Product References
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.
Frontiers in immunology
Masle-Farquhar E,Jeelall Y,White J,Bier J,Deenick EK,Brink R,Horikawa K,Goodnow CC
25-5773-82 was used in Flow cytometry/Cell sorting to reveal CARD11 as an important, cell-autonomous positive regulator of TFH, TREG and TFR cells.
Mon Mar 27 00:00:00 EDT 2023
Construction of a CCL20-centered circadian-signature based prognostic model in cervical cancer.
Cancer cell international
Yu Y,Liu Y,Li Y,Yang X,Han M,Fan Q
25-5773-82 was used in Flow cytometry/Cell sorting to unravel a prognostic risk model based upon circadian oscillation and verified its solidity.
Mon May 15 00:00:00 EDT 2023
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
25-5773-82 was used in Flow cytometry/Cell sorting to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Nature immunology
Horkova V,Drobek A,Paprckova D,Niederlova V,Prasai A,Uleri V,Glatzova D,Kraller M,Cesnekova M,Janusova S,Salyova E,Tsyklauri O,Kadlecek TA,Krizova K,Platzer R,Schober K,Busch DH,Weiss A,Huppa JB,Stepanek O
25-5773-82 was used in Flow cytometry/Cell sorting to reveal the role of co-receptor-bound LCK in T cell biology, show that CD4- and CD8-bound LCK drive T cell development and effector immune responses using qualitatively different mechanisms and identify the co-receptor-LCK interactions as promising targets for immunomodulation.
Sun Jan 01 00:00:00 EST 2023
Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.
Cell reports
Hester AK,Semwal MK,Cepeda S,Xiao Y,Rueda M,Wimberly K,Venables T,Dileepan T,Kraig E,Griffith AV
25-5773-82 was used in Flow cytometry/Cell sorting to study the effects and mechanisms of age on thymic dysfunction.
Tue Feb 15 00:00:00 EST 2022
Antagonistic Antibody Targeting TNFR2 Inhibits Regulatory T Cell Function to Promote Anti-Tumor Activity.
Frontiers in immunology
Chen Y,Jia M,Wang S,Xu S,He N
25-5773-82 was used in flow cytometry to investigate the immunomodulatory and anti-tumor activity of AN3025.
Mon May 02 00:00:00 EDT 2022
PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.
Nature communications
Kim DK,Jeong J,Lee DS,Hyeon DY,Park GW,Jeon S,Lee KB,Jang JY,Hwang D,Kim HM,Jung K
25-5773-82 was used in Flow cytometry/Cell sorting to study the mechanism underlying chemotherapy-induced fibrosis in PDAC.
Sat Oct 22 00:00:00 EDT 2022
Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity.
Cancer immunology research
Han S,Liu ZQ,Chung DC,Paul MS,Garcia-Batres CR,Sayad A,Elford AR,Gold MJ,Grimshaw N,Ohashi PS
25-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that the hypersecretion of IFNγ serves as a key mechanism by which Cbl-b-deficient CD8+ T cells are rendered resistant to Tregs.
Fri Apr 01 00:00:00 EDT 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
25-5773-82 was used in Flow cytometry/Cell sorting to determine if attenuated host autophagy is sufficient to induce tumor rejection through reinforced adaptive immunity and whether dietary glutamine supplementation, mimicking attenuated host autophagy, is capable of promoting antitumor immunity.
Tue Aug 16 00:00:00 EDT 2022
Resveratrol reduces lactate production and modifies the ovarian cancer immune microenvironment.
Neoplasma
Chen J,Huang ST,Chen JG,He JH,Lin WM,Huang ZH,Ye HY,He SY
25-5773-82 was used in Flow cytometry/Cell sorting to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.
Thu Sep 01 00:00:00 EDT 2022
Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis.
Cell & bioscience
Zhao X,Liang W,Wang Y,Yi R,Luo L,Wang W,Sun N,Yu M,Xu W,Sheng Q,Lu L,Pang J,Lv Z,Wang F
25-5773-82 was used in Flow Cytometry to examine the ontogeny of intestinal lamina propria lymphocytes in the early life of mice.
