Product References
BAT6026, a novel anti-OX40 antibody with enhanced antibody dependent cellular cytotoxicity effect for cancer immunotherapy.
Frontiers in oncology
Liang S,Zheng D,Liu X,Mei X,Zhou C,Xiao C,Qin C,Yue H,Lin J,Liu C,Li S,Yu JC
48-5773-82 was used in Flow cytometry/Cell sorting to warrant further development of BAT6026 into clinical trials for patients with cancer.
Tue Aug 15 00:00:00 EDT 2023
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer.
NPJ breast cancer
Teo ZL,O'Connor MJ,Versaci S,Clarke KA,Brown ER,Percy LW,Kuykhoven K,Mintoff CP,Savas P,Virassamy B,Luen SJ,Byrne A,Sant S,Lindeman GJ,Darcy PK,Loi S
48-5773-82 was used in Flow cytometry/Cell sorting to identify baseline tumour-infiltrating lymphocyte (TIL) levels as a potential predictive biomarker of response to PARPi, WEE1i and immunotherapies in BRCA1/2 wild-type TNBC.
Tue Aug 15 00:00:00 EDT 2023
CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
Cell reports. Medicine
Huseni MA,Wang L,Klementowicz JE,Yuen K,Breart B,Orr C,Liu LF,Li Y,Gupta V,Li C,Rishipathak D,Peng J,Şenbabaoǧlu Y,Modrusan Z,Keerthivasan S,Madireddi S,Chen YJ,Fraser EJ,Leng N,Hamidi H,Koeppen H,Ziai J,Hashimoto K,Fassò M,Williams P,McDermott DF,Rosenberg JE,Powles T,Emens LA,Hegde PS,Mellman I,Turley SJ,Wilson MS,Mariathasan S,Molinero L,Merchant M,West NR
48-5773-82 was used in Flow cytometry/Cell sorting to identify interleukin 6 (IL-6) as a correlate of poor response to atezolizumab (anti-PD-L1) in large clinical trials of advanced kidney, breast, and bladder cancers.
Tue Jan 17 00:00:00 EST 2023
Microbiota-assisted iron uptake promotes immune tolerance in the intestine.
Nature communications
Zhu L,Li G,Liang Z,Qi T,Deng K,Yu J,Peng Y,Zheng J,Song Y,Chang X
48-5773-82 was used in Flow cytometry/Cell sorting to reveal an association between nutrient uptake and immune tolerance in the intestine.
Mon May 15 00:00:00 EDT 2023
Ischemic Stroke Impacts the Gut Microbiome, Ileal Epithelial and Immune Homeostasis.
iScience
Ge Y,Zadeh M,Yang C,Candelario-Jalil E,Mohamadzadeh M
48-5773-82 was used in Flow cytometry/Cell sorting to provide a comprehensive overview of stroke-induced intestinal dysbiosis and unveil responsive gene programming within iECs with implications for disease development.
Fri Nov 18 00:00:00 EST 2022
A neutrophil/TGF-β axis limits the pathogenicity of allergen-specific CD4+ T cells.
JCI insight
Whitehead GS,Thomas SY,Nakano K,Royer DJ,Burke CG,Nakano H,Cook DN
48-5773-82 was used in Flow Cytometry to conclude that a neutrophil/TGF-β axis acts during TLR-mediated allergic sensitization to fine-tune the phenotype of developing allergen-specific CD4+ T cells and limit their pathogenicity, suggesting a novel immunotherapeutic approach to control eosinophilia in asthma.
Tue Feb 22 00:00:00 EST 2022
Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
Cancer immunology research
Mujal AM,Combes AJ,Rao AA,Binnewies M,Samad B,Tsui J,Boissonnas A,Pollack JL,Argüello RJ,Meng MV,Porten SP,Ruhland MK,Barry KC,Chan V,Krummel MF
48-5773-82 was used in Flow Cytometry to show that holistic analysis of monocyte-to-macrophage differentiation creates a framework for critically different immune states.
Fri Apr 01 00:00:00 EDT 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
48-5773-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 EST 2022
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells.
