Product References
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Cancer discovery
Chen S,Vedula RS,Cuevas-Navarro A,Lu B,Hogg SJ,Wang E,Benbarche S,Knorr K,Kim WJ,Stanley RF,Cho H,Erickson C,Singer M,Cui D,Tittley S,Durham BH,Pavletich TS,Fiala E,Walsh MF,Inoue D,Monette S,Taylor J,Rosen N,McCormick F,Lindsley RC,Castel P,Abdel-Wahab O
12-5790-82 was used in Flow cytometry/Cell sorting to reveal proteolysis of non-canonical RAS proteins as novel regulators of HSC self-renewal, define the function of RIT1 and LZTR1 mutations in leukemia, and identify means to overcome drug resistance due to LZTR1 downregulation.
Wed Oct 05 00:00:00 EDT 2022
Rad52 mediates class-switch DNA recombination to IgD.
Nature communications
Xu Y,Zhou H,Post G,Zan H,Casali P
12-5790-82 was used in Immunohistochemistry (Paraffin) to show that Rad52 mediates IgD CSR through microhomology-mediated A-EJ in concert with Zfp318 downregulation.
Mon Feb 21 00:00:00 EST 2022
Rad52 mediates class-switch DNA recombination to IgD.
Nature communications
Xu Y,Zhou H,Post G,Zan H,Casali P
12-5790-82 was used in Immunohistochemistry (Paraffin) to show that Rad52 mediates IgD CSR through microhomology-mediated A-EJ in concert with Zfp318 downregulation.
Mon Feb 21 00:00:00 EST 2022
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
Nature
Xu J,Xu K,Jung S,Conte A,Lieberman J,Muecksch F,Lorenzi JCC,Park S,Schmidt F,Wang Z,Huang Y,Luo Y,Nair MS,Wang P,Schulz JE,Tessarollo L,Bylund T,Chuang GY,Olia AS,Stephens T,Teng IT,Tsybovsky Y,Zhou T,Munster V,Ho DD,Hatziioannou T,Bieniasz PD,Nussenzweig MC,Kwong PD,Casellas R
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies.
mAbs
Zhang R,Prabakaran P,Yu X,Mackness BC,Boudanova E,Hopke J,Sancho J,Saleh J,Cho H,Zhang N,Simonds-Mannes H,Stimple SD,Hoffmann D,Park A,Chowdhury PS,Rao SP
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Wed Jan 19 00:00:00 EST 2022
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Fri Oct 15 00:00:00 EDT 2021
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I
12-5790-82 was used in Flow Cytometry to identify extrinsic regulators of B-ALL survival supporting new immune-based therapeutic approaches for high-risk B-ALL treatment.
Mon Jun 08 00:00:00 EDT 2020
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Cell stem cell
Youk J,Kim T,Evans KV,Jeong YI,Hur Y,Hong SP,Kim JH,Yi K,Kim SY,Na KJ,Bleazard T,Kim HM,Fellows M,Mahbubani KT,Saeb-Parsy K,Kim SY,Kim YT,Koh GY,Choi BS,Ju YS,Lee JH
12-5790 was used in Flow cytometry/Cell sorting to provide deep insights into the pathogenesis of SARS-CoV-2 and the application of defined 3D hAT2 cultures as models for respiratory diseases.
Thu Dec 03 00:00:00 EST 2020
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
12-5790 was used in Flow cytometry/Cell sorting to develop a new approach to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
Identification of serine residues in the connexin43 carboxyl tail important for BCR-mediated spreading of B-lymphocytes.
Journal of cell science
Pournia F,Dang-Lawson M,Choi K,Mo V,Lampe PD,Matsuuchi L
12-5790 was used in Flow cytometry/Cell sorting to identify specific serine residues in the Cx43 CT that are phosphorylated following BCR stimulation.
Tue Mar 10 00:00:00 EDT 2020
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Tue Feb 11 00:00:00 EST 2020
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.
Cell reports
Fallet B,Hao Y,Florova M,Cornille K,de Los Aires AV,Girelli Zubani G,Ertuna YI,Greiff V,Menzel U,Hammad K,Merkler D,Reddy ST,Weill JC,Reynaud CA,Pinschewer DD
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Tue Jan 28 00:00:00 EST 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
12-5790 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
12-5790 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
12-5790 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Science (New York, N.Y.)
