,Kowalczyk-Zięba I,Wocławek-Potocka I
12-5773-82 was used in Flow cytometry/Cell sorting to show, for the first time, the presence of CD4+FOXP3+CD25+ Tregs and CD3-NKp46+ NK cells in the endometrium of non-pregnant cycling mares.
Wed Nov 30 00:00:00 EST 2022
Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice.
Genomics, proteomics & bioinformatics
Li M,Guo W,Dong Y,Wang W,Tian C,Zhang Z,Yu T,Zhou H,Gui Y,Xue K,Li J,Jiang F,Sarapultsev A,Wang H,Zhang G,Luo S,Fan H,Hu D
12-5773-82 was used in Flow cytometry/Cell sorting to provide the strong evidence that CSR may be a promising therapeutic drug for UC.
Fri Apr 01 00:00:00 EDT 2022
Neoantigen cancer vaccine augments anti-CTLA-4 efficacy.
NPJ vaccines
Salvatori E,Lione L,Compagnone M,Pinto E,Conforti A,Ciliberto G,Aurisicchio L,Palombo F
12-5773-82 was used in Flow Cytometry to support the use of NCV delivered by DNA-EP with αCTLA-4 and suggest a new combined therapy for clinical testing.
Wed Feb 02 00:00:00 EST 2022
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.
BMC pharmacology & toxicology
Yang Y,Song S,Nie Y,Chen R,Chen P
12-5773-82 was used in Flow Cytometry to demonstrate that lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.
Tue Mar 22 00:00:00 EDT 2022
Controlling Herpes Simplex Virus-Induced Immunoinflammatory Lesions Using Metabolic Therapy: a Comparison of 2-Deoxy-d-Glucose with Metformin.
Journal of virology
Berber E,Rouse BT
12-5773-82 was used in Flow cytometry/Cell sorting to support the value of metabolic reprogramming to control viral immunoinflammatory lesions, but the approach used should be chosen with caution.
Wed Jul 27 00:00:00 EDT 2022
Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction.
STAR protocols
Harada Y,Miyamoto K,Sujino T
12-5773-82 was used in Flow cytometry/Cell sorting to present an approach that can induce more CD4+CD8αα+ T cells by artificially creating a hypoxic environment in vitro.
Fri Dec 16 00:00:00 EST 2022
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
International journal of molecular sciences
El-Hindi K,Brachtendorf S,Hartel JC,Oertel S,Birod K,Merz N,Trautmann S,Thomas D,Weigert A,Schäufele TJ,Scholich K,Schiffmann S,Ulshöfer T,Utermöhlen O,Grösch S
12-5773-82 was used in Immunohistochemistry to show that CerS4 knockdown plays an important role in colitis and CAC, and sheds light on the effect of CerS4 on the T-cell signaling pathway.
Mon Feb 07 00:00:00 EST 2022
PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome-Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice.
Investigative ophthalmology & visual science
Guo X,Dang W,Li N,Wang Y,Sun D,Nian H,Wei R
12-5773-82 was used in Flow cytometry/Cell sorting to show that fenofibrate potently attenuated LG inflammation in a model of autoimmune dry eye, and this effect might partially result from regulating Th1/Th17/Treg cell responses by activating PPAR-α/LXR-β signaling.
Wed Jun 01 00:00:00 EDT 2022
Liangxue Tongyu Prescription Alleviates Brain Damage in Acute Intracerebral Hemorrhage Rats by Regulating Intestinal Mucosal Barrier Function.
Evidence-based complementary and alternative medicine : eCAM
Zhou Y,Zhang Z,Sun Y,Zhou D,Zhao Y,Li J,Guo W
12-5773-82 was used in Flow cytometry/Cell sorting to show that LTP can effectively reduce the degree of brain damage in AICH rats, and the mechanism may be that it can play a neuroprotective role by regulating the function of the intestinal mucosal barrier.
Tue Jan 03 00:00:00 EST 2023
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Cell
Marangoni F,Zhakyp A,Corsini M,Geels SN,Carrizosa E,Thelen M,Mani V,Prüßmann JN,Warner RD,Ozga AJ,Di Pilato M,Othy S,Mempel TR
12-5773-82 was used in Flow cytometry/Cell sorting to conclude that Treg cells self-regulate through a CTLA-4- and CD28-dependent feedback loop that adjusts their population size to the amount of local co-stimulation.
Thu Jul 22 00:00:00 EDT 2021
Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.
Signal transduction and targeted therapy
Gao Y,Bi D,Xie R,Li M,Guo J,Liu H,Guo X,Fang J,Ding T,Zhu H,Cao Y,Xing M,Zheng J,Xu Q,Xu Q,Wei Q,Qin H
12-5773-82 was used in Flow Cytometry to study the effect of Fusobacterium nucleatum on anti-PD-L1 therapy in colorectal cancer.
Fri Nov 19 00:00:00 EST 2021
Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats.
Brain, behavior, and immunity
Loupy KM,Cler KE,Marquart BM,Yifru TW,D'Angelo HM,Arnold MR,Elsayed AI,Gebert MJ,Fierer N,Fonken LK,Frank MG,Zambrano CA,Maier SF,Lowry CA
12-5773-82 was used in Flow Cytometry to support the hypothesis that treatment with different M. vaccae strains may immunize the host against stress-induced dysregulation of physiology and behavior.
Fri Jan 01 00:00:00 EST 2021
Dynamic changes in the systemic immune responses of spinal cord injury model mice.
Neural regeneration research
Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B
12-5773 was used in Flow cytometry/Cell sorting to decipher the dynamics of systemic immune responses, initiated by spinal cord injury.
Mon Feb 01 00:00:00 EST 2021
CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.
Molecular medicine reports
Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J
12-5773-82 was used in Flow Cytometry to elucidate whether overexpressed C‚X‚C motif chemokine receptor 3 affects regulatory T cells and consequently reduces renal ischemia‚reperfusion injury.
Thu Jul 01 00:00:00 EDT 2021
Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.
Experimental and therapeutic medicine
Zhang Y,Wang L,Li X,Geng J
12-5773-82 was used in Flow Cytometry to study the immunomodulatory mechanisms of brain damage caused by HHcy in Wistar-Kyoto rats.
Sat May 01 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-5773-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects.
iScience
Cheng G,Hardy M,Topchyan P,Zander R,Volberding P,Cui W,Kalyanaraman B
12-5773-82 was used in Flow Cytometry to substitute the hydroxyl group in HU with a triphenylphosphonium cation attached to an alkyl group with different chain lengths, forming a new class of mitochondria-targeted HU (Mito-HU).
Fri Jun 25 00:00:00 EDT 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
12-5773-82 was used in Flow Cytometry to identify disease-relevant regulators of T cell fate by examining mutations that modify risk for multiple sclerosis.
Tue Aug 24 00:00:00 EDT 2021
Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells.
Scientific reports
Mizumaki K,Horii M,Kano M,Komuro A,Matsushita T
12-5773-82 was used in Flow Cytometry to investigate the role of regulator B-cells in interleukin-23-mediated psoriasis-like inflammation in mice.
Fri Jan 22 00:00:00 EST 2021
Fine-tuning of antigen-specific immune responses by regulatory T cells activated via antigen recognition-independent and humoral factor-dependent mechanisms.
Scandinavian journal of immunology
Kojima H,Kashiwakura Y,Kanno Y,Hashiguchi M,Kobata T
12-5773-82 was used in Flow cytometry/Cell sorting to suggest that Tregs are activated by cytokines, mainly IL-2, released from T cells that are activated by a specific antigen.
Tue Jun 01 00:00:00 EDT 2021
Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy.
Science advances
Alsaiari SK,Qutub SS,Sun S,Baslyman W,Aldehaiman M,Alyami M,Almalik A,Halwani R,Merzaban J,Mao Z,Khashab NM
12-5773-82 was used in Flow Cytometry to envisage that such a biocompatible and biodegradable immunotherapeutic delivery system may promote the development and the translation of hybrid superstructures into smart and personalized delivery platforms.
Fri Jan 01 00:00:00 EST 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
12-5773-82 was used in Flow Cytometry to enable the design of strategies to target the IDO1 and AHR pathways for enhancing anti-tumor immunity in ovarian cancer.
Fri Oct 29 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
12-5773-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
12-5773-82 was used in Flow Cytometry to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.
Mon Dec 13 00:00:00 EST 2021
CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade.
Cancers
Vackova J,Polakova I,Johari SD,Smahel M
12-5773-82 was used in Flow Cytometry to conclude that the immunosuppressive role of tumor-cell-expressed CD80 should be considered in research into biomarkers for the prediction of cancer patients' sensitivity to immune checkpoint inhibitors and for the development of a tumor-cell-specific CD80 blockade.
Fri Apr 16 00:00:00 EDT 2021
Evaluation of tumor immunity after administration of conditionally replicative adenoviral vector in canine osteosarcoma patients.
Heliyon
Agarwal P,Gammon EA,Sandey M,Lindley SS,Koehler JW,Matz BM,Smith AN,Kashentseva EA,Dmitriev IP,Curiel DT,Smith BF
12-5773-82 was used in Flow Cytometry to propose that OC-CAVE1 (CAV2 with the E1A promoter replaced with the osteocalcin promotor) may also enhance existing immunity against tumors by overcoming immune tolerance via exposure of new epitopes and cytokine signaling.
Mon Feb 01 00:00:00 EST 2021
IFNγ-Producing γ/δ T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation.
Frontiers in immunology
Lewis EL,Tulina N,Anton L,Brown AG,Porrett PM,Elovitz MA
12-5773-82 was used in Flow Cytometry to investigates how inflammation transverses across multiple anatomic compartments from the maternal reproductive tract to the fetal brain and what specific cell types in the fetal brain may cause long-term neuronal injury.
Wed Jan 05 00:00:00 EST 2022
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
12-5773-82 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
Nature communications
Liu Y,Debo B,Li M,Shi Z,Sheng W,Shi Y
12-5773-82 was used in Flow Cytometry to demonstrate that histone demethylase LSD1 acts to enforce an epigenetic program in progenitor exhausted CD8+ T cells to antagonize the TCF1-mediated progenitor maintenance and to promote terminal differentiation.
Wed Nov 24 00:00:00 EST 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
12-5773 was used in Flow cytometry/Cell sorting to test a hypothesis that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease-like brain β-amyloid (Aβ) pathology.
Sat May 01 00:00:00 EDT 2021
A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19.
bioRxiv : the preprint server for biology
Brumeanu TD,Vir P,Karim AF,Kar S,Benetiene D,Lok M,Greenhouse J,Putmon-Taylor T,Kitajewski C,Chung KK,Pratt KP,Casares SA
12-5773-82 was used in Immunohistochemistry to develop a novel pre-clinical mouse model to study COVID-19 immunopathology.
Fri Jan 29 00:00:00 EST 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
12-5773-82 was used in Flow cytometry/Cell sorting to assess the sphingosine-1-phosphate receptor modulator fingolimod as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendations.
Tue Jun 01 00:00:00 EDT 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
12-5773 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y
12-5773 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.
Mon Feb 01 00:00:00 EST 2021
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Zhou J,Lu Y,Wu W,Feng Y
12-5773-82 was used in Flow Cytometry to show that the restoration of Treg populations by taurine normalizes the inflammatory response, reduces AR symptomology, and reduces histopathologic signs of AR.
Sat Jun 19 00:00:00 EDT 2021
Photothermal therapy combined with neoantigen cancer vaccination for effective immunotherapy against large established tumors and distant metastasis.
Advanced therapeutics
Nam J,Son S,Park KS,Moon JJ
12-5773-82 was used in Flow cytometry/Cell sorting to conclude that PTT combined with neoantigen cancer vaccine is a promising nano-immunotherapy for personalized therapy of advanced cancer.
Sun Aug 01 00:00:00 EDT 2021
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
12-5773-82 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
Myocardial infarction accelerates breast cancer via innate immune reprogramming.
Nature medicine
Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,Jones LW,Moore KJ
12-5773 was used in Flow cytometry/Cell sorting to show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. I.
Tue Sep 01 00:00:00 EDT 2020
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Immunity
Śledzińska A,Vila de Mucha M,Bergerhoff K,Hotblack A,Demane DF,Ghorani E,Akarca AU,Marzolini MAV,Solomon I,Vargas FA,Pule M,Ono M,Seddon B,Kassiotis G,Ariyan CE,Korn T,Marafioti T,Lord GM,Stauss H,Jenner RG,Peggs KS,Quezada SA
12-5773 was used in Flow cytometry/Cell sorting to underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4+ T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation.
Tue Jan 14 00:00:00 EST 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-5773 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Combined Prebiotic and Microbial Intervention Improves Oral Cholera Vaccination Responses in a Mouse Model of Childhood Undernutrition.
Cell host & microbe
Di Luccia B,Ahern PP,Griffin NW,Cheng J,Guruge JL,Byrne AE,Rodionov DA,Leyn SA,Osterman AL,Ahmed T,Colonna M,Barratt MJ,Delahaye NF,Gordon JI
12-5773-82 was used in Flow Cytometry to provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.
Wed Jun 10 00:00:00 EDT 2020
Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice.
Allergy
Hirata SI,Nagatake T,Sawane K,Hosomi K,Honda T,Ono S,Shibuya N,Saito E,Adachi J,Abe Y,Isoyama J,Suzuki H,Matsunaga A,Tomonaga T,Kiyono H,Kabashima K,Arita M,Kunisawa J
12-5773 was used in Flow cytometry/Cell sorting to suggest that an inhibitory mechanism in infant skin allergy is induced through maternal metabolism of dietary ω3 polyunsaturated fatty acids in mice.
Sat Aug 01 00:00:00 EDT 2020
Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease.
Haematologica
Matsuoka S,Hashimoto D,Kadowaki M,Ohigashi H,Hayase E,Yokoyama E,Hasegawa Y,Tateno T,Chen X,Aoyama K,Oka H,Onozawa M,Takeda K,Akashi K,Teshima T
12-5773 was used in Flow cytometry/Cell sorting to identify that donor T-cell MyD88/interleukin-1-receptor associated kinase 4 pathway as a potential novel therapeutic target against graft-versus host disease after allo-SCT.
Wed Jan 01 00:00:00 EST 2020
Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice.
Aging cell
Runyan CE,Welch LC,Lecuona E,Shigemura M,Amarelle L,Abdala-Valencia H,Joshi N,Lu Z,Nam K,Markov NS,McQuattie-Pimentel AC,Piseaux-Aillon R,Politanska Y,Sichizya L,Watanabe S,Williams KJN,Budinger GRS,Sznajder JI,Misharin AV
12-5773 was used in Flow cytometry/Cell sorting to suggest that a loss of phagocytic function in a CX3CR1+ tissue-resident skeletal muscle macrophage population in old mice precludes satellite cell proliferation and recovery of skeletal muscle function after influenza A pneumonia.
Tue Sep 01 00:00:00 EDT 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
12-5773 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 EDT 2020
Heparin affects the induction of regulatory T cells independent of anti-coagulant activity and suppresses allogeneic immune responses.
Clinical and experimental immunology
Kashiwakura Y,Kojima H,Kanno Y,Hashiguchi M,Kobata T
12-5773-82 was used in Flow Cytometry to analyse the effect of heparin on regulatory T cells in allogenic immune responses.
Thu Oct 01 00:00:00 EDT 2020
High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.
European journal of nutrition
Magnuson AM,Regan DP,Booth AD,Fouts JK,Solt CM,Hill JL,Dow SW,Foster MT
12-5773-82 was used in Flow Cytometry to investigate if lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.
Mon Jun 01 00:00:00 EDT 2020
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Integrative cancer therapies
Takaku S,Shimizu M,Takahashi H
12-5773-82 was used in Flow cytometry/Cell sorting to indicate that in the absence of NKT cells, JTT augments antitumor immunity by CD8+ T cells, suggesting that this Kampo medicine is a promising anticancer adjuvant when negative immune regulation is partially relieved.
Mon Mar 23 00:00:00 EDT 2020
Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis.
Iranian journal of basic medical sciences
Ge N,Peng J,Yu L,Huang S,Xu L,Su Y,Chen L
12-5773 was used in Flow cytometry/Cell sorting to investigate the regulation of Th17 and Treg cells in orthodontic tooth movement during periodontal inflammation.
Thu Oct 01 00:00:00 EDT 2020
NK and T Cell Differentiation at the Maternal-Fetal Interface in Sows During Late Gestation.
Frontiers in immunology
Stas MR,Koch M,Stadler M,Sawyer S,Sassu EL,Mair KH,Saalmüller A,Gerner W,Ladinig A
12-5773-82 was used in Flow Cytometry to investigate the immune cell phenotype on late gestation in pigs.
Tue Jun 22 00:00:00 EDT 2021
Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.
eLife
Domingo-Gonzalez R,Zanini F,Che X,Liu M,Jones RC,Swift MA,Quake SR,Cornfield DN,Alvira CM
12-5773 was used in Flow cytometry/Cell sorting to present an atlas of the murine lung immune compartment during early postnatal development.
Tue Jun 02 00:00:00 EDT 2020
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Aging
Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W
12-5773 was used in Flow cytometry/Cell sorting to provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.
Fri Jan 24 00:00:00 EST 2020
IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils.
Oncoimmunology
Kienzl M,Hasenoehrl C,Valadez-Cosmes P,Maitz K,Sarsembayeva A,Sturm E,Heinemann A,Kargl J,Schicho R
12-5773 was used in Flow cytometry/Cell sorting to emphasize the potential use of IL-33 as an adjuvants in CRC immunotherapy.
Tue Jun 16 00:00:00 EDT 2020
Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis.
Cell reports
Yu AI,Zhao L,Eaton KA,Ho S,Chen J,Poe S,Becker J,Gonzalez A,McKinstry D,Hasso M,Mendoza-Castrejon J,Whitfield J,Koumpouras C,Schloss PD,Martens EC,Chen GY
12-5773 was used in Flow cytometry/Cell sorting to suggest that microbial dysbiosis can contribute to colon tumor susceptibility by hyperstimulating CD8 T cells to promote chronic inflammation and early T cell exhaustion, which can reduce anti-tumor immunity.
Tue Apr 07 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
12-5773-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses.
Cell reports
Nadafi R,Gago de Graça C,Keuning ED,Koning JJ,de Kivit S,Konijn T,Henri S,Borst J,Reijmers RM,van Baarsen LGM,Mebius RE
12-5773-82 was used in Flow Cytometry to uncover the ability of LNSCs to suppress the early activation of autoreactive immune cells and maintain peripheral tolerance.
Tue Mar 24 00:00:00 EDT 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
12-5773 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
12-5773 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 EDT 2020
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
12-5773 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury.
Aging
Luo Y,Wang B,Liu J,Ma F,Luo D,Zheng Z,Lu Q,Zhou W,Zheng Y,Zhang C,Wang Q,Sha W,Chen H
12-5773 was used in Flow cytometry/Cell sorting to show ginsenoside RG1 enhances paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury.
Thu Dec 03 00:00:00 EST 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
12-5773 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 EST 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
12-5773 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 EDT 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
12-5773 was used in Flow cytometry/Cell sorting to show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism.
Fri Jul 24 00:00:00 EDT 2020
Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation.
PloS one
Zhang A,Paidassi H,Lacy-Hulbert A,Savill J
12-5773-82 was used in Flow Cytometry to study the role of apoptotic cells arising spontaneously in the healthy mouse gut in inducing the CD103+ immunoregulatory phenotype in dendritic cells migrating to mesenteric lymph nodes.
Tue Sep 08 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
12-5773 was used in Flow cytometry/Cell sorting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response.
Parasites & vectors
Xiao J,Guan F,Sun L,Zhang Y,Zhang X,Lu S,Liu W
12-5773-82 was used in Flow Cytometry to show that Schistosoma japonicum infection modulates the differentiation of B cell subsets that have the capability to affect the CD4+ T cell response.
Fri Mar 20 00:00:00 EDT 2020
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
12-5773 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.
Mon Jun 14 00:00:00 EDT 2021
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.