Cell metabolism
Elia I,Rowe JH,Johnson S,Joshi S,Notarangelo G,Kurmi K,Weiss S,Freeman GJ,Sharpe AH,Haigis MC
48-5773-82 was used in Flow cytometry/Cell sorting to identify pyruvate dehydrogenase as a potential drug target to allow CD8+ T cells to retain cytotoxicity and overcome a lactate-enriched tumor microenvironment.
Tue Aug 02 00:00:00 EDT 2022
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
Cell reports
VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB
48-5773-82 was used in Flow cytometry/Cell sorting to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.
Tue Oct 18 00:00:00 EDT 2022
Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation.
The Journal of investigative dermatology
Dragan M,Sun P,Chen Z,Ma X,Vu R,Shi Y,Villalta SA,Dai X
48-5773-82 was used in Flow cytometry/Cell sorting to show that skin epithelia-specific deletion of Ovol1, which encodes a skin diseaselinked transcriptional repressor, impairs the epidermal barrier and aggravates psoriasis-like skin inflammation in mice in part by enhancing neutrophil accumulation and abscess formation.
Tue Mar 01 00:00:00 EST 2022
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
48-5773-82 was used in Flow Cytometry to conclude that epigenetic immunoediting may drive an acquired immune evasion program in the most aggressive mesenchymal GBM subtype by reshaping the tumor immune microenvironment.
Thu Apr 29 00:00:00 EDT 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
48-5773-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 EDT 2021
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Frontiers in immunology
Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW
48-5773-82 was used in Flow Cytometry to report that as with Mef2d, the deletion of Mef2c in Tregs switches off the expression of Il10 and Icos and leads to enhanced antitumor immunity in syngeneic models of lung cancer.
Fri Dec 17 00:00:00 EST 2021
Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes.
Communications biology
Panea C,Zhang R,VanValkenburgh J,Ni M,Adler C,Wei Y,Ochoa F,Schmahl J,Tang Y,Siao CJ,Poueymirou W,Espert J,Lim WK,Atwal GS,Murphy AJ,Sleeman MA,Hovhannisyan Z,Haxhinasto S
48-5773-82 was used in Flow Cytometry to show that Btnl2 suppressed homeostatic proliferation of γδ IELs preferentially in the ileum.
Mon Jul 26 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
48-5773-82 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
48-5773-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.
Tue Nov 23 00:00:00 EST 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
48-5773-82 was used in Flow cytometry/Cell sorting to study the breadth of anti-haemagglutinin (HA) IgG, serum cytokines, and B and T cell responses by flow cytometry before and after influenza vaccination.
Tue Nov 02 00:00:00 EDT 2021
Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring.
PloS one
McCall JL,Blair HC,Blethen KE,Hall C,Elliott M,Barnett JB
48-5773-82 was used in Flow cytometry/Cell sorting to study the effects of prenatal Cd exposure on the development of autoimmune diabetes and arthritis.
Fri Nov 12 00:00:00 EST 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
48-5773-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.
Immunity
Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C
48-5773 was used in Flow cytometry/Cell sorting to show that febrile temperature selectively regulated Th17 cell differentiation in vitro in enhancing interleukin-17 (IL-17), IL-17F, and IL-22 expression.
Tue Feb 18 00:00:00 EST 2020
Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Cell host & microbe
Wiesner DL,Merkhofer RM,Ober C,Kujoth GC,Niu M,Keller NP,Gern JE,Brockman-Schneider RA,Evans MD,Jackson DJ,Warner T,Jarjour NN,Esnault SJ,Feldman MB,Freeman M,Mou H,Vyas JM,Klein BS
48-5773 was used in Flow cytometry/Cell sorting to conclude that club cells detect junction damage as mechanical stress, which signals danger via TRPV4, calcium, and calcineurin to initiate allergic sensitization.
Wed Apr 08 00:00:00 EDT 2020
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Nature immunology
Harb H,Stephen-Victor E,Crestani E,Benamar M,Massoud A,Cui Y,Charbonnier LM,Arbag S,Baris S,Cunnigham A,Leyva-Castillo JM,Geha RS,Mousavi AJ,Guennewig B,Schmitz-Abe K,Sioutas C,Phipatanakul W,Chatila TA
48-5773 was used in Flow cytometry/Cell sorting to find that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (Treg) cells is necessary for allergens and particulate matter pollutants to promote airway inflammation.
Sun Nov 01 00:00:00 EDT 2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V
48-5773-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.