Tue Jan 04 00:00:00 EST 2022
Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.
Scientific reports
Rivet-Noor CR,Merchak AR,Li S,Beiter RM,Lee S,Thomas JA,Fernández-Castañeda A,Shin JB,Gaultier A
25-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that neither CD4 specific Ahr nor Rorc are necessary for the development of stress-induced anxiety- or depressive-like behaviors.
Sat May 21 00:00:00 EDT 2022
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.
Blood
Zaiken MC,Flynn R,Paz KG,Rhee SY,Jin S,Mohamed FA,Saha A,Thangavelu G,Park PMC,Hemming ML,Sage PT,Sharpe AH,DuPage M,Bluestone JA,Panoskaltsis-Mortari A,Cutler CS,Koreth J,Antin JH,Soiffer RJ,Ritz J,Luznik L,Maillard I,Hill GR,MacDonald KPA,Munn DH,Serody JS,Murphy WJ,Kean LS,Zhang Y,Bradner JE,Qi J,Blazar BR
25-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that EZH2 is obligatory for the initiation of cGVHD/BO.
Thu May 12 00:00:00 EDT 2022
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.
Immunity
Shi L,Sun Z,Su W,Xu F,Xie D,Zhang Q,Dai X,Iyer K,Hitchens TK,Foley LM,Li S,Stolz DB,Chen K,Ding Y,Thomson AW,Leak RK,Chen J,Hu X
25-5773-82 was used in Immunohistochemistry to reveal Treg cells as a neurorestorative target for stroke recovery.
Tue Jul 13 00:00:00 EDT 2021
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Cancer cell
Srivastava S,Furlan SN,Jaeger-Ruckstuhl CA,Sarvothama M,Berger C,Smythe KS,Garrison SM,Specht JM,Lee SM,Amezquita RA,Voillet V,Muhunthan V,Yechan-Gunja S,Pillai SPS,Rader C,Houghton AM,Pierce RH,Gottardo R,Maloney DG,Riddell SR
25-5773-82 was used in Flow Cytometry to test strategies for enhancing efficacy of CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like orphan receptor 1 (ROR1) infiltrating tumors.
Mon Feb 08 00:00:00 EST 2021
Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice.
Journal of immunology (Baltimore, Md. : 1950)
Carlson PM,Mohan M,Patel RB,Birstler J,Nettenstrom L,Sheerar D,Fox K,Rodriguez M,Hoefges A,Hernandez R,Zahm C,Kim K,McNeel DG,Weichert J,Morris ZS,Sondel PM
25-5773-82 was used in Flow Cytometry to confirm the utility of our cryopreservation protocol by comparing tumors treated with in situ tumor vaccines, analyzing both fresh and cryopreserved tumor samples with similar results.
Thu Jul 15 00:00:00 EDT 2021
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
mAbs
Schofield DJ,Percival-Alwyn J,Rytelewski M,Hood J,Rothstein R,Wetzel L,McGlinchey K,Adjei G,Watkins A,Machiesky L,Chen W,Andrews J,Groves M,Morrow M,Stewart RA,Leinster A,Wilkinson RW,Hammond SA,Luheshi N,Dobson C,Oberst M
25-5773-82 was used in Flow cytometry/Cell sorting to show that anti-PD-L1 and anti-CTLA-4 murine surrogates with pharmacologic properties similar to those of durvalumab and tremelimumab demonstrated anti-tumor activity in a subset of commonly used mouse syngeneic tumor models.
Thu Oct 14 00:00:00 EDT 2021
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
mAbs
Schofield DJ,Percival-Alwyn J,Rytelewski M,Hood J,Rothstein R,Wetzel L,McGlinchey K,Adjei G,Watkins A,Machiesky L,Chen W,Andrews J,Groves M,Morrow M,Stewart RA,Leinster A,Wilkinson RW,Hammond SA,Luheshi N,Dobson C,Oberst M
25-5773-82 was used in Flow cytometry/Cell sorting to show that anti-PD-L1 and anti-CTLA-4 murine surrogates with pharmacologic properties similar to those of durvalumab and tremelimumab demonstrated anti-tumor activity in a subset of commonly used mouse syngeneic tumor models.