Nature
Bénéchet AP,De Simone G,Di Lucia P,Cilenti F,Barbiera G,Le Bert N,Fumagalli V,Lusito E,Moalli F,Bianchessi V,Andreata F,Zordan P,Bono E,Giustini L,Bonilla WV,Bleriot C,Kunasegaran K,Gonzalez-Aseguinolaza G,Pinschewer DD,Kennedy PTF,Naldini L,Kuka M,Ginhoux F,Cantore A,Bertoletti A,Ostuni R,Guidotti LG,Iannacone M
12-5773 was used in Flow cytometry/Cell sorting to show that priming by Kupffer cells, which are not natural targets of hepatitis B, leads to differentiation of CD8+ T cells into effector cells that form dense, extravascular clusters of immotile cells scattered throughout the liver.
Tue Oct 01 00:00:00 EDT 2019
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
12-5773-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.
Wed May 01 00:00:00 EDT 2019
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Immunity
Chun E,Lavoie S,Fonseca-Pereira D,Bae S,Michaud M,Hoveyda HR,Fraser GL,Gallini Comeau CA,Glickman JN,Fuller MH,Layden BT,Garrett WS
12-5773 was used in Flow cytometry/Cell sorting to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.
Tue Nov 19 00:00:00 EST 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
12-5773-82 was used in Flow Cytometry to show ROP16III in type III strain Toxoplasma gondii can influence the subacute CNS immune response and mediate parasitic survival and persistence.
Tue Oct 01 00:00:00 EDT 2019
Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.
Molecular medicine (Cambridge, Mass.)
Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ
12-5773 was used in Flow cytometry/Cell sorting to study the effects of fimasartan on neointimal formation and systemic inflammation following carotid artery injury.
Mon Jul 15 00:00:00 EDT 2019
Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.
The American journal of Chinese medicine
Li Q,Shan Q,Sang X,Zhu R,Chen X,Cao G
12-5773 was used in Flow cytometry/Cell sorting to investigate the effects of total glycoside of peony on experimental colitis mice.
Fri Mar 15 00:00:00 EDT 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
12-5773 was used in Flow cytometry/Cell sorting to explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells on liver fibrosis.
Tue Jun 11 00:00:00 EDT 2019
PD-1 inhibitors dependent CD8+ T cells inhibit mouse colon cancer cell metastasis.
OncoTargets and therapy
Gao CE,Zhang M,Song Q,Dong J
12-5773-82 was used in Flow Cytometry to investigate the function of PD-1 inhibitor on the metastasisi of mouse colon cancer cells.
Mon Apr 11 00:00:00 EDT 2022
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
12-5773 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
Generation of Foxp3+CD25- Regulatory T-Cell Precursors Requires c-Rel and IκBNS.
Frontiers in immunology
Schuster M,Plaza-Sirvent C,Visekruna A,Huehn J,Schmitz I
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that NF-κB is essential for the generation of alternative CD25-Foxp3+ precursors, as well.
Thu Jun 04 00:00:00 EDT 2020
Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.
Frontiers in immunology
Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC
12-5773-82 was used in Flow cytometry/Cell sorting to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.
Tue Nov 17 00:00:00 EST 2020
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma.
Oncotarget
Takahashi Y,Yasui T,Minami K,Tamari K,Hayashi K,Otani K,Seo Y,Isohashi F,Koizumi M,Ogawa K
12-5773 was used in Flow cytometry/Cell sorting to understand the efficacy of combining carbon ion irradiation and dual immune checkpoint blockade therapy to treat local and distant sites in osteosarcoma in mice.
Fri Jan 18 00:00:00 EST 2019
Gut microbiota density influences host physiology and is shaped by host and microbial factors.
eLife
Contijoch EJ,Britton GJ,Yang C,Mogno I,Li Z,Ng R,Llewellyn SR,Hira S,Johnson C,Rabinowitz KM,Barkan R,Dotan I,Hirten RP,Fu SC,Luo Y,Yang N,Luong T,Labrias PR,Lira S,Peter I,Grinspan A,Clemente JC,Kosoy R,Kim-Schulze S,Qin X,Castillo A,Hurley A,Atreja A,Rogers J,Fasihuddin F,Saliaj M,Nolan A,Reyes-Mercedes P,Rodriguez C,Aly S,Santa-Cruz K,Peters L,Suárez-Fariñas M,Huang R,Hao K,Zhu J,Zhang B,Losic B,Irizar H,Song WM,Di Narzo A,Wang W,Cohen BL,DiMaio C,Greenwald D,Itzkowitz S,Lucas A,Marion J,Maser E,Ungaro R,Naymagon S,Novak J,Shah B,Ullman T,Rubin P,George J,Legnani P,Telesco SE,Friedman JR,Brodmerkel C,Plevy S,Cho JH,Colombel JF,Schadt EE,Argmann C,Dubinsky M,Kasarskis A,Sands B,Faith JJ
12-5773-82 was used in Flow Cytometry to identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, and assay this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions.
Tue Jan 22 00:00:00 EST 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that p53 activation mediated by APG-115 promotes antitumor immunity in the tumor microenvironment (TME) regardless of the Trp53 status of tumors per se.
Thu Nov 28 00:00:00 EST 2019
Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer.
Nature communications
Zhao J,Wen X,Tian L,Li T,Xu C,Wen X,Melancon MP,Gupta S,Shen B,Peng W,Li C
12-5773-82 was used in Flow Cytometry to suggest that IRE is a promising approach to potentiate the efficacy of immune checkpoint blockade in PDAC.
Fri Feb 22 00:00:00 EST 2019
Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model.
International journal of molecular sciences
Wai CYY,Leung NYH,Leung PSC,Chu KH
12-5773-82 was used in Flow Cytometry to demonstrate the potency of hypoallergen-encoding DNA vaccines as a therapeutic strategy for human shellfish allergy via the vigorous induction of functional Treg cells.
Thu Sep 19 00:00:00 EDT 2019
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Nature metabolism
Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM
12-5773-82 was used in Flow Cytometry to demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.
Tue Jan 01 00:00:00 EST 2019
Loss of TET2 and TET3 in regulatory T cells unleashes effector function.
Nature communications
Yue X,Lio CJ,Samaniego-Castruita D,Li X,Rao A
12-5773 was used in Flow cytometry/Cell sorting to indicate Tet2 and Tet3 are guardians of regulatory T cell stability and immune homeostasis.
Wed May 01 00:00:00 EDT 2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Yasuda K,Kitagawa Y,Kawakami R,Isaka Y,Watanabe H,Kondoh G,Kohwi-Shigematsu T,Sakaguchi S,Hirota K
12-5773-82 was used in Flow Cytometry to indicate that Satb1 regulates the specific gene expression and function of effector Th17 cells in tissue inflammation.
Fri Feb 01 00:00:00 EST 2019
Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.
Frontiers in immunology
Zinser E,Naumann R,Wild AB,Michalski J,Deinzer A,Stich L,Kuhnt C,Steinkasserer A,Knippertz I
12-5773 was used in Flow cytometry/Cell sorting to provide preclinical tools to guide the function of CD83/sCD83 for therapeutic purposes by generating Bacterial Artificial Chromosomes transgenic mice.
Fri Oct 16 00:00:00 EDT 2020
Antibody-Mediated Delivery of VEGFC Ameliorates Experimental Chronic Colitis.
ACS pharmacology & translational science
Tacconi C,Schwager S,Cousin N,Bajic D,Sesartic M,Sundberg JP,Neri D,Detmar M
12-5773-82 was used in Flow Cytometry to investigate whether targeted delivery of the pro-lymphangiogenic vascular endothelial growth factor C to the site of inflammation may represent a new, clinically feasible strategy for treating inflammatory bowel disease.
Fri Oct 11 00:00:00 EDT 2019
Frontline Science: Abnormalities in the gut mucosa of non-obese diabetic mice precede the onset of type 1 diabetes.
Journal of leukocyte biology
Miranda MCG,Oliveira RP,Torres L,Aguiar SLF,Pinheiro-Rosa N,Lemos L,Guimarães MA,Reis D,Silveira T,Ferreira Ê,Moreira TG,Cara DC,Maioli TU,Kelsall BL,Carlos D,Faria AMC
12-5773-82 was used in Flow cytometry/Cell sorting to show that disorders in the intestinal mucosa of NOD mice can potentially interfere with the development of T1D due the close relationship between the gut and the pancreas.
Sun Sep 01 00:00:00 EDT 2019
MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.
Frontiers in immunology
Demeyer A,Skordos I,Driege Y,Kreike M,Hochepied T,Baens M,Staal J,Beyaert R
12-5773 was used in Flow cytometry/Cell sorting to establish that suppression of autoimmune responses is due to the T-cell intrinsic role of MALT1 proteolytic activity.
Mon Oct 05 00:00:00 EDT 2020
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.
Nature communications
Pascual-García M,Bonfill-Teixidor E,Planas-Rigol E,Rubio-Perez C,Iurlaro R,Arias A,Cuartas I,Sala-Hojman A,Escudero L,Martínez-Ricarte F,Huber-Ruano I,Nuciforo P,Pedrosa L,Marques C,Braña I,Garralda E,Vieito M,Squatrito M,Pineda E,Graus F,Espejo C,Sahuquillo J,Tabernero J,Seoane J
12-5773-82 was used in Flow Cytometry to study the effect of the combination of LIF neutralising antibodies with the inhibition of the PD1 immune checkpoint on tumour progression.
Tue Jun 11 00:00:00 EDT 2019
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
JCI insight
Lee CG,Kwon HK,Kang H,Kim Y,Nam JH,Won YH,Park S,Kim T,Kang K,Rudra D,Jun CD,Park ZY,Im SH
12-5773 was used in Flow cytometry/Cell sorting to reveal a protective role of Ets1 in restricting pathogenic Th cell responses and suggest a potential therapeutic target for atopic dermatitis (AD) treatment.
Thu Mar 07 00:00:00 EST 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
12-5773 was used in Flow cytometry/Cell sorting to reveal a link between mitochondrial function, lysosomal integrity and MHC class I presentation in intestinal epithelial cells.
Thu Jun 28 00:00:00 EDT 2018
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Cancer cell
Arce Vargas F,Furness AJS,Litchfield K,Joshi K,Rosenthal R,Ghorani E,Solomon I,Lesko MH,Ruef N,Roddie C,Henry JY,Spain L,Ben Aissa A,Georgiou A,Wong YNS,Smith M,Strauss D,Hayes A,Nicol D,O'Brien T,Mårtensson L,Ljungars A,Teige I,Frendéus B,Pule M,Marafioti T,Gore M,Larkin J,Turajlic S,Swanton C,Peggs KS,Quezada SA
12-5773 was used in Flow cytometry/Cell sorting to examine the importance of Fc-gamma receptor binding in contributing to the activity of anti-CTLA4 antibodies.
Mon Apr 09 00:00:00 EDT 2018
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature immunology
Gabryšová L,Alvarez-Martinez M,Luisier R,Cox LS,Sodenkamp J,Hosking C,Pérez-Mazliah D,Whicher C,Kannan Y,Potempa K,Wu X,Bhaw L,Wende H,Sieweke MH,Elgar G,Wilson M,Briscoe J,Metzis V,Langhorne J,Luscombe NM,O'Garra A
12-5773 was used in Flow cytometry/Cell sorting to study the role of c-Maf as a regulator of the expression of cytokine-encoding genes.
Tue May 01 00:00:00 EDT 2018
Rapid chromatin repression by Aire provides precise control of immune tolerance.
Nature immunology
Koh AS,Miller EL,Buenrostro JD,Moskowitz DM,Wang J,Greenleaf WJ,Chang HY,Crabtree GR
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity yet promote immune tolerance.
Thu Feb 01 00:00:00 EST 2018
PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
The Journal of clinical investigation
Kraakman MJ,Liu Q,Postigo-Fernandez J,Ji R,Kon N,Larrea D,Namwanje M,Fan L,Chan M,Area-Gomez E,Fu W,Creusot RJ,Qiang L
12-5773 was used in Immunocytochemistry-immunoflourescence to show that targeted PPARγ mutations result in constitutive deacetylation, increased energy expenditure and protect from visceral adiposity and diet-induced obesity by augmenting brown remodelling of white adipose tissues.
Fri Jun 01 00:00:00 EDT 2018
PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
The Journal of clinical investigation
Kraakman MJ,Liu Q,Postigo-Fernandez J,Ji R,Kon N,Larrea D,Namwanje M,Fan L,Chan M,Area-Gomez E,Fu W,Creusot RJ,Qiang L
12-5773 was used in Immunocytochemistry-immunoflourescence to show that targeted PPARγ mutations result in constitutive deacetylation, increased energy expenditure and protect from visceral adiposity and diet-induced obesity by augmenting brown remodelling of white adipose tissues.
Fri Jun 01 00:00:00 EDT 2018
CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.
The Journal of clinical investigation
Maeda K,Otomo K,Yoshida N,Abu-Asab MS,Ichinose K,Nishino T,Kono M,Ferretti A,Bhargava R,Maruyama S,Bickerton S,Fahmy TM,Tsokos MG,Tsokos GC
12-5773 was used in Flow cytometry/Cell sorting to explore the role of Ca2+/calmodulin-dependent kinase signalling in podocytes.
Wed Aug 01 00:00:00 EDT 2018
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
12-5773 was used in Flow cytometry/Cell sorting to study the retrograde traffic of linker for activation of T cells from the plasma membrane to the Golgi-trans-Golgi network.
Mon Apr 02 00:00:00 EDT 2018
Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis.
The Journal of allergy and clinical immunology
Nguyen DX,Cotton A,Attipoe L,Ciurtin C,Doré CJ,Ehrenstein MR
14-4777 was used in Flow cytometry/Cell sorting to determine whether adalimumab's ability to boost Treg cells in vitro using PBMCs before treatment would predict clinical response.
Sat Sep 01 00:00:00 EDT 2018
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
12-5773 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Tue Feb 27 00:00:00 EST 2018
Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Frontiers in immunology
Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K
12-5773 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.
Tue Jun 25 00:00:00 EDT 2019
Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
LaMothe RA,Kolte PN,Vo T,Ferrari JD,Gelsinger TC,Wong J,Chan VT,Ahmed S,Srinivasan A,Deitemeyer P,Maldonado RA,Kishimoto TK
12-5773-82 was used in Flow cytometry/Cell sorting to further show that tolerogenic nanoparticles can trigger the expansion of endogenous Tregs specific to a target Ag.
Thu Mar 21 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
12-5773-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Mice Is Associated With an Important Splenic Atrophy and Relative B Lymphopenia.
Frontiers in endocrinology
Bodart G,Farhat K,Renard-Charlet C,Becker G,Plenevaux A,Salvatori R,Geenen V,Martens H
12-5773 was used in Flow cytometry/Cell sorting to examine the precise control exerted by the somatotrope growth hormone(GH)-releasing hormone/GH/insulin-like growth factor 1 axis on the immune system.
Sun Apr 10 00:00:00 EDT 2022
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
12-5773 was used in Flow cytometry/Cell sorting to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus infection.
Thu Oct 01 00:00:00 EDT 2020
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells.
Frontiers in cellular neuroscience
Osorio-Barrios F,Prado C,Contreras F,Pacheco R
12-5773 was used in Flow cytometry/Cell sorting to indicate a complex role for DRD5-signalling in CD4+ T-cells-driven responses potentiating early inflammation mediated by effector T-cells in experimental autoimmune encephalomyelitis.
Thu Oct 01 00:00:00 EDT 2020
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.
Nature communications
Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K
12-5773 was used in Flow cytometry/Cell sorting to define the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17.
Tue Oct 30 00:00:00 EDT 2018
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction.
Oncoimmunology
Idorn M,Olsen M,Halldórsdóttir HR,Skadborg SK,Pedersen M,Høgdall C,Høgdall E,Met Ö,Thor Straten P
12-5773 was used in Flow cytometry/Cell sorting to study whether T cells expressing chemokine receptors matching chemokine expression in the tumour microenvironment would improve homing to immunosuppressive tumour sites.
Tue Jan 12 00:00:00 EST 2021
Experimental Combined Immunotherapy of Tumours with Major Histocompatibility Complex Class I Downregulation.
International journal of molecular sciences
Grzelak A,Polakova I,Smahelova J,Vackova J,Pekarcikova L,Tachezy R,Smahel M
12-5773 was used in Flow cytometry/Cell sorting to investigate immunotherapy in the mouse TC-1/A9 model of human papillomavirus type 16-associated tumours characterised by major histocompatibility complex class I downregulation.
Wed Nov 21 00:00:00 EST 2018
Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation.
Scientific reports
Weng TY,Wu HF,Li CY,Hung YH,Chang YW,Chen YL,Hsu HP,Chen YH,Wang CY,Chang JY,Lai MD
12-5773 was used in Flow cytometry/Cell sorting to examine the therapeutic efficacy and the immune effects of homoharringtonine in two murine lung tumour models, xenograft and transgenic, carrying the Kras mutations G12D and G12C respectively.
Tue May 29 00:00:00 EDT 2018
Regulatory T cells are required for normal and activin-promoted wound repair in mice.
European journal of immunology
Haertel E,Joshi N,Hiebert P,Kopf M,Werner S
12-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that Treg depletion in wounds facilitates the expansion of an αβ T-cell population with features of Th1 and Th2 cells, and suggest that concomitant changes in the cytokine milieu disturb the healing process.
Fri Jun 01 00:00:00 EDT 2018
Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.
Physiology & behavior
Magnuson AM,Fouts JK,Regan DP,Booth AD,Dow SW,Foster MT
12-5773-82 was used in Flow cytometry/Cell sorting to elucidate how the lymphatic system may contribute to the comorbidities associated with visceral adipose tissue accumulation.
Fri Jun 01 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that Chitinase-3-like-1 is a regulator of Th1 and CTL, which could be a potential anti-tumor immunity target.
Mon Feb 05 00:00:00 EST 2018
The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses.
Oncoimmunology
Rekers NH,Olivo Pimentel V,Yaromina A,Lieuwes NG,Biemans R,Zegers CML,Germeraad WTV,Van Limbergen EJ,Neri D,Dubois LJ,Lambin P
12-5773 was used in Flow cytometry/Cell sorting to show that radiotherapy and L19-IL2 can activate a curative abscopal effect, with a long-lasting immunological memory.
Tue Jan 12 00:00:00 EST 2021
Characterization of the Inflammatory Response in Dystrophic Muscle Using Flow Cytometry.
Methods in molecular biology (Clifton, N.J.)
Kastenschmidt JM,Avetyan I,Villalta SA
12-5773 was used in Flow cytometry/Cell sorting to highlight methods for the isolation and study of immune cell populations from muscles of mouse models of DMD.
Tue Jun 05 00:00:00 EDT 2018
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.
Nature communications
Chen S,Fang L,Guo W,Zhou Y,Yu G,Li W,Dong K,Liu J,Luo Y,Wang B,Li Z,Zhao C,Sun Z,Shen Y,Leng Q,Zhou D,Han Z,Huang H,Ren H,Xu G,Feng X
12-5773 was used in Flow cytometry/Cell sorting to identify Lkb1 as a regulatory switch in dendritic cells for controlling regulatory T cell homeostasis, immune response and tolerance.
Thu Dec 13 00:00:00 EST 2018
Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Nature communications
Fujiwara H,Docampo MD,Riwes M,Peltier D,Toubai T,Henig I,Wu SJ,Kim S,Taylor A,Brabbs S,Liu C,Zajac C,Oravecz-Wilson K,Sun Y,Núñez G,Levine JE,van den Brink MRM,Ferrara JLM,Reddy P
12-5773 was used in Flow cytometry/Cell sorting to study the importance of G-protein-coupled receptor 43 for the attenuation of gastrointestinal graft-versus-host disease in multiple clinically relevant murine models.
Mon Sep 10 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
12-5773 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells.
Cancer letters
Li A,Barsoumian HB,Schoenhals JE,Cushman TR,Caetano MS,Wang X,Valdecanas DR,Niknam S,Younes AI,Li G,Woodward WA,Cortez MA,Welsh JW
12-5773-82 was used in Flow cytometry/Cell sorting to conclude that IDO1 inhibition holds promise for treating lung cancer that does not respond to anti-PD1 therapy.