Thu Jun 04 00:00:00 EDT 2020
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
The Journal of clinical investigation
Di Giorgio E,Wang L,Xiong Y,Akimova T,Christensen LM,Han R,Samanta A,Trevisanut M,Bhatti TR,Beier UH,Hancock WW
48-5773 was used in Flow cytometry/Cell sorting to study the role played by MEF2D in sustaining effector Foxp3+ Treg functions without abrogating their basal actions suggests its suitability for drug discovery efforts in cancer therapy.
Tue Dec 01 00:00:00 EST 2020
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
The Journal of clinical investigation
Xiong Y,Wang L,Di Giorgio E,Akimova T,Beier UH,Han R,Trevisanut M,Kalin JH,Cole PA,Hancock WW
48-5773 was used in Flow cytometry/Cell sorting to analyse the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1 or Hdac2 and Lsd1 enzymes.
Wed Apr 01 00:00:00 EDT 2020
Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance.
Mucosal immunology
Dobson HE,Dias LDS,Kohn EM,Fites S,Wiesner DL,Dileepan T,Kujoth GC,Abraham A,Ostroff GR,Klein BS,Wüthrich M
48-5773 was used in Flow cytometry/Cell sorting to report the identification of a novel fungal antigen that we harnessed for mucosal vaccination and tetramer generation to test whether we can elicit protective, antigen-specific tissue-resident memory (Trm) CD4+ T cells in the lung parenchyma.
Fri May 01 00:00:00 EDT 2020
Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism.
Journal of materials chemistry. B
Mangal JL,Inamdar S,Yang Y,Dutta S,Wankhede M,Shi X,Gu H,Green M,Rege K,Curtis M,Acharya AP
48-5773-82 was used in Flow Cytometry to investigate if intracellular delivery of key-metabolites in a sustained manner provides a new direction in immunometabolism field-based immunotherapy with potential applications in different diseases associated with immune disorders.
Wed Jun 24 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
48-5773 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy.
Nature communications
Baumann D,Hägele T,Mochayedi J,Drebant J,Vent C,Blobner S,Noll JH,Nickel I,Schumacher C,Boos SL,Daniel AS,Wendler S,Volkmar M,Strobel O,Offringa R
48-5773 was used in Flow cytometry/Cell sorting to show that targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) does not impair dendritic cell-mediated T cell priming and activation.
Fri May 01 00:00:00 EDT 2020
Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
Cell reports
Jaeger N,McDonough RT,Rosen AL,Hernandez-Leyva A,Wilson NG,Lint MA,Russler-Germain EV,Chai JN,Bacharier LB,Hsieh CS,Kau AL
48-5773 was used in Flow cytometry/Cell sorting to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI).
Tue Nov 03 00:00:00 EST 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
48-5773-82 was used in Flow Cytometry to find that cell migration-inducing protein (Cemip) is the major inducible gene responsible for hyaluronan catabolism in mice.
Tue Jan 07 00:00:00 EST 2020
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
Communications biology
Benitez AA,Khalil-Agüero S,Nandakumar A,Gupta NT,Zhang W,Atwal GS,Murphy AJ,Sleeman MA,Haxhinasto S
48-5773 was used in Flow cytometry/Cell sorting to show that tumor rejection induced by immune checkpoint blockade is significantly enhanced in Aire-deficient mice, the epitome of central tolerance breakdown.
Wed Jul 08 00:00:00 EDT 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
48-5773 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
48-5773 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
48-5773 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 EST 2020
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.
Cell reports
Clark NM,Martinez LM,Murdock S,deLigio JT,Olex AL,Effi C,Dozmorov MG,Bos PD
48-5773 was used in Flow cytometry/Cell sorting to highlight the strong myeloid dependency of breast cancer and provide the basis for the development of therapeutic strategies based on manipulation of the IFN-γ signaling pathway in monocytes.
Tue Dec 08 00:00:00 EST 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
48-5773-82 was used in Flow Cytometry to conclude that PEGylation of antigenic peptides is an effective and feasible strategy to improve Treg-inducing, peptide-based vaccines with potential use for the treatment of autoimmune diseases, allergies, and transplant rejection.
Thu Apr 29 00:00:00 EDT 2021
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
48-5773 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 EDT 2020
Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.