Saunders KO,Wiehe K,Tian M,Acharya P,Bradley T,Alam SM,Go EP,Scearce R,Sutherland L,Henderson R,Hsu AL,Borgnia MJ,Chen H,Lu X,Wu NR,Watts B,Jiang C,Easterhoff D,Cheng HL,McGovern K,Waddicor P,Chapdelaine-Williams A,Eaton A,Zhang J,Rountree W,Verkoczy L,Tomai M,Lewis MG,Desaire HR,Edwards RJ,Cain DW,Bonsignori M,Montefiori D,Alt FW,Haynes BF
12-5790-81 was used in Flow Cytometry to study the efficacy of vaccinations with immunogens which bind to bnAb B cell precursors in initiating bnAB B cell development.
Fri Dec 06 00:00:00 EST 2019
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal
Schoeler K,Aufschnaiter A,Messner S,Derudder E,Herzog S,Villunger A,Rajewsky K,Labi V
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
DNA immunization using in vivo electroporation for generating monoclonal antibodies Against Mouse IL-9R.
Bio-protocol
Takatsuka S,Yamada H,Haniuda K,Ichihashi M,Chiba J,Kitamura D
12-5790-82 was used in Flow cytometry/Cell sorting to report an application of the original mouse immunization method in rats to generate anti-mouse IL-9R mAbs which could react with the native form of mouse IL-9R on cell surfaces.
Wed Feb 20 00:00:00 EST 2019
Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Miller ML,McIntosh CM,Wang Y,Chen L,Wang P,Lei YM,Daniels MD,Watkins E,Mora Solano C,Chong AS,Alegre ML
12-5790-82 was used in Flow cytometry/Cell sorting to demonstrate transplant tolerance-associated T cell-intrinsic dysfunction that is resistant to memory development even after Lm-mediated disruption of tolerance.
Tue Nov 19 00:00:00 EST 2019
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
12-5790 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae.
Frontiers in immunology
Farhat K,Bodart G,Charlet-Renard C,Desmet CJ,Moutschen M,Beguin Y,Baron F,Melin P,Quatresooz P,Parent AS,Desmecht D,Sirard JC,Salvatori R,Martens H,Geenen VG
Wed Sep 25 00:00:00 EDT 2019
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.
Journal of immunology (Baltimore, Md. : 1950)
Tang H,Wang H,Lin Q,Fan F,Zhang F,Peng X,Fang X,Liu J,Ouyang K
12-5790 was used in Flow cytometry/Cell sorting to determine the function of 1,4,5-trisphosphate receptor-mediated Ca2+ release in B cells.
Sat Jul 15 00:00:00 EDT 2017
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
Cell
Tian M,Cheng C,Chen X,Duan H,Cheng HL,Dao M,Sheng Z,Kimble M,Wang L,Lin S,Schmidt SD,Du Z,Joyce MG,Chen Y,DeKosky BJ,Chen Y,Normandin E,Cantor E,Chen RE,Doria-Rose NA,Zhang Y,Shi W,Kong WP,Choe M,Henry AR,Laboune F,Georgiev IS,Huang PY,Jain S,McGuire AT,Georgeson E,Menis S,Douek DC,Schief WR,Stamatatos L,Kwong PD,Shapiro L,Haynes BF,Mascola JR,Alt FW
12-5790 was used in RT-PCR to describe a mouse vaccination model that allows a germline human IGHV1-2(*)02 segment to undergo normal V(D)J recombination.
Thu Sep 08 00:00:00 EDT 2016
Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms.
Blood
Lykken JM,Horikawa M,Minard-Colin V,Kamata M,Miyagaki T,Poe JC,Tedder TF
12-5790 was used in Flow cytometry/Cell sorting to elucidate the mechanisms through which non-Hodgkin lymphomas initially resist or gain resistance to immunotherapy.
Thu Apr 14 00:00:00 EDT 2016
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.
Genes & development
Ikawa T,Masuda K,Endo TA,Endo M,Isono K,Koseki Y,Nakagawa R,Kometani K,Takano J,Agata Y,Katsura Y,Kurosaki T,Vidal M,Koseki H,Kawamoto H
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2016
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Proceedings of the National Academy of Sciences of the United States of America
Lu G,Duan J,Shu S,Wang X,Gao L,Guo J,Zhang Y
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Tue Feb 02 00:00:00 EST 2016
Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Cell death and differentiation
Belle JI,Petrov JC,Langlais D,Robert F,Cencic R,Shen S,Pelletier J,Gros P,Nijnik A
12-5790 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the transcriptional activation of p53 stress responses in Mysm1-deficient haematopoietic stem and progenitor cells.