Sat Sep 01 00:00:00 EDT 2018
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
12-5773-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.
Cell host & microbe
Entwistle LJ,Pelly VS,Coomes SM,Kannan Y,Perez-Lloret J,Czieso S,Silva Dos Santos M,MacRae JI,Collinson L,Sesay A,Nikolov N,Metidji A,Helmby H,Hui DY,Wilson MS
12-5773 was used in Flow cytometry/Cell sorting to uncover epithelial-cell-derived Pla2g1b as an essential mediator of helminth killing.
Wed Oct 11 00:00:00 EDT 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
12-5773 was used in Flow cytometry/Cell sorting to identify miR-146a as an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells.
Mon Oct 02 00:00:00 EDT 2017
A type 2 cytokine axis for thymus emigration.
The Journal of experimental medicine
White AJ,Baik S,Parnell SM,Holland AM,Brombacher F,Jenkinson WE,Anderson G
12-5773 was used in Flow cytometry/Cell sorting to show the thymic microenvironment expresses the type 2 IL-4R complex and is functionally responsive to its known ligands, IL-4 and IL-13.
Mon Aug 07 00:00:00 EDT 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
12-5773 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.
The EMBO journal
Kawasaki T,Ito K,Miyata H,Akira S,Kawai T
12-5773 was used in Flow cytometry/Cell sorting to examine the role of a phosphoinositide kinase PIKfyve in alveolar macrophage development and function.
Wed Jun 14 00:00:00 EDT 2017
Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Schampel A,Volovitch O,Koeniger T,Scholz CJ,Jörg S,Linker RA,Wischmeyer E,Wunsch M,Hell JW,Ergün S,Kuerten S
12-5773 was used in Flow cytometry/Cell sorting to show that nimodipine application generates a favourable environment for regenerative processes and could be a treatment option for multiple sclerosis.
Tue Apr 18 00:00:00 EDT 2017
Capacity of tTreg generation is not impaired in the atrophied thymus.
PLoS biology
Oh J,Wang W,Thomas R,Su DM
12-5773 was used in Flow cytometry/Cell sorting to mechanistically study thymic Treg cell generation in the atrophied thymus using postnatal thymic epithelial cell-defective and naturally aged mouse models.
Wed Nov 01 00:00:00 EDT 2017
Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells.
Frontiers in immunology
Yang WC,Hwang YS,Chen YY,Liu CL,Shen CN,Hong WH,Lo SM,Shen CR
12-5773 was used in Flow cytometry/Cell sorting to suggest the essential role of IL-4 in supporting Treg-mediated immune suppression, which may benefit the development of therapeutic strategies for autoimmune diseases.
Sun Apr 10 00:00:00 EDT 2022
Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.
Cell proliferation
Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT
12-5773 was used in Flow cytometry/Cell sorting to investigate whether secondary lymphatics within visceral adiposity contribute to disease risk.
Sun Oct 01 00:00:00 EDT 2017
Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells.
Immunology
Shiokawa A,Kotaki R,Takano T,Nakajima-Adachi H,Hachimura S
12-5773 was used in Flow cytometry/Cell sorting to investigate the expression of these molecules on MLN CD11c+ cells.
Fri Sep 01 00:00:00 EDT 2017
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.
Journal of virology
Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK
12-5773 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.
Mon May 15 00:00:00 EDT 2017
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.
Immunology and cell biology
Alberdi M,Iglesias M,Tejedor S,Merino R,López-Rodríguez C,Aramburu J
12-5773 was used in Flow cytometry/Cell sorting to show that NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.
Sun Jan 01 00:00:00 EST 2017
The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Pan B,Wang X,Kojima S,Nishioka C,Yokoyama A,Honda G,Xu K,Ikezoe T
12-5773 was used in Flow cytometry/Cell sorting to identify G-protein coupled receptor 15 expressed on T cells as a receptor/sensor of thrombomodulin.
Mon May 01 00:00:00 EDT 2017
Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance.
Journal of immunology (Baltimore, Md. : 1950)
Yang H,Guo HZ,Li XY,Lin J,Zhang W,Zhao JM,Zhang HX,Chen SJ,Chen Z,Zhu J
Sat Jul 01 00:00:00 EDT 2017
Cooperation of Gastric Mononuclear Phagocytes with Helicobacter pylori during Colonization.
Journal of immunology (Baltimore, Md. : 1950)
Viladomiu M,Bassaganya-Riera J,Tubau-Juni N,Kronsteiner B,Leber A,Philipson CW,Zoccoli-Rodriguez V,Hontecillas R
12-5773 was used in Flow cytometry/Cell sorting to report the induction of IL-10-driven regulatory responses mediated by CD11b+F4/80hiCD64+CX3CR1+ MNPs that contribute to maintaining high levels of Helicobacter pylori loads in the stomach by modulating effector T cell responses at the gastric mucosa.
Sat Apr 15 00:00:00 EDT 2017
Effect of Early-life Gut Mucosal Compromise on Disease Progression in NOD Mice.
Comparative medicine
Bendtsen KM,Hansen CH,Krych L,Buschard K,Farlov H,Hansen AK
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that mucus reduction and subsequent increased host-bacterial contact did not affect overall disease progression in nonobese diabetic mice.
Sun Oct 01 00:00:00 EDT 2017
TLR2-/- Mice Display Increased Clearance of Dermatophyte Trichophyton mentagrophytes in the Setting of Hyperglycemia.
Frontiers in cellular and infection microbiology
Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.
Mon Sep 18 00:00:00 EDT 2017
Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure.
Scientific reports
Roth-Walter F,Bergmayr C,Meitz S,Buchleitner S,Stremnitzer C,Fazekas J,Moskovskich A,Müller MA,Roth GA,Manzano-Szalai K,Dvorak Z,Neunkirchner A,Jensen-Jarolim E
12-5773 was used in Flow cytometry/Cell sorting to provide a novel explanation for why smokers have a lower allergy, but higher cancer risk.
Thu Mar 23 00:00:00 EDT 2017
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Nature communications
Campos Carrascosa L,Klein M,Kitagawa Y,Lückel C,Marini F,König A,Guralnik A,Raifer H,Hagner-Benes S,Rädler D,Böck A,Kang C,Lohoff M,Garn H,Schaub B,Berberich-Siebelt F,Sakaguchi S,Bopp T,Huber M
12-5773 was used in Flow cytometry/Cell sorting to study the opposing effects of interferon regulatory factor1 and IRF4 on T helper 9 cell differentiation.
Fri May 12 00:00:00 EDT 2017
Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma.
PloS one
Takahashi Y,Yasui T,Tamari K,Minami K,Otani K,Isohashi F,Seo Y,Kambe R,Koizumi M,Ogawa K
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that radiation therapy enhances the efficacy of immune checkpoint blockade therapy, thus providing a promising therapeutic option for osteosarcoma.
Mon Jan 08 00:00:00 EST 2018
C3d regulates immune checkpoint blockade and enhances antitumor immunity.
JCI insight
Platt JL,Silva I,Balin SJ,Lefferts AR,Farkash E,Ross TM,Carroll MC,Cascalho M
12-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which tumours engage T cell checkpoint regulators and expanding Tregs, showing that C3d regulates immune checkpoint blockade and enhances antitumor immunity.
Thu May 04 00:00:00 EDT 2017
The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice.
PloS one
Nenasheva T,Nikolaev A,Diykanov D,Sukhanova A,Tcyganov E,Panteleev A,Bocharova I,Serdyuk Y,Nezlin L,Radaeva T,Adrianov N,Rubtsov Y,Lyadova I
12-5773 was used in Flow cytometry/Cell sorting to emphasize the importance of the evaluation of MSC effects locally at the site of their predominant post-injection localization and question MSC usefulness as anti-TB treatment.
Tue Sep 19 00:00:00 EDT 2017
PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton.
eLife
Britton GJ,Ambler R,Clark DJ,Hill EV,Tunbridge HM,McNally KE,Burton BR,Butterweck P,Sabatos-Peyton C,Hampton-O'Neil LA,Verkade P,Wülfing ChC,Wraith DC
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of protein kinase PKCθ in linking proximal T cell and notch signaling by a spatiotemporally constrained mechanism.
Tue Jan 31 00:00:00 EST 2017
Ceramide synthesis regulates T cell activity and GVHD development.
JCI insight
Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.
Thu May 18 00:00:00 EDT 2017
CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway.
Stem cell research & therapy
Wei Y,Hu Z,Gu W,Liu G,Shi B,Liu E,Liu T
12-5773 was used in Flow cytometry/Cell sorting to suggest that CD44+CD117+ T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.
Thu Mar 09 00:00:00 EST 2017
Priming is key to effective incorporation of image-guided thermal ablation into immunotherapy protocols.
JCI insight
Silvestrini MT,Ingham ES,Mahakian LM,Kheirolomoom A,Liu Y,Fite BZ,Tam SM,Tucci ST,Watson KD,Wong AW,Monjazeb AM,Hubbard NE,Murphy WJ,Borowsky AD,Ferrara KW
12-5773 was used in Flow cytometry/Cell sorting to examine the importance of priming before pairing image-guided thermal ablation with immunotherapy protocols in the treatment of cancer.
Thu Mar 23 00:00:00 EDT 2017
Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.
Nature communications
Klein JC,Moses K,Zelinskyy G,Sody S,Buer J,Lang S,Helfrich I,Dittmer U,Kirschning CJ,Brandau S
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that cells deficient in endosomal TLR3, 7 and 9 leads to tumour regression and anti-tumour immunity.
Thu Mar 16 00:00:00 EDT 2017
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.
Nature immunology
Martin BN,Wang C,Zhang CJ,Kang Z,Gulen MF,Zepp JA,Zhao J,Bian G,Do JS,Min B,Pavicic PG,El-Sanadi C,Fox PL,Akitsu A,Iwakura Y,Sarkar A,Wewers MD,Kaiser WJ,Mocarski ES,Rothenberg ME,Hise AG,Dubyak GR,Ransohoff RM,Li X
12-5773 was used in Flow cytometry/Cell sorting to reveal a critical role for IL-1β produced by a T(H)17 cell-intrinsic ASC-NLRP3-caspase-8 inflammasome during inflammation of the central nervous system.
Sun May 01 00:00:00 EDT 2016
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory signals and Foxp3 balance mTORC1 signaling and glucose metabolism to control the proliferation and suppressive function of Treg cells.
Thu Dec 01 00:00:00 EST 2016
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation.
The Journal of clinical investigation
Nguyen HD,Chatterjee S,Haarberg KM,Wu Y,Bastian D,Heinrichs J,Fu J,Daenthanasanmak A,Schutt S,Shrestha S,Liu C,Wang H,Chi H,Mehrotra S,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to study the metabolic reprogramming of donor T cells following allogeneic haematopoietic cell transplantation.
Fri Apr 01 00:00:00 EDT 2016
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
The Journal of experimental medicine
Hu Y,Kim JH,He K,Wan Q,Kim J,Flach M,Kirchhausen T,Vortkamp A,Winau F
12577382 was used in flow cytometry to study the role of TMEM16F in limiting T cell responses in mice infected with virus
Mon Nov 14 00:00:00 EST 2016
IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation.
The Journal of experimental medicine
Lin CC,Bradstreet TR,Schwarzkopf EA,Jarjour NN,Chou C,Archambault AS,Sim J,Zinselmeyer BH,Carrero JA,Wu GF,Taneja R,Artyomov MN,Russell JH,Edelson BT
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that IL-1β induces Bhlhe40 expression in polarized Th17 cells, and Bhlhe40-expressing cells exhibited an encephalitogenic transcriptional signature.
Mon Feb 08 00:00:00 EST 2016
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
The Journal of experimental medicine
Wan X,Thomas JW,Unanue ER
12-5773 was used in Flow cytometry/Cell sorting to investigate the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.
Mon May 30 00:00:00 EDT 2016
Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.
Molecular metabolism
Pomié C,Blasco-Baque V,Klopp P,Nicolas S,Waget A,Loubières P,Azalbert V,Puel A,Lopez F,Dray C,Valet P,Lelouvier B,Servant F,Courtney M,Amar J,Burcelin R,Garidou L
12-5773 was used in Flow cytometry/Cell sorting to investigate how glycemia and insulin sensitivity can be regulated by triggering the adaptive immunity to microbiota interaction.
Wed Jun 01 00:00:00 EDT 2016
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Madsen PM,Motti D,Karmally S,Szymkowski DE,Lambertsen KL,Bethea JR,Brambilla R
12-5773 was used in Flow cytometry/Cell sorting to provide evidence that TNFR2 in oligodendrocytes is important for oligodendrocyte differentiation, thereby sustaining tmTNF-dependent repair in neuroimmune disease.
Wed May 04 00:00:00 EDT 2016
Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4⁺ T cell response against MC38 colon carcinoma.
International journal of oncology
Wojas-Turek J,Szczygieł A,Kicielińska J,Rossowska J,Piasecki E,Pajtasz-Piasecka E
12-5773 was used in Flow cytometry/Cell sorting to show that an application of cyclophosphamide supported by dendritic cell based vaccines affected differentiation of the activity of CD4+ T cell subpopulations accompanied by an alteration in CD8+ cell number.
Mon Feb 01 00:00:00 EST 2016
The Use of Toll-like Receptor 4 Agonist to Reshape the Immune Signature in Ovarian Cancer.
Anticancer research
Vindevogel E,Baert T,VAN Hoylandt A,Verbist G,Vande Velde G,Garg AD,Agostinis P,Vergote I,Coosemans AN
12-5773 was used in Flow cytometry/Cell sorting to investigate whether LPS is a beneficial adjuvant in dendritic cell mono-immunotherapy of ovarian cancer.
Tue Nov 01 00:00:00 EDT 2016
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease.
Journal of hematology & oncology
Fransolet G,Ehx G,Somja J,Delens L,Hannon M,Muller J,Dubois S,Drion P,Caers J,Humblet-Baron S,Delvenne P,Beguin Y,Conteduca G,Baron F
12-5773 was used in Flow cytometry/Cell sorting to assessed the impact of azacytidine on cGVHD in a murine model of sclerodermic cGVHD.
Mon Jul 04 00:00:00 EDT 2016
Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice.
Oncotarget
Wang Y,Tian J,Tang X,Rui K,Tian X,Ma J,Ma B,Xu H,Lu L,Wang S
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of MDSCs in IBD, showing that exosomes released by granulocytic MDSCs attenuate DSS-induced colitis in mice.
Tue Mar 29 00:00:00 EDT 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
12-5773-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
12-5773 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model.
Frontiers in microbiology
Hidalgo-Cantabrana C,Algieri F,Rodriguez-Nogales A,Vezza T,Martínez-Camblor P,Margolles A,Ruas-Madiedo P,Gálvez J
12-5773 was used in Flow cytometry/Cell sorting to indicate that strains of B. animalis subsp. lactis producing EPS that confer a mucoid-ropy phenotype could represent promising candidates to perform further studies targeting intestinal inflammatory processes.
Mon Jul 04 00:00:00 EDT 2016
Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.
The Journal of biological chemistry
Maganti AV,Tersey SA,Syed F,Nelson JB,Colvin SC,Maier B,Mirmira RG
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that PPAR-γ activation directly improves Β cell function and survival in non-obese diabetic mice.
Fri Oct 21 00:00:00 EDT 2016
In Vitro Influence of Mycophenolic Acid on Selected Parameters of Stimulated Peripheral Canine Lymphocytes.
PloS one
Guzera M,Szulc-Dąbrowska L,Cywińska A,Archer J,Winnicka A
12-5773 was used in Immunofluorescence to determine markers of changes in stimulated peripheral canine lymphocytes after treatment with mycophenolic acid (MPA) in vitro, showing that MPA caused decreased expression of CD3, CD8 and CD25 surface antigens and inhibited lymphocyte activation and proliferation.
Wed Jul 19 00:00:00 EDT 2017
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Scientific reports
Lee SH,Moon YM,Seo HB,Kim SY,Kim EK,Yi J,Nam MK,Min JK,Park SH,Rhim H,Cho ML
12-5773 was used in Flow cytometry/Cell sorting to study the suppression of autoimmune arthritis and regulation of STAT3 activation via HtrA2.
Fri Dec 23 00:00:00 EST 2016
PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.
PloS one
Jones K,Ballesteros A,Mentink-Kane M,Warren J,Rattila S,Malech H,Kang E,Dveksler G
12-5773 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-specific glycoprotein 9, a potential predictive biomarker of pre-eclampsia, plays an immunoregulatory role during pregnancy.
Wed Jul 26 00:00:00 EDT 2017
Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.
PloS one
Bähr A,Käser T,Kemter E,Gerner W,Kurome M,Baars W,Herbach N,Witter K,Wünsch A,Talker SC,Kessler B,Nagashima H,Saalmüller A,Schwinzer R,Wolf E,Klymiuk N
12-5773 was used in Flow cytometry/Cell sorting to establish a novel pig model with ubiquitous expression of LEA29Y that are viable and reproductive.
Mon Jul 10 00:00:00 EDT 2017
A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.
JCI insight
Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG
12-5773 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.
Thu Jul 21 00:00:00 EDT 2016
Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo.
Scientific reports
Ciarlo E,Heinonen T,Herderschee J,Fenwick C,Mombelli M,Le Roy D,Roger T
12-5773 was used in Flow cytometry/Cell sorting to support the safety of propionate-based therapies, either via direct supplementation or via the diet/microbiota, to treat non-infectious inflammation-related disorders, without increasing the risk of infection.
Tue Nov 29 00:00:00 EST 2016
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.
Oncotarget
Manrique SZ,Dominguez AL,Mirza N,Spencer CD,Bradley JM,Finke JH,Lee JJ,Pease LR,Gendler SJ,Cohen PA
12-5773 was used in Flow cytometry/Cell sorting to assess whether chemotherapy-induced leukodepletion could be immunopotentiated by co-administering TLRa to emulate a life-threatening infection.
Tue Jul 12 00:00:00 EDT 2016
1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.
Cell death & disease
Wei C,Mei J,Tang L,Liu Y,Li D,Li M,Zhu X
12-5773 was used in Flow cytometry/Cell sorting to investigate the high percentage of peritoneal Treg in endometriosis patients, showing that 1-Methyl-tryptophan attenuates Treg differentiation due to the inhibition of estrogen-IDO1-MRC2 axis.
Thu Dec 01 00:00:00 EST 2016
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Scientific reports
Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH
12-5773 was used in Flow cytometry/Cell sorting to suggest that NFAT1 switches on activation induced cell death in CD4+/CD8+ T cells to maintain peripheral tolerance and prevent inflammatory skin disease.
Mon Jan 18 00:00:00 EST 2016
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
Nature immunology
Weist BM,Kurd N,Boussier J,Chan SW,Robey EA
12-5773 was used in Flow cytometry/Cell sorting to investigate the sources of thymic IL-2 that limit access to the Treg developmental niche, showing that niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
Mon Jun 01 00:00:00 EDT 2015
A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway.
Cellular & molecular immunology
Hsu LH,Li KP,Chu KH,Chiang BL
12-5773 was used in Flow cytometry/Cell sorting to suggest that B-1a cells induce a functionally and phenotypically distinct Treg population that is dissimilar to the reported Foxp3(+) Treg or Tr1 cells.
Fri May 01 00:00:00 EDT 2015
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.
Science translational medicine
Hu-Lieskovan S,Mok S,Homet Moreno B,Tsoi J,Robert L,Goedert L,Pinheiro EM,Koya RC,Graeber TG,Comin-Anduix B,Ribas A
12-5773 was used in Flow cytometry/Cell sorting to investigate the use of BRAF and MEK inhibitors with immunotherapy in patients with BRAF(V600E) melanoma.
Wed Mar 18 00:00:00 EDT 2015
Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice.
Cellular and molecular gastroenterology and hepatology
Omenetti S,Brogi M,Goodman WA,Croniger CM,Eid S,Huang AY,Laffi G,Roskams T,Cominelli F,Pinzani M,Pizarro TT
12-5773 was used in Flow cytometry/Cell sorting to investigate how activated intrahepatic CD4(+) T-cells induce liver inflammation and contribute to experimental ileitis via locally-impaired hepatic immunosuppressive function.