Thu Oct 14 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
25-5773-82 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
Cross-Reactivity and Functionality of Approved Human Immune Checkpoint Blockers in Dogs.
Cancers
Pantelyushin S,Ranninger E,Guerrera D,Hutter G,Maake C,Markkanen E,Bettschart-Wolfensberger R,Rohrer Bley C,Läubli H,Vom Berg J
25-5773 was used in Flow cytometry/Cell sorting to assess suitability of seven FDA-approved human ICIs to target CTLA-4 or PD-1/PD-L1 in dogs.
Sat Feb 13 00:00:00 EST 2021
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Journal of cellular and molecular medicine
Ge Y,Huang M,Wu Y,Dong N,Yao YM
25-5773-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.
Wed Jan 01 00:00:00 EST 2020
Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection.
Cell reports
Alterauge D,Bagnoli JW,Dahlström F,Bradford BM,Mabbott NA,Buch T,Enard W,Baumjohann D
25-5773-82 was used in Flow Cytometry to evaluate the contributions of the CXCR5 receptor and Bcl6 transcription factor in maintaining T follicular helper cells and germinal centres.
Tue Oct 06 00:00:00 EDT 2020
CD4+ T-Cell Differentiation In Vitro.
Methods in molecular biology (Clifton, N.J.)
Yang W,Chen X,Hu H
25-5773-82 was used in Flow cytometry/Cell sorting to study the regulating mechanism and function of Th cells, dependent on in vitro CD4+ T-cell differentiation.
Tue Jan 26 00:00:00 EST 2021
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
25-5773 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 EDT 2020
CTLA-4 immunotherapy exposes differences in immune response along with different tumor progression in colorectal cancer.
Aging
Fu X,Luo H,Zheng Y,Wang S,Zhong Z,Wang Y,Yang Y
25-5773 was used in Flow cytometry/Cell sorting to reveal the ongoing changes in the immune microenvironment during tumor progression and anti-CTLA-4 antibody immunotherapy effect depends on the expression level of immune factors.
Sat Aug 29 00:00:00 EDT 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
25-5773-82 was used in Flow Cytometry to indicate a potential alternative to IVIg for therapeutic intervention in case of pregnancy failures.
Mon Jun 29 00:00:00 EDT 2020
Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.
Immunity
Chisolm DA,Cheng W,Colburn SA,Silva-Sanchez A,Meza-Perez S,Randall TD,Weinmann AS
25-5773 was used in Flow cytometry/Cell sorting to present strategies to analyze next-generation sequencing datasets to define genetic variation in B6 congenic and transgenic strains.
Tue Jul 16 00:00:00 EDT 2019
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Lindahl H,Guerreiro-Cacais AO,Bedri SK,Linnerbauer M,Lindén M,Abdelmagid N,Tandre K,Hollins C,Irving L,Glover C,Jones C,Alfredsson L,Rönnblom L,Kockum I,Khademi M,Jagodic M,Olsson T
25-5773-82 was used in Flow Cytometry to study the genetic risk variant rs17066096 and the candidate gene that encodes IL-22 binding protein (IL-22BP).
Thu Aug 15 00:00:00 EDT 2019
Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1.
Nature communications
Leclerc M,Voilin E,Gros G,Corgnac S,de Montpréville V,Validire P,Bismuth G,Mami-Chouaib F
25-5773-82 was used in Flow Cytometry to conclude that Nrp-1 could be a target for developing combined immunotherapies.
Fri Jul 26 00:00:00 EDT 2019
A novel rapamycin analog is highly selective for mTORC1 in vivo.
Nature communications
Schreiber KH,Arriola Apelo SI,Yu D,Brinkman JA,Velarde MC,Syed FA,Liao CY,Baar EL,Carbajal KA,Sherman DS,Ortiz D,Brunauer R,Yang SE,Tzannis ST,Kennedy BK,Lamming DW
25-5773-82 was used in Flow Cytometry to report the identification of DL001, a FKBP12-dependent rapamycin analog 40x more selective for mTORC1 than rapamycin.
Fri Jul 19 00:00:00 EDT 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
25-5773 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
Increased Incidence of Colon Tumors in AOM-Treated Apc 1638N/+ Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine.