Cell
Binnewies M,Mujal AM,Pollack JL,Combes AJ,Hardison EA,Barry KC,Tsui J,Ruhland MK,Kersten K,Abushawish MA,Spasic M,Giurintano JP,Chan V,Daud AI,Ha P,Ye CJ,Roberts EW,Krummel MF
48-5773 was used in Flow cytometry/Cell sorting to highlight a pathway that restrains cDC2 and whose reversal enhances CD4+ Tconv abundance and controls tumor growth.
Thu Apr 18 00:00:00 EDT 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
48-5773-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
Nature immunology
LaFleur MW,Nguyen TH,Coxe MA,Miller BC,Yates KB,Gillis JE,Sen DR,Gaudiano EF,Al Abosy R,Freeman GJ,Haining WN,Sharpe AH
48-5773 was used in Flow cytometry/Cell sorting to indicate that increasing the number of cytotoxic Tim-3+CD8+ T cells can promote effective anti-tumor immunity and implicate PTPN2 in immune cells as an attractive cancer immunotherapy target.
Tue Oct 01 00:00:00 EDT 2019
Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
The Journal of clinical investigation
Wachsmuth LP,Patterson MT,Eckhaus MA,Venzon DJ,Gress RE,Kanakry CG
48-5773-82 was used in Flow Cytometry to prompt a paradigm-shift in our mechanistic understanding of PTCy.
Tue Mar 26 00:00:00 EDT 2019
B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes.
Frontiers in immunology
Egia-Mendikute L,Arpa B,Rosell-Mases E,Corral-Pujol M,Carrascal J,Carrillo J,Mora C,Chapman H,Panosa A,Vives-Pi M,Stratmann T,Serreze D,Verdaguer J
48-5773-82 was used in Flow cytometry/Cell sorting to evaluates the T- and B-lymphocyte phenotype in two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice.
Tue Oct 13 00:00:00 EDT 2020
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Cell reports
Garg G,Muschaweckh A,Moreno H,Vasanthakumar A,Floess S,Lepennetier G,Oellinger R,Zhan Y,Regen T,Hiltensperger M,Peter C,Aly L,Knier B,Palam LR,Kapur R,Kaplan MH,Waisman A,Rad R,Schotta G,Huehn J,Kallies A,Korn T
48-5773 was used in Flow cytometry/Cell sorting to identify a Blimp1-dependent pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.
Tue Feb 12 00:00:00 EST 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
48-5773 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
JCI insight
Lowe MM,Boothby I,Clancy S,Ahn RS,Liao W,Nguyen DN,Schumann K,Marson A,Mahuron KM,Kingsbury GA,Liu Z,Munoz Sandoval P,Rodriguez RS,Pauli ML,Taravati K,Arron ST,Neuhaus IM,Harris HW,Kim EA,Shin US,Krummel MF,Daud A,Scharschmidt TC,Rosenblum MD
48-5773 was used in Flow cytometry/Cell sorting to compare healthy skin Tregs with those in peripheral blood, inflamed psoriatic skin, and metastatic melanoma.
Thu Dec 19 00:00:00 EST 2019
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
48-5773 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 EDT 2018
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
48-5773 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
48-5773-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes.
Frontiers in immunology
Bardua M,Haftmann C,Durek P,Westendorf K,Buttgereit A,Tran CL,McGrath M,Weber M,Lehmann K,Addo RK,Heinz GA,Stittrich AB,Maschmeyer P,Radbruch H,Lohoff M,Chang HD,Radbruch A,Mashreghi MF
48-5773 was used in Flow Cytometry to study the role of miR-31 on the motility of proinflammatory T helper 1 cells.
Wed Oct 02 00:00:00 EDT 2019
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
JCI insight
McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V
48-5773 was used in Flow cytometry/Cell sorting to assess the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase 1 axis as a druggable mitochondrial target for promoting immunometabolic and organ homeostasis during sepsis.
Thu Aug 09 00:00:00 EDT 2018
PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs.
Nature communications
Tordesillas L,Lozano-Ojalvo D,Dunkin D,Mondoulet L,Agudo J,Merad M,Sampson HA,Berin MC
48-5773 was used in Flow cytometry/Cell sorting to show how topical antigen is acquired and presented by dendritic cells in the skin.