Wed Jul 01 00:00:00 EDT 2015
Regulatory T Cells Modulate DNA Vaccine Immunogenicity at Early Time via Functional CD4(+) T Cells and Antigen Duration.
Frontiers in immunology
Qin L,Jiang G,Han J,Letvin NL
12-5773 was used in Flow cytometry/Cell sorting to suggest that Treg cells control early DNA vaccine immunogenicity via antigen duration and functional CD4(+) T-cell responses.
Tue Oct 20 00:00:00 EDT 2015
Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
The Journal of investigative dermatology
Mairhofer DG,Ortner D,Tripp CH,Schaffenrath S,Fleming V,Heger L,Komenda K,Reider D,Dudziak D,Chen S,Becker JC,Flacher V,Stoitzner P
12-5773 was used in Flow cytometry/Cell sorting to characterise the immune status and functional properties of immune cells in a spontaneous melanoma mouse model.
Sun Nov 01 00:00:00 EDT 2015
Host STAT2/type I interferon axis controls tumor growth.
International journal of cancer
Yue C,Xu J,Tan Estioko MD,Kotredes KP,Lopez-Otalora Y,Hilliard BA,Baker DP,Gallucci S,Gamero AM
12-5773 was used in Flow cytometry/Cell sorting to show in a syngeneic tumor transplantation model that STAT2 reduces tumor growth.
Thu Jan 01 00:00:00 EST 2015
The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response.
Immunology and cell biology
Lin W,Fan Z,Suo Y,Deng Y,Zhang M,Wang J,Wei X,Chu Y
12-5773 was used in Immunocytochemistry to indicate that bullseye immunological synapse formation is mediated by cytotoxic T-lymphocyte antigen-4, and may negatively control T-cell activation as a suppressive synapse.
Thu Jan 01 00:00:00 EST 2015
Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.
Journal of immunology (Baltimore, Md. : 1950)
Ladell K,Hazenberg MD,Fitch M,Emson C,McEvoy-Hein Asgarian BK,Mold JE,Miller C,Busch R,Price DA,Hellerstein MK,McCune JM
12-5773 was used in Flow cytometry/Cell sorting to partially implicate chronic Ag exposure for the depleted adaptive immune response observed in HIV patients.
Sun Nov 01 00:00:00 EDT 2015
Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Coder BD,Wang H,Ruan L,Su DM
12-5773 was used in Flow cytometry/Cell sorting to determine the inflammatory consequences associated with the progressive, age-related shrinking of the thymus.
Mon Jun 15 00:00:00 EDT 2015
Modulating DNA methylation in activated CD8+ T cells inhibits regulatory T cell-induced binding of Foxp3 to the CD8+ T Cell IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950)
Miller MM,Akaronu N,Thompson EM,Hood SF,Fogle JE
12-5773 was used in Flow cytometry/Cell sorting to study the molecular events occurring at the IL-2 promoter, leading to suppression of IL-2 production.
Sun Feb 01 00:00:00 EST 2015
Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Saida Y,Watanabe S,Tanaka T,Baba J,Sato K,Shoji S,Igarashi N,Kondo R,Okajima M,Koshio J,Ichikawa K,Nozaki K,Ishikawa D,Koya T,Miura S,Tanaka J,Kagamu H,Yoshizawa H,Nakata K,Narita I
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that both regulatory T cells and effector CD8(+) T cells from lymphopenic recipients play critical roles in the development of antitumour immunity after lymphodepletion.
Wed Jul 15 00:00:00 EDT 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of the Interleukin-1 receptor type 2 (IL-1R2) as a regulator of arthritis, by acting specifically on macrophages as a decoy receptor for IL-1.
Wed Apr 01 00:00:00 EDT 2015
Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance.
Transplantation
Lal G,Nakayama Y,Sethi A,Singh AK,Burrell BE,Kulkarni N,Brinkman CC,Iwami D,Zhang T,Bromberg JS
12577382 was used in flow cytometry and immunohistochemistry to determine if specific B cell subsets or if B cell-derived interleukin-10 contributes to tolerance
Tue Sep 01 00:00:00 EDT 2015
iPSC-MSCs Combined with Low-Dose Rapamycin Induced Islet Allograft Tolerance Through Suppressing Th1 and Enhancing Regulatory T-Cell Differentiation.
Stem cells and development
Cheng PP,Liu XC,Ma PF,Gao C,Li JL,Lin YY,Shao W,Han S,Zhao B,Wang LM,Fu JZ,Meng LX,Li Q,Lian QZ,Xia JJ,Qi ZQ
12-5773 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of iPSC-mesechymal stem cells on diabetic mice.
Sat Aug 01 00:00:00 EDT 2015
PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate.
Veterinary research
Rodríguez-Gómez IM,Käser T,Gómez-Laguna J,Lamp B,Sinn L,Rümenapf T,Carrasco L,Saalmüller A,Gerner W
12-5773 was used in Immunohistochemistry to characterise the phenotypes of porcine reproductive and respiratory syndrome virus-infected monocyte-derived dendritic cells.
Wed May 20 00:00:00 EDT 2015
PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate.
Veterinary research
Rodríguez-Gómez IM,Käser T,Gómez-Laguna J,Lamp B,Sinn L,Rümenapf T,Carrasco L,Saalmüller A,Gerner W
12-5773 was used in Immunohistochemistry to characterise the phenotypes of porcine reproductive and respiratory syndrome virus-infected monocyte-derived dendritic cells.
Wed May 20 00:00:00 EDT 2015
ERβ and ERα Differentially Regulate NKT and Vγ4+ T-cell Activation and T-regulatory Cell Response in Coxsackievirus B3 Infected Mice.
Journal of clinical & cellular immunology
Huber S
12-5773 was used in Flow cytometry/Cell sorting to determine the relative role and mechanism of action of estrogen receptor alpha and beta in myocarditis susceptibility.
Tue Sep 29 00:00:00 EDT 2020
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
12-5773 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 EDT 2015
Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice.
PloS one
Schutt SD,Fu J,Nguyen H,Bastian D,Heinrichs J,Wu Y,Liu C,McDonald DG,Pidala J,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to show that Ibrutinib is an effective prophylaxis against mouse models of cGVHD with minimal toxicity.
Fri Jun 03 00:00:00 EDT 2016
Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Nature communications
Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG
12-5773 was used in Flow cytometry/Cell sorting to investigate interactions that cause inflammation and influence colon cancer progression.
Fri Apr 24 00:00:00 EDT 2015
CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.
Oncotarget
Concepcion AR,Salas JT,Sáez E,Sarvide S,Ferrer A,Portu A,Uriarte I,Hervás-Stubbs S,Oude Elferink RP,Prieto J,Medina JF
12-5773 was used in Flow cytometry/Cell sorting to study the behaviour of intrahepatic T cells during different stages of life within Ae2a,b(-/-) mice.
Tue Oct 06 00:00:00 EDT 2015
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
Journal of translational medicine
Ghonim MA,Pyakurel K,Ibba SV,Al-Khami AA,Wang J,Rodriguez P,Rady HF,El-Bahrawy AH,Lammi MR,Mansy MS,Al-Ghareeb K,Ramsay A,Ochoa A,Naura AS,Boulares AH
12-5773 was used in Flow cytometry/Cell sorting to examine the efficacy of olaparib in blocking established allergic airway inflammation and hyperresponsiveness similar to those observed in human asthma in animal models of the disease.
Tue Jul 14 00:00:00 EDT 2015
In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide.
PloS one
van Herwijnen MJ,van der Zee R,van Eden W,Broere F
12-5773 was used in Flow cytometry/Cell sorting to determine whether natural nTregs or induced iTregs were targeted after Hsp70-peptide immunisation.
Mon Mar 28 00:00:00 EDT 2016
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
12-5773 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.
Nature communications
Pan W,Zhu S,Dai D,Liu Z,Li D,Li B,Gagliani N,Zheng Y,Tang Y,Weirauch MT,Chen X,Zhu W,Wang Y,Chen B,Qian Y,Chen Y,Fang J,Herbst R,Richman L,Jallal B,Harley JB,Flavell RA,Yao Y,Shen N
12-5773 was used in Flow cytometry/Cell sorting to suggest miR-125a as a critical factor in controlling autoimmune diseases through stabilizing Treg-mediated immune homeostasis.
Tue May 12 00:00:00 EDT 2015
Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model.
Oncotarget
Wu L,Wu MO,De la Maza L,Yun Z,Yu J,Zhao Y,Cho J,de Perrot M
12-5773 was used in Flow cytometry/Cell sorting to investigate the local and abscopal effects of targeting the CTLA-4 T cell inhibitory receptor in a murine mesothelioma model.
Wed May 20 00:00:00 EDT 2015
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets.
Oncotarget
Ehx G,Hannon M,Beguin Y,Humblet-Baron S,Baron F
12-5773 was used in Flow cytometry/Cell sorting to evaluate a novel staining method with the potential to monitor the responses of various Treg subsets to IL-2 therapy.
Tue Dec 22 00:00:00 EST 2015
CD4(+)CD25(-)Foxp3(+) T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax.
Journal of translational medicine
Tang Y,Peng LP,Qin GX,Sun JT,Xu LJ,Jiang YF
12-5773 was used in Flow cytometry/Cell sorting to determine that CD4(+)CD25(-)Foxp3(+) T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax.
Tue Aug 18 00:00:00 EDT 2015
DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.
International journal of clinical and experimental medicine
Wang Q,Cao W,Yang ZG,Zhao GF
12-5773 was used in Flow cytometry/Cell sorting to show that DNA vaccine which targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity.
Fri Jan 15 00:00:00 EST 2016
Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma.
PloS one
Paoloni M,Mazcko C,Selting K,Lana S,Barber L,Phillips J,Skorupski K,Vail D,Wilson H,Biller B,Avery A,Kiupel M,LeBlanc A,Bernhardt A,Brunkhorst B,Tighe R,Khanna C
12-5773 was used in Flow cytometry/Cell sorting to evaluate the safety, serum pharmacokinetics, anti-tumour activity, and immune modulation of NHS-IL12 in dogs with naturally occurring cancers.
Wed Apr 13 00:00:00 EDT 2016
Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.
PloS one
Min HK,Kim SM,Baek SY,Woo JW,Park JS,Cho ML,Lee J,Kwok SK,Kim SW,Park SH
12-5773 was used in Immunofluorescence to investigate the anti-arthritic effects of anthocyanin extracted from black soybean seed coats in both murine and human cells.
Tue Jun 14 00:00:00 EDT 2016
The 15N and 46R Residues of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Enhance Regulatory T Lymphocytes Proliferation.
PloS one
Fan B,Liu X,Bai J,Li Y,Zhang Q,Jiang P
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the mechanisms of immunity to PRRSV strains by the induction of CD4+ CD25+ Foxp3+ Tregs, and outline how these mechanisms vary between classical and highly pathogenic strains.
Tue Jun 14 00:00:00 EDT 2016
Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer.
PloS one
Ito F,Ku AW,Bucsek MJ,Muhitch JB,Vardam-Kaur T,Kim M,Fisher DT,Camoriano M,Khoury T,Skitzki JJ,Gollnick SO,Evans SS
12-5773 was used in Flow cytometry/Cell sorting to study how pre-resectional RFA of primary tumors delayed growth of distant tumors through a mechanism that depends on systemic CD8+ T cell-mediated antitumor immunity.
Mon Jun 20 00:00:00 EDT 2016
Indirubin Increases CD4+CD25+Foxp3+ Regulatory T Cells to Prevent Immune Thrombocytopenia in Mice.
PloS one
Zhang A,Ning B,Sun N,Wei J,Ju X
12-5773 was used in Flow cytometry/Cell sorting to elucidate the effect of the Chinese medicine, indirubin, on Treg cells in immune thrombocytopenia (ITP) CBA mice.
Thu Jun 23 00:00:00 EDT 2016
A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice.
Gastroenterology
Keenan BP,Saenger Y,Kafrouni MI,Leubner A,Lauer P,Maitra A,Rucki AA,Gunderson AJ,Coussens LM,Brockstedt DG,Dubensky TW,Hassan R,Armstrong TD,Jaffee EM
12-5773 was used in Flow cytometry/Cell sorting to show that immunising KPC mice with Listeria monocytogenes expressing Kras(G12D), and depletion of Treg cells, reduces progression of early stage PanINs.
Sun Jun 01 00:00:00 EDT 2014
α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.
Blood
Marcondes AM,Karoopongse E,Lesnikova M,Margineantu D,Welte T,Dinarello CA,Hockenbery D,Janciauskiene S,Deeg HJ
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of α-1-antitrypsin in graft-versus-host disease, showing that α-1-Antitrypsin-modified donor cells suppress graft-versus-host disease but enhance the graft-versus-leukemia effect.
Thu Oct 30 00:00:00 EDT 2014
An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.
Blood
Gibbins JD,Ancelet LR,Weinkove R,Compton BJ,Painter GF,Petersen TR,Hermans IF
12-5773 was used in Flow cytometry/Cell sorting to investigate the efficacy of an intravenously administered vaccine consisting of irradiated leukemia cells loaded with α-GalCer.
Thu Nov 06 00:00:00 EST 2014
Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation.
The Journal of experimental medicine
Akiyama N,Shinzawa M,Miyauchi M,Yanai H,Tateishi R,Shimo Y,Ohshima D,Matsuo K,Sasaki I,Hoshino K,Wu G,Yagi S,Inoue J,Kaisho T,Akiyama T
12-5773 was used in Flow cytometry/Cell sorting to suggest that the negative RANKL-Spi-B-OPG feedback mechanism finely tunes mTEC development and function.
Mon Nov 17 00:00:00 EST 2014
Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.
Arthritis & rheumatology (Hoboken, N.J.)
Ding Y,Li J,Yang P,Luo B,Wu Q,Zajac AJ,Wildner O,Hsu HC,Mountz JD
12-5773 was used in Flow cytometry/Cell sorting to indicate that high levels of IL-21 selectively enhance Tfh cell differentiation but inhibit Tfr cell commitment and the suppressive function of Tfr cells on Tfh cells and B cells.
Mon Sep 01 00:00:00 EDT 2014
MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.
The Journal of allergy and clinical immunology
Malmhäll C,Alawieh S,Lu Y,Sjöstrand M,Bossios A,Eldh M,Rådinger M
12-5773 was used in Flow cytometry/Cell sorting to investigate the contribution of microRNA-155 to TH2-mediated allergen-induced airway inflammation in a mouse model.
Thu May 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
12-5773 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.
Tue Jul 01 00:00:00 EDT 2014
CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Clement M,Fornasa G,Guedj K,Ben Mkaddem S,Gaston AT,Khallou-Laschet J,Morvan M,Nicoletti A,Caligiuri G
12-5773 was used in Flow cytometry/Cell sorting to investigate the effect exerted by CD31 signalling in dendritic cells.
Tue Mar 25 00:00:00 EDT 2014
Intravenous injection of MVA virus targets CD8+ lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist.
Cancer immunology research
Fend L,Gatard-Scheikl T,Kintz J,Gantzer M,Schaedler E,Rittner K,Cochin S,Fournel S,Préville X
12-5773 was used in Flow cytometry/Cell sorting to evaluate the impact of injection routes on therapeutic efficacy of a Modified Vaccinia virus Ankara viral vector expressing the human mucin 1 tumour-associated xeno-antigen.
Mon Dec 01 00:00:00 EST 2014
Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Koulis C,Chen YC,Hausding C,Ahrens I,Kyaw TS,Tay C,Allen T,Jandeleit-Dahm K,Sweet MJ,Akira S,Bobik A,Peter K,Agrotis A
12-5773 was used in Flow cytometry/Cell sorting to investigate whether TLR9 has a role in the development of atherosclerosis in apolipoprotein E-deficient mice.
Sat Mar 01 00:00:00 EST 2014
Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.
Hypertension (Dallas, Tex. : 1979)
Gómez-Guzmán M,Jiménez R,Romero M,Sánchez M,Zarzuelo MJ,Gómez-Morales M,O'Valle F,López-Farré AJ,Algieri F,Gálvez J,Pérez-Vizcaino F,Sabio JM,Duarte J
12-5773 was used in Flow cytometry/Cell sorting to investigate the effects of hydroxychloroquine on hypertension, endothelial dysfunction, and renal injury in a mouse model of systemic lupus erythematosus.
Fri Aug 01 00:00:00 EDT 2014
Type 1 diabetes in NOD mice unaffected by mast cell deficiency.
Diabetes
Gutierrez DA,Fu W,Schonefeldt S,Feyerabend TB,Ortiz-Lopez A,Lampi Y,Liston A,Mathis D,Rodewald HR
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in the onset and incidence of type 1 diabetes, showing that mast cell deficiency does not affect diabetes.
Sat Nov 01 00:00:00 EDT 2014
Immunosuppressive effect of compound K on islet transplantation in an STZ-induced diabetic mouse model.
Diabetes
Ma PF,Jiang J,Gao C,Cheng PP,Li JL,Huang X,Lin YY,Li Q,Peng YZ,Cai MC,Shao W,Zhu Q,Han S,Qin Q,Xia JJ,Qi ZQ
12-5773 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of Cpd K in diabetic mice.
Wed Oct 01 00:00:00 EDT 2014
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.
Mucosal immunology
Akimova T,Xiao H,Liu Y,Bhatti TR,Jiao J,Eruslanov E,Singhal S,Wang L,Han R,Zacharia K,Hancock WW,Beier UH
12-5773 was used in Flow cytometry/Cell sorting to discover that sirt1 appears to be promising target for pharmacologic therapy of IBD as a result of promoting iTreg development.
Mon Sep 01 00:00:00 EDT 2014
Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.
Laboratory investigation; a journal of technical methods and pathology
Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X
12-5773 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..
Sat Feb 01 00:00:00 EST 2014
Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Huang W,Qi Q,Hu J,Huang F,Laufer TM,August A
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that dendritic cells-MHCII and IL-2-inducible T cell kinase regulate the functional development of IMP CD4(+) T cells.
Tue Apr 01 00:00:00 EDT 2014
CD1d(hi)CD5+ B cells expanded by GM-CSF in vivo suppress experimental autoimmune myasthenia gravis.
Journal of immunology (Baltimore, Md. : 1950)
Sheng JR,Quan S,Soliven B
12-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the tolorogenic effects of B10 cells in Experimental Autoimmune Myasthenia Gravis.
Mon Sep 15 00:00:00 EDT 2014
Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
Journal of immunology (Baltimore, Md. : 1950)
Zasłona Z,Przybranowski S,Wilke C,van Rooijen N,Teitz-Tennenbaum S,Osterholzer JJ,Wilkinson JE,Moore BB,Peters-Golden M
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that rAMs dampen, whereas circulating monocytes promote, early events in allergic lung inflammation.
Wed Oct 15 00:00:00 EDT 2014
TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Manoharan I,Hong Y,Suryawanshi A,Angus-Hill ML,Sun Z,Mellor AL,Munn DH,Manicassamy S
12-5773 was used in Flow cytometry/Cell sorting to investigate how diametric signals from the pathogen recognition receptors TLR2 and dectin-1 are coordinated in dendritic cells to regulate or incite immunity.
Wed Oct 15 00:00:00 EDT 2014
Progression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spread.
Journal of immunology (Baltimore, Md. : 1950)
Kersh AE,Edwards LJ,Evavold BD
12-5773 was used in Immunofluorescence to study how a high frequency of T cells specific for a single myelin Ag governs the transition from acute symptoms through remission, relapse, and chronic disease states.
Sat Nov 01 00:00:00 EDT 2014
Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Sawant DV,Gravano DM,Vogel P,Giacomin P,Artis D,Vignali DA
12-5773 was used in Flow cytometry/Cell sorting to explore the functional role of Tregs post-low-dose infection with Trichuris muris.
Sat Mar 15 00:00:00 EDT 2014
Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy.
Transplantation
Hirohashi T,Chase CM,DellaPelle P,Sebastian D,Farkesh E,Colvin RB,Russell PS,Alessandrini A,Madsen JC
12-5773 was used in Flow cytometry/Cell sorting to clarify the interrelationship between NK and CD4 cells in cardiac allograft vasculopathy, showing that it is promoted by depletion of Tregs.