Frontiers in oncology
Metzger R,Maruskova M,Krebs S,Janssen KP,Krug AB
25-5773-82 was used in Flow cytometry/Cell sorting to develop a model with higher resemblance to human CRC and to characterize tumor infiltrating immune cells in spontaneously developing colon tumors compared to small intestinal tumors.
Thu Oct 01 00:00:00 EDT 2020
Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity.
Cancer research
Büll C,Boltje TJ,Balneger N,Weischer SM,Wassink M,van Gemst JJ,Bloemendal VR,Boon L,van der Vlag J,Heise T,den Brok MH,Adema GJ
25-5773 was used in Flow cytometry/Cell sorting to show that sialic acid sugars function as important modulators of the immunosuppressive tumor microenvironment that limit potent antitumor immunity.
Sun Jul 01 00:00:00 EDT 2018
Subcutaneous administration of a neutralizing IL-1β antibody prolongs limb allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hautz T,Grahammer J,Moser D,Eberhart N,Zelger B,Zelger B,Blumer MJ,Drasche A,Wolfram D,Troppmair J,Öfner D,Schneeberger S
25-5773 was used in Flow cytometry/Cell sorting to study the effect of intragraft treatment with a neutralisin IL-1B antibody in limb transplantation.
Wed Aug 01 00:00:00 EDT 2018
Comparative Analysis of the Regulatory T Cells Dynamics in Peripheral Blood in Human and Porcine Polytrauma.
Frontiers in immunology
Serve R,Sturm R,Schimunek L,Störmann P,Heftrig D,Teuben MPJ,Oppermann E,Horst K,Pfeifer R,Simon TP,Kalbas Y,Pape HC,Hildebrand F,Marzi I,Relja B
25-5773 was used in Flow cytometry/Cell sorting to demonstrate a comparable decrease of Treg early after polytrauma, and strengthen the immunological significance of the porcine polytrauma model and that Treg subpopulation CD4+CD25+CD127- was characterized in porcine samples.
Mon Jun 24 00:00:00 EDT 2019
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Frontiers in immunology
Cobbold SP,Adams E,Howie D,Waldmann H
25-5773 was used in Flow cytometry/Cell sorting to develop an in vitro model of T cell differentiation suited to testing how manipulation of components of the microenvironment might be therapeutically exploited.
Mon Jan 31 00:00:00 EST 2022
The antitumor effects of entinostat in ovarian cancer require adaptive immunity.
Cancer
Smith HJ,McCaw TR,Londono AI,Katre AA,Meza-Perez S,Yang ES,Forero A,Buchsbaum DJ,Randall TD,Straughn JM,Norian LA,Arend RC
25-5773-82 was used in Flow Cytometry to evaluate whether entinostat treatment and resultant MHCII expression would enhance beneficial immune responses and impair tumor growth in mice with ovarian cancer.
Sat Dec 15 00:00:00 EST 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
25-5773 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity.
Proceedings of the National Academy of Sciences of the United States of America
Cao D,Cao QM,Subramaniam S,Yugo DM,Heffron CL,Rogers AJ,Kenney SP,Tian D,Matzinger SR,Overend C,Catanzaro N,LeRoith T,Wang H,Piñeyro P,Lindstrom N,Clark-Deener S,Yuan L,Meng XJ
25-5773 was used in Flow cytometry/Cell sorting to develop a pig model of chronic hepatitis E virus (HEV) infection and examine immune correlates leading to chronicity.
Mon Jul 03 00:00:00 EDT 2017
The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
Immunology
Gonçalves AC,Ferreira LS,Manente FA,de Faria CMQG,Polesi MC,de Andrade CR,Zamboni DS,Carlos IZ
25-5773 was used in Flow cytometry/Cell sorting to indicate that the NLRP3 inflammasome contributes to protecion against infection from S. schenckii by linking the innate recognition of S. schenckii to the adaptive immune response.
Thu Jun 01 00:00:00 EDT 2017
CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway.
PloS one
Alexander KL,Katz J,Elson CO
25-5773 was used in Flow cytometry/Cell sorting to generate a fusion protein, CBirTox, in order to amplify the TregIgA pathway.