Fri Dec 07 00:00:00 EST 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
48-5773 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 EDT 2018
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
JCI insight
Liu HJ,Lizotte PH,Du H,Speranza MC,Lam HC,Vaughan S,Alesi N,Wong KK,Freeman GJ,Sharpe AH,Henske EP
48-5773 was used in Flow cytometry/Cell sorting to demonstrate for the first time to our knowledge that checkpoint blockade may have clinical efficacy for TSC and LAM, and possibly other benign tumor syndromes, potentially yielding complete and durable clinical responses.
Thu Apr 19 00:00:00 EDT 2018
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Nature medicine
West NR,Hegazy AN,Owens BMJ,Bullers SJ,Linggi B,Buonocore S,Coccia M,Görtz D,This S,Stockenhuber K,Pott J,Friedrich M,Ryzhakov G,Baribaud F,Brodmerkel C,Cieluch C,Rahman N,Müller-Newen G,Owens RJ,Kühl AA,Maloy KJ,Plevy SE,Keshav S,Travis SPL,Powrie F
48-5773 was used in Flow cytometry/Cell sorting to study how cytokine oncostatin M is a potential biomarker and therapeutic target for IBD, and has particular relevance for anti-TNF-resistant patients.
Mon May 01 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
48-5773 was used in Flow cytometry/Cell sorting to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 EDT 2017
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
Kitagawa Y,Ohkura N,Kidani Y,Vandenbon A,Hirota K,Kawakami R,Yasuda K,Motooka D,Nakamura S,Kondo M,Taniuchi I,Kohwi-Shigematsu T,Sakaguchi S
48-5773 was used in Flow cytometry/Cell sorting to suggest that Satb1-dependent Treg cell-specific super-enhancer activation is crucial for Treg cell lineage specification in the thymus.
Wed Feb 01 00:00:00 EST 2017
T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination.
Frontiers in immunology
Hemmi M,Tachibana M,Fujimoto N,Shoji M,Sakurai F,Kobiyama K,Ishii KJ,Akira S,Mizuguchi H
48-5773 was used in Flow cytometry/Cell sorting to study how Th17 cells translate systemic type I interferon signalling into a gut-mucosal cytotoxic T lymphocyte response following adenoviral vector vaccination.
Wed Nov 20 00:00:00 EST 2019
Eosinophils are required to suppress Th2 responses in Peyer's patches during intestinal infection by nematodes.
Mucosal immunology
Strandmark J,Steinfelder S,Berek C,Kühl AA,Rausch S,Hartmann S
48-5773 was used in Flow cytometry/Cell sorting to study whether eosinophils affect the local T-cell and antibody response in the gut-associated lymphoid tissue during enteric infections.
Mon May 01 00:00:00 EDT 2017
Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.
Arthritis research & therapy
Urushima H,Fujimoto M,Mishima T,Ohkawara T,Honda H,Lee H,Kawahata H,Serada S,Naka T
48-5773 was used in Flow cytometry/Cell sorting to investigate the contribution of leucine-rich alpha 2 glycoprotein to Th17 differentiation and collagen-induced arthritis.
Wed Jun 14 00:00:00 EDT 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
48-5773 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Maternal treatment with short-chain fatty acids modulates the intestinal microbiota and immunity and ameliorates type 1 diabetes in the offspring.
PloS one
Needell JC,Ir D,Robertson CE,Kroehl ME,Frank DN,Zipris D
48-5773 was used in Flow cytometry/Cell sorting to study the effect of maternal therapy with short chain fatty acids on the modulation of intestinal microbiota and the reversal of virus-induced pro-inflammatory responses.
Mon Oct 16 00:00:00 EDT 2017
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity
Cao W,Kayama H,Chen ML,Delmas A,Sun A,Kim SY,Rangarajan ES,McKevitt K,Beck AP,Jackson CB,Crynen G,Oikonomopoulos A,Lacey PN,Martinez GJ,Izard T,Lorenz RG,Rodriguez-Palacios A,Cominelli F,Abreu MT,Hommes DW,Koralov SB,Takeda K,Sundrud MS
48-5773-82 was used in flow cytometry to suggest that coordinated interaction between mucosal Teff cells and CBAs in the ileum regulate intestinal immune homeostasis.