Mon Oct 27 00:00:00 EDT 2014
Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus.
Lupus science & medicine
Liu MF,Wang CR
12-5773 was used in Flow cytometry/Cell sorting to show that increased frequencies of Th17 cells positively correlate with disease activity and proteinuria in SLE patients, confirming the dysregulation of Th17/IL-17 in SLE.
Thu Jan 01 00:00:00 EST 2015
Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity.
Mediators of inflammation
Monk JM,Turk HF,Fan YY,Callaway E,Weeks B,Yang P,McMurray DN,Chapkin RS
12-5773 was used in Flow cytometry/Cell sorting to investigate the relationship between PGE2 levels and Th17 cells in regard to disease outcomes in a mouse model of colitis.
Wed Apr 08 00:00:00 EDT 2015
Both positive and negative effects on immune responses by expression of a second class II MHC molecule.
Molecular immunology
Ni PP,Wang Y,Allen PM
12-5773 was used in Flow cytometry/Cell sorting to suggest that expressing additional class II MHCs causes more severe autoimmunity, providing an explanation for limiting MHC expression.
Sat Nov 01 00:00:00 EDT 2014
Protein-bound polysaccharide-K reduces the proportion of regulatory T cells in vitro and in vivo.
Oncology reports
Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K
12-5773 was used in Flow cytometry/Cell sorting to investigate the potential of PSK to augment antitumour immunity.
Wed Jan 01 00:00:00 EST 2014
Neutrophils have a protective role during early stages of Leishmania amazonensis infection in BALB/c mice.
Parasite immunology
Sousa LM,Carneiro MB,Resende ME,Martins LS,Dos Santos LM,Vaz LG,Mello PS,Mosser DM,Oliveira MA,Vieira LQ
12-5773 was used in Flow cytometry/Cell sorting to indicate that neutrophils control parasite numbers and limit lesion development during early Leishmania amazonensis infection in BALB/c mice.
Wed Jan 01 00:00:00 EST 2014
Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.
Experimental animals
Akitsu A,Kakuta S,Saijo S,Iwakura Y
12-5773 was used in Flow cytometry/Cell sorting to explore the relationship between IL-17A-producing cells and Treg cells in immune homeostasis of the colon.
Wed Oct 22 00:00:00 EDT 2014
Immune privilege of the CNS is not the consequence of limited antigen sampling.
Scientific reports
Harris MG,Hulseberg P,Ling C,Karman J,Clarkson BD,Harding JS,Zhang M,Sandor A,Christensen K,Nagy A,Sandor M,Fabry Z
12-5773 was used in Flow cytometry/Cell sorting to define the mechanisms contributing to CNS immune privilege.
Fri Mar 21 00:00:00 EDT 2014
Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation.
PloS one
Binsfeld M,Beguin Y,Belle L,Otjacques E,Hannon M,Briquet A,Heusschen R,Drion P,Zilberberg J,Bogen B,Baron F,Caers J
12-5773 was used in Flow cytometry/Cell sorting to investigate the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice.
Tue Dec 15 00:00:00 EST 2015
Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells.
PloS one
Wang X,Qin J,Zhao RC,Zenke M
12-5773 was used in Flow cytometry/Cell sorting to compare immunogenicity of fibroblast- and sertoli cell-derived iPS cells, showing that sertoli cell-derived iPS cells have lower immunogenicity.
Tue Nov 17 00:00:00 EST 2015
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.
Nature communications
Lin CC,Bradstreet TR,Schwarzkopf EA,Sim J,Carrero JA,Chou C,Cook LE,Egawa T,Taneja R,Murphy TL,Russell JH,Edelson BT
12-5773 was used in Flow cytometry/Cell sorting to study the factors affecting pathogenicity of TH cells in experimental autoimmune encephalomyelitis (EAE), showing that Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in EAE.
Thu Apr 03 00:00:00 EDT 2014
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.
eLife
Burger ML,Leung KK,Bennett MJ,Winoto A
12-5773 was used in Flow cytometry/Cell sorting to show that T cell-specific expression of a Bcl2 BH3 mutant transgene results in enhanced rescue of thymocytes from negative selection.
Tue Sep 02 00:00:00 EDT 2014
Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.
PloS one
Funda DP,Fundova P,Hansen AK,Buschard K
12-5773 was used in Flow cytometry/Cell sorting to investigate whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process, showing that i.n. administration of gliadin prevents type 1 diabetes in NOD mice.
Tue Jan 13 00:00:00 EST 2015
The dual role of scavenger receptor class A in development of diabetes in autoimmune NOD mice.
PloS one
Shimizu M,Yasuda H,Hara K,Takahashi K,Nagata M,Yokono K
12-5773 was used in Flow cytometry/Cell sorting to study the role of scavenger receptor class A in autoimmune disease.
Mon Jun 29 00:00:00 EDT 2015
Purinergic signaling on leukocytes infiltrating the LPS-injured lung.
PloS one
Friebe D,Yang T,Schmidt T,Borg N,Steckel B,Ding Z,Schrader J
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of extracellular nucleotides/nucleosides in acute lung injury, showing purinergic signaling on leukocytes infiltrating the injured lung.
Thu Jan 15 00:00:00 EST 2015
Nematode-induced interference with vaccination efficacy targets follicular T helper cell induction and is preserved after termination of infection.
PLoS neglected tropical diseases
Haben I,Hartmann W,Breloer M
12-5773 was used in Flow cytometry/Cell sorting to analyse the effects on vaccination of Litomosoides sigmodontis infection in mice.
Mon Sep 01 00:00:00 EDT 2014
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.
The Journal of clinical investigation
Bonito AJ,Aloman C,Fiel MI,Danzl NM,Cha S,Weinstein EG,Jeong S,Choi Y,Walsh MC,Alexandropoulos K
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of TRAF6 and medullary thymic epithelial cells (mETCs) in autoimmunity, showing that mETC depletion leads to autoimmune hepatitis.
Thu Aug 01 00:00:00 EDT 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-5773 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.
Molecular therapy : the journal of the American Society of Gene Therapy
Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW
12-5773 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.
Fri Feb 01 00:00:00 EST 2013
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.
Arteriosclerosis, thrombosis, and vascular biology
Ait-Oufella H,Herbin O,Lahoute C,Coatrieux C,Loyer X,Joffre J,Laurans L,Ramkhelawon B,Blanc-Brude O,Karabina S,Girard CA,Payré C,Yamamoto K,Binder CJ,Murakami M,Tedgui A,Lambeau G,Mallat Z
12-5773 was used in Flow cytometry/Cell sorting to study the proatherogenic properties of PLA2G10, a type of several secreted phospholipase A2.
Fri Mar 01 00:00:00 EST 2013
Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells.
British journal of pharmacology
Rouse M,Singh NP,Nagarkatti PS,Nagarkatti M
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that I3C and DIM may serve as novel therapeutics to suppress neuroinflammation seen during MS through activation of AhR.
Mon Jul 01 00:00:00 EDT 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
12-5773 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
Sensitive GC-MS/MS method to measure deuterium labeled deoxyadenosine in DNA from limited mouse cell populations.
Analytical chemistry
Farthing DE,Buxbaum NP,Bare CV,Treadwell SM,Kapoor V,Williams KM,Gress RE
12-5773 was used in Flow cytometry/Cell sorting to develop a rapid and sensitive GC-MS/MS method to quantitatively measure low levels of deoxyadenosine and its isotopologues from limited mouse cell populations.
Tue May 07 00:00:00 EDT 2013
Invariant NKT cells suppress CD8(+) T-cell-mediated allergic contact dermatitis independently of regulatory CD4(+) T cells.
The Journal of investigative dermatology
Goubier A,Vocanson M,Macari C,Poyet G,Herbelin A,Nicolas JF,Dubois B,Kaiserlian D
12-5773 was used in Flow cytometry/Cell sorting to study the role of invariant natural killer T cells as potent downregulators of CD8 T cell-mediated contact hypersensitivity.
Mon Apr 01 00:00:00 EDT 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
12-5773 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Inflammatory bowel diseases
Klimesova K,Kverka M,Zakostelska Z,Hudcovic T,Hrncir T,Stepankova R,Rossmann P,Ridl J,Kostovcik M,Mrazek J,Kopecny J,Kobayashi KS,Tlaskalova-Hogenova H
12-5773 was used in Flow cytometry/Cell sorting to compare the populations of regulatory T cells in the colons of untreated and antibiotic-treated mice with colitis-associated cancer.
Wed May 01 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
12-5773 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.
European journal of immunology
Yu Y,Wang D,Kaosaard K,Liu C,Fu J,Haarberg K,Anasetti C,Beg AA,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of c-Rel in transplant tolerance and graft-versus-host disease (GVHD), showing that it is an essential transcription factor for the development of acute GVHD.
Sun Sep 01 00:00:00 EDT 2013
Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine.
Cancer immunology, immunotherapy : CII
Peng S,Lyford-Pike S,Akpeng B,Wu A,Hung CF,Hannaman D,Saunders JR,Wu TC,Pai SI
12-5773 was used in Flow cytometry/Cell sorting to demonstrate a decreased vaccine-induced CD8(+) T-cell frequency after administration of CTX.
Tue Jan 01 00:00:00 EST 2013
Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis.
The American journal of pathology
Huber SA,Roberts B,Moussawi M,Boyson JE
12-5773 was used in Flow cytometry/Cell sorting to confirm that NKT cells are protective for myocarditis but pathogenic in the liver.
Fri Feb 01 00:00:00 EST 2013
Parental dietary fat intake alters offspring microbiome and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Myles IA,Fontecilla NM,Janelsins BM,Vithayathil PJ,Segre JA,Datta SK
12-5773 was used in Flow cytometry/Cell sorting to reveal that parental fat consumption can leave a "lard legacy", impacting offspring immunity and health.
Sun Sep 15 00:00:00 EDT 2013
Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Oderup C,LaJevic M,Butcher EC
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of canonical and noncanonical Wnts in immune tolerance, showing that they program dendritic cell responses for tolerance.
Sat Jun 15 00:00:00 EDT 2013
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Zhang W,Usherwood EJ
12-5773 was used in Flow cytometry/Cell sorting to investigate the generation, phenotype and function of IL-10 producing CD8+ T cells during persistent virus infection.
Mon Jul 01 00:00:00 EDT 2013
Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival.
Journal of immunology (Baltimore, Md. : 1950)
Bock F,Rössner S,Onderka J,Lechmann M,Pallotta MT,Fallarino F,Boon L,Nicolette C,DeBenedette MA,Tcherepanova IY,Grohmann U,Steinkasserer A,Cursiefen C,Zinser E
12-5773 was used in Flow cytometry/Cell sorting to investigate the local immunomodulatory properties of soluble CD83 application.
Thu Aug 15 00:00:00 EDT 2013
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A
12-5773 was used in Immunocytochemistry to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.
Fri Mar 01 00:00:00 EST 2013
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.
Journal of immunology (Baltimore, Md. : 1950)
Mc Guire C,Wieghofer P,Elton L,Muylaert D,Prinz M,Beyaert R,van Loo G
12-5773 was used in Flow cytometry/Cell sorting to study the role of MALT1 in the development of experimental autoimmune encephalomyelitis.
Fri Mar 15 00:00:00 EDT 2013
Adenosine A₂A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Han KL,Thomas SV,Koontz SM,Changpriroa CM,Ha SK,Malech HL,Kang EM
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that specific activation of the adenosine A(2A) receptor inhibits acute graft-versus-host disease through an increase of donor-derived regulatory T cells.
Tue Jan 01 00:00:00 EST 2013
Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Swanson RM,Gavin MA,Escobar SS,Rottman JB,Lipsky BP,Dube S,Li L,Bigler J,Wolfson M,Arnett HA,Viney JL
12-5773 was used in Flow cytometry/Cell sorting to investigate the mechanism by which butyrophilin-like 2 modulates B7 costimulation and regulatory T cell development.
Fri Mar 01 00:00:00 EST 2013
Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Park SY,Jing X,Gupta D,Dziarski R
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the proinflammatory effect of peptidoglycan recognition protein (Pglyrp)1 during the development of allergic asthma.
Mon Apr 01 00:00:00 EDT 2013
Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice.
World journal of gastroenterology
Zhao HM,Huang XY,Zuo ZQ,Pan QH,Ao MY,Zhou F,Liu HN,Liu ZY,Liu DY
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that probiotics treat experimental colitis by increasing regulatory T-cell number and regulating Th1 and Th2 cytokine ratios.
Thu Feb 07 00:00:00 EST 2013
n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.
The Journal of nutrition
Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS
12-5773 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.
Sun Sep 01 00:00:00 EDT 2013
Sex differences in TLR2 and TLR4 expression and their effect on coxsackievirus-induced autoimmune myocarditis.
Experimental and molecular pathology
Roberts BJ,Moussawi M,Huber SA
12-5773 was used in Flow cytometry/Cell sorting to show the suppression of T regulatory cells by TLR signalling in males, not females correlates with the increased myocarditis susceptibility of males.
Fri Feb 01 00:00:00 EST 2013
Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.
Cell stress & chaperones
Spiering R,van der Zee R,Wagenaar J,van Eden W,Broere F
12-5773 was used in Flow cytometry/Cell sorting to indicate that Mt- and mouse HSP70-treated BMDC can suppress PGIA via an IL-10-producing T cell-dependent manner.
Mon Jul 01 00:00:00 EDT 2013
An increased number of CD4+CD25+ cells induced by an oral administration of Lactobacillus plantarum NRIC0380 are involved in antiallergic activity.
International archives of allergy and immunology
Yoshida T,Fujiwara W,Enomoto M,Nakayama S,Matsuda H,Sugiyama H,Shimojoh M,Okada S,Hattori M
12-5773 was used in Flow cytometry/Cell sorting to study how increased CD4+CD25+ cells are involved in antiallergic activity.
Fri Feb 07 00:00:00 EST 2014
The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis.
Immunobiology
Rouse M,Nagarkatti M,Nagarkatti PS
12-5773 was used in Flow cytometry/Cell sorting to investigate the effect of administration of IL-2 on the development of EAE, showing that pre-treatment causes significant amelioration of EAE.
Mon Apr 01 00:00:00 EDT 2013
Reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
The Journal of biological chemistry
Stehle F,Schulz K,Fahldieck C,Kalich J,Lichtenfels R,Riemann D,Seliger B
12-5773 was used in Flow cytometry/Cell sorting to investigate the reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
Fri Jun 07 00:00:00 EDT 2013
Adoptive transfer of regulatory T cells protects against Coxsackievirus B3-induced cardiac fibrosis.
PloS one
Cao Y,Xu W,Xiong S
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in the development of viral myocarditis-caused cardiac fibrosis.
Tue Apr 08 00:00:00 EDT 2014
Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine.
Clinical and vaccine immunology : CVI
Rosas-Jorquera CE,Sardinha LR,Pretel FD,Bombeiro AL,D'Império Lima MR,Alvarez JM
12-5773 was used in Flow cytometry/Cell sorting to investigate how to help in elucidating the necessary elements for a successful therapeutic vaccine which may reduce cardiomyopathy in chronically infected human patients.
Fri Feb 01 00:00:00 EST 2013
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.
PloS one
Selemidis S,Seow HJ,Broughton BR,Vinh A,Bozinovski S,Sobey CG,Drummond GR,Vlahos R
12-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms that regulate lung inflammation in influenza A infection.
Tue Oct 22 00:00:00 EDT 2013
DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.
BMC immunology
Cao J,Jin Y,Li W,Zhang B,He Y,Liu H,Xia N,Wei H,Yan J
12-5773 was used in Flow cytometry/Cell sorting to investigate anti-tumoural efficacy and underlying mechanisms of DC-targeting DNA vaccines in mouse breast cancer models, showing that it induces potent anti-tumour immunity in mice.
Wed Aug 14 00:00:00 EDT 2013
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
12-5773 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Ulmus davidiana var. japonica Nakai upregulates eosinophils and suppresses Th1 and Th17 cells in the small intestine.
PloS one
Lee HS,Jang MS,Kim JH,Hong CP,Lee EJ,Jeun EJ,Kim C,Kim EK,Ahn KS,Yang BG,Ahn KS,Jang YP,Ahn KS,Kim YM,Jang MH
12-5773 was used in Flow cytometry/Cell sorting to investigate the frequency and cytokine profile of the major immune cells in mice treated orally with UDE.
Sat Aug 02 00:00:00 EDT 2014
Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.
PloS one
Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ
12-5773 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.
Mon Jul 29 00:00:00 EDT 2013
IL-17A and IL-2-expanded regulatory T cells cooperate to inhibit Th1-mediated rejection of MHC II disparate skin grafts.
PloS one
Vokaer B,Charbonnier LM,Lemaître PH,Spilleboudt C,Le Moine A
12-5773 was used in Flow cytometry/Cell sorting to evaluate the effect of IL-17A neutralisation in a mouse model of skin transplantation.
Thu Jul 24 00:00:00 EDT 2014
Beneficial role of rapamycin in experimental autoimmune myositis.
PloS one
Prevel N,Allenbach Y,Klatzmann D,Salomon B,Benveniste O
12-5773 was used in Flow cytometry/Cell sorting to investigate the effect of rapamycin on different immune cell sub-populations in experimental autoimmune myositis.
Fri Jul 25 00:00:00 EDT 2014
Analysis of the dynamics of infiltrating CD4(+) T cell subsets in the heart during experimental Trypanosoma cruzi infection.
PloS one
Sanoja C,Carbajosa S,Fresno M,Gironès N
12-5773 was used in Flow cytometry/Cell sorting to compare CD4+ T cell subsets after infection with the T. cruzi Y strain in susceptible and nonsusceptible mice.
Thu Jan 16 00:00:00 EST 2014
TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice.
PloS one
Nawijn MC,Motta AC,Gras R,Shirinbak S,Maazi H,van Oosterhout AJ
12-5773 was used in Flow cytometry/Cell sorting to evaluate the novel long term therapeutic potential of local Tregs up-reguation by intranasel TLR-2 agonist Pam3Cys in asthmatic mice.
Mon Aug 26 00:00:00 EDT 2013
Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes.
Oncoimmunology
Guirnalda P,Wood L,Goenka R,Crespo J,Paterson Y
12-5773 was used in Flow cytometry/Cell sorting to conclude that the administration of monocytogenes-based anticancer vaccines regulates TH1 chemokine responses.
Thu Aug 01 00:00:00 EDT 2013
Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice.
PloS one
Corsetti PP,de Almeida LA,Carvalho NB,Azevedo V,Silva TM,Teixeira HC,Faria AC,Oliveira SC
12-5773 was used in Flow cytometry/Cell sorting to evaluate the contribution of IL-10 in host immune response and pathology during B. abortus infection.
Sun Jun 15 00:00:00 EDT 2014
Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection.
PloS one
Silva-Filho JL,Souza MC,Ferreira-Dasilva CT,Silva LS,Costa MF,Padua TA,Henriques Md,Morrot A,Savino W,Caruso-Neves C,Pinheiro AA
12-5773 was used in Flow cytometry/Cell sorting to provide evidence for the potential role of Ang II in regulating the splenic immune response.
Tue Nov 26 00:00:00 EST 2013
Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses.
Virology journal
Iyer AV,Pahar B,Chouljenko VN,Walker JD,Stanfield B,Kousoulas KG
12-5773 was used in Flow cytometry/Cell sorting to suggest that glycoprotein K-deleted HSV-1 virus may be used as a vaccine against virulent HSV-1 and HSV-2 genital infections.
Mon Oct 28 00:00:00 EDT 2013
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Immunity
Hadeiba H,Lahl K,Edalati A,Oderup C,Habtezion A,Pachynski R,Nguyen L,Ghodsi A,Adler S,Butcher EC
12-5773 was used in Flow cytometry/Cell sorting to explore the mechanisms underlying the contribution to immune tolerance conducted by peripheral dendritic cells.
Fri Mar 23 00:00:00 EDT 2012
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Circulation
Dinh TN,Kyaw TS,Kanellakis P,To K,Tipping P,Toh BH,Bobik A,Agrotis A
12-5773 was used in Flow cytometry/Cell sorting to examine the capacity of a modified IL-2/anti-IL-2 monoclonal antibody treatment to expand Tregs and attenuate atherosclerosis in mice.