Mon Oct 09 00:00:00 EDT 2017
Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells.
Stem cell research & therapy
Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ
25-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which adipose tissue stem cells (ASCs) reduce allergic symptoms and eosinophilic inflammation following injection, showing that culture supernatant of ASCs also reduced allergic airway inflammation.
Mon Jan 23 00:00:00 EST 2017
The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.
BMC complementary and alternative medicine
Xie L,Zhong X,Liu D,Liu L,Xia Z
25-5773 was used in Flow cytometry/Cell sorting to show that freeze-dried powder from G. lucidum mycelia could potentially be used to treat recurrent oral ulceration.
Fri Dec 01 00:00:00 EST 2017
Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model.
International journal of inflammation
Lanzke N,Menk M,von Haefen C,Sargsyan L,Scharf B,Wernecke KD,Spies CD
25-5773 was used in Flow cytometry/Cell sorting to study the interactions between alcohol, infection and surgery and determine their influence on the differentiation and functionality of T helper cells.
Fri Mar 11 00:00:00 EST 2022
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Aging cell
Arriola Apelo SI,Neuman JC,Baar EL,Syed FA,Cummings NE,Brar HK,Pumper CP,Kimple ME,Lamming DW
25-5773 was used in Flow cytometry/Cell sorting to identify an intermittent rapamycin dosing schedule with minimal serious side effects.
Mon Feb 01 00:00:00 EST 2016
Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells.
Scientific reports
Wang DW,Dong N,Wu Y,Zhu XM,Wang CT,Yao YM
25-5773-82 was used in Flow Cytometry to conclude that rhIL-37 enhances the suppressive activity of CD4+CD25+ Tregs and might be a potential immunomodulator for the treatment of septic complications.
Mon Dec 12 00:00:00 EST 2016
Monoclonal regulatory T cells provide insights into T cell suppression.
Scientific reports
Gubser C,Schmaler M,Rossi SW,Palmer E
25-5773 was used in Flow cytometry/Cell sorting to investigate how Tregs function at a cellular and molecular level using monoclonal Tregs.
Mon May 23 00:00:00 EDT 2016
Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma.
Oncoimmunology
Kroesen M,Büll C,Gielen PR,Brok IC,Armandari I,Wassink M,Looman MW,Boon L,den Brok MH,Hoogerbrugge PM,Adema GJ
25-5773 was used in Flow cytometry/Cell sorting to discover a basis for clinical testing of anti-GD2 plus Vorinostat combination therapy in NBL patients.
Wed Jun 01 00:00:00 EDT 2016
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
25-5773 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Oncotarget
Colbeck EJ,Hindley JP,Smart K,Jones E,Bloom A,Bridgeman H,McPherson RC,Turner DG,Ladell K,Price DA,O'Connor RA,Anderton SM,Godkin AJ,Gallimore AM
25-5773 was used in Flow cytometry/Cell sorting to study the enrichment of tumor-infiltrating Treg populations and assess the role of IL-2 in pertubation of Treg frequencies in tumors.
Tue Sep 22 00:00:00 EDT 2015
Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.
Scientific reports
Singh K,Hjort M,Thorvaldson L,Sandler S
25-5773 was used in Flow cytometry/Cell sorting to investigate the use of Helios and Nrp1 as markers for thymic-derived Tregs, showing that Helios may be a more reliable marker than Nrp1.
Wed Jan 14 00:00:00 EST 2015
PD-1 regulates extrathymic regulatory T-cell differentiation.
European journal of immunology
Chen X,Fosco D,Kline DE,Meng L,Nishi S,Savage PA,Kline J
25-5773 was used in Flow cytometry/Cell sorting to investigate the regulation of extrathymic regulatory T-cell differentiation by PD-1.
Mon Sep 01 00:00:00 EDT 2014
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine
Molofsky AB,Nussbaum JC,Liang HE,Van Dyken SJ,Cheng LE,Mohapatra A,Chawla A,Locksley RM
25-5773 was used in Flow cytometry/Cell sorting to study how ILC2s are resident in visceral adipose tissue and promote eosinophils and alternatively activated macrophages, implicated in metabolic homeostasis.