Sun May 01 00:00:00 EDT 2016
Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Miller ML,Chen J,Daniels MD,McKeague MG,Wang Y,Yin D,Vu V,Chong AS,Alegre ML
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that transferred CD4+TCR-Tg T-cells alter many aspects of endogenous alloimmunity.
Sat Oct 01 00:00:00 EDT 2016
Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells.
PLoS pathogens
Frenkel D,Zhang F,Guirnalda P,Haynes C,Bockstal V,Radwanska M,Magez S,Black SJ
12-5790 was used in Flow cytometry/Cell sorting to investigate the mechanism by which natural killer cells in Trypanosoma brucei infected mice kill B cells, suppress humoral immunity and induce early mortality.
Fri Jul 01 00:00:00 EDT 2016
Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13.
Genesis (New York, N.Y. : 2000)
Yu M,Al-Dallal S,Al-Haj L,Panjwani S,McCartney AS,Edwards SM,Manjunath P,Walker C,Awgulewitsch A,Hentges KE
12-5790 was used in Flow cytometry/Cell sorting to study the regulatory factors controlling the mouse zinc-finger gene Zfp521; a B-cell proto-oncogene.
Sat Oct 01 00:00:00 EDT 2016
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system.
Nature communications
Cheong TC,Compagno M,Chiarle R
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Wed Mar 09 00:00:00 EST 2016
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
The Journal of experimental medicine
Fiala GJ,Janowska I,Prutek F,Hobeika E,Satapathy A,Sprenger A,Plum T,Seidl M,Dengjel J,Reth M,Cesca F,Brummer T,Minguet S,Schamel WW
12-5790 was used in Flow cytometry/Cell sorting to study Kidins220/ARMS binding to the B cell antigen receptor and its regulation of B cell development and activation.
Mon Sep 21 00:00:00 EDT 2015
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Mon Apr 18 00:00:00 EDT 2016
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
The Journal of experimental medicine
Rouaud P,Saintamand A,Saad F,Carrion C,Lecardeur S,Cogné M,Denizot Y
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Mon May 05 00:00:00 EDT 2014
Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950)
Bökers S,Urbat A,Daniel C,Amann K,Smith KG,Espéli M,Nitschke L
12-5790 was used in Flow cytometry/Cell sorting to study how loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis.
Tue Apr 01 00:00:00 EDT 2014
The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice.
The Journal of biological chemistry
Koenig PA,Nicholls PK,Schmidt FI,Hagiwara M,Maruyama T,Frydman GH,Watson N,Page DC,Ploegh HL
12-5790 was used in Flow cytometry/Cell sorting to identify an essential function for the ubiquitin-proteasome-system in spermiogenesis.
Fri Dec 12 00:00:00 EST 2014
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
eLife
Kläsener K,Maity PC,Hobeika E,Yang J,Reth M
12-5790 was used in Flow cytometry/Cell sorting to provide direct evidence for the opening of B cell antigen receptor dimers during B cell activation.
Tue Jun 24 00:00:00 EDT 2014
Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.
Leukemia
DiLillo DJ,Weinberg JB,Yoshizaki A,Horikawa M,Bryant JM,Iwata Y,Matsushita T,Matta KM,Chen Y,Venturi GM,Russo G,Gockerman JP,Moore JO,Diehl LF,Volkheimer AD,Friedman DR,Lanasa MC,Hall RP,Tedder TF
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that malignant IL-10-competent CLL cells exhibit regulatory functions comparable to normal B10 cells.
Tue Jan 01 00:00:00 EST 2013
Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function.
Leukemia
DiLillo DJ,Weinberg JB,Yoshizaki A,Horikawa M,Bryant JM,Iwata Y,Matsushita T,Matta KM,Chen Y,Venturi GM,Russo G,Gockerman JP,Moore JO,Diehl LF,Volkheimer AD,Friedman DR,Lanasa MC,Hall RP,Tedder TF
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that malignant IL-10-competent CLL cells exhibit regulatory functions comparable to normal B10 cells.