Tue Dec 19 00:00:00 EST 2017
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids.
Immunity
Cao W,Kayama H,Chen ML,Delmas A,Sun A,Kim SY,Rangarajan ES,McKevitt K,Beck AP,Jackson CB,Crynen G,Oikonomopoulos A,Lacey PN,Martinez GJ,Izard T,Lorenz RG,Rodriguez-Palacios A,Cominelli F,Abreu MT,Hommes DW,Koralov SB,Takeda K,Sundrud MS
48-5773-82 was used in flow cytometry to suggest that coordinated interaction between mucosal Teff cells and CBAs in the ileum regulate intestinal immune homeostasis.
Tue Dec 19 00:00:00 EST 2017
Regulatory T cell frequencies and phenotypes following anti-viral vaccination.
PloS one
de Wolf ACMT,van Aalst S,Ludwig IS,Bodinham CL,Lewis DJ,van der Zee R,van Eden W,Broere F
48-5773 was used in Flow cytometry/Cell sorting to determine the impact of anti-viral vaccination on Treg homeostasis.
Fri Sep 22 00:00:00 EDT 2017
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.
Nature communications
Jandl C,Liu SM,Cañete PF,Warren J,Hughes WE,Vogelzang A,Webster K,Craig ME,Uzel G,Dent A,Stepensky P,Keller B,Warnatz K,Sprent J,King C
48-5773 was used in Flow cytometry/Cell sorting to identify a mechanism by which IL-21 reinforces humoural immunity by influencing the phenotype of T follicular cells to limit their expansion.
Fri Mar 17 00:00:00 EDT 2017
CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.
Circulation research
Li J,McArdle S,Gholami A,Kimura T,Wolf D,Gerhardt T,Miller J,Weber C,Ley K
48-5773 was used in Flow cytometry/Cell sorting to investigate the role of CCR5 in regulating T-cell homing to the atherosclerotic aorta and the functionality of the CCR5+ T effector cells.
Fri May 13 00:00:00 EDT 2016
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
48-5773 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.
Thu Dec 01 00:00:00 EST 2016
Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer.
Cancer research
Liu J,Blake SJ,Harjunpää H,Fairfax KA,Yong MC,Allen S,Kohrt HE,Takeda K,Smyth MJ,Teng MW
48-5773 was used in Flow cytometry/Cell sorting to develop a model that may be used to preclinically assess the therapeutic window of novel immunotherapy combinations in different tumor types.
Thu Sep 15 00:00:00 EDT 2016
Generation of the First TCR Transgenic Mouse with CD4(+) T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide.
Frontiers in immunology
Jansen MA,van Herwijnen MJ,van Kooten PJ,Hoek A,van der Zee R,van Eden W,Broere F
48-5773 was used in Flow cytometry/Cell sorting to generate a novel mouse model to allow the study of primary antigen-specific T cells.
Fri Mar 25 00:00:00 EDT 2016
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.
Mucosal immunology
Gold MJ,Hiebert PR,Park HY,Stefanowicz D,Le A,Starkey MR,Deane A,Brown AC,Liu G,Horvat JC,Ibrahim ZA,Sukkar MB,Hansbro PM,Carlsten C,VanEeden S,Sin DD,McNagny KM,Knight DA,Hirota JA
48-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms governing induction of innate immune responses and allergic sensitisation by particulate matter.
Sun May 01 00:00:00 EDT 2016
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Mucosal immunology
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
48-5773 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).
PLoS pathogens
Yasuma K,Yasunaga J,Takemoto K,Sugata K,Mitobe Y,Takenouchi N,Nakagawa M,Suzuki Y,Matsuoka M
48-5773 was used in Flow cytometry/Cell sorting to show that HTLV-1 bZIP factor-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favourable to HTLV-1 in vitro.
Fri Jan 01 00:00:00 EST 2016
Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45.
Journal of immunology research
Pritsch M,Ben-Khaled N,Chaloupka M,Kobold S,Berens-Riha N,Peter A,Liegl G,Schubert S,Hoelscher M,Löscher T,Wieser A
48-5773 was used in Flow cytometry/Cell sorting to provide the rationale for further development of outer membrane vesicles (OMV) as a vaccination strategy in malaria and other diseases.