Mon Mar 11 00:00:00 EDT 2013
IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Pérez-de Puig I,Miró F,Salas-Perdomo A,Bonfill-Teixidor E,Ferrer-Ferrer M,Márquez-Kisinousky L,Planas AM
25-5773 was used in Flow cytometry/Cell sorting to study the the anti-inflammatory role of IL-10 in ischemic brain recovery in mice model.
Sun Dec 01 00:00:00 EST 2013
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Qiao G,Zhao Y,Li Z,Tang PQ,Langdon WY,Yang T,Zhang J
25-5773 was used in Flow cytometry/Cell sorting to investigate the role of Casitas-B-lineage lymphoma protein-b in activation of iTregs.
Mon Jul 15 00:00:00 EDT 2013
Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products.
Veterinary research
McNeilly TN,Rocchi M,Bartley Y,Brown JK,Frew D,Longhi C,McLean L,McIntyre J,Nisbet AJ,Wattegedera S,Huntley JF,Matthews JB
25-5773 was used in Flow cytometry/Cell sorting to identify a mechanism by which T. circumcincta may modulate the host adaptive immune response, potentially assisting survival of the parasite within the host.
Wed Aug 21 00:00:00 EDT 2013
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.
PloS one
Nakanishi W,Yamaguchi S,Matsuda A,Suzukawa M,Shibui A,Nambu A,Kondo K,Suto H,Saito H,Matsumoto K,Yamasoba T,Nakae S
25-5773 was used in Flow cytometry/Cell sorting to determine that IL-33, but not IL-25, is crucial for the development of house dust mice antigen-induced allergic rhinitis.
Thu Sep 18 00:00:00 EDT 2014
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
Nature biotechnology
Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD
25-5773 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.
Sat Dec 01 00:00:00 EST 2012
Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes.
Molecular therapy : the journal of the American Society of Gene Therapy
Leconet W,Petit P,Peraldi-Roux S,Bresson D
25-5773 was used in Flow cytometry/Cell sorting to provide new insights into the development of siRNA-based therapeutics for the treatment of T1D.
Sat Dec 01 00:00:00 EST 2012
Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection.
Comparative immunology, microbiology and infectious diseases
Wen K,Bui T,Li G,Liu F,Li Y,Kocher J,Yuan L
25-5773 was used in Flow cytometry/Cell sorting to characterise immune modulating functions of porcine γδ T cell subsets in rotavirus infection.
Sun Jul 01 00:00:00 EDT 2012
Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells.
The Journal of biological chemistry
Karman J,Jiang JL,Gumlaw N,Zhao H,Campos-Rivera J,Sancho J,Zhang J,Jiang C,Cheng SH,Zhu Y
25-5773 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of bispecific biologics targeting of earlier T cell progenitors to guide a modulated immune response.
Fri Mar 30 00:00:00 EDT 2012
Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.
PloS one
Almolda B,Costa M,Montoya M,González B,Castellano B
25-5773 was used in Flow cytometry/Cell sorting to reveal a unique pattern of lymphocyte infiltration and cytokine secretion in the acute experimental autoimmune encephalomyelitis model in Lewis rat.
Mon Mar 26 00:00:00 EDT 2012
Partial regulatory T cell depletion prior to acute feline immunodeficiency virus infection does not alter disease pathogenesis.
PloS one
Mikkelsen SR,Long JM,Zhang L,Galemore ER,VandeWoude S,Dean GA
25-5773 was used in Flow cytometry/Cell sorting to study the role of CD4(+)CD25(hi)FoxP3(+) immunosuppressive regulatory T cells during acute feline immunodeficiency virus infection.
Fri Feb 25 00:00:00 EST 2011
In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus.
Virology
Mikkelsen SR,Reckling SK,Egan EA,Dean GA
25-5773 was used in Flow cytometry/Cell sorting to suggest that the short-term depletion of Treg cells during chronic HIV-1 infection may offer an opportunity for therapeutic vaccination in patients with controlled viral replication.
Sun Aug 01 00:00:00 EDT 2010
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 EST 2010