Tue Jan 01 00:00:00 EST 2013
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
eLife
Olive V,Sabio E,Bennett MJ,De Jong CS,Biton A,McGann JC,Greaney SK,Sodir NM,Zhou AY,Balakrishnan A,Foth M,Luftig MA,Goga A,Speed TP,Xuan Z,Evan GI,Wan Y,Minella AC,He L
12-5790 was used in Flow cytometry/Cell sorting to suggest that the unique gene structure of a polycistronic oncomir means there is a delicate balance between oncogene and tumour suppresor crosstalk.
Tue Oct 15 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow.
Arthritis and rheumatism
Li J,Ju Y,Bouta EM,Xing L,Wood RW,Kuzin I,Bottaro A,Ritchlin CT,Schwarz EM
12-5790 was used in Flow cytometry/Cell sorting to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells.
Tue Jan 01 00:00:00 EST 2013
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
12-5790-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
12-5790 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 EDT 2011
Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses.
European journal of immunology
Bossen C,Tardivel A,Willen L,Fletcher CA,Perroud M,Beermann F,Rolink AG,Scott ML,Mackay F,Schneider P
12-5790 was used in Flow cytometry/Cell sorting to study the functional importance of B-cell-activating factor of the TNF family processing by proteolytic cleavage.
Tue Mar 01 00:00:00 EST 2011
CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice.
Arthritis research & therapy
Li J,Zhou Q,Wood RW,Kuzin I,Bottaro A,Ritchlin CT,Xing L,Schwarz EM
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that asymmetric knee arthritis in TNF-Tg mice occurs simultaneously with ipsilateral PLN and ILN collapse.
Wed Aug 31 00:00:00 EDT 2011
Mechanism for pre-B cell loss in VH-mutant rabbits.
Journal of immunology (Baltimore, Md. : 1950)
Robbins GR,Knight KL
12-5790 was used in Flow cytometry/Cell sorting to demonstrate that MARCH2 (membrane-associated RING-CH protein 2) negatively regulates autophagy.
Tue Nov 01 00:00:00 EDT 2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
12-5790 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 EDT 2011
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
Nature immunology
Capasso M,Bhamrah MK,Henley T,Boyd RS,Langlais C,Cain K,Dinsdale D,Pulford K,Khan M,Musset B,Cherny VV,Morgan D,Gascoyne RD,Vigorito E,DeCoursey TE,MacLennan IC,Dyer MJ
12-5790 was used in Flow cytometry/Cell sorting to investigate how HVCN1 modulates BCR signal strength through regulation of BCR-dependent generation of reactive oxygen species.
Mon Mar 01 00:00:00 EST 2010
Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Kuzin I,Moshkani S,Proulx ST,Xing L,Skrombolas D,Dunn R,Sanz I,Schwarz EM,Bottaro A
12-5790 was used in Flow cytometry/Cell sorting to investigate the pathogenic role of B lymphocytes in rheumatoid arthritis, showing that CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis.
Tue Jun 01 00:00:00 EDT 2010
CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors.
Journal of immunology (Baltimore, Md. : 1950)
Haynes NM,Hawkins ED,Li M,McLaughlin NM,Hämmerling GJ,Schwendener R,Winoto A,Wensky A,Yagita H,Takeda K,Kershaw MH,Darcy PK,Smyth MJ
12-5790 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms contributing to the antitumour activity of selective antagonism of death receptors 4 and 5, showing that CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy.
Thu Jul 01 00:00:00 EDT 2010
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
miR-19 is a key oncogenic component of mir-17-92.
Genes & development
Olive V,Bennett MJ,Walker JC,Ma C,Jiang I,Cordon-Cardo C,Li QJ,Lowe SW,Hannon GJ,He L
12-5790 was used in Flow cytometry/Cell sorting to reveal the essential role of miR-19 in mediating the oncogenic activity of mir-17-92.
Tue Dec 15 00:00:00 EST 2009
Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation.
Proteomics
Fathi A,Pakzad M,Taei A,Brink TC,Pirhaji L,Ruiz G,Sharif Tabe Bordbar M,Gourabi H,Adjaye J,Baharvand H,Salekdeh GH
12-5790 was used in Flow cytometry/Cell sorting to analyse human embryonic stem cell line, Royan H5, in undifferentiated cells and different stages of spontaneous differentiation by embryoid body formation.
Sun Nov 01 00:00:00 EDT 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-5790 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using IgM monoclonal antibody (Product # 12-5790-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007