Mon Mar 06 00:00:00 EST 2017
Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes.
Infection and immunity
Maaz D,Rausch S,Richter D,Krücken J,Kühl AA,Demeler J,Blümke J,Matuschka FR,von Samson-Himmelstjerna G,Hartmann S
48-5773 was used in Flow cytometry/Cell sorting to analyse the immunological impact of the nematode/tick coinfection, showing that susceptibility to ticks and Lyme disease is not affected by coinfection.
Sun May 01 00:00:00 EDT 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
48-5773 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
Loss of immune tolerance to IL-2 in type 1 diabetes.
Nature communications
Pérol L,Lindner JM,Caudana P,Nunez NG,Baeyens A,Valle A,Sedlik C,Loirat D,Boyer O,Créange A,Cohen JL,Rogner UC,Yamanouchi J,Marchant M,Leber XC,Scharenberg M,Gagnerault MC,Mallone R,Battaglia M,Santamaria P,Hartemann A,Traggiai E,Piaggio E
48-5773 was used in Flow cytometry/Cell sorting to study the role of the loss of immune tolerance to IL-2 in type 1 diabetes.
Thu Oct 06 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
48-5773 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
PloS one
Goldstein JD,Burlion A,Zaragoza B,Sendeyo K,Polansky JK,Huehn J,Piaggio E,Salomon BL,Marodon G
48-5773 was used in Flow cytometry/Cell sorting to investigate the role of the JAK/STAT pathway in controlling Foxp3 in the short term, showing dynamic regulation of Foxp3 expression.
Thu Aug 25 00:00:00 EDT 2016
Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis.
JCI insight
Cline-Smith A,Gibbs J,Shashkova E,Buchwald ZS,Novack DV,Aurora R
48-5773 was used in Flow cytometry/Cell sorting to study how pulsing low doses of RANKL induces TcREG, which provides a potential treatment for postmenopausal osteoporosis.
Thu Aug 18 00:00:00 EDT 2016
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Cancer research
Ngiow SF,Young A,Jacquelot N,Yamazaki T,Enot D,Zitvogel L,Smyth MJ
48-5773 was used in Flow cytometry/Cell sorting to provide a framework to interrogate intra-tumour CD8(+) T-cell PD1 and immune PDL1 levels and response in human cancer.
Tue Sep 15 00:00:00 EDT 2015
A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3+ CD8 T Cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Buchwald ZS,Yang C,Nellore S,Shashkova EV,Davis JL,Cline A,Ko J,Novack DV,DiPaolo R,Aurora R
48-5773 was used in Flow cytometry/Cell sorting to study the bone anabolic effect of receptor activator of NF-κB ligand in a murine model of osteoporosis.
Sat Aug 01 00:00:00 EDT 2015
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NI,Cowan JE,Nakamura K,Bacon A,Baik S,White AJ,Parnell SM,Jenkinson EJ,Jenkinson WE,Anderson G
48-5773 was used in Flow cytometry/Cell sorting to elucidate the conditions controlling medullary thymic epithelial cell (mTEC) homeostasis and the production of mTEC-dependent Foxp3(+) Tregs.
Tue Sep 15 00:00:00 EDT 2015
Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.
PloS one
Schuldt NJ,Auger JL,Hogquist KA,Binstadt BA
48-5773 was used in Flow cytometry/Cell sorting to investigate dual TCRβ expression in T cells.
Thu Jun 23 00:00:00 EDT 2016
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice.
Science translational medicine
Faith JJ,Ahern PP,Ridaura VK,Cheng J,Gordon JI
48-5773 was used in Flow cytometry/Cell sorting to describe a method in which a clonally arrayed collection of cultured, sequenced bacteria was generated from one of several human fecal microbiota samples found to transmit a particular phenotype to recipient germ-free mice.
Wed Jan 22 00:00:00 EST 2014
Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells.
Mucosal immunology
Akimova T,Xiao H,Liu Y,Bhatti TR,Jiao J,Eruslanov E,Singhal S,Wang L,Han R,Zacharia K,Hancock WW,Beier UH
48-5773 was used in Flow cytometry/Cell sorting to discover that sirt1 appears to be promising target for pharmacologic therapy of IBD as a result of promoting iTreg development.