Tue Sep 04 00:00:00 EDT 2012
Type I interferons maintain Foxp3 expression and T-regulatory cell functions under inflammatory conditions in mice.
Gastroenterology
Lee SE,Li X,Kim JC,Lee J,González-Navajas JM,Hong SH,Park IK,Rhee JH,Raz E
12-5773 was used in Flow cytometry/Cell sorting to study the role of type I interferons during intestinal homeostasis regulation in a T cell-induced colitis mouse model.
Sun Jul 01 00:00:00 EDT 2012
Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia.
Blood
Baba J,Watanabe S,Saida Y,Tanaka T,Miyabayashi T,Koshio J,Ichikawa K,Nozaki K,Koya T,Deguchi K,Tan C,Miura S,Tanaka H,Tanaka J,Kagamu H,Yoshizawa H,Nakata K,Narita I
12-5773 was used in Flow cytometry/Cell sorting to demonstrate a significant increase of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) in sublethally irradiated lymphopenic mice.
Thu Sep 20 00:00:00 EDT 2012
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Cellular & molecular immunology
Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y
12-5773 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.
Sun Jan 01 00:00:00 EST 2012
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Cellular & molecular immunology
Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L
12-5773 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.
Thu Mar 01 00:00:00 EST 2012
Absence of MyD88 signaling induces donor-specific kidney allograft tolerance.
Journal of the American Society of Nephrology : JASN
Wu H,Noordmans GA,O'Brien MR,Ma J,Zhao CY,Zhang GY,Kwan TK,Alexander SI,Chadban SJ
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that MyD88 deficiency is associated with an altered balance of Tregs over Th17 cells, promoting tolerance instead of rejection.
Mon Oct 01 00:00:00 EDT 2012
A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation.
Cardiovascular research
Fornasa G,Clement M,Groyer E,Gaston AT,Khallou-Laschet J,Morvan M,Guedj K,Kaveri SV,Tedgui A,Michel JB,Nicoletti A,Caligiuri G
12-5773 was used in Flow cytometry/Cell sorting to evaluate the therapeutic potential of the murine CD31-derived peptide in an experimental model of accelerated atherosclerosis and abdominal aortic aneurysms formation.
Sun Apr 01 00:00:00 EDT 2012
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America
van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F
12-5773 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.
Tue Aug 28 00:00:00 EDT 2012
Regulatory T-cell response to apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Ait-Oufella H,Yu W,Fredrikson GN,Aubier B,Perez N,Barateau V,Nilsson J,Tedgui A,Mallat Z
12-5773 was used in Flow cytometry/Cell sorting to investigate how the induction of a specific Treg cell response to Apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.
Thu Mar 01 00:00:00 EST 2012
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Burrell BE,Bromberg JS
12-5773 was used in Flow cytometry/Cell sorting to elucidate the key factors that determine the fate of graft reactive T cells.
Thu Mar 01 00:00:00 EST 2012
Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes.
Oncogene
Zaynagetdinov R,Stathopoulos GT,Sherrill TP,Cheng DS,McLoed AG,Ausborn JA,Polosukhin VV,Connelly L,Zhou W,Fingleton B,Peebles RS,Prince LS,Yull FE,Blackwell TS
12-5773 was used in Flow cytometry/Cell sorting to study whether nuclear factor kP provides an interface between persistent lung inflammation and carcinogenesis.
Thu Jun 28 00:00:00 EDT 2012
Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.
Cancer immunology, immunotherapy : CII
Alb M,Sie C,Adam C,Chen S,Becker JC,Schrama D
12-5773 was used in Flow cytometry/Cell sorting to investigate the cellular and cytokine-dependent immunosuppressive mechanisms in tumour-bearing grm1-transgenic mice.
Sat Dec 01 00:00:00 EST 2012
TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions.
Journal of virology
J Reddy PB,Schreiber TH,Rajasagi NK,Suryawanshi A,Mulik S,Veiga-Parga T,Niki T,Hirashima M,Podack ER,Rouse BT
12-5773 was used in Flow cytometry/Cell sorting to describe a novel combination therapy approach to control chronic inflammation in a wide range of diseases.
Mon Oct 01 00:00:00 EDT 2012
Donor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease.
Journal of leukocyte biology
Tawara I,Sun Y,Liu C,Toubai T,Nieves E,Evers R,Alrubaie M,Mathewson N,Tamaki H,Reddy P
12-5773 was used in Flow cytometry/Cell sorting to determine the functional relevance of the source of IL-10 and its role in the biology of acute graft-versus-host disease.
Sun Apr 01 00:00:00 EDT 2012
Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice.
Arthritis research & therapy
Xiao ZY,Chen SH,Cheng JP,Zhou WX,Zhang YX,Yang RF,Yun LH
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the protective effects of Y27 against autoimmune nephritis.
Thu Nov 01 00:00:00 EDT 2012
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Cowan JE,Baik S,Parnell SM,White AJ,Penninger JM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-5773 was used in Flow cytometry/Cell sorting to study how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in foetal and adult hemopoietic cross-talk.
Sat Dec 15 00:00:00 EST 2012
Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Kheradmand T,Wang S,Bryant J,Tasch JJ,Lerret N,Pothoven KL,Houlihan JL,Miller SD,Zhang ZJ,Luo X
12-5773 was used in Flow cytometry/Cell sorting to investigate mechanisms of inducting donor-specific tolerance in allogeneic recipients by strategic exposure to donor Ags prior to transplantation.
Sun Jul 15 00:00:00 EDT 2012
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.
Wed Feb 15 00:00:00 EST 2012
IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution.
Journal of immunology (Baltimore, Md. : 1950)
Le Campion A,Pommier A,Delpoux A,Stouvenel L,Auffray C,Martin B,Lucas B
12-5773 was used in Flow cytometry/Cell sorting to suggest that the proliferation of regulatory CD4(+) T cells in response to lymphopenia appears to be primarily controlled by IL-2.
Mon Oct 01 00:00:00 EDT 2012
Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Sonobe Y,Li H,Jin S,Kishida S,Kadomatsu K,Takeuchi H,Mizuno T,Suzumura A
12-5773 was used in Flow cytometry/Cell sorting to suggest that midkine aggravates experimental autoimmune encephalomyelitis by suppressing tolerogenic dendritic cell development, thereby impairing regulatory T-cell differentiation.
Thu Mar 15 00:00:00 EDT 2012
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Gowdy KM,Cardona DM,Nugent JL,Giamberardino C,Thomas JM,Mukherjee S,Martinu T,Foster WM,Plevy SE,Pastva AM,Wright JR,Palmer SM
12-5773 was used in Flow cytometry/Cell sorting to hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the development of Graft-versus-host disease after allogeneic BMT.
Tue May 15 00:00:00 EDT 2012
Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamanishi H,Murakami H,Ikeda Y,Abe M,Kumagi T,Hiasa Y,Matsuura B,Onji M
12-5773 was used in Flow cytometry/Cell sorting to identify a major protein of CBA related to the pathogenesis of IBD and establish a therapeutic approach using Ag-pulsed regulatory dendritic cells.
Thu Mar 01 00:00:00 EST 2012
Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
Human gene therapy
Zhang P,Sun B,Osada T,Rodriguiz R,Yang XY,Luo X,Kemper AR,Clay TM,Koeberl DD
12-5773 was used in Flow cytometry/Cell sorting to indicate that acid α-glucosidase gene therapy should combine hepatic and nonhepatic expression for Pompe treatment.
Tue May 01 00:00:00 EDT 2012
Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.
The Journal of nutrition
Monk JM,Jia Q,Callaway E,Weeks B,Alaniz RC,McMurray DN,Chapkin RS
12-5773 was used in Flow cytometry/Cell sorting to test the hypothesis that (n-3) PUFA is protective against colonic inflammation during colitis.
Sun Jan 01 00:00:00 EST 2012
Erythromycin enhances CD4+Foxp3+ regulatory T-cell responses in a rat model of smoke-induced lung inflammation.
Mediators of inflammation
Bai J,Qiu SL,Zhong XN,Huang QP,He ZY,Zhang JQ,Liu GN,Li MH,Deng JM
12-5773 was used in Flow cytometry/Cell sorting to indicate that erythromycin enhances regulatory T-cell responses, associated with the inhibition of smoking-induced inflammation in the lungs of rats.
Wed Sep 26 00:00:00 EDT 2012
The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population.
Stem cells and development
Svobodova E,Krulova M,Zajicova A,Pokorna K,Prochazkova J,Trosan P,Holan V
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the importance of MSCs in regulating differentiation and development of Th17 cells from naive CD4+CD25- precursors.
Tue Apr 10 00:00:00 EDT 2012
A Semliki forest virus vector engineered to express IFNα induces efficient elimination of established tumors.
Gene therapy
Quetglas JI,Fioravanti J,Ardaiz N,Medina-Echeverz J,Baraibar I,Prieto J,Smerdou C,Berraondo P
12-5773 was used in Flow cytometry/Cell sorting to assess the ability of a Semliki Forest virus vector expressing IFNα to induce significant anti-tumour responses in a subcutaneous tumour model of murine colon adenocarcinoma.
Thu Mar 01 00:00:00 EST 2012
Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.
Experimental and therapeutic medicine
Choi YJ,Yang KM,Kim SD,Yoo YH,Lee SW,Seo SY,Suh H,Yee ST,Jeong MH,Jo WS
12-5773 was used in Flow cytometry/Cell sorting to reveal the suppressive effect HS-1793 has on Treg cells, and its likely contribution to tumor-specific cytotoxic T lymphocyte responses.
Sun Apr 01 00:00:00 EDT 2012
Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy.
PloS one
Golias J,Schwarzer M,Wallner M,Kverka M,Kozakova H,Srutkova D,Klimesova K,Sotkovsky P,Palova-Jelinkova L,Ferreira F,Tuckova L
12-5773 was used in Flow cytometry/Cell sorting to investigate how thermal processing influences the ability of ovalbumin to induce allergic symptoms in a mouse model.
Mon Dec 17 00:00:00 EST 2012
Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation.
PloS one
Kyaw T,Tay C,Hosseini H,Kanellakis P,Gadowski T,MacKay F,Tipping P,Bobik A,Toh BH
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that B2 cells are important contributors to the development of atherosclerosis, and to determine the mechanism of contribution.
Mon May 14 00:00:00 EDT 2012
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.
PloS one
Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS
12-5773 was used in Flow cytometry/Cell sorting to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.
Thu Jun 20 00:00:00 EDT 2013
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
12-5773 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
Impact of dietary gluten on regulatory T cells and Th17 cells in BALB/c mice.
PloS one
Antvorskov JC,Fundova P,Buschard K,Funda DP
12-5773 was used in Flow cytometry/Cell sorting to study the effect of a gluten-free diet compared to a gluten-containing standard diet on selected T cell subsets in mice.
Mon Aug 20 00:00:00 EDT 2012
Activation-induced FoxP3 expression regulates cytokine production in conventional T cells stimulated with autologous dendritic cells.
Clinical and vaccine immunology : CVI
Cavatorta DJ,Erb HN,Felippe MJ
12-5773 was used in Flow cytometry/Cell sorting to investigate inducers of the autologous mixed leukocyte reaction.
Mon Oct 01 00:00:00 EDT 2012
Phenotypical and functional analysis of intraepithelial lymphocytes from small intestine of mice in oral tolerance.
Clinical & developmental immunology
Ruberti M,Fernandes LG,Simioni PU,Gabriel DL,Yamada AT,Tamashiro WM
12-5773 was used in Flow cytometry/Cell sorting to evaluate the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes.
Fri Mar 01 00:00:00 EST 2013
Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress.
PloS one
Spiering R,van der Zee R,Wagenaar J,Kapetis D,Zolezzi F,van Eden W,Broere F
12-5773 was used in Flow cytometry/Cell sorting to suggest that treatment of mouse bone marrow DCs with carvacrol and thermal stress induces functionally tolerogenic DCs that suppress autoimmune arthritis.
Wed Apr 10 00:00:00 EDT 2013
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC gastroenterology
Majowicz A,van der Marel S,te Velde AA,Meijer SL,Petry H,van Deventer SJ,Ferreira V
12-5773 was used in Flow cytometry/Cell sorting to identify a new method to generate in vitro iTreg cells (TregPMA cells) with demonstrated functionality in vivo.
Mon Dec 03 00:00:00 EST 2012
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.
PloS one
Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in the mechanisms involved in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function.
Thu Mar 28 00:00:00 EDT 2013
IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability.
PloS one
Hindinger C,Bergmann CC,Hinton DR,Phares TW,Parra GI,Hussain S,Savarin C,Atkinson RD,Stohlman SA
12-5773 was used in Flow cytometry/Cell sorting to investigate how astrocytes play a critical role in limiting CNS autoimmune disease dependent upon a neuroprotective signaling pathway mediated by engagement of IFN-γ receptors.
Thu Jan 10 00:00:00 EST 2013
Suppressive effects on the immune response and protective immunity to a JEV DNA vaccine by co-administration of a GM-CSF-expressing plasmid in mice.
PloS one
Chen H,Gao N,Fan D,Wu J,Zhu J,Li J,Wang J,Chen Y,An J
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that co-immunization with granulocyte-macrophage colony-stimulating factor causes substantial dampening of vaccine-induced antibody responses.
Tue Sep 04 00:00:00 EDT 2012
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.
Blood
Semple K,Nguyen A,Yu Y,Wang H,Anasetti C,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the role of CD28-mediated Lck signaling in suppressing iTreg generation, under strong CD28 costimulation.
Thu Mar 17 00:00:00 EDT 2011
Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice.
The Journal of clinical investigation
Hammerschmidt SI,Friedrichsen M,Boelter J,Lyszkiewicz M,Kremmer E,Pabst O,Förster R
12-5773 was used in Flow cytometry/Cell sorting to investigate the effectiveness of retinoic acid-assisted subcutaneous immunisation as a novel approach to vaccination against enteropathogens.
Mon Aug 01 00:00:00 EDT 2011
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.
The Journal of clinical investigation
Li J,Bessho K,Shivakumar P,Mourya R,Mohanty SK,Dos Santos JL,Miura IK,Porta G,Bezerra JA
12-5773 was used in Flow cytometry/Cell sorting to assess whether Th1-independent mechanisms can activate effector cells to induce biliary atresia.
Tue Nov 01 00:00:00 EDT 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
12-5773 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.
The Journal of experimental medicine
Ohmichi Y,Hirakawa J,Imai Y,Fukuda M,Kawashima H
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that PNAd is essential for lymphocyte homing to NALT and nasal allergic responses.
Mon May 09 00:00:00 EDT 2011
IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization.
Journal of autoimmunity
Li CR,Deiro MF,Godebu E,Bradley LM
12-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms that regulate adaptive regulatory T cells.
Tue Nov 01 00:00:00 EDT 2011
Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tawara I,Koyama M,Liu C,Toubai T,Thomas D,Evers R,Chockley P,Nieves E,Sun Y,Lowler KP,Malter C,Nishimoto N,Hill GR,Reddy P
12-5773 was used in Flow cytometry/Cell sorting to confirm and extended the relevance of IL-6 deficiency on graft-versus-host disease and the graft-versus-tumour effect.
Sat Jan 01 00:00:00 EST 2011
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Lal G,Yin N,Xu J,Lin M,Schroppel S,Ding Y,Marie I,Levy DE,Bromberg JS
12-5773 was used in Flow cytometry/Cell sorting to investigate how different inflammatory signals affect Foxp3 expression and Tregs plasticity, showing that distinct signals have physiologically divergent effects on Foxp3 epigenetic regulation.
Tue Feb 01 00:00:00 EST 2011
Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells.
Diabetes
Muller YD,Golshayan D,Ehirchiou D,Wyss JC,Giovannoni L,Meier R,Serre-Beinier V,Puga Yung G,Morel P,Bühler LH,Seebach JD
12-5773 was used in Flow cytometry/Cell sorting to evaluate how STZ-induced diabetes affects adaptive immunity and the consequences thereof on allograft rejection.
Thu Sep 01 00:00:00 EDT 2011
Active immunization using a single dose immunotherapeutic abates established EAE via IL-10 and regulatory T cells.
European journal of immunology
Rynda-Apple A,Huarte E,Maddaloni M,Callis G,Skyberg JA,Pascual DW
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the feasibility of using pσ1 as a tolerogen platform for antigen-specific tolerance induction, and highlight its potential use as an immunotherapeutic for autoimmunity.
Tue Feb 01 00:00:00 EST 2011
A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats.
Molecular medicine (Cambridge, Mass.)
Takabatake Y,Li XK,Mizui M,Miyasato K,Matsui I,Kawada N,Imai E,Hünig T,Takahara S,Wada T,Furuichi K,Rakugi H,Isaka Y
12-5773 was used in Flow cytometry/Cell sorting to investigate whether a superagonistic monoclonal antibody for CD28 could prevent nephrotoxic serum-induced nephritis.
Tue Dec 27 00:00:00 EST 2011
Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells.
Journal of leukocyte biology
Gautreau L,Chabannes D,Heslan M,Josien R
12-5773 was used in Flow cytometry/Cell sorting to analyse the role of pDCs versus cDCs on regulatory T cell responses.
Thu Sep 01 00:00:00 EDT 2011
Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells.
Journal of leukocyte biology
Gautreau L,Chabannes D,Heslan M,Josien R
12-5773 was used in Flow cytometry/Cell sorting to analyse the role of pDCs versus cDCs on regulatory T cell responses.
Thu Sep 01 00:00:00 EDT 2011
Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.
Cancer gene therapy
Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A
12-5773 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.
Wed Jun 01 00:00:00 EDT 2011
An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection.
Journal of immunology (Baltimore, Md. : 1950)
Kroetz DN,Deepe GS
12-5773 was used in Flow cytometry/Cell sorting to show that CCR5 signalling regulates pathogen persistence in murine histoplasmosis by regulating the thymic egress of Tregs.
Sun May 15 00:00:00 EDT 2011
4-1BB triggering ameliorates experimental autoimmune encephalomyelitis by modulating the balance between Th17 and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kim YH,Choi BK,Shin SM,Kim CH,Oh HS,Park SH,Lee DG,Lee MJ,Kim KH,Vinay DS,Kwon BS
12-5773 was used in Flow cytometry/Cell sorting to identify an additional mechanism for the 4-1BB-triggered suppression of autoimmune responses.
Mon Aug 01 00:00:00 EDT 2011
Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency.
Journal of immunology (Baltimore, Md. : 1950)
Reddy PB,Sehrawat S,Suryawanshi A,Rajasagi NK,Mulik S,Hirashima M,Rouse BT
12-5773 was used in Flow cytometry/Cell sorting to study the role of the inhibitory interaction between T cell Ig and mucin domain-containing molecule 3-expressing CD8 T cells and galectin 9 in herpes simplex virus latency and reactivation.
Thu Dec 01 00:00:00 EST 2011
CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Okamoto M,Takeda K,Schedel M,Ohnishi H,Dakhama A,Gelfand EW
12-5773 was used in Flow cytometry/Cell sorting to identify the critical role of CD8-T regulatory cell interactions in regulating the suppressive phenotype of nTregs through control of IL-6 production.
Sat Jan 01 00:00:00 EST 2011
Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Park SY,Gupta D,Hurwich R,Kim CH,Dziarski R
12-5773 was used in Flow cytometry/Cell sorting to indicate that Pglyrp2 limits overactivation of Th17 cells, by promoting accumulation of regulatory T-cells at inflammation sites, protecting skin from an inflammatory response.
Thu Dec 01 00:00:00 EST 2011
Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Medina-Echeverz J,Fioravanti J,Zabala M,Ardaiz N,Prieto J,Berraondo P
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the combination of IL-12 and CPA eliminates intratumoral Treg and MDSC, while inducing the appearance of IMC within the tumor microenvironment.
Sat Jan 15 00:00:00 EST 2011
MHC-independent genetic factors control the magnitude of CD4+ T cell responses to amyloid-β peptide in mice through regulatory T cell-mediated inhibition.
Journal of immunology (Baltimore, Md. : 1950)
Toly-Ndour C,Lui G,Nunes MM,Bruley-Rosset M,Aucouturier P,Dorothée G
12-5773 was used in Flow cytometry/Cell sorting to examine whether non-MHC genetic factors modulate the strength of CD4+ T cell responses to amyloid-β peptide.
Tue Nov 01 00:00:00 EDT 2011
H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
del Rio R,Sun Y,Alard P,Tung KS,Teuscher C
12-5773 was used in Flow cytometry/Cell sorting to confirm that quantitative trait loci on a range of chromosomes control susceptibility to autoimmune ovarian dysgenesis.
Sat Jan 01 00:00:00 EST 2011
Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Smith KA,Hochweller K,Hämmerling GJ,Boon L,MacDonald AS,Maizels RM
12-5773 was used in Functional assays to identify that the preferential expansion of a novel population of CD11c(lo) non-plasmacytoid DCs is associated with the pro-regulatory environment of chronic intestinal helminth infection.
Wed Jun 15 00:00:00 EDT 2011
Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Collins EL,Jager LD,Dabelic R,Benitez P,Holdstein K,Lau K,Haider MI,Johnson HM,Larkin J
12-5773 was used in Flow cytometry/Cell sorting to show that CD4(+)/SOCS1-KIR combined treatment can synergistically promote the long-term survival of perinatal lethal SOCS1(-/-) mice.
Thu Sep 01 00:00:00 EDT 2011
Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris.
International immunology
Yokoyama T,Matsuda S,Takae Y,Wada N,Nishikawa T,Amagai M,Koyasu S
12-5773 was used in Flow cytometry/Cell sorting to indicate that Tregs capable of suppressing T(h) cells that drive autoantibody production can develop without the target antigen.
Wed Jun 01 00:00:00 EDT 2011
Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells.
International immunology
Wada H,Kojo S,Kusama C,Okamoto N,Sato Y,Ishizuka B,Seino K
12-5773 was used in Flow cytometry/Cell sorting to illustrate that current in vitro differentiation systems using induced pluripotent stem cells are insufficient for inducing B-cell lineage.
Sat Jan 01 00:00:00 EST 2011
Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Xiong Z,Ohlfest JR
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that topical application of the TLR7 agonist imiquimod can enhance T-cell responses to intracranial tumors as a single agent in mice.
Fri Apr 01 00:00:00 EDT 2011
Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation.
Infection and immunity
Souza AL,Souza PR,Pereira CA,Fernandes A,Guabiraba R,Russo RC,Vieira LQ,Corrêa A,Teixeira MM,Negrão-Corrêa D
12-5773 was used in Flow cytometry/Cell sorting to discover that CCR5 deletion is deleterious to Schistosoma mansoni infected mice, which is associated with enhanced fibrosis and granulomatous inflammation.
Fri Apr 01 00:00:00 EDT 2011
GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.
Journal of neuroimmunology
Sheng JR,Muthusamy T,Prabhakar BS,Meriggioli MN
12-5773 was used in Flow cytometry/Cell sorting to explore the role of induced antigen specific Tregs in the effects of GM-CSF in murine experimental autoimmune myasthenia gravis.
Thu Dec 15 00:00:00 EST 2011
Immunization with cationized BSA inhibits progression of disease in ApoBec-1/LDL receptor deficient mice with manifest atherosclerosis.
Immunobiology
Kolbus D,Wigren M,Ljungcrantz I,Söderberg I,Alm R,Björkbacka H,Nilsson J,Fredrikson GN
12-5773 was used in Flow cytometry/Cell sorting to show that immunisation with cationised BSA induces an immune response against apolipoprotein B as well as an activation of Treg cells.
Wed Jun 01 00:00:00 EDT 2011
Increased T regulatory cells lead to development of Th2 immune response in male SJL mice.
Autoimmunity
Hussain S,Kirwin SJ,Stohlman SA
12-5773 was used in Flow cytometry/Cell sorting to study the importance of an increased frequency of IL-10 secreting regulatory T cells in promoting resistance to autoimmune disease in male SJL mice.
Sun May 01 00:00:00 EDT 2011
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
The Journal of surgical research
Brennan TV,Tang Q,Liu FC,Hoang V,Bi M,Bluestone JA,Kang SM
12-5773 was used in Flow cytometry/Cell sorting to evaluate whether Tregs with a defined allospecificity are more effective than polyclonal Tregs at suppressing allograft rejection.
Fri Jul 01 00:00:00 EDT 2011
PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity.
PloS one
Keijzer C,Slütter B,van der Zee R,Jiskoot W,van Eden W,Broere F
12-5773-82 was used in encapsulating nanoparticles to uncover a role for PLGA nanoparticles to enhance CD4(+) T-cell mediated immunomodulation after nasal application.
Mon Mar 26 00:00:00 EDT 2012
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
PloS one
Côté AL,Byrne KT,Steinberg SM,Zhang P,Turk MJ
12-5773 was used in Flow cytometry/Cell sorting to support further use of CD4 T cell depletion therapy for inducing long-lived immunity to cancer.
Mon Mar 26 00:00:00 EDT 2012
Ex vivo generation of regulatory T cells: characterization and therapeutic evaluation in a model of chronic colitis.
Methods in molecular biology (Clifton, N.J.)
Karlsson F,Robinson-Jackson SA,Gray L,Zhang S,Grisham MB
12-5773 was used in Flow cytometry/Cell sorting to develop a relatively simple ex vivo method to generate large numbers of Foxp3-expressing iTregs.
Wed Feb 02 00:00:00 EST 2011
c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.
PloS one
Grigoriadis G,Vasanthakumar A,Banerjee A,Grumont R,Overall S,Gleeson P,Shannon F,Gerondakis S
12-5773 was used in Flow cytometry/Cell sorting to show that c-Rel generates a permissive state for foxp3 transcription during the development of nTreg precursors.
Thu Mar 15 00:00:00 EDT 2012
Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension.
BMC immunology
Rabieyousefi M,Soroosh P,Satoh K,Date F,Ishii N,Yamashita M,Oka M,McMurtry IF,Shimokawa H,Nose M,Sugamura K,Ono M
12-5773 was used in Flow cytometry/Cell sorting to characterize a new pulmonary arterial hypertension (PAH) animal model including the involvement of the OX40 ligand-associated immune response.
Thu Dec 15 00:00:00 EST 2011
CD4+FoxP3+ regulatory T cells from Gαi2-/- mice are functionally active in vitro, but do not prevent colitis.
PloS one
Götlind YY,Raghavan S,Bland PW,Hörnquist EH
12-5773 was used in Flow cytometry/Cell sorting to examine whether a CD4(+)FoxP3(+) Treg defect underpins the pathogenesis of colitis in the Gαi2(-/-) colitis model.
Fri Jun 08 00:00:00 EDT 2012
The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses.
Blood
Comerford I,Nibbs RJ,Litchfield W,Bunting M,Harata-Lee Y,Haylock-Jacobs S,Forrow S,Korner H,McColl SR
12-5773 was used in Flow cytometry/Cell sorting to examine the effects of CCX-CKR scavenger function on the localisation, kinetics, and nature of adaptive immune responses in vivo.
Thu Nov 18 00:00:00 EST 2010
2-Gy whole-body irradiation significantly alters the balance of CD4+ CD25- T effector cells and CD4+ CD25+ Foxp3+ T regulatory cells in mice.
Cellular & molecular immunology
Qu Y,Zhang B,Liu S,Zhang A,Wu T,Zhao Y
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD4+ CD25+ Foxp3+ Treg cells are more resistant to ionizing irradiation-induced cell death than CD4+ CD25+ T-cells.
Mon Nov 01 00:00:00 EDT 2010
Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology.
The Journal of experimental medicine
Hao J,Liu R,Piao W,Zhou Q,Vollmer TL,Campagnolo DI,Xiang R,La Cava A,Van Kaer L,Shi FD
12-5773 was used in Flow cytometry/Cell sorting to suggest an organ-specific activity of NK cells on the magnitude of CNS inflammation, providing potential new targets for therapeutic intervention.
Mon Aug 30 00:00:00 EDT 2010
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
12-5773 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mitsui J,Nishikawa H,Muraoka D,Wang L,Noguchi T,Sato E,Kondo S,Allison JP,Sakaguchi S,Old LJ,Kato T,Shiku H
12-5773 was used in Flow cytometry/Cell sorting to explore the use of anti-CTLA-4/anti-GITR mAb combination treatment to reject established tumours.
Sat May 15 00:00:00 EDT 2010
Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kong LY,Gelbard A,Wei J,Reina-Ortiz C,Wang Y,Yang EC,Hailemichael Y,Fokt I,Jayakumar A,Qiao W,Fuller GN,Overwijk WW,Priebe W,Heimberger AB
12-5773 was used in Immunocytochemistry to investigate whether WP1193 would enhance the anti-tumour activity of interferon-alpha against metastatic melanoma.
Sat May 01 00:00:00 EDT 2010
Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kong LY,Gelbard A,Wei J,Reina-Ortiz C,Wang Y,Yang EC,Hailemichael Y,Fokt I,Jayakumar A,Qiao W,Fuller GN,Overwijk WW,Priebe W,Heimberger AB
12-5773 was used in Immunocytochemistry to investigate whether WP1193 would enhance the anti-tumour activity of interferon-alpha against metastatic melanoma.
Sat May 01 00:00:00 EDT 2010
Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.
Cancer gene therapy
Whelan MC,Casey G,MacConmara M,Lederer JA,Soden D,Collins JK,Tangney M,O'Sullivan GC
12-5773 was used in Flow cytometry/Cell sorting to study the use of a combined immunogene therapy and regulatory T-cell inactivation against weakly immunogenic solid tumours.
Thu Jul 01 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
12-5773 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Tawara I,Shlomchik WD,Jones A,Zou W,Nieves E,Liu C,Toubai T,Duran-Struuck R,Sun Y,Clouthier SG,Evers R,Lowler KP,Levy RB,Reddy P
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of host APCs in the suppression of GVHD by donor regulatory T-cells.
Fri Oct 01 00:00:00 EDT 2010
CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Adeegbe D,Matsutani T,Yang J,Altman NH,Malek TR
12-5773 was used in Flow cytometry/Cell sorting to measure T cell receptor diversity in regulatory T cells after transfer into IL-2Rbeta knockout mice.
Fri Jan 01 00:00:00 EST 2010
Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Costello P,Nicolas R,Willoughby J,Wasylyk B,Nordheim A,Treisman R
12-5773 was used in Flow cytometry/Cell sorting to assess whether the serum response factor cofactors SAP-1, Elk-1, and Net are functionally equivalent.
Thu Jul 15 00:00:00 EDT 2010
Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice.
Journal of immunology (Baltimore, Md. : 1950)
Goldberg GL,Dudakov JA,Reiseger JJ,Seach N,Ueno T,Vlahos K,Hammett MV,Young LF,Heng TS,Boyd RL,Chidgey AP
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that sex steroid ablation enhances T-cell recovery following cyclophosphamide treatment of mice.
Tue Jun 01 00:00:00 EDT 2010
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura K,Farber JM,Kelsall BL
12-5773 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.
Wed Sep 15 00:00:00 EDT 2010
Critical role of regulatory T cells in Th17-mediated minor antigen-disparate rejection.
Journal of immunology (Baltimore, Md. : 1950)
Vokaer B,Van Rompaey N,Lemaître PH,Lhommé F,Kubjak C,Benghiat FS,Iwakura Y,Petein M,Field KA,Goldman M,Le Moine A,Charbonnier LM
12-5773 was used in Flow cytometry/Cell sorting to discover the ability of Tregs to promote the Th17/neutrophil-mediated pathway of rejection as a potential drawback of Treg-based cell therapy.
Wed Sep 15 00:00:00 EDT 2010
T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950)
Jones TG,Finkelman FD,Austen KF,Gurish MF
12-5773 was used in Flow cytometry/Cell sorting to reveal an unexpected role for T regulatory cells in antigen-induced pulmonary inflammation.
Sun Aug 01 00:00:00 EDT 2010
Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.
Journal of cell science
Barnwell EM,van Deursen FJ,Jeacock L,Smith KA,Maizels RM,Acosta-Serrano A,Matthews K
12-5773 was used in Flow cytometry/Cell sorting to show the expression profile and extracellular release of ESAG9 proteins represents an aspect of trypanosome transmission in their mammalian host.
Fri Oct 01 00:00:00 EDT 2010
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
Gene therapy
Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that dystrophin gene transfer induces anti-dystrophin immunity that are diminished by temporal removal of host immune cells.
Wed Sep 01 00:00:00 EDT 2010
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
PloS one
Rynda A,Maddaloni M,Ochoa-Repáraz J,Callis G,Pascual DW
12-5773 was used in Flow cytometry/Cell sorting to demonstrate the potential for IL-28 as an alternative therapy for EAE.
Thu Jan 14 00:00:00 EST 2010
A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis.
Arthritis and rheumatism
Wieten L,van der Zee R,Spiering R,Wagenaar-Hilbers J,van Kooten P,Broere F,van Eden W
12-5773 was used in Flow cytometry/Cell sorting to study whether the boosting of endogenous heat-shock protein expression can restore effective immunoregulation through T cells specific for stress proteins.
Thu Apr 01 00:00:00 EDT 2010
ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression.
PloS one
Gravano DM,McLelland BT,Horiuchi K,Manilay JO
12-5773 was used in Flow cytometry/Cell sorting to show that absence of Adam17 in thymic epithelial cells is dispensable for normal T-cell development.
Wed Oct 20 00:00:00 EDT 2010
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.
PloS one
Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH
12-5773 was used in Immunohistochemistry on paraffin embedded tissues to investigate the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival, showing that it induces T regulatory cell mediated tolerance.
Mon Apr 26 00:00:00 EDT 2010
Regulatory T cells modulate postischemic neovascularization.
Circulation
Zouggari Y,Ait-Oufella H,Waeckel L,Vilar J,Loinard C,Cochain C,Récalde A,Duriez M,Levy BI,Lutgens E,Mallat Z,Silvestre JS
12-5773 was used in Flow cytometry/Cell sorting to study the role of Treg cell activation in postischemic response and vessel growth.
Tue Oct 06 00:00:00 EDT 2009
Themis, a T cell-specific protein important for late thymocyte development.
Nature immunology
Lesourne R,Uehara S,Lee J,Song KD,Li L,Pinkhasov J,Zhang Y,Weng NP,Wildt KF,Wang L,Bosselut R,Love PE
12-5773 was used in Flow cytometry/Cell sorting to explore the role of the T cell-specific protein, Themis, during thymocyte positive selection.
Sat Aug 01 00:00:00 EDT 2009
Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts.
Blood
Cui Y,Zhang H,Meadors J,Poon R,Guimond M,Mackall CL
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that targeted therapies delivered to mimic the "physiology of lymphopenia" enhance the efficacy of adoptive immunotherapy in lymphoreplete hosts.
Thu Oct 29 00:00:00 EDT 2009
Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.
The Journal of clinical investigation
Darrasse-Jèze G,Bergot AS,Durgeau A,Billiard F,Salomon BL,Cohen JL,Bellier B,Podsypanina K,Klatzmann D
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that the appearance of tumour cells is immediately sensed by CD44hi memory Tregs that are specific for self antigens.
Tue Sep 01 00:00:00 EDT 2009
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
The Journal of experimental medicine
Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ
12-5773 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.
Fri Jan 16 00:00:00 EST 2009
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.
The Journal of experimental medicine
Zhu J,Davidson TS,Wei G,Jankovic D,Cui K,Schones DE,Guo L,Zhao K,Shevach EM,Paul WE
12-5773 was used in Flow cytometry/Cell sorting to show that Gfi-1, a transcriptional repressor, has a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103(+) iTreg cells.
Mon Feb 16 00:00:00 EST 2009
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.
The Journal of experimental medicine
Taleb S,Romain M,Ramkhelawon B,Uyttenhove C,Pasterkamp G,Herbin O,Esposito B,Perez N,Yasukawa H,Van Snick J,Yoshimura A,Tedgui A,Mallat Z
12-5773 was used in Flow cytometry/Cell sorting to examine the downstream effects of the loss of suppressor of cytokine signalling 3 in T cells.
Mon Sep 28 00:00:00 EDT 2009
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
12-5773 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
12-5773 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Immune rejection of mouse tumors expressing mutated self.
Cancer research
Duan F,Lin Y,Liu C,Engelhorn ME,Cohen AD,Curran M,Sakaguchi S,Merghoub T,Terzulli S,Wolchok JD,Houghton AN
12-5773 was used in Flow cytometry/Cell sorting to study the T-cell responses to mutated self during tumour growth in vivo, including levels of response, kinetics, and correlates that predict tumour rejection.
Wed Apr 15 00:00:00 EDT 2009
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology
Barnes MJ,Krebs P,Harris N,Eidenschenk C,Gonzalez-Quintial R,Arnold CN,Crozat K,Sovath S,Moresco EM,Theofilopoulos AN,Beutler B,Hoebe K
12-5773 was used in Flow cytometry/Cell sorting to investigate methods to distinguish between Tregs of thymic or peripheral origin, showing that commitment requires CARMA1 in the thymus but not in the periphery.
Tue Mar 03 00:00:00 EST 2009
Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.
European journal of immunology
Chen ML,Yan BS,Kozoriz D,Weiner HL
12-5773 was used in Flow cytometry/Cell sorting to suggest that induction or amplification of CD8+LAP+ cells may be a therapeutic strategy to help control autoimmune processes.
Tue Dec 01 00:00:00 EST 2009
A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells.
Cancer immunology, immunotherapy : CII
Kong LY,Wei J,Sharma AK,Barr J,Abou-Ghazal MK,Fokt I,Weinberg J,Rao G,Grimm E,Priebe W,Heimberger AB
12-5773 was used in in vitro experiments to suggest that WP1066 enhances T-cell cytotoxicity against melanoma through inhibition of regulatory T-cells.
Wed Jul 01 00:00:00 EDT 2009
Treatment of chronic viral hepatitis in woodchucks by prolonged intrahepatic expression of interleukin-12.
Journal of virology
Crettaz J,Otano I,Ochoa-Callejero L,Benito A,Paneda A,Aurrekoetxea I,Berraondo P,Rodríguez-Madoz JR,Astudillo A,Kreppel F,Kochanek S,Ruiz J,Menne S,Prieto J,Gonzalez-Aseguinolaza G
12-5773-82 was used in Flow Cytometry to conclude that IL-12-based gene therapy is an efficient approach to treat chronic hepadnavirus infection in woodchucks with viral loads below 10(10) vg/ml.
Sun Mar 01 00:00:00 EST 2009
Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads.
Journal of immunology (Baltimore, Md. : 1950)
Myers L,Messer RJ,Carmody AB,Hasenkrug KJ
12-5773 was used in Flow cytometry/Cell sorting to reveal Treg-mediated suppression of CD8(+) T cells in specific tissues which correlates with profound effects on localised levels of chronic infection.
Sat Aug 01 00:00:00 EDT 2009
In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Ahangarani RR,Janssens W,VanderElst L,Carlier V,VandenDriessche T,Chuah M,Weynand B,Vanoirbeek JA,Jacquemin M,Saint-Remy JM
12-5773 was used in Flow cytometry/Cell sorting to design a method for in vivo induction of Ag-specific Tregs, in BALB/c H-2d, that share characteristics with type 1 Tregs.
Tue Dec 15 00:00:00 EST 2009
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Howie D,Nolan KF,Daley S,Butterfield E,Adams E,Garcia-Rueda H,Thompson C,Saunders NJ,Cobbold SP,Tone Y,Tone M,Waldmann H
12-5773 was used in Flow cytometry/Cell sorting to investigate how T cells preoccupied with immune defense use the MS4A family to enhance sensitivity to extrinsic Ag stimulation, ensuring its elimination.
Thu Oct 01 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-5773 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
12-5773 was used in Flow cytometry/Cell sorting to study the role of Tc17 cells in influenza infection, showing that they protect against lethality.