Mon Sep 01 00:00:00 EDT 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
48-5773 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gruber RC,Ray AK,Johndrow CT,Guzik H,Burek D,de Frutos PG,Shafit-Zagardo B
48-5773 was used in Flow cytometry/Cell sorting to test whether intracerebroventricular delivery of growth arrest-specific protein 6 during EAE in mice improves the clinical course of disease.
Wed Dec 03 00:00:00 EST 2014
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
The Journal of clinical investigation
Knight DA,Ngiow SF,Li M,Parmenter T,Mok S,Cass A,Haynes NM,Kinross K,Yagita H,Koya RC,Graeber TG,Ribas A,McArthur GA,Smyth MJ
48-5773 was used in Flow cytometry/Cell sorting to investigate the contribution of host immunity to the anti-melanoma activity of BRAF inhibitors.
Fri Mar 01 00:00:00 EST 2013
Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100.
Frontiers in immunology
Tse K,Gonen A,Sidney J,Ouyang H,Witztum JL,Sette A,Tse H,Ley K
48-5773 was used in Flow cytometry/Cell sorting to investigate antigen specificity of T-cells induced by vaccination with low-density lipoprotein or oxidised low-density lipoprotein, and the mechanism of protection.
Mon Jan 13 00:00:00 EST 2014
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
48-5773 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.
Bone
Buchwald ZS,Kiesel JR,Yang C,DiPaolo R,Novack DV,Aurora R
48-5773 was used in Flow cytometry/Cell sorting to provide in vivo evidence that osteoclast-induced Treg cells have anti-resorptive activity and repress the immune system.
Sun Sep 01 00:00:00 EDT 2013
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
48-5773 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America
van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F
48-5773 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.
Tue Aug 28 00:00:00 EDT 2012
Prevention of virus-induced type 1 diabetes with antibiotic therapy.
Journal of immunology (Baltimore, Md. : 1950)
Hara N,Alkanani AK,Ir D,Robertson CE,Wagner BD,Frank DN,Zipris D
48-5773 was used in Flow cytometry/Cell sorting to suggest that gut microbiota may be involved in promoting virus-induced type 1 diabetes in the LEW1.WR1 rat model.
Mon Oct 15 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
48-5773 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease.
Journal of neuroinflammation
St-Amour I,Bousquet M,Paré I,Drouin-Ouellet J,Cicchetti F,Bazin R,Calon F
48-5773 was used in Flow cytometry/Cell sorting to investigate the potential neurorestorative effect of IVIg treatment in mice.
Tue Oct 09 00:00:00 EDT 2012
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
PloS one
Buchwald ZS,Kiesel JR,DiPaolo R,Pagadala MS,Aurora R
48-5773 was used in Flow cytometry/Cell sorting to demonstrate the effects of activated CD8 T cell-produced cytokines on osteoclast activity.
Thu Nov 08 00:00:00 EST 2012
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
48-5773 was used in Flow cytometry/Cell sorting to investigate the relative contributions of different APC populations in IBD, showing that CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses.
Thu Dec 01 00:00:00 EST 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
48-5773 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
Host-based Th2 cell therapy for prolongation of cardiac allograft viability.
PloS one
Amarnath S,Chen H,Foley JE,Costanzo CM,Sennesh JD,Solomon MA,Fowler DH
48-5773 was used in Flow cytometry/Cell sorting to provide support for the rationale to use direct host T cell therapy for prolongation of allograft viability.
Fri Apr 29 00:00:00 EDT 2011
Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus.
PloS one
Goldstein JD,Balderas RS,Marodon G
48-5773 was used in Flow cytometry/Cell sorting to report higher levels of phosphorylated STAT-5 in nTreg cells in the murine thymus and, to a lesser extent, in the periphery compared to other CD4(+)CD8(-) subsets.
Tue Apr 26 00:00:00 EDT 2011
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 EST 2010
High-avidity autoreactive CD4+ T cells induce host CTL, overcome T(regs) and mediate tumor destruction.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Brandmaier AG,Leitner WW,Ha SP,Sidney J,Restifo NP,Touloukian CE
48-5773 was used in an ELISpot assay to develop a model of melanoma immunotherapy focused on the exploitation of high-avidity CD4+ T cells that become generated in germline antigen-deficient mice.
Tue Sep 01 00:00:00 EDT 2009