Sun Mar 15 00:00:00 EDT 2009
The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Scott GN,DuHadaway J,Pigott E,Ridge N,Prendergast GC,Muller AJ,Mandik-Nayak L
12-5773 was used in Flow cytometry/Cell sorting to suggest that IDO is not simply immunosuppressive, but plays a more complex role in modulating inflammatory responses.
Mon Jun 15 00:00:00 EDT 2009
Regulation of Th17 differentiation by epidermal fatty acid-binding protein.
Journal of immunology (Baltimore, Md. : 1950)
Li B,Reynolds JM,Stout RD,Bernlohr DA,Suttles J
12-5773 was used in Flow cytometry/Cell sorting to provide evidence to support that expression of E-FABP by CD4+ T cells contributes to the control of IL-6 stimulation of the IL-21/ROR/IL-17 pathway and to the Th17/Treg counter-balance.
Mon Jun 15 00:00:00 EDT 2009
Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Brambilla R,Persaud T,Hu X,Karmally S,Shestopalov VI,Dvoriantchikova G,Ivanov D,Nathanson L,Barnum SR,Bethea JR
12-5773 was used in Flow cytometry/Cell sorting to display the potential neuroprotective benefits of transgenic inhibition of NF-kappaB following autoimmune encephalomyelitis.
Sun Mar 01 00:00:00 EST 2009
Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Lin YC,Chang LY,Huang CT,Peng HM,Dutta A,Chen TC,Yeh CT,Lin CY
12-5773 was used in Flow cytometry/Cell sorting to study the contribution of various Treg cell types to the maintenance of concomitant tumour immunity.
Fri May 15 00:00:00 EDT 2009
SHIP regulates the reciprocal development of T regulatory and Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Locke NR,Patterson SJ,Hamilton MJ,Sly LM,Krystal G,Levings MK
12-5773 was used in Immunohistochemistry to investigate whether SHIP, a lipid phosphatase that regulates PI3K activity, also plays a role in the development and function of Tregs.
Wed Jul 15 00:00:00 EDT 2009
Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.
International immunology
Boldizsar F,Tarjanyi O,Nemeth P,Mikecz K,Glant TT
12-5773 was used in Flow cytometry/Cell sorting to indicate that repeatedly injected antigen leads to the recruitment and activation of immune cells in the peritoneum.
Fri May 01 00:00:00 EDT 2009
In situ adenovirus vaccination engages T effector cells against cancer.
Vaccine
Tuve S,Liu Y,Tragoolpua K,Jacobs JD,Yumul RC,Li ZY,Strauss R,Hellström KE,Disis ML,Roffler S,Lieber A
12-5773 was used in Flow cytometry/Cell sorting to show Ad-specific T cells were anti-tumor-reactive despite the presence of active regulatory T cell-mediated immune tolerance inside MMC tumors.
Wed Jun 24 00:00:00 EDT 2009
In situ adenovirus vaccination engages T effector cells against cancer.
Vaccine
Tuve S,Liu Y,Tragoolpua K,Jacobs JD,Yumul RC,Li ZY,Strauss R,Hellström KE,Disis ML,Roffler S,Lieber A
12-5773 was used in Flow cytometry/Cell sorting to show Ad-specific T cells were anti-tumor-reactive despite the presence of active regulatory T cell-mediated immune tolerance inside MMC tumors.
Wed Jun 24 00:00:00 EDT 2009
Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancer.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Zingg U,Montani M,Frey DM,Dirnhofer S,Went P,Oertli D
12-5773 was used in Immunohistochemistry-immunofluorescence to study the influence of radio-chemotherapy on tumour-infiltrating lymphocytes in oesophageal squamous cell cancer.
Tue Dec 01 00:00:00 EST 2009
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Reproduction (Cambridge, England)
Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP
12-5773 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.
Thu Oct 01 00:00:00 EDT 2009
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Reproduction (Cambridge, England)
Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP
12-5773 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.
Thu Oct 01 00:00:00 EDT 2009
Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10.
Infection and immunity
Pacífico LG,Marinho FA,Fonseca CT,Barsante MM,Pinho V,Sales-Junior PA,Cardoso LS,Araújo MI,Carvalho EM,Cassali GD,Teixeira MM,Oliveira SC
12-5773 was used in Flow cytometry/Cell sorting to study the critical role of CD4(+) CD25(+) Foxp3(+) regulatory T cells in experimental asthma modulation independent of IL-10.
Thu Jan 01 00:00:00 EST 2009
CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis.
Infection and immunity
Fang R,Ismail N,Shelite T,Walker DH
12-5773 was used in Flow cytometry/Cell sorting to suggest that CD4(+) CD25(+) T cells generated in acute murine spotted fever rickettsiosis are Th1-cell-related adaptive T-regulatory cells.
Tue Sep 01 00:00:00 EDT 2009
Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis.
Infection and immunity
Thirumalapura NR,Crossley EC,Walker DH,Ismail N
12-5773 was used in Flow cytometry/Cell sorting to indicate that persistent ehrlichial infection contributes to heterologous protection by stimulating the maintenance of memory T-cell response.
Tue Dec 01 00:00:00 EST 2009
Role of regulatory T cells in coronavirus-induced acute encephalitis.
Virology
Anghelina D,Zhao J,Trandem K,Perlman S
12-5773 was used in Flow cytometry/Cell sorting to show that Tregs may help to limit immunopathological disease without delaying virus clearance in coronavirus-induced acute encephalitis.
Sun Mar 15 00:00:00 EDT 2009
Induction of Foxp3-expressing regulatory T-cells by donor blood transfusion is required for tolerance to rat liver allografts.
PloS one
Abe Y,Urakami H,Ostanin D,Zibari G,Hayashida T,Kitagawa Y,Grisham MB
12-5773 was used in Flow cytometry/Cell sorting to show that preoperative donor-specific blood transfusion induces formation of CD4(+) T-cells which give rise to fully functional CD4(+)CD45RC(-)Foxp3(+)Tregs.
Mon Nov 23 00:00:00 EST 2009
Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses.
Arthritis and rheumatism
Satpute SR,Rajaiah R,Polumuri SK,Moudgil KD
12-5773 was used in Flow cytometry/Cell sorting to investigate the protective effects of soluble mycobacterial Hsp65 against adjuvant-induced arthritis (AIA).
Thu Jan 01 00:00:00 EST 2009
Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.
PloS one
Chen G,Han G,Feng J,Wang J,Wang R,Xu R,Shen B,Qian J,Li Y
12-5773 was used in Flow cytometry/Cell sorting to investigate how structural analysis of epitopes may aid predictions of protective epitopes to expand functional Tregs.
Sun Sep 13 00:00:00 EDT 2009
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood
Mazzucchelli R,Hixon JA,Spolski R,Chen X,Li WQ,Hall VL,Willette-Brown J,Hurwitz AA,Leonard WJ,Durum SK
12-5773 was used in Flow cytometry/Cell sorting to examine whether regulatory T cells require the IL-7 pathway by analysing IL-7Ralpha(-/-) mice.
Wed Oct 15 00:00:00 EDT 2008
Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells.
Blood
Gatza E,Rogers CE,Clouthier SG,Lowler KP,Tawara I,Liu C,Reddy P,Ferrara JL
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that the transfer of cells treated with extracorporeal photopheresis reverses established graft versus host disease.
Fri Aug 15 00:00:00 EDT 2008
Deficiency of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus-grafted nude mice suffering from autoimmune diseases.
Cellular & molecular immunology
Zhang B,Sun C,Qu Y,Zhang A,Liu J,Zhang L,Niu Z,Zhao Y
12-5773 was used in Immunofluorescence to demonstrate that decreased levels, altered phenotype and functional deficiency of mouse CD4+CD25+ Treg cells may contribute to the development of AID in pig thymus-grafted nude mice.
Wed Oct 01 00:00:00 EDT 2008
Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.
Journal of autoimmunity
Hondowicz BD,Fields ML,Nish SA,Larkin J,Caton AJ,Erikson J
12-5773 was used in Flow cytometry/Cell sorting to show that Treg cells block lpr/lpr gld/gld Th cells from providing help to anti-chromatin B cells in an in vivo transfer system.
Mon Sep 01 00:00:00 EDT 2008
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kong LY,Abou-Ghazal MK,Wei J,Chakraborty A,Sun W,Qiao W,Fuller GN,Fokt I,Grimm EA,Schmittling RJ,Archer GE,Sampson JH,Priebe W,Heimberger AB
12-5773 was used in Flow cytometry/Cell sorting to discover the antitumor, cytotoxic effects of WP1066 and its ability to induce antitumor immune responses.
Mon Sep 15 00:00:00 EDT 2008
Nitric oxide is a key component in inflammation-accelerated tumorigenesis.
Cancer research
Hussain SP,He P,Subleski J,Hofseth LJ,Trivers GE,Mechanic L,Hofseth AB,Bernard M,Schwank J,Nguyen G,Mathe E,Djurickovic D,Haines D,Weiss J,Back T,Gruys E,Laubach VE,Wiltrout RH,Harris CC
12-5773 was used in Flow cytometry/Cell sorting to test the hypothesis that an inflammatory microenvironment with an enhanced level of nitric oxide accelerates spontaneous tumour development (tumorigenesis).
Mon Sep 01 00:00:00 EDT 2008
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.
Proceedings of the National Academy of Sciences of the United States of America
Huber M,Brüstle A,Reinhard K,Guralnik A,Walter G,Mahiny A,von Löw E,Lohoff M
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of IRF4 in Th17 differentiation, showing that it is essential for IL-21-mediated induction, amplification, and stabilisation of the Th17 phenotype.
Tue Dec 30 00:00:00 EST 2008
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice.
European journal of immunology
Zou L,Mendez F,Martin-Orozco N,Peterson EJ
12-5773 was used in Flow cytometry/Cell sorting to investigate the role of ADAP in a T cell-driven autoimmune response, showing that deficiency leads to defective positive selection in T cell lymphopenia and increased autoimmune diabetes.
Tue Apr 01 00:00:00 EDT 2008
Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vorachek WR,Steppan LB,Mourich DV,Kerkvliet NI
12-5773 was used in Flow cytometry/Cell sorting to further characterise TCDD-CD4(+) cells by comparison with CD4(+) T-regs and vehicle-treated cells.
Fri Aug 15 00:00:00 EDT 2008
CD28 controls differentiation of regulatory T cells from naive CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Guo F,Iclozan C,Suh WK,Anasetti C,Yu XZ
12-5773 was used in Flow cytometry/Cell sorting to investigate whether and how CD28 and ICOS control the differentiation of Tregs from naive T cells.
Fri Aug 15 00:00:00 EDT 2008
Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells.
Journal of immunology (Baltimore, Md. : 1950)
Godebu E,Summers-Torres D,Lin MM,Baaten BJ,Bradley LM
12-5773 was used in Flow cytometry/Cell sorting to examine the ability of adaptive/induced polyclonal regulatory CD4 cells to reverse and protect against type I diabetes.
Fri Aug 01 00:00:00 EDT 2008
Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.
Journal of immunology (Baltimore, Md. : 1950)
Rynda A,Maddaloni M,Mierzejewska D,Ochoa-Repáraz J,Maslanka T,Crist K,Riccardi C,Barszczewska B,Fujihashi K,McGhee JR,Pascual DW
12-5773 was used in Flow cytometry/Cell sorting to investigate whether targeting a model Ag to microfold cells via psigma1 could induce a state of unresponsiveness, showing that low-dose tolerance is mediated by psigma1.
Tue Apr 15 00:00:00 EDT 2008
TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis.
Journal of immunology (Baltimore, Md. : 1950)
Deepe GS,Gibbons RS
12-5773 was used in Flow cytometry/Cell sorting to investigate whether neutralisation of TNF-alpha triggers the emergence of T cells that dampen immunity.
Tue Jan 15 00:00:00 EST 2008
Natural regulatory (CD4+CD25+FOXP+) T cells control the production of pro-inflammatory cytokines during Plasmodium chabaudi adami infection and do not contribute to immune evasion.
International journal for parasitology
Cambos M,Bélanger B,Jacques A,Roulet A,Scorza T
12-5773 was used in Flow cytometry/Cell sorting to suggest that the expansion and activation of natural Tregs represents a counter-regulatory response to the overwhelming inflammation associated with lethal P.c. adami infection.
Fri Feb 01 00:00:00 EST 2008
Regulatory T cells are locally induced during intravaginal infection of mice with Neisseria gonorrhoeae.
Infection and immunity
Imarai M,Candia E,Rodriguez-Tirado C,Tognarelli J,Pardo M,Pérez T,Valdés D,Reyes-Cerpa S,Nelson P,Acuna-Castillo C,Maisey K
12-5773 was used in Immunofluorescence to further investigate the murine model of N. gonorrhoeae infection and examine the immune response against the bacteria.
Mon Dec 01 00:00:00 EST 2008
Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis.
PloS one
Jaron B,Maranghi E,Leclerc C,Majlessi L
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that attenuation of Treg subset concomitant to BCG vaccination positively impacts its effectiveness against Mycobacterium tuberculosis infection.
Wed Jul 30 00:00:00 EDT 2008
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.
Immunity
Cao X,Cai SF,Fehniger TA,Song J,Collins LI,Piwnica-Worms DR,Ley TJ
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that granzyme B and perforin are relevant for Treg cell-mediated suppression of tumor clearance in vivo.
Mon Oct 01 00:00:00 EDT 2007
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
The Journal of experimental medicine
Tarbell KV,Petit L,Zuo X,Toy P,Luo X,Mqadmi A,Yang H,Suthanthiran M,Mojsov S,Steinman RM
12-5773 was used in Flow cytometry/Cell sorting to investigate whether dendritic cell-expanded islet antigen-specific CD4+ CD25+ suppressor T cells could treat diabetes at later stages of disease.
Mon Jan 22 00:00:00 EST 2007
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
The Journal of experimental medicine
Tarbell KV,Petit L,Zuo X,Toy P,Luo X,Mqadmi A,Yang H,Suthanthiran M,Mojsov S,Steinman RM
12-5773 was used in Flow cytometry/Cell sorting to investigate whether dendritic cell-expanded islet antigen-specific CD4+ CD25+ suppressor T cells could treat diabetes at later stages of disease.
Mon Jan 22 00:00:00 EST 2007
Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue.
The Journal of experimental medicine
Kocks JR,Davalos-Misslitz AC,Hintzen G,Ohl L,Förster R
12-5773 was used in Flow cytometry/Cell sorting to investigate the factors affecting the presence or absence of bronchus-associated lymphoid tissue in mouse lungs.
Mon Apr 16 00:00:00 EDT 2007
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.
The Journal of experimental medicine
Jankovic D,Kullberg MC,Feng CG,Goldszmid RS,Collazo CM,Wilson M,Wynn TA,Kamanaka M,Flavell RA,Sher A
12-5773 was used in Flow cytometry/Cell sorting to study the production of interleukin-10 by T cells in response to intracellular protozoan infection.
Mon Feb 19 00:00:00 EST 2007
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Luo X,Tarbell KV,Yang H,Pothoven K,Bailey SL,Ding R,Steinman RM,Suthanthiran M
12-5773 was used in Flow cytometry/Cell sorting to reveal a role for DCs in the induction of antigen-specific CD4(+)CD25(+)Foxp3(+) T cells.
Tue Feb 20 00:00:00 EST 2007
Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology
Taleb S,Herbin O,Ait-Oufella H,Verreth W,Gourdy P,Barateau V,Merval R,Esposito B,Clément K,Holvoet P,Tedgui A,Mallat Z
12-5773 was used in Flow cytometry/Cell sorting to identify a critical role for leptin/leptin receptor signalling in the modulation of the regulatory immune response in atherosclerosis.
Sat Dec 01 00:00:00 EST 2007
Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.
Journal of leukocyte biology
Nakae S,Iwakura Y,Suto H,Galli SJ
12-5773 was used in Immunofluorescence to compare the cell surface marker expression profiles of Th1 and Th17 cells.
Tue May 01 00:00:00 EDT 2007
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells.
International immunopharmacology
Kopf H,de la Rosa GM,Howard OM,Chen X
12-5773 was used in Flow cytometry/Cell sorting to find that rapamycin and cyclosporine A (CsA) potently inhibited the TGFbeta and IL-6-induced generation of IL-17-producing cells.
Sat Dec 15 00:00:00 EST 2007
Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells.
Transplantation
Grazia TJ,Plenter RJ,Doan AN,Kelly BP,Weber SM,Kurche JS,Cushing SO,Gill RG,Pietra BA
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that B7-deficient T-cells are capable of acute cardiac allograft rejection in a B7-replete environment.
Fri Jun 15 00:00:00 EDT 2007
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells.
Bone marrow transplantation
Coenen JJ,Koenen HJ,van Rijssen E,Kasran A,Boon L,Hilbrands LB,Joosten I
12-5773 was used in Flow cytometry/Cell sorting to analyse the differential effects of cyclosporine A and rapamycin on the maintenance and ontogeny of Tregs in a mouse model of GVHD.
Tue May 01 00:00:00 EDT 2007
Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis.
Infection and immunity
Fang R,Ismail N,Soong L,Popov VL,Whitworth T,Bouyer DH,Walker DH
12-5773 was used in Flow cytometry/Cell sorting to suggest that Rickettsiae targets DCs to stimulate a protective response in resistant hosts but suppressive adaptive immunity in susceptible hosts.
Fri Jun 01 00:00:00 EDT 2007
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine
Fife BT,Guleria I,Gubbels Bupp M,Eagar TN,Tang Q,Bour-Jordan H,Yagita H,Azuma M,Sayegh MH,Bluestone JA
12-5773 was used in Blocking experiments to develop an antigen-specific therapy, insulin-coupled antigen-presenting cells, to treat diabetes in diabetic mice after disease onset.
Mon Nov 27 00:00:00 EST 2006
Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin.
Journal of the American Society of Nephrology : JASN
Wang YM,Zhang GY,Wang Y,Hu M,Wu H,Watson D,Hori S,Alexander IE,Harris DC,Alexander SI
12-5773 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3-transduced regulatory T-cells may have a protective therapeutic role against chronic proteinuric renal disease.
Wed Mar 01 00:00:00 EST 2006
Effect of adenovirus-mediated heat shock protein expression and oncolysis in combination with low-dose cyclophosphamide treatment on antitumor immune responses.
Cancer research
Di Paolo NC,Tuve S,Ni S,Hellström KE,Hellström I,Lieber A
12-5773 was used in Flow cytometry/Cell sorting to give a rationale for testing approaches that suppress Tregs in combination with oncolytic or immunostimulatory vectors.
Sun Jan 15 00:00:00 EST 2006
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
Proceedings of the National Academy of Sciences of the United States of America
Yamazaki S,Patel M,Harper A,Bonito A,Fukuyama H,Pack M,Tarbell KV,Talmor M,Ravetch JV,Inaba K,Steinman RM
12-5773 was used in Flow cytometry/Cell sorting to evaluate the ability of dendritic cells to expand alloantigen-specific Tregs during the mixed leukocyte reaction.
Tue Feb 21 00:00:00 EST 2006
c-FLIP inhibits chemotherapy-induced colorectal cancer cell death.
Oncogene
Longley DB,Wilson TR,McEwan M,Allen WL,McDermott U,Galligan L,Johnston PG
12-5773 was used in Flow cytometry/Cell sorting to study the effect of c-FLIP on the apoptotic response to chemotherapies used in colorectal cancer.
Thu Feb 09 00:00:00 EST 2006
Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.
European journal of immunology
Chen X,Winkler-Pickett RT,Carbonetti NH,Ortaldo JR,Oppenheim JJ,Howard OM
12-5773 was used in Flow cytometry/Cell sorting to show that pertussis toxin down-regulates CD4+CD25+ Treg cell number and function, reducing the immune response in experimental autoimmune encephalomyelitis.
Wed Mar 01 00:00:00 EST 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
12-5773 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.
The Journal of experimental medicine
Chang X,Gao JX,Jiang Q,Wen J,Seifers N,Su L,Godfrey VL,Zuo T,Zheng P,Liu Y
12-5773 was used in Flow cytometry/Cell sorting to show that the FoxP3 Scurfy mutation leads to defective thymopoiesis, caused by inactivation of FoxP3 in the thymic stromal cells.
Mon Oct 17 00:00:00 EDT 2005
